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COVID-19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age-associated B cells
Naim Mahroum,Yehuda Shoenfeld
doi : 10.1111/1756-185X.14259
Volume 25, Issue 1 p. 5-6
2021 Asia-Pacific League of Associations for Rheumatology clinical practice guideline for treatment of gout
Jose Paulo P. Lorenzo,Ma. Hanna Monica Z. Sollano,Evelyn O. Salido,Julie Li-Yu,Sandra A. Tankeh-Torres,Ida Ayu Ratih Wulansari Manuaba,Md Mujibur Rahman,Binoy J. Paul,Mo Yin Mok,Monika De Silva,Prasanta Padhan,Ai Lee Lim,Melvin Marcial,Jennifer Jeanne Vicera,Syed Atiqul Haq,Sami Salman,Chiranthi K. Liyanage,Helen I. Keen,Cheng Yew Kuang,James Cheng-Chung Wei,Rakhma Yanti Hellