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Vigilante Injustice — Deputizing and Weaponizing the Public to Stop Abortions
R. Alta Charo, J.D.
doi : 10.1056/NEJMp2114886
N Engl J Med 2021; 385:1441-1443
Eviction and the Necessary Conditions for Health
Katie Moran-McCabe, J.D., and Scott Burris, J.D.
doi : 10.1056/NEJMp2031947
N Engl J Med 2021; 385:1443-1445
The Drug-Dosing Conundrum in Oncology — When Less Is More
Mirat Shah, M.D., Atiqur Rahman, Ph.D., Marc R. Theoret, M.D., and Richard Pazdur, M.D.
doi : 10.1056/NEJMp2109826
N Engl J Med 2021; 385:1445-1447
Empagliflozin in Heart Failure with a Preserved Ejection Fraction
Stefan D. Anker, M.D., Ph.D., Javed Butler, M.D., Gerasimos Filippatos, M.D., Ph.D., João P. Ferreira, M.D., Edimar Bocchi, M.D., Michael Böhm, M.D., Ph.D., Hans-Peter Brunner–La Rocca, M.D., Dong-Ju Choi, M.D., Vijay Chopra, M.D., Eduardo Chuquiure-Valenzuela, M.D., Nadia Giannetti, M.D., Juan Esteban Gomez-Mesa, M.D., Stefan Janssens, M.D., Ph.D., James L. Januzzi, M.D., Jose R. Gonzalez-Juanatey, M.D., Bela Merkely, M.D., Stephen J. Nicholls, M.D., Sergio V. Perrone, M.D., Ileana L. Piña, M.D., Piotr Ponikowski, M.D., Michele Senni, M.D., David Sim, M.D., Jindrich Spinar, M.D., Iain Squire, M.D., Stefano Taddei, M.D., Hiroyuki Tsutsui, M.D., Subodh Verma, M.D., Dragos Vinereanu, M.D., Jian Zhang, M.D., Ph.D., Peter Carson, M.D., Carolyn Su Ping Lam, M.D., Nikolaus Marx, M.D., Cordula Zeller, Dipl.Math., Naveed Sattar, M.D., Waheed Jamal, M.D., Sven Schnaidt, M.Sc., Janet M. Schnee, M.D., Martina Brueckmann, M.D., Stuart J. Pocock, Ph.D., Faiez Zannad, M.D., Ph.D., and Milton Packer, M.D. for the EMPEROR-Preserved Trial Investigators*
doi : 10.1056/NEJMoa2107038
N Engl J Med 2021; 385:1451-1461
Sodium–glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain.
Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder
Linmarie Sikich, M.D., Alexander Kolevzon, M.D., Bryan H. King, M.D., Christopher J. McDougle, M.D., Kevin B. Sanders, M.D., Soo-Jeong Kim, M.D., Marina Spanos, Ph.D., Tara Chandrasekhar, M.D., M.D. Pilar Trelles, M.D., Carol M. Rockhill, M.D., Michelle L. Palumbo, M.D., Allyson Witters Cundiff, M.D., Alicia Montgomery, M.B., B.S., Paige Siper, Ph.D., Mendy Minjarez, Ph.D., Lisa A. Nowinski, Ph.D., Sarah Marler, M.A., Lauren C. Shuffrey, Ph.D., Cheryl Alderman, B.S., Jordana Weissman, B.A., Brooke Zappone, B.S., Jennifer E. Mullett, R.N., Hope Crosson, B.S.W., Natalie Hong, M.S., Stephen K. Siecinski, B.S., Stephanie N. Giamberardino, Sc.M., Sheng Luo, Ph.D., Lilin She, Ph.D., Manjushri Bhapkar, M.S., Russell Dean, M.S., Abby Scheer, M.S.I.S., Jacqueline L. Johnson, Dr.P.H., Simon G. Gregory, Ph.D., and Jeremy Veenstra-VanderWeele, M.D.
doi : 10.1056/NEJMoa2103583
N Engl J Med 2021; 385:1462-1473
Experimental studies and small clinical trials have suggested that treatment with intranasal oxytocin may reduce social impairment in persons with autism spectrum disorder. Oxytocin has been administered in clinical practice to many children with autism spectrum disorder.
