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The Menopause Transition: Signs, Symptoms, and Management Options
Nanette Santoro, Cassandra Roeca, Brandilyn A Peters, Genevieve Neal-Perry
doi : 10.1210/clinem/dgaa764
Volume 106, Issue 1, January 2021, Pages 1–15
Menopause, the permanent cessation of menses, reflects oocyte depletion and loss of gonadal steroids. It is preceded by a transition state, the perimenopause, which is characterized by the gradual loss of oocytes, altered responsiveness to gonadal steroid feedback, wide hormonal fluctuations, and irregular menstrual patterns. The goal of this mini-review is to discuss the basic pathophysiology of the menopausal transition and the hormonal and nonhormonal management of clinicopathology attributed to it.
Adrenally Directed Medical Therapies for Cushing Syndrome
Nicholas A Tritos
doi : 10.1210/clinem/dgaa778
Volume 106, Issue 1, January 2021, Pages 16–25
Endogenous Cushing syndrome (CS) is characterized by excess cortisol secretion, which is driven by tumorous secretion of corticotropin in the majority of patients. Untreated, CS results in substantial morbidity and mortality. Tumor-directed surgery is generally the first-line therapy for CS. However, hypercortisolism may persist or recur postoperatively; in other cases, the underlying tumor may not be resectable or its location may not be known. Yet other patients may be acutely ill and require stabilization before definitive surgery. In all these cases, additional interventions are needed, including adrenally directed medical therapies.
Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment
Naomi Todd, Ross McNally, Abdelrahim Alqudah, Djurdja Jerotic, Sonja Suvakov ...
doi : 10.1210/clinem/dgaa403
Volume 106, Issue 1, January 2021, Pages 26–41
Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies.
International Histopathology Consensus for Unilateral Primary Aldosteronism
Tracy Ann Williams, Celso E Gomez-Sanchez, William E Rainey, Thomas J Giordano, Alfred K Lam ...
doi : 10.1210/clinem/dgaa484
Volume 106, Issue 1, January 2021, Pages 42–54
Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA).
Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes
Clara Vi?als, Aleix Beneyto, Juan-Fernando Mart?n-SanJosé, Clara Furi?-Novejarque, Arthur Bertachi ...
doi : 10.1210/clinem/dgaa562
Volume 106, Issue 1, January 2021, Pages 55–63
To evaluate the safety and performance of a new multivariable closed-loop (MCL) glucose controller with automatic carbohydrate recommendation during and after unannounced and announced exercise in adults with type 1 diabetes (T1D).
Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients
Yi Guo, Shiyun Luo, Yongxin Ye, Songping Yin, Jiahua Fan ...
doi : 10.1210/clinem/dgaa644
Volume 106, Issue 1, January 2021, Pages 64–79
Intermittent fasting (IF) is an effective strategy to improve cardiometabolic health.
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity
Harshal A Deshmukh, Anne Lundager Madsen, Ana Vi?uela, Christian Theil Have, Niels Grarup ...
doi : 10.1210/clinem/dgaa653
Volume 106, Issue 1, January 2021, Pages 80–90
Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity.
Inhibition of BRAF Sensitizes Thyroid Carcinoma to Immunotherapy by Enhancing tsMHCII-mediated Immune Recognition
Jingtai Zhi, Peitao Zhang, Wei Zhang, Xianhui Ruan, Mengran Tian ...
doi : 10.1210/clinem/dgaa656
Volume 106, Issue 1, January 2021, Pages 91–107
Multiple mechanisms play roles in restricting the ability of T-cells to recognize and eliminate tumor cells.
Effects of Oral Contraception and Lifestyle Modification on Incretins and TGF-? Superfamily Hormones in PCOS
Aesha Shah, William C Dodson, Penny M Kris-Etherton, Allen R Kunselman, Christy M Stetter ...
doi : 10.1210/clinem/dgaa682
Volume 106, Issue 1, January 2021, Pages 108–119
To examine the effects of common treatments for polycystic ovary syndrome (PCOS) on a panel of hormones (reproductive/metabolic).
Immune Co-inhibitory Receptors PD-1, CTLA-4, TIM-3, LAG-3, and TIGIT in Medullary Thyroid Cancers: A Large Cohort Study
Xiao Shi, Cui-Wei Li, Li-Cheng Tan, Shi-Shuai Wen, Tian Liao ...
doi : 10.1210/clinem/dgaa701
Volume 106, Issue 1, January 2021, Pages 120–132
Programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte activation gene-3 (LAG-3), and T-cell immunoglobulin and ITIM domain (TIGIT) are considered major immune co-inhibitory receptors (CIRs) and the most promising immunotherapeutic targets in cancer treatment, but they are largely unexplored in medullary thyroid carcinoma (MTC).
Determinants of Cardiovascular Risk in 7000 Youth With Type 1 Diabetes in the Australasian Diabetes Data Network
Jenny J Couper, Timothy W Jones, Melissa Chee, Helen L Barrett, Philip Bergman ...
doi : 10.1210/clinem/dgaa727
Volume 106, Issue 1, January 2021, Pages 133–142
Cardiovascular disease occurs prematurely in type 1 diabetes. The additional risk of overweight is not well characterized.
Metabolite Signature of Albuminuria Involves Amino Acid Pathways in 8661 Finnish Men Without Diabetes
Lilian Fernandes Silva, Jagadish Vangipurapu, Ulf Smith, Markku Laakso
doi : 10.1210/clinem/dgaa661
Volume 106, Issue 1, January 2021, Pages 143–152
To investigate the metabolite signature of albuminuria in individuals without diabetes or chronic kidney disease to identify possible mechanisms that result in increased albuminuria and elevated risk of type 2 diabetes (T2D).
Characterizing the Clinical and Genetic Spectrum of Polycystic Ovary Syndrome in Electronic Health Records
Ky’Era V Actkins, Kritika Singh, Donald Hucks, Digna R Velez Edwards, Melinda Aldrich ...
doi : 10.1210/clinem/dgaa675
Volume 106, Issue 1, January 2021, Pages 153–167
Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility, yet current diagnostic criteria are ineffective at identifying patients whose symptoms reside outside strict diagnostic criteria. As a result, PCOS is underdiagnosed and its etiology is poorly understood.
Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring
Caroline T B Juel, Thomas F Dejgaard, Carsten P Hansen, Jan H Storkholm, Tina Vilsb?ll ...
doi : 10.1210/clinem/dgaa731
Volume 106, Issue 1, January 2021, Pages 168–173
The extent of the glycemic variability in diabetes secondary to total pancreatectomy is not fully understood.
11?HSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension
Rowan S Hardy, Hannah Botfield, Keira Markey, James L Mitchell, Zerin Alimajstorovic ...
doi : 10.1210/clinem/dgaa766
Volume 106, Issue 1, January 2021, Pages 174–187
The enzyme 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) determines prereceptor metabolism and activation of glucocorticoids within peripheral tissues. Its dysregulation has been implicated in a wide array of metabolic diseases, leading to the development of selective 11?-HSD1 inhibitors. We examined the impact of the reversible competitive 11?-HSD1 inhibitor, AZD4017, on the metabolic profile in an overweight female cohort with idiopathic intracranial hypertension (IIH).
Progression of acromegalic arthropathy in long-term controlled acromegaly patients: 9 years of longitudinal follow-up
Iris C M Pelsma, Nienke R Biermasz, Wouter R van Furth, Alberto M Pereira, Herman M Kroon ...
doi : 10.1210/clinem/dgaa747
Volume 106, Issue 1, January 2021, Pages 188–200
Joint complaints in patients with acromegaly are common, although the long-term disease course is largely unknown.
Dietary Fiber, Genetic Variations of Gut Microbiota-derived Short-chain Fatty Acids, and Bone Health in UK Biobank
Tao Zhou, Mengying Wang, Hao Ma, Xiang Li, Yoriko Heianza ...
doi : 10.1210/clinem/dgaa740
Volume 106, Issue 1, January 2021, Pages 201–210
Dietary fiber intake may relate to bone health.
Quality of Life and its Determinants in Patients With Treated Acromegaly: A Cross-Sectional Nationwide Study in China
Xiaopeng Guo, Kailu Wang, Siyue Yu, Lu Gao, Zihao Wang ...
doi : 10.1210/clinem/dgaa750
Volume 106, Issue 1, January 2021, Pages 211–225
Quality of life (QoL) continues to be impaired in acromegaly after treatment.
Evaluation and Treatment of Amiodarone-Induced Thyroid Disorders
Dorina Ylli, Leonard Wartofsky, Kenneth D Burman
doi : 10.1210/clinem/dgaa686
Volume 106, Issue 1, January 2021, Pages 226–236
Amiodarone is a class III antiarrhythmic drug containing 37% iodine by weight, with a structure similar to that of thyroid hormones. Deiodination of amiodarone releases large amounts of iodine that can impair thyroid function, causing either hypothyroidism or thyrotoxicosis in susceptible individuals reflecting ~20% of patients administered the drug. Not only the excess iodine, but also the amiodarone (or its metabolite, desethylamiodarone) itself may cause thyroid dysfunction by direct cytotoxicity on thyroid cells. We present an overview of the epidemiology and pathophysiology of amiodarone-induced thyroid disorders, with a focus on the various forms of clinical presentation and recommendations for personalized management of each form.
Approach to the Patient with MODY-Monogenic Diabetes
David T Broome, Kevin M Pantalone, Sangeeta R Kashyap, Louis H Philipson
doi : 10.1210/clinem/dgaa710
Volume 106, Issue 1, January 2021, Pages 237–250
Maturity-onset diabetes of the young, or MODY-monogenic diabetes, is a not-so-rare collection of inherited disorders of non-autoimmune diabetes mellitus that remains insufficiently diagnosed despite increasing awareness. These cases are important to efficiently and accurately diagnose, given the clinical implications of syndromic features, cost-effective treatment regimen, and the potential impact on multiple family members. Proper recognition of the clinical manifestations, family history, and cost-effective lab and genetic testing provide the diagnosis.
Approach to the Patient: Management of the Post–Bariatric Surgery Patient With Weight Regain
Nawfal W Istfan, Marine Lipartia, Wendy A Anderson, Donald T Hess, Caroline M Apovian
doi : 10.1210/clinem/dgaa702
Volume 106, Issue 1, January 2021, Pages 251–263
Weight regain (WR) after bariatric surgery is emerging as a common clinical problem due to the increase in the number of procedures performed. Early interventions are necessary to curtail the potential recurrence of comorbid conditions. However, it is often difficult to recognize WR early enough to introduce mitigating measures because there are no current guidelines for timely diagnosis and assessment of the severity of this condition.
Fracture Risk and Management of Discontinuation of Denosumab Therapy: A Systematic Review and Position Statement by ECTS
Elena Tsourdi, M Carola Zillikens, Christian Meier, Jean-Jacques Body, Elena Gonzalez Rodriguez ...
doi : 10.1210/clinem/dgaa756
Volume 106, Issue 1, January 2021, Pages 264–281
Denosumab discontinuation is characterized by an increase in bone turnover overriding pretreatment status, a rapid bone loss in the majority and multiple vertebral fractures (VFx) in some patients.
Weight Gain After Thyroidectomy: A Systematic Review and Meta-Analysis
Christine N Huynh, Janina V Pearce, Le Kang, Francesco S Celi
doi : 10.1210/clinem/dgaa754
Volume 106, Issue 1, January 2021, Pages 282–291
Weight gain is a major driver of dissatisfaction and decreased quality of life in patients with hypothyroidism. Data on the changes in body weight following thyroidectomy are conflicting.
Association of Thyroid Hormone Therapy with Mortality in Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis
Carol Chiung-Hui Peng, Huei-Kai Huang, Brian Bo-Chang Wu, Rachel Huai-En Chang, Yu-Kang Tu ...
doi : 10.1210/clinem/dgaa777
Volume 106, Issue 1, January 2021, Pages 292–303
Benefits of thyroid hormone therapy on mortality in adults with subclinical hypothyroidism remain undetermined.
Prospective Longitudinal Assessment of Linear Growth and Adult Height in Female Adolescents With Anorexia Nervosa
Dalit Modan-Moses, Amit Yaroslavsky, Orit Pinhas-Hamiel, Yael Levy-Shraga, Brigitte Kochavi ...
doi : 10.1210/clinem/dgaa510
Volume 106, Issue 1, January 2021, Pages e1–e10
Growth retardation is an established complication of anorexia nervosa (AN); however, findings concerning the adult height of AN patients are inconsistent.
The Renal Extraction and the Natriuretic Action of GLP-1 in Humans Depend on Interaction With the GLP-1 Receptor
Ali Asmar, Per K Cramon, Meena Asmar, Lene Simonsen, Charlotte M Sorensen ...
doi : 10.1210/clinem/dgaa643
Volume 106, Issue 1, January 2021, Pages e11–e19
The natriuretic effect of glucagon-like peptide-1 (GLP-1) in humans is independent of changes in renal plasma flow (RPF) and glomerular filtration rate (GFR) but may involve suppression of angiotensin II (ANG II) and a significant (~45%) renal extraction of GLP-1. The current study was designed to investigate the consequences for the renal extraction and the natriuretic effect of blocking GLP-1 receptors with the specific GLP-1 receptor antagonist, Exendin 9–39 (Ex 9–39).
Slit2 Regulates Hyaluronan & Cytokine Synthesis in Fibrocytes: Potential Relevance to Thyroid-Associated Ophthalmopathy
Roshini Fernando, Terry J Smith
doi : 10.1210/clinem/dgaa684
Volume 106, Issue 1, January 2021, Pages e20–e33
CD34+ fibrocytes have been implicated in development of thyroid-associated ophthalmopathy (TAO), a consequential autoimmune manifestation of Graves disease (GD). In TAO, CD34+ fibrocytes appear to masquerade as CD34+ orbital fibroblasts mixed with CD34- OF (collectively, GD-OF). Slit2, an axon guidance glycoprotein, is expressed by CD34- OF and attenuates GD-OF gene expression. Cardinal features of TAO include hyaluronan (HA) accumulation and cytokine-driven inflammation.
