One-year access to more than 500 world journals available in the system
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Blood Donation by Gay and Bisexual Men — The Need for a Policy Update
Amitai S. Miller, B.A., and Sean Cahill, Ph.D.
doi : 10.1056/NEJMp2112329
N Engl J Med 2021; 385:1537-1539
“All Labor Has Dignity” — The Case for Wage Equity for Essential Health Care Workers
Lawson Ung, M.D., Fatima Cody Stanford, M.D., M.P.H., M.P.A., M.B.A., and James Chodosh, M.D., M.P.H.
doi : 10.1056/NEJMp2108695
N Engl J Med 2021; 385:1539-1542
Peak Moments — When Kindergarten Is High Risk
Sasha D. Mallett, M.D., M.P.H.
doi : 10.1056/NEJMp2113422
N Engl J Med 2021; 385:1543-1545
A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH
Sven M. Francque, M.D., Ph.D., Pierre Bedossa, M.D., Ph.D., Vlad Ratziu, M.D., Ph.D., Quentin M. Anstee, M.D., Ph.D., Elisabetta Bugianesi, M.D., Ph.D., Arun J. Sanyal, M.D., Rohit Loomba, M.D., M.H.Sc., Stephen A. Harrison, M.D., Rozalina Balabanska, M.D., Lyudmila Mateva, M.D., Ph.D., Nicolas Lanthier, M.D., Ph.D., Naim Alkhouri, M.D., Christophe Moreno, M.D., Ph.D., Jörn M. Schattenberg, M.D., Diana Stefanova-Petrova, M.D., Luisa Vonghia, M.D., Ph.D., Régine Rouzier, M.D., Maeva Guillaume, M.D., Ph.D., Alexander Hodge, M.B., B.S., Ph.D., Manuel Romero-Gómez, M.D., Ph.D., Philippe Huot-Marchand, M.Sc., Martine Baudin, M.D., Marie-Paule Richard, M.D., Jean-Louis Abitbol, M.D., Pierre Broqua, Ph.D., Jean-Louis Junien, Ph.D., and Manal F. Abdelmalek, M.D., M.P.H. for the NATIVE Study Group*
doi : 10.1056/NEJMoa2036205
N Engl J Med 2021; 385:1547-1558
Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need. Lanifibranor is a pan-PPAR (peroxisome proliferator–activated receptor) agonist that modulates key metabolic, inflammatory, and fibrogenic pathways in the pathogenesis of NASH.
Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease
Arun J. Sanyal, M.D., Mark L. Van Natta, M.H.S., Jeanne Clark, M.D., M.P.H., Brent A. Neuschwander-Tetri, M.D., AnnaMae Diehl, M.D., Srinivasan Dasarathy, M.D., Rohit Loomba, M.D., M.H.Sc., Naga Chalasani, M.D., Kris Kowdley, M.D., Bilal Hameed, M.D., Laura A. Wilson, Sc.M., Katherine P. Yates, Sc.M., Patricia Belt, B.S., Mariana Lazo, M.D., Ph.D., David E. Kleiner, M.D., Ph.D., Cynthia Behling, M.D., Ph.D., and James Tonascia, Ph.D. for the NASH Clinical Research Network (CRN)*
doi : 10.1056/NEJMoa2029349
N Engl J Med 2021; 385:1559-1569
The prognoses with respect to mortality and hepatic and nonhepatic outcomes across the histologic spectrum of nonalcoholic fatty liver disease (NAFLD) are not well defined.
AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis
Johann Morelle, M.D., Ph.D., Céline Marechal, Ph.D., Zanzhe Yu, M.D., Ph.D., Huguette Debaix, M.Sc., Tanguy Corre, Ph.D., Mark Lambie, M.D., Ph.D., Marion Verduijn, Ph.D., Friedo Dekker, Ph.D., Philippe Bovy, M.D., Pieter Evenepoel, M.D., Ph.D., Bert Bammens, M.D., Ph.D., Rafael Selgas, M.D., Ph.D., Maria A. Bajo, M.D., Ph.D., Annemieke M. Coester, M.D., Ph.D., Amadou Sow, M.D., Ph.D., Nicolas Hautem, Ph.D., Dirk G. Struijk, M.D., Ph.D., Raymond T. Krediet, M.D., Ph.D., Jean-Luc Balligand, M.D., Ph.D., Eric Goffin, M.D., Ralph Crott, Ph.D., Pierre Ripoche, Ph.D., Simon Davies, M.D., and Olivier Devuyst, M.D., Ph.D.
doi : 10.1056/NEJMoa2034279
N Engl J Med 2021; 385:1570-1580
Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribute to that variability.
