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Why Is Aducanumab Priced at $56,000 per Patient? Lessons for Drug-Pricing Reform
James C. Robinson, Ph.D., M.P.H.
doi : 10.1056/NEJMp2113679
N Engl J Med 2021; 385:2017-2019
Medicare Coverage of Aducanumab — Implications for State Budgets
Rachel E. Sachs, J.D., M.P.H., and Nicholas Bagley, J.D.
doi : 10.1056/NEJMp2115297
N Engl J Med 2021; 385:2019-2021
The Little Things
Jessica C. Stuart, M.D.
doi : 10.1056/NEJMp2112424
N Engl J Med 2021; 385:2021-2023
Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults
Mark D. Neuman, M.D., Rui Feng, Ph.D., Jeffrey L. Carson, M.D., Lakisha J. Gaskins, M.H.S., Derek Dillane, M.D., Daniel I. Sessler, M.D., Frederick Sieber, M.D., Jay Magaziner, Ph.D., M.S.Hyg., Edward R. Marcantonio, M.D., Samir Mehta, M.D., Diane Menio, M.S., Sabry Ayad, M.D., Trevor Stone, M.D., Steven Papp, M.D., Eric S. Schwenk, M.D., Nabil Elkassabany, M.D., Mitchell Marshall, M.D., J. Douglas Jaffe, D.O., Charles Luke, M.D., Balram Sharma, M.D., Syed Azim, M.D., Robert A. Hymes, M.D., Ki-Jinn Chin, M.D., Richard Sheppard, M.D., Barry Perlman, M.D., Ph.D., Joshua Sappenfield, M.D., Ellen Hauck, D.O., Ph.D., Mark A. Hoeft, M.D., Mark Giska, M.D., Yatish Ranganath, M.D., Tiffany Tedore, M.D., Stephen Choi, M.D., Jinlei Li, M.D., Ph.D., M. Kwesi Kwofie, M.D., Antoun Nader, M.D., Robert D. Sanders, M.D., Brian F.S. Allen, M.D., Kamen Vlassakov, M.D., Stephen Kates, M.D., Lee A. Fleisher, M.D., James Dattilo, B.S., Ann Tierney, M.S., Alisa J. Stephens-Shields, Ph.D., and Susan S. Ellenberg, Ph.D. for the REGAIN Investigators*
doi : 10.1056/NEJMoa2113514
N Engl J Med 2021; 385:2025-2035
The effects of spinal anesthesia as compared with general anesthesia on the ability to walk in older adults undergoing surgery for hip fracture have not been well studied.
Belzutifan for Renal Cell Carcinoma in von Hippel–Lindau Disease
Eric Jonasch, M.D., Frede Donskov, M.D., Ph.D., Othon Iliopoulos, M.D., W. Kimryn Rathmell, M.D., Ph.D., Vivek K. Narayan, M.D., Benjamin?L. Maughan, M.D., Stephane Oudard, M.D., Tobias Else, M.D., Jodi K. Maranchie, M.D., Sarah J. Welsh, M.D., Sanjay? Thamake, Ph.D., Eric K. Park, M.D., Rodolfo F. Perini, M.D., W. Marston Linehan, M.D., and Ramaprasad Srinivasan, M.D., Ph.D. for the MK-6482-004 Investigators*
doi : 10.1056/NEJMoa2103425
N Engl J Med 2021; 385:2036-2046
Patients with von Hippel–Lindau (VHL) disease have a high incidence of renal cell carcinoma owing to VHL gene inactivation and constitutive activation of the transcription factor hypoxia-inducible factor 2? (HIF-2?).
Live Birth with or without Preimplantation Genetic Testing for Aneuploidy
Junhao Yan, M.D., Ph.D., Yingying Qin, M.D., Ph.D., Han Zhao, M.D., Ph.D., Yun Sun, M.D., Ph.D., Fei Gong, M.D., Ph.D., Rong Li, M.D., Xiaoxi Sun, M.D., Ph.D., Xiufeng Ling, M.D., Ph.D., Hong Li, M.D., Cuifang Hao, M.D., Ph.D., Jichun Tan, Ph.D., Jing Yang, M.D., Ph.D., Yimin Zhu, M.D., Ph.D., Fenghua Liu, M.D., Dawei Chen, Ph.D., Daimin Wei, M.D., Ph.D., Juanjuan Lu, M.S., Tianxiang Ni, M.D., Ph.D., Wei Zhou, M.D., Ph.D., Keliang Wu, Ph.D., Yuan Gao, Ph.D., Yuhua Shi, M.D., Ph.D., Yao Lu, M.D., Ting Zhang, Ph.D., Wei Wu, M.D., Xiang Ma, M.D., Ph.D., Hailan Ma, Ph.D., Jing Fu, Ph.D., Junqiang Zhang, Ph.D., Qingxia Meng, M.D., Heping Zhang, Ph.D., Richard S. Legro, M.D., and Zi-Jiang Chen, M.D., Ph.D.
doi : 10.1056/NEJMoa2103613
N Engl J Med 2021; 385:2047-2058
Embryo selection with preimplantation genetic testing for aneuploidy (PGT-A) may improve pregnancy outcomes after initial embryo transfer. However, it remains uncertain whether PGT-A improves the cumulative live-birth rate as compared with conventional in vitro fertilization (IVF).