Adolescent Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Young Adulthood
Aya Bardugo, Cole D Bendor, Inbar Zucker, Miri Lutski, Tali Cukierman-Yaffe ...
doi : 10.1210/clinem/dgaa753
Volume 106, Issue 1, January 2021, Pages e34–e44
The long-term risk of type 2 diabetes in adolescents with nonalcoholic fatty liver disease (NAFLD) is unclear.
Aldosterone is Aberrantly Regulated by Various Stimuli in a High Proportion of Patients with Primary Aldosteronism
Matthieu St-Jean, Isabelle Bourdeau, Marc Martin, André Lacroix
doi : 10.1210/clinem/dgaa703
Volume 106, Issue 1, January 2021, Pages e45–e60
In primary aldosteronism (PA), aldosterone secretion is relatively independent of the renin–angiotensin system, but can be regulated by several other stimuli.
Performance of 4 Creatinine-based Equations in Assessing Glomerular Filtration Rate in Adults with Diabetes
Neda Zafari, Mojtaba Lotfaliany, Graeme J O’Keefe, Kartik Kishore, Niloufar Torkamani ...
doi : 10.1210/clinem/dgaa722
Volume 106, Issue 1, January 2021, Pages e61–e73
To evaluate diagnostic performance of glomerular filtration rate (GFR) estimated by modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), full age spectrum (FAS), and revised Lund–Malm? (r-LM) equations in adults with diabetes.
Effect of Treatment of Periodontitis on Incretin Axis in Obese and Nonobese Individuals: A Cohort Study
Jeanie Suvan, Stefano Masi, Zoe Harrington, Eleonora Santini, Francesco Raggi ...
doi : 10.1210/clinem/dgaa757
Volume 106, Issue 1, January 2021, Pages e74–e82
Periodontitis confers an increased risk of developing type 2 diabetes and, in patients with obesity, it might interfere with the incretin axis. The effect of periodontal treatment on glucoregulatory hormones remains unknown.
Effect of Exercise Intensity on Exogenous Glucose Requirements to Maintain Stable Glycemia At High Insulin Levels in Type 1 Diabetes
Vinutha B Shetty, Paul A Fournier, Nirubasini Paramalingam, Wayne Soon, Heather C Roby ...
doi : 10.1210/clinem/dgaa768
Volume 106, Issue 1, January 2021, Pages e83–e93
Under basal insulin levels, there is an inverted U relationship between exercise intensity and exogenous glucose requirements to maintain stable blood glucose levels in type 1 diabetes (T1D), with no glucose required for intense exercise (80% V?O2 peak), implying that high-intensity exercise is not conducive to hypoglycemia.
Postoperative Day 1 Morning Cortisol Value as a Biomarker to Predict Long-term Remission of Cushing Disease
Fang Wang, Michael P Catalino, Wenya Linda Bi, Ian F Dunn, Timothy R Smith ...
doi : 10.1210/clinem/dgaa773
Volume 106, Issue 1, January 2021, Pages e94–e102
Recurrence of Cushing disease (CD) can occur even decades after surgery. Biomarkers to predict recurrence of CD after surgery have been studied but are inconclusive.
Diabetes, Active Disease, and Afternoon Serum Cortisol Levels Predict Cushing’s Disease Mortality: A Cohort Study
Paola Rold?n-Sarmiento, César Ernesto Lam-Chung, José Miguel Hinojosa-Amaya, Mariana Morales-Garc?a, Mar?a Fernanda Guillén-Placencia ...
doi : 10.1210/clinem/dgaa774
Volume 106, Issue 1, January 2021, Pages e103–e111
Cushing’s disease (CD) is a life-threating disease, with increased mortality in comparison with the general population.
Sex/Gender Modifies the Association Between the MC4R p.Ile269Asn Mutation and Type 2 Diabetes in the Mexican Population
Miguel V?zquez-Moreno, Daniel Locia-Morales, Adan Valladares-Salgado, Tanmay Sharma, Niels Wacher-Rodarte ...
doi : 10.1210/clinem/dgaa726
Volume 106, Issue 1, January 2021, Pages e112–e117
Studies in mice and humans suggest that melanocortin-4 receptor (MC4R) deficiency affects body weight in a sex-/gender-dependent manner. However, similar evidence for type 2 diabetes (T2D) is scarce.