Covid-19 Breakthrough Infections in Vaccinated Health Care Workers
Moriah Bergwerk, M.B., B.S., Tal Gonen, B.A., Yaniv Lustig, Ph.D., Sharon Amit, M.D., Marc Lipsitch, Ph.D., Carmit Cohen, Ph.D., Michal Mandelboim, Ph.D., Einav Gal Levin, M.D., Carmit Rubin, N.D., Victoria Indenbaum, Ph.D., Ilana Tal, R.N., Ph.D., Malka Zavitan, R.N., M.A., Neta Zuckerman, Ph.D., Adina Bar-Chaim, Ph.D., Yitshak Kreiss, M.D., and Gili Regev-Yochay, M.D.
doi : 10.1056/NEJMoa2109072
N Engl J Med 2021; 385:1474-1484
Despite the high efficacy of the BNT162b2 messenger RNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough infections have been reported, including infections among health care workers. Data are needed to characterize these infections and define correlates of breakthrough and infectivity.
Efficacy of a Cell-Culture–Derived Quadrivalent Influenza Vaccine in Children
Terence Nolan, M.B., B.S., Ph.D., Alexandre C. Fortanier, Ph.D., Brett Leav, M.D., Airi Põder, M.D., Lulu C. Bravo, M.D., Henryk T. Szyma?ski, M.D., Marten Heeringa, Ph.D., Wim Vermeulen, Ph.D., Vince Matassa, Ph.D., Igor Smolenov, M.D., Ph.D., and Jonathan M. Edelman, M.D.
doi : 10.1056/NEJMoa2024848
N Engl J Med 2021; 385:1485-1495
Cell-culture–derived influenza vaccines may enable a closer antigenic match to circulating strains of influenza virus by avoiding egg-adapted mutations.
Aspergillus Infections
George R. Thompson, III, M.D., and Jo-Anne H. Young, M.D.
doi : 10.1056/NEJMra2027424
N Engl J Med 2021; 385:1496-1509
Placement of a Double-Lumen Endotracheal Tube
David Hao, M.D., Daniel Saddawi-Konefka, M.D., Sarah Low, M.D., Paul Alfille, M.D., and Keith Baker, M.D., Ph.D.
doi : 10.1056/NEJMvcm2026684
N Engl J Med 2021; 385:e52
Skeletal Fluorosis
Lakshman Meena, M.D., and Ranjan Gupta, M.D., D.M.
doi : 10.1056/NEJMicm2103503
N Engl J Med 2021; 385:1510
Nocardial Brain Abscesses
Yi-Wei Lee, M.D., and Hsin-Yi Liu, M.D.
doi : 10.1056/NEJMicm2104629
N Engl J Med 2021; 385:e53
Case 31-2021: A 21-Year-Old Man with Sore Throat, Epistaxis, and Oropharyngeal Petechiae
Hanno Hock, M.D., Ph.D., Hillary R. Kelly, M.D., Eric A. Meyerowitz, M.D., Matthew J. Frigault, M.D., and Lucas R. Massoth, M.D.
doi : 10.1056/NEJMcpc2027096
N Engl J Med 2021; 385:1511-1520
SGLT2 Inhibition in Heart Failure with a Preserved Ejection Fraction — A Win against a Formidable Foe
Mark H. Drazner, M.D.
doi : 10.1056/NEJMe2113008
N Engl J Med 2021; 385:1522-1524
Oxytocin for Autism Spectrum Disorder — Down, but Not Out
Daniel H. Geschwind, M.D., Ph.D.
doi : 10.1056/NEJMe2110158
N Engl J Med 2021; 385:1524-1525
Audio Interview: Reporting on Covid-19
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Katherine J. Wu, Ph.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2115837
N Engl J Med 2021; 385:e66
Data in Crisis — Rethinking Disaster Preparedness in the United States
Satchit Balsari, M.D., M.P.H., Mathew V. Kiang, Sc.D., and Caroline O. Buckee, D.Phil.
doi : 10.1056/NEJMms2104654
N Engl J Med 2021; 385:1526-1530
Empagliflozin and Major Renal Outcomes in Heart Failure
doi : 10.1056/NEJMc2112411
N Engl J Med 2021; 385:1531-1533
Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion
doi : 10.1056/NEJMc2113891
N Engl J Med 2021; 385:1533-1535
On Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons
doi : 10.1056/NEJMc2113516
N Engl J Med 2021; 385:1535-1536
Decoding Speech from Cortical Surface Electrical Activity
doi : 10.1056/NEJMc2113384
N Engl J Med 2021; 385:e55
Vadadustat for Anemia in Patients with Dialysis-Dependent or Non–Dialysis-Dependent Chronic Kidney Disease
doi : 10.1056/NEJMc2110095
N Engl J Med 2021; 385:e56
A Trial of a Transglutaminase 2 Inhibitor in Celiac Disease
doi : 10.1056/NEJMc2112688
N Engl J Med 2021; 385:e57
Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons
doi : 10.1056/NEJMx210016
N Engl J Med 2021; 385:1536
