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Spotlight on the January 4 Issue
José G. Merino
doi : 10.1212/WNL.0000000000013039
vol. 98 no. 1 1-2
Message From the Editors to Our Reviewers
José G. Merino, Olga Ciccarelli, Bradford B. Worrall, Anthony A. Amato, Rebecca Burch, Stacey L. Clardy, Peter Hedera, Linda A. Hershey, Barbara C. Jobst, Renée A. Shellhaas, Elizabeth Silbermann, Roy E. Strowd, Rawan Tarawneh
doi : 10.1212/WNL.0000000000013044
vol. 98 no. 1 3-11
Multiple Sclerosis Diagnostic Criteria
Gary R. Cutter, Marcus W. Koch
doi : 10.1212/WNL.0000000000013014
vol. 98 no. 1 12-13
Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome
Massimo Filippi, Paolo Preziosa, Alessandro Meani, Gloria Dalla Costa, Sarlota Mesaros, Jelena Drulovic, Jovana Ivanovic, Alex Rovira, Mar Tintorè, Xavier Montalban, Olga Ciccarelli, Wallace Brownlee, Katherine Miszkiel, Christian Enzinger, Michael Khalil, Frederik Barkhof, Eva M.M. Strijbis, Jette L. Frederiksen, Stig P. Cramer, Enrico Fainardi, Maria Pia Amato, Claudio Gasperini, Serena Ruggieri, Vittorio Martinelli, Giancarlo Comi, Maria A. Rocca, on behalf of the MAGNIMS Study Group
doi : 10.1212/WNL.0000000000013016
vol. 98 no. 1 e1-e14
To compare the performance of the 2017 revisions to the McDonald criteria with the 2010 McDonald criteria in establishing multiple sclerosis (MS) diagnosis and predicting prognosis in patients with clinically isolated syndrome (CIS) suggestive of MS.
Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population
Milou J. Angevaare, Jet M.J. Vonk, Laiss Bertola, Laura Zahodne, Caitlin Wei-Ming Watson, Amelia Boehme, Nicole Schupf, Richard Mayeux, Mirjam I. Geerlings, Jennifer J. Manly
doi : 10.1212/WNL.0000000000013017
vol. 98 no. 1 e15-e26
To investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and subsequent course of MCI at follow-up, including sustained MCI diagnosis, classification as cognitively normal, and progression to dementia.
Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts
Madeline Uretsky, Sylvain Bouix, Ronald J. Killiany, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Asim Z. Mian, Karen Buch, Chad Farris, Daniel H. Daneshvar, Brigid Dwyer, Lee Goldstein, Douglas Katz, Christopher Nowinski, Robert Cantu, Neil Kowall, Bertrand Russell Huber, Robert A. Stern, Victor E. Alvarez, Thor D. Stein, Ann McKee, Jesse Mez, Michael L. Alosco
doi : 10.1212/WNL.0000000000013012
vol. 98 no. 1 e27-e39
Late neuropathologies of repetitive head impacts from contact sports can include chronic traumatic encephalopathy (CTE) and white matter degeneration. White matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) MRI scans are often viewed as microvascular disease from vascular risk, but might have unique underlying pathologies and risk factors in the setting of repetitive head impacts. We investigated the neuropathologic correlates of antemortem WMH in brain donors exposed to repetitive head impacts. The association between WMH and repetitive head impact exposure and informant-reported cognitive and daily function were tested.
Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease
Chadwick W. Christine, R. Mark Richardson, Amber D. Van Laar, Marin E. Thompson, Elisabeth M. Fine, Omar S. Khwaja, Chunming Li, Grace S. Liang, Andreas Meier, Eiry W. Roberts, Madeline L. Pfau, Josh R. Rodman, Krystof S. Bankiewicz, Paul S. Larson
doi : 10.1212/WNL.0000000000012952
vol. 98 no. 1 e40-e50
To report final, 36-month safety and clinical outcomes from the PD-1101 trial of NBIb-1817 (VY-AADC01) in participants with moderately advanced Parkinson disease (PD) and motor fluctuations.
Hemiplegic Migraine Associated With PRRT2 Variations
Florence Riant, Caroline Roos, Agathe Roubertie, Cécile Barbance, Jessica Hadjadj, Stéphane Auvin, Guillaume Baille, Marion Beltramone, Cécile Boulanger, Alice Cahn, Florina Cata, Emmanuel Cheuret, Jean-Christophe Cuvellier, Antoine Defo, Genevieve Demarquay, Anne Donnet, Nicolas Gaillard, Evelyne Massardier, Nathalie Guy, Sylvie Lamoureux, Laurence Le Moigno, Christian Lucas, Diana Ratiu, Sylvain Redon, Caroline Rey, Christel Thauvin, François Viallet, Elisabeth Tournier-Lasserve, Anne Ducros
doi : 10.1212/WNL.0000000000012947
vol. 98 no. 1 e51-e61
PRRT2 variants have been reported in a few cases of patients with hemiplegic migraine. To clarify the role of PRRT2 in familial hemiplegic migraine, we studied this gene in a large cohort of affected probands.
Serum Neuron-Specific Enolase Thresholds for Predicting Postcardiac Arrest Outcome
Kartavya Sharma, Merin John, Song Zhang, Gary Gronseth
doi : 10.1212/WNL.0000000000012967
vol. 98 no. 1 e62-e72
To determine thresholds of serum neuron-specific enolase (NSE) for prediction of poor outcome after cardiac arrest with >95% specificity using a unique method of multiple thresholds meta-analysis.