The Plasma Metabolomic Profile is Differently Associated with Liver Fat, Visceral Adipose Tissue, and Pancreatic Fat
Lars Lind, Samira Salihovic, Ulf Risérus, Joel Kullberg, Lars Johansson ...
doi : 10.1210/clinem/dgaa693
Volume 106, Issue 1, January 2021, Pages e118–e129
Metabolic differences between ectopic fat depots may provide novel insights to obesity-related diseases.
Mental Health in Patients With Adrenal Incidentalomas: Is There a Relation With Different Degrees of Cortisol Secretion?
Valentina Morelli, Alberto Ghielmetti, Alice Caldiroli, Silvia Grassi, Francesca Marzia Siri ...
doi : 10.1210/clinem/dgaa695
Volume 106, Issue 1, January 2021, Pages e130–e139
Cushing’s syndrome frequently causes mental health impairment. Data in patients with adrenal incidentaloma (AI) are lacking.
Fatty Acid Metabolism and Associations with Insulin Sensitivity Differs Between Black and White South African Women
Julia H Goedecke, Elin Chorell, Paul J van Jaarsveld, Ulf Risérus, Tommy Olsson
doi : 10.1210/clinem/dgaa696
Volume 106, Issue 1, January 2021, Pages e140–e151
Genetic differences in desaturase genes and consequently fatty acid metabolism have been reported. The aims were to examine ethnic differences in serum fatty acid composition and desaturase indices, and assess the ethnic-specific associations with insulin sensitivity (IS) and liver fat in black and white South African (SA) women.
Phenotypic Variability of Patients With PAX8 Variants Presenting With Congenital Hypothyroidism and Eutopic Thyroid
N?ria Camats, Noelia Baz-Red?n, M?nica Fern?ndez-Cancio, Mar?a Clemente, Ariadna Campos-Martorell ...
doi : 10.1210/clinem/dgaa711
Volume 106, Issue 1, January 2021, Pages e152–e170
Thyroid dyshormonogenesis is a heterogeneous group of hereditary diseases produced by a total/partial blockage of the biochemical processes of thyroid-hormone synthesis and secretion. Paired box 8 (PAX8) is essential for thyroid morphogenesis and thyroid hormone synthesis. We aimed to identify PAX8 variants in patients with thyroid dyshormonogenesis and to analyze them with in vitro functional studies.
Dimethandrolone Undecanoate, a Novel, Nonaromatizable Androgen, Increases P1NP in Healthy Men Over 28 Days
Arthi Thirumalai, Fiona Yuen, John K Amory, Andrew N Hoofnagle, Ronald S Swerdloff ...
doi : 10.1210/clinem/dgaa761
Volume 106, Issue 1, January 2021, Pages e171–e181
Dimethandrolone undecanoate (DMAU) is being developed as a male contraceptive. Daily oral administration of DMAU, a potent androgen that is not aromatized, markedly suppresses serum testosterone (T) and estradiol (E2) in healthy men. E2 deficiency can increase bone resorption in men.
Molecular Analysis of the CYP11B2 Gene in 62 Patients with Hypoaldosteronism Due to Aldosterone Synthase Deficiency
Christina Merakou, Irene Fylaktou, Amalia Sertedaki, Maria Dracopoulou, Antonis Voutetakis ...
doi : 10.1210/clinem/dgaa765
Volume 106, Issue 1, January 2021, Pages e182–e191
Isolated congenital hypoaldosteronism presents in early infancy with symptoms including vomiting, severe dehydration, salt wasting, and failure to thrive. The main causes of this rare autosomal recessive disorder is pathogenic variants of the CYP11B2 gene leading to aldosterone synthase deficiency.
Real-World Estimates of Adrenal Insufficiency–Related Adverse Events in Children With Congenital Adrenal Hyperplasia
Salma R Ali, Jillian Bryce, Houra Haghpanahan, James D Lewsey, Li En Tan ...
doi : 10.1210/clinem/dgaa694
Volume 106, Issue 1, January 2021, Pages e192–e203
Although congenital adrenal hyperplasia (CAH) is known to be associated with adrenal crises (AC), its association with patient- or clinician-reported sick day episodes (SDE) is less clear.
A Pilot Study of Gut-Brain Signaling After Octreotide Therapy for Unintentional Weight Loss After Esophagectomy
Conor F Murphy, Nicholas Stratford, Neil G Docherty, Brendan Moran, Jessie A Elliott ...
doi : 10.1210/clinem/dgaa697
Volume 106, Issue 1, January 2021, Pages e204–e216
Recurrence-free patients after esophageal cancer surgery face long-term nutritional consequences, occurring in the context of an exaggerated postprandial gut hormone response. Acute gut hormone suppression influences brain reward signaling and eating behavior. This study aimed to suppress gut hormone secretion and characterize reward responses and eating behavior among postesophagectomy patients with unintentional weight loss.