Obesity-Associated GNAS Mutations and the Melanocortin Pathway
Edson Mendes de Oliveira, Ph.D., Julia M. Keogh, B.Sc., Fleur Talbot, M.B., B.S., Ph.D., Elana Henning, B.Soc.Sc., Rachel Ahmed, B.Sc., Aliki Perdikari, Ph.D., Rebecca Bounds, Ph.D., Natalia Wasiluk, M.Sc., Vikram Ayinampudi, B.Sc., Inês Barroso, Ph.D., Jacek Mokrosi?ski, Ph.D., Deepthi Jyothish, M.B., B.S., Sharon Lim, M.B., Ch.B., Sanjay Gupta, M.B., B.S., Melanie Kershaw, M.B., Ch.B., Cristina Matei, M.D., Praveen Partha, M.B., B.S., Tabitha Randell, M.B., Ch.B., Antoinette McAulay, M.B., Ch.B., M.D., Louise C. Wilson, M.B., Ch.B., Tim Cheetham, M.B., Ch.B., M.D., Elizabeth C. Crowne, M.B., B.S., M.D., Peter Clayton, M.B., Ch.B., M.D., and I. Sadaf Farooqi, M.B., Ch.B., Ph.D.
doi : 10.1056/NEJMoa2103329
N Engl J Med 2021; 385:1581-1592
GNAS encodes the G?s (stimulatory G-protein alpha subunit) protein, which mediates G protein–coupled receptor (GPCR) signaling. GNAS mutations cause developmental delay, short stature, and skeletal abnormalities in a syndrome called Albright’s hereditary osteodystrophy. Because of imprinting, mutations on the maternal allele also cause obesity and hormone resistance (pseudohypoparathyroidism).
Point-of-Care Ultrasonography
José L. Díaz-Gómez, M.D., Paul H. Mayo, M.D., and Seth J. Koenig, M.D.
doi : 10.1056/NEJMra1916062
N Engl J Med 2021; 385:1593-1602
Testicular Torsion
Manjeet Kumar, M.B., B.S., and Vishal Gautam, M.B., B.S.
doi : 10.1056/NEJMicm2110702
N Engl J Med 2021; 385:1603
Emphysematous Hepatitis
Alex Bofill, M.D., and Francesc Marco, M.D., Ph.D.
doi : 10.1056/NEJMicm2108779
N Engl J Med 2021; 385:e58
Case 32-2021: A 14-Year-Old Girl with Swelling of the Jaw and Hypercalcemia
Thomas O. Carpenter, M.D., Hillary R. Kelly, M.D., Jordan S. Sherwood, M.D., Zachary S. Peacock, M.D., D.M.D., and Vania Nosé, M.D., Ph.D.
doi : 10.1056/NEJMcpc2107351
N Engl J Med 2021; 385:1604-1613
Nonalcoholic Steatohepatitis — Opportunities and Challenges
Guadalupe Garcia-Tsao, M.D.
doi : 10.1056/NEJMe2110989
N Engl J Med 2021; 385:1615-1617
Aquaporin-1 Expression and Ultrafiltration of the Peritoneal Membrane
Daniel G. Bichet, M.D.
doi : 10.1056/NEJMe2114645
N Engl J Med 2021; 385:1617-1619
Obesity and G?s Variants
Harald Jüppner, M.D.
doi : 10.1056/NEJMe2113123
N Engl J Med 2021; 385:1619-1622
Audio Interview: A New Look at Covid-19 Vaccine Boosters
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2116820
N Engl J Med 2021; 385:e72
Optogenetics — The Might of Light
Michael Häusser, Ph.D.
doi : 10.1056/NEJMcibr2111915
N Engl J Med 2021; 385:1623-1626
SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3
doi : 10.1056/NEJMc2113468
N Engl J Med 2021; 385:1627-1629
Covid-19 Breakthrough Infections in Vaccinated Health Care Workers
doi : 10.1056/NEJMc2113497
N Engl J Med 2021; 385:1629-1631
Ruxolitinib for Chronic Graft-versus-Host Disease
doi : 10.1056/NEJMc2113499
N Engl J Med 2021; 385:1631-1632
Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease
doi : 10.1056/NEJMx210010
N Engl J Med 2021; 385:1632
