New England Journal of Medicine




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Methods of Public Health Research — Strengthening Causal Inference from Observational Data

Miguel A. Hernán, M.D., Dr.P.H.

doi : 10.1056/NEJMp2113319

N Engl J Med 2021; 385:1345-1348

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The No Surprises Act and Informed Financial Consent

Barak Richman, J.D., Ph.D., Mark Hall, J.D., and Kevin Schulman, M.D.

doi : 10.1056/NEJMp2109971

N Engl J Med 2021; 385:1348-1351

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Integrating Research into Community Practice — Toward Increased Diversity in Clinical Trials

Janet Woodcock, M.D., Richardae Araojo, Pharm.D., Twyla Thompson, Pharm.D., and Gary A. Puckrein, Ph.D.

doi : 10.1056/NEJMp2107331

N Engl J Med 2021; 385:1351-1353

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Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings

Mark G. Thompson, Ph.D., Edward Stenehjem, M.D., Shaun Grannis, M.D., Sarah W. Ball, Sc.D., Allison L. Naleway, Ph.D., Toan C. Ong, Ph.D., Malini B. DeSilva, M.D., M.P.H., Karthik Natarajan, Ph.D., Catherine H. Bozio, Ph.D., M.P.H., Ned Lewis, M.P.H., Kristin Dascomb, M.D., Ph.D., Brian E. Dixon, M.P.A., Ph.D., Rebecca J. Birch, M.P.H., Stephanie A. Irving, M.H.S., Suchitra Rao, M.D., Elyse Kharbanda, M.D., M.P.H., Jungmi Han, B.S., Sue Reynolds, Ph.D., M.P.H., Kristin Goddard, M.P.H., Nancy Grisel, M.P.P., William F. Fadel, Ph.D., Matthew E. Levy, Ph.D., Jill Ferdinands, Ph.D., Bruce Fireman, M.A., Julie Arndorfer, M.P.H., Nimish R. Valvi, Dr.P.H., Elizabeth A. Rowley, Dr.P.H., Palak Patel, M.B., B.S., M.P.H., Ousseny Zerbo, Ph.D., Eric P. Griggs, M.P.H., Rachael M. Porter, M.P.H., Maria Demarco, Ph.D., Lenee Blanton, M.P.H., Andrea Steffens, M.P.H., Yan Zhuang, Ph.D., Natalie Olson, M.P.H., Michelle Barron, M.D., Patricia Shifflett, R.N., Stephanie J. Schrag, D.Phil., Jennifer R. Verani, M.D., M.P.H., Alicia Fry, M.D., M.P.H., Manjusha Gaglani, M.B., B.S., Eduardo Azziz-Baumgartner, M.D., M.P.H., and Nicola P. Klein, M.D., Ph.D.

doi : 10.1056/NEJMoa2110362

N Engl J Med 2021; 385:1355-1371

There are limited data on the effectiveness of the vaccines against symptomatic coronavirus disease 2019 (Covid-19) currently authorized in the United States with respect to hospitalization, admission to an intensive care unit (ICU), or ambulatory care in an emergency department or urgent care clinic.

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Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis

Lotte Boxhoorn, M.D., Sven M. van Dijk, M.D., Ph.D., Janneke van Grinsven, M.D., Ph.D., Robert C. Verdonk, M.D., Ph.D., Marja A. Boermeester, M.D., Ph.D., Thomas L. Bollen, M.D., Ph.D., Stefan A.W. Bouwense, M.D., Ph.D., Marco J. Bruno, M.D., Ph.D., Vincent C. Cappendijk, M.D., Ph.D., Cornelis H.C. Dejong, M.D., Ph.D., Peter van Duijvendijk, M.D., Ph.D., Casper H.J. van Eijck, M.D., Ph.D., et al., for the Dutch Pancreatitis Study Group*

doi : 10.1056/NEJMoa2100826

N Engl J Med 2021; 385:1372-1381

Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown.

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Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19

Michael Dougan, M.D., Ph.D., Ajay Nirula, M.D., Ph.D., Masoud Azizad, M.D., Bharat Mocherla, M.D., Robert L. Gottlieb, M.D., Ph.D., Peter Chen, M.D., Corey Hebert, M.D., Russell Perry, M.D., Joseph Boscia, M.D., Barry Heller, M.D., Jason Morris, M.D., Chad Crystal, M.D., Awawu Igbinadolor, M.D., Gregory Huhn, M.D., M.P.H.T.M., Jose Cardona, M.D., Imad Shawa, M.D., Princy Kumar, M.D., Andrew C. Adams, Ph.D., Jacob Van Naarden, B.S., Kenneth L. Custer, Ph.D., M.B.A., Michael Durante, M.S., Gerard Oakley, M.D., Andrew E. Schade, M.D., Ph.D., Timothy R. Holzer, Ph.D., Philip J. Ebert, Ph.D., Richard E. Higgs, M.S., Nicole L. Kallewaard, Ph.D., Janelle Sabo, Pharm.D., Dipak R. Patel, M.D., Ph.D., Matan C. Dabora, M.D., M.B.A., Paul Klekotka, M.D., Ph.D., Lei Shen, Ph.D., and Daniel M. Skovronsky, M.D., Ph.D. for the BLAZE-1 Investigators*