Development of Machine Learning Models for Predicting Postoperative Delayed Remission in Patients With Cushing’s Disease
Yanghua Fan, Yichao Li, Xinjie Bao, Huijuan Zhu, Lin Lu ...
doi : 10.1210/clinem/dgaa698
Volume 106, Issue 1, January 2021, Pages e217–e231
Postoperative hypercortisolemia mandates further therapy in patients with Cushing’s disease (CD). Delayed remission (DR) is defined as not achieving postoperative immediate remission (IR), but having spontaneous remission during long-term follow-up.
Targeting Corticotroph HDAC and PI3-Kinase in Cushing Disease
Dongyun Zhang, Robert Damoiseaux, Lilit Babayan, Everett Kanediel Rivera-Meza, Yingying Yang ...
doi : 10.1210/clinem/dgaa699
Volume 106, Issue 1, January 2021, Pages e232–e246
Cushing disease (CD) is a life-threatening disorder. Therapeutic goals include symptom relief, biochemical control, and tumor growth inhibition. Current medical therapies for CD by and large exert no action on tumor growth.
Serum Irisin Levels in Central Precocious Puberty and Its Variants
Esra Kutlu, ?lker Tolga ?zgen, Huri Bulut, Abdurrahim Koçyi?it, Hafize Otçu ...
doi : 10.1210/clinem/dgaa720
Volume 106, Issue 1, January 2021, Pages e247–e254
The exact mechanisms that trigger the onset of puberty are not well known. Adipomyokines are postulated to stimulate the central neural network. In the present study, we investigated irisin levels in girls with central precocious puberty (CPP), slowly progressing precocious puberty (SPPP), or premature thelarche (PT); we also studied prepubertal girls and to determine if this adipomyokine could be used as a marker in this context.
Norms for Clinical Use of CXM, a Real-Time Marker of Height Velocity
Ryan F Coghlan, Robert C Olney, Bruce A Boston, Daniel T Coleman, Brian Johnstone ...
doi : 10.1210/clinem/dgaa721
Volume 106, Issue 1, January 2021, Pages e255–e264
Height velocity (HV) is difficult to assess because growth is very slow. The current practice of calculating it from measurements taken at several-month intervals is insufficient for managing children with growth disorders. We identified a bone growth by-product (collagen X biomarker, CXM) in blood that in preliminary analysis in healthy children correlated strongly with conventionally determined HV and displayed a pattern resembling published norms for HV vs age.
Inactivation of a Frameshift TSH Receptor Variant Val711Phefs*18 is Due to Acquisition of a Hydrophobic Degron
Chiho Sugisawa, Makoto Ono, Kenichi Kashimada, Tomonobu Hasegawa, Satoshi Narumi
doi : 10.1210/clinem/dgaa772
Volume 106, Issue 1, January 2021, Pages e265–e272
Inactivating variants of thyrotropin (thyroid-stimulating hormone; TSH) receptor (TSHR) cause congenital hypothyroidism. More than 60 such variants have been reported so far, most of which were located in the extracellular or transmembrane domain.
UPLC-MS/MS-based Lipidomic Profiles Revealed Aberrant Lipids Associated with Invasiveness of Silent Corticotroph Adenoma
Zihao Wang, Xiaopeng Guo, Wenze Wang, Lu Gao, Xinjie Bao ...
doi : 10.1210/clinem/dgaa708
Volume 106, Issue 1, January 2021, Pages e273–e287
The accumulation of aberrant lipids and abnormal lipid metabolism in silent corticotroph adenomas (SCAs) could contribute to changes in clinical phenotypes, especially sphenoid sinus invasion.
Interactions of Anemia, FGF-23, and Bone in Healthy Adults—Results From the Study of Health in Pomerania (SHIP)
Anke Hannemann, Matthias Nauck, Henry V?lzke, Heike Weidner, Uwe Platzbecker ...
doi : 10.1210/clinem/dgaa716
Volume 106, Issue 1, January 2021, Pages e288–e299
Osteoporosis and anemia are among the most common diseases in the aging population with an increasing prevalence worldwide.
The PNPLA3-I148M Variant Confers an Antiatherogenic Lipid Profile in Insulin-resistant Patients
Panu K Luukkonen, Sami Qadri, Tiina E Lehtim?ki, Anne Juuti, Henna Sammalkorpi ...
doi : 10.1210/clinem/dgaa729
Volume 106, Issue 1, January 2021, Pages e300–e315
The I148M (rs738409-G) variant in PNPLA3 increases liver fat content but may be protective against cardiovascular disease. Insulin resistance (IR) amplifies the effect of PNPLA3-I148M on liver fat.