Fatigue in Patients With Multiple System Atrophy
Lingyu Zhang, Bei Cao, Yanbing Hou, Xiaojing Gu, Qian-Qian Wei, Ruwei Ou, Bi Zhao, Wei Song, Huifang Shang
doi : 10.1212/WNL.0000000000012968
vol. 98 no. 1 e73-e82
Nonmotor symptoms are common in patients with multiple system atrophy (MSA), but there is limited knowledge regarding fatigue in MSA. This study aimed to investigate the frequency and evolution of fatigue and the factors related to fatigue and its progression in patients with MSA at an early stage.
Synaptic Damage and Its Clinical Correlates in People With Early Huntington Disease
Aline Delva, Laura Michiels, Michel Koole, Koen Van Laere, Wim Vandenberghe
doi : 10.1212/WNL.0000000000012969
vol. 98 no. 1 e83-e94
Synaptic damage has been proposed to play a major role in the pathophysiology of Huntington disease (HD), but in vivo evidence in humans is lacking. We performed a PET imaging study to assess synaptic damage and its clinical correlates in early HD in vivo.
Polyneuropathy Quality Measurement Set
Brian C. Callaghan, Carmel Armon, Vera Bril, Lindsay Colbert, William S. David, David R. Del Toro, Kenneth Fink, Lyell K. Jones, Robert Kleemeier, Leslie C. MacGregor, Amy Bennett, Anant Shenoy
doi : 10.1212/WNL.0000000000013037
vol. 98 no. 1 22-30
Oral and Topical Treatment of Painful Diabetic Polyneuropathy: Practice Guideline Update Summary
Raymond Price, Don Smith, Gary Franklin, Gary Gronseth, Michael Pignone, William S. David, Carmel Armon, Bruce A. Perkins, Vera Bril, Alexander Rae-Grant, John Halperin, Nicole Licking, Mary Dolan O'Brien, Scott R. Wessels, Leslie C. MacGregor, Kenneth Fink, Lawrence B. Harkless, Lindsay Colbert, Brian C. Callaghan
doi : 10.1212/WNL.0000000000013038
vol. 98 no. 1 31-43
To update the 2011 American Academy of Neurology (AAN) guideline on the treatment of painful diabetic neuropathy (PDN) with a focus on topical and oral medications and medical class effects.
Training in Neurology: Resident Perception of the Utility and Applicability of Global Neurology Morning Reports
Andrew M. Agostini, Michael R. Halstead, Arun Venkatesan, Deanna R. Saylor
doi : 10.1212/WNL.0000000000012950
vol. 98 no. 1 44-47
Interest in global health is increasing among neurology residents. However, funding, time, and, recently, COVID-19 travel restrictions remain barriers to widespread participation. To meet this need, we instituted virtual global neurology morning reports with the objectives of (1) improving knowledge about neurologic diseases common in sub-Saharan Africa and (2) developing clinical reasoning skills through consideration of diagnostic and therapeutic limitations in resource-limited settings. Interactive case-based sessions were presented from Zambia via videoconference by a Johns Hopkins faculty member or Zambian neurology trainee. An anonymous cross-sectional survey was conducted among Johns Hopkins neurology residents. Of eligible participants, 69% (n = 30) completed the survey, 66% of whom were female, and 33% reported prior in-person global health experience. Although most participants did not anticipate a career in global health, the majority (85%) reported that exposure to global health was important. All but 1 participant (96%) reported satisfaction with the global neurology morning reports, with 100% reporting that they were useful to their clinical knowledge and 86% reporting that they were useful to their clinical practice. All respondents felt that morning reports should continue, and 69% ranked the educational value of the experience in the top quartile of the residency curriculum. Resident satisfaction with and perceived utility of global neurology morning reports were high, although the majority did not plan to pursue global neurology opportunities as part of their career. Remote learning opportunities may increase interest in global health among neurology residents.
Clinical Reasoning: A 56-Year-Old Man With Unusual Presentation of Subacute Encephalopathy and Seizure
Tian Wang, Amy Li Safadi, Earn Chun Christabel Lee, Nathan Bicher, Brian Barry, Bilaal Sirdar, Gholam K. Motamedi, Benjamin Osborne
doi : 10.1212/WNL.0000000000012951
vol. 98 no. 1 e95-e102
Teaching NeuroImage: Bilateral Nucleus Tractus Solitarius Lesions in Neurogenic Respiratory Failure
Bindu Parayil Sankaran, Saskia B. Wortman, Michel A. Willemsen, Shanti Balasubramaniam
doi : 10.1212/WNL.0000000000012614
vol. 98 no. 1 e103-e104
Teaching NeuroImage: Bilateral Middle Cerebellar Peduncle Stroke in Giant Cell Arteritis
Yasmin Aghajan, Richard N. Mitchell, Shamik Bhattacharyya, Tiffany Y.-T. Hsu, Joshua P. Klein
doi : 10.1212/WNL.0000000000012953
vol. 98 no. 1 e105-e106
Editors' Note: Risk of Hospitalization and Death Associated With Pimavanserin Use in Older Adults With Parkinson Disease
Aravind Ganesh, Steven Galetta
doi : 10.1212/WNL.0000000000013041
vol. 98 no. 1 48
Reader Response: Risk of Hospitalization and Death Associated With Pimavanserin Use in Older Adults With Parkinson Disease
Ponni Subbiah, Dilesh Doshi, Mary Ellen Turner
doi : 10.1212/WNL.0000000000013042
vol. 98 no. 1 49
Author Response: Risk of Hospitalization and Death Associated With Pimavanserin Use in Older Adults With Parkinson Disease
Y. Joseph Hwang, G. Caleb Alexander, Thomas J. Moore, Hemalkumar B. Mehta
doi : 10.1212/WNL.0000000000013043
vol. 98 no. 1 49-50