doi : 10.1056/NEJMoa2102685

N Engl J Med 2021; 385:1382-1392

Patients with underlying medical conditions are at increased risk for severe coronavirus disease 2019 (Covid-19). Whereas vaccine-derived immunity develops over time, neutralizing monoclonal-antibody treatment provides immediate, passive immunity and may limit disease progression and complications.

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Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

Yinon M. Bar-On, M.Sc., Yair Goldberg, Ph.D., Micha Mandel, Ph.D., Omri Bodenheimer, M.Sc., Laurence Freedman, Ph.D., Nir Kalkstein, B.Sc., Barak Mizrahi, M.Sc., Sharon Alroy-Preis, M.D., Nachman Ash, M.D., Ron Milo, Ph.D., and Amit Huppert, Ph.D.

doi : 10.1056/NEJMoa2114255

N Engl J Med 2021; 385:1393-1400

On July 30, 2021, the administration of a third (booster) dose of the BNT162b2 messenger RNA vaccine (Pfizer–BioNTech) was approved in Israel for persons who were 60 years of age or older and who had received a second dose of vaccine at least 5 months earlier. Data are needed regarding the effect of the booster dose on the rate of confirmed coronavirus 2019 disease (Covid-19) and the rate of severe illness.

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Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

Chee-Wah Tan, Ph.D., Wan-Ni Chia, Ph.D., Barnaby E. Young, M.R.C.P., Feng Zhu, Ph.D., Beng-Lee Lim, M.Sc., Wan-Rong Sia, B.S., Tun-Linn Thein, M.P.H., Mark I.-C. Chen, Ph.D., Yee-Sin Leo, F.R.C.P., David C. Lye, F.R.C.P., and Lin-Fa Wang, Ph.D.

doi : 10.1056/NEJMoa2108453

N Engl J Med 2021; 385:1401-1406

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Autoimmune Hemolytic Anemias

Sigbjørn Berentsen, M.D., Ph.D., and Wilma Barcellini, M.D.

doi : 10.1056/NEJMra2033982

N Engl J Med 2021; 385:1407-1419

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Pearly Penile Papules

Mar Ramirez-Lluch, M.D., and Angela Hernandez-Martin, M.D.

doi : 10.1056/NEJMicm2106984

N Engl J Med 2021; 385:1420

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Intracardiac Cement Embolism

Gabe Weininger, B.S., and John A. Elefteriades, M.D., Ph.D.

doi : 10.1056/NEJMicm2032931

N Engl J Med 2021; 385:e49

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Hard to Swallow

Michael J. Litt, M.D., Ph.D., Mary W. Montgomery, M.D., Kirstin M. Small, M.D., Amy L. Miller, M.D., Ph.D., and Joseph Loscalzo, M.D., Ph.D.

doi : 10.1056/NEJMcps2100980

N Engl J Med 2021; 385:1421-1427

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Striving for Diversity in Research Studies

doi : 10.1056/NEJMe2114651

N Engl J Med 2021; 385:1429-1430

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Covid-19 Vaccine Effectiveness and the Test-Negative Design

Natalie E. Dean, Ph.D., Joseph W. Hogan, Sc.D., and Mireille E. Schnitzer, Ph.D.

doi : 10.1056/NEJMe2113151

N Engl J Med 2021; 385:1431-1433

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Drainage for Infected Pancreatic Necrosis — Is the Waiting the Hardest Part?

Todd H. Baron, M.D.

doi : 10.1056/NEJMe2110313

N Engl J Med 2021; 385:1433-1435

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Audio Interview: Are Covid-19 Vaccine Boosters Necessary?

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2115835

N Engl J Med 2021; 385:e63

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In Gratitude for mRNA Vaccines

Lynda M. Stuart, M.D., Ph.D.

doi : 10.1056/NEJMcibr2111445

N Engl J Med 2021; 385:1436-1438

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Adjuvant Olaparib in BRCA-Mutated Breast Cancer

doi : 10.1056/NEJMc2112373

N Engl J Med 2021; 385:1439-1440

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Sudden Cardiac Death and Myocardial Fibrosis in Persons with HIV

doi : 10.1056/NEJMc2112481

N Engl J Med 2021; 385:e50

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Hematuria in Adults

doi : 10.1056/NEJMc2113014

N Engl J Med 2021; 385:e51

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