Quality of Life in Patients with Neuroendocrine Neoplasms: The Role of Severity, Clinical Heterogeneity, and Resilience
Cristiano Scandurra, Roberta Modica, Nelson Mauro Maldonato, Pasquale Dolce, Greta G Dipietrangelo ...
doi : 10.1210/clinem/dgaa760
Volume 106, Issue 1, January 2021, Pages e316–e327
Although health-related quality of life (HRQoL) is a fundamental outcome in oncological clinical trials, its evaluation in the neuroendocrine neoplasm (NEN) research field is still limited.
Use of Preoperative Imaging in Primary Hyperparathyroidism
David T Broome, Robert Naples, Richard Bailey, Zehra Tekin, Moska Hamidi ...
doi : 10.1210/clinem/dgaa779
Volume 106, Issue 1, January 2021, Pages e328–e337
Preoperative imaging is performed routinely to guide surgical management in primary hyperparathyroidism, but the optimal imaging modalities are debated.
Newborn Screening for Congenital Hypothyroidism: the Benefit of Using Differential TSH Cutoffs in a 2-Screen Program
Silvana Caiulo, Carlo Corbetta, Marianna Di Frenna, Emanuela Medda, Simona De Angelis ...
doi : 10.1210/clinem/dgaa789
Volume 106, Issue 1, January 2021, Pages e338–e349
Analysis of a 2-screen program for congenital hypothyroidism (CH) was performed using differential dried-blood spot thyrotropin (bTSH) cutoffs of 10 mU/L at first screening (all infants) and 5 mU/L at second screening (selected infants).
Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update
Gustavo Armaiz-Pena, Shahida K Flores, Zi-Ming Cheng, Xhingyu Zhang, Emmanuel Esquivel ...
doi : 10.1210/clinem/dgaa741
Volume 106, Issue 1, January 2021, Pages e350–e364
This work aimed to evaluate genotype-phenotype associations in individuals carrying germline variants of transmembrane protein 127 gene (TMEM127), a poorly known gene that confers susceptibility to pheochromocytoma (PHEO) and paraganglioma (PGL).
When Exercising for Metabolic Health, the Work is Never Done, But HIIT Will Save You Time
Joseph W Beals, Brandon D Kayser
doi : 10.1210/clinem/dgaa451
Volume 106, Issue 1, January 2021, Pages e365–e366
Cure of Cushing’s Disease: Still an Elusive Goal?
Nicholas A Tritos
doi : 10.1210/clinem/dgaa460
Volume 106, Issue 1, January 2021, Pages e367–e369
Insulin-like Factor 3 Emerges from the Shadow of Testosterone as a Leydig Cell Biomarker
Jorma Toppari
doi : 10.1210/clinem/dgaa603
Volume 106, Issue 1, January 2021, Pages e370–e371
Menstrual Cycle in Adolescents: Updating the Normal Pattern
Noah Gruber, Dalit Modan-Moses
doi : 10.1210/clinem/dgaa688
Volume 106, Issue 1, January 2021, Pages e372–e374
Ghrelin: Growth Hormone Release to Hunger Hormone to Glucose Regulation: Lessons From a Rare Genetic Disorder
Sonali Malhotra, Lynne L Levitsky
doi : 10.1210/clinem/dgaa762
Volume 106, Issue 1, January 2021, Pages e375–e376
Innovations in Diabetes Care for a Better “New Normal” Beyond COVID-19
Shivani Agarwal, Michelle L Griffith, Elizabeth J Murphy, Carol Greenlee, Jeffrey Boord ...
doi : 10.1210/clinem/dgaa704
Volume 106, Issue 1, January 2021, Pages e377–e381
The coronavirus disease pandemic has created opportunities for innovation in diabetes care that were not possible before. From the lens of this “new normal” state, we have an opportunity to rapidly implement, test, and iterate models of diabetes care to achieve the quadruple aim of improving medical outcomes, patient experience, provider satisfaction, and reducing costs. In this perspective, we discuss several innovative diabetes models of care which promote collaborative care models and improve access to high-quality specialty diabetes care. We discuss ongoing threats to diabetes care innovation, and offer practical solutions to foster evolution and sustain current strides made during the pandemic.
New Horizons: Emerging Therapies and Targets in Thyroid Cancer
Matthew D Ringel
doi : 10.1210/clinem/dgaa687
Volume 106, Issue 1, January 2021, Pages e382–e388
The treatment of patients with progressive metastatic follicular cell-derived and medullary thyroid cancers that do not respond to standard therapeutic modalities presents a therapeutic challenge. As a deeper understanding of the molecular drivers for these tumors has occurred and more potent and specific compounds are developed, the number of Food and Drug Administration (FDA)-approved treatments for thyroid cancer has expanded. In addition, with the advent of disease-agnostic target-directed FDA approvals an ever-broadening number of therapeutic options are available for clinicians and patients.