Belzutifan, a Potent HIF2? Inhibitor, in the Pacak–Zhuang Syndrome
Junne Kamihara, M.D., Ph.D., Kayla V. Hamilton, M.S., C.G.C., Jessica A. Pollard, M.D., Catherine M. Clinton, M.S., Jill A. Madden, Ph.D., C.G.C., Jasmine Lin, M.S., Alma Imamovic, M.Sc., Catherine B. Wall, N.P., Ari J. Wassner, M.D., Brent R. Weil, M.D., M.P.H., Matthew M. Heeney, M.D., Sara O. Vargas, M.D., William G. Kaelin, Jr., M.D., Katherine A. Janeway, M.D., Rodolfo F. Perini, M.D., Naseem J. Zojwalla, M.D., Stephan D. Voss, M.D., Ph.D., and Steven G. DuBois, M.D.
doi : 10.1056/NEJMoa2110051
N Engl J Med 2021; 385:2059-2065
New Horizons in the Treatment of Osteosarcoma
Paul S. Meltzer, M.D., Ph.D., and Lee J. Helman, M.D.
doi : 10.1056/NEJMra2103423
N Engl J Med 2021; 385:2066-2076
Tinea Capitis Due to Microsporum canis
Tingting Wang, M.B., B.S., and Jia-Qi Chen, M.D., Ph.D.
doi : 10.1056/NEJMicm2108047
N Engl J Med 2021; 385:2077
Pyostomatitis Vegetans
Massimo Petruzzi, D.D.S., Ph.D., and Fedora della Vella, D.D.S.
doi : 10.1056/NEJMicm2108327
N Engl J Med 2021; 385:e77
Case 36-2021: A 22-Year-Old Man with Pain and Erythema of the Left Hand
Lisa G. Winston, M.D., Marisa L. Winkler, M.D., Ph.D., Arvin Kheterpal, M.D., and Julian A. Villalba, M.D.
doi : 10.1056/NEJMcpc2107357
N Engl J Med 2021; 385:2078-2086
Patient-Centered Outcomes after General and Spinal Anesthesia
James P. Rathmell, M.D., and Michael S. Avidan, M.B., B.Ch.
doi : 10.1056/NEJMe2116017
N Engl J Med 2021; 385:2088-2089
Changing the Course of an Orphan Disease
Manuela Schmidinger, M.D.
doi : 10.1056/NEJMe2114846
N Engl J Med 2021; 385:2090-2091
Audio Interview: What’s Gone Right in Our Battle against Covid-19
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2118514
N Engl J Med 2021; 385:e95
Treatment of Diabetes — To Pump or Not to Pump
James O’Connell, M.B., B.Ch, B.A.O., David M. Nathan, M.D., Timothy O’Brien, M.D., Ph.D., and Derek T. O’Keeffe, M.D., Ph.D.
doi : 10.1056/NEJMclde2112076
N Engl J Med 2021; 385:2092-2095
The Imperative of Responsible Innovation in Reproductive Medicine
Sebastiaan Mastenbroek, Ph.D., Guido de Wert, Ph.D., and Eli Y. Adashi, M.D.
doi : 10.1056/NEJMsb2101718
N Engl J Med 2021; 385:2096-2100
Effectiveness of BNT162b2 Vaccine against Delta Variant in Adolescents
doi : 10.1056/NEJMc2114290
N Engl J Med 2021; 385:2101-2103
Vaccine-Induced Thrombocytopenia with Severe Headache
doi : 10.1056/NEJMc2112974
N Engl J Med 2021; 385:2103-2105
Efpeglenatide and Heart and Kidney Outcomes in Type 2 Diabetes
doi : 10.1056/NEJMc2115776
N Engl J Med 2021; 385:2105-2107
Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock
doi : 10.1056/NEJMc2114890
N Engl J Med 2021; 385:2107-2109
MRI-Targeted Biopsy in Prostate Cancer Screening
doi : 10.1056/NEJMc2115775
N Engl J Med 2021; 385:2109-2111
Fetal Surgery for Severe Left Diaphragmatic Hernia
doi : 10.1056/NEJMc2115673
N Engl J Med 2021; 385:2111-2112