Letter to the Editor from Monlun et al: “Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Post-Partum
Marie Monlun, Ninon Foussard, Laurence Blanco, Kamel Mohammedi, Vincent Rigalleau
doi : 10.1210/clinem/dgaa397
Volume 106, Issue 1, January 2021, Pages e389–e390
Letter to the Editor from Smith et al: Osteosarcopenia in Reproductive-Aged Women with Polycystic Ovary Syndrome: A Multicenter Case-Control Study
Cassandra Smith, David Scott, Peter Ebeling, Itamar Levinger
doi : 10.1210/clinem/dgaa669
Volume 106, Issue 1, January 2021, Pages e391–e392
Letter to the Editor: “Prevention of Adrenal Crisis: Cortisol Responses to Major Stress Compared to Stress Dose Hydrocortisone Delivery”
Richard I Dorin, Frank K Urban, III, Clifford R Qualls
doi : 10.1210/clinem/dgaa709
Volume 106, Issue 1, January 2021, Pages e393–e394
Letter to the Editor: “Prevention of Adrenal Crisis: Cortisol Responses to Major Stress Compared to Stress Dose Hydrocortisone Delivery”
Ying Jie Chee, Mahendran Dinesh, Su Chi Lim
doi : 10.1210/clinem/dgaa717
Volume 106, Issue 1, January 2021, Pages e395–e396
Letter to the Editor: “A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness”
Pierre Bougnères
doi : 10.1210/clinem/dgaa734
Volume 106, Issue 1, January 2021, Pages e397–e398
Letter to the Editor: “US-guided Microwave Ablation of Low-risk Papillary Thyroid Microcarcinoma: Longer-term Results of a Prospective Study”
Shijie Yang, Chao Jin, Xiequn Xu
doi : 10.1210/clinem/dgaa767
Volume 106, Issue 1, January 2021, Pages e399–e400
Response to Letter to the Editor From Marie Monlun: “Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Postpartum”
Camille E Powe, Kaitlyn James, John M Higgins
doi : 10.1210/clinem/dgaa402
Volume 106, Issue 1, January 2021, Pages e401–e402
Response to Letter to the Editor From Min Gong et al: “Risk for Infections During Treatment With Denosumab for Osteoporosis: A Systematic Review and Meta-analysis”
Talia Diker-Cohen, Dana Rosenberg, Tomer Avni, Daniel Shepshelovich, Gloria Tsvetov ...
doi : 10.1210/clinem/dgaa446
Volume 106, Issue 1, January 2021, Page e403
Response to Letter to the Editor: “Prevention of Adrenal Crisis: Cortisol Response to Major Stress Compared to Stress Dose Hydrocortisone Delivery”
Alessandro Prete, Angela E Taylor, Irina Bancos, David J Smith, Mark A Foster ...
doi : 10.1210/clinem/dgaa712
Volume 106, Issue 1, January 2021, Pages e404–e406
Response to Letter to the Editor from Chee et al: “Prevention of Adrenal Crisis: Cortisol Response to Major Stress Compared to Stress Dose Hydrocortisone Delivery”
Alessandro Prete, Angela E Taylor, Irina Bancos, David J Smith, Mark A Foster ...
doi : 10.1210/clinem/dgaa719
Volume 106, Issue 1, January 2021, Pages e407–e408
Response to Letter to the Editor: “A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness”
Joel N Hirschhorn, Andrew Dauber, Laura Audi, Sailaja Vedantam, Michael B Ranke ...
doi : 10.1210/clinem/dgaa735
Volume 106, Issue 1, January 2021, Pages e409–e410
Corrigendum to: “Association of Cryptorchidism With a Specific Haplotype of the Estrogen Receptor ? Gene: Implication for the Susceptibility to Estrogenic Environmental Endocrine Disruptors”
doi : 10.1210/clinem/dgaa685
Volume 106, Issue 1, January 2021, Page e411
Corrigendum to: “Conflicts of Interest in Clinical Practice Guidelines: Accelerating an Evolution. An Endocrine Society Consensus Statement”
doi : 10.1210/clinem/dgaa770
Volume 106, Issue 1, January 2021, Page e412
Corrigendum to: “Reduced Calcium Sensing Receptor (CaSR) Expression is Epigenetically Deregulated in Parathyroid Adenomas”
doi : 10.1210/clinem/dgaa784
Volume 106, Issue 1, January 2021, Page e413
Erratum to: “Evolution of the Primary Aldosteronism Syndrome: Updating the Approach”
doi : 10.1210/clinem/dgaa724
Volume 106, Issue 1, January 2021, Page e414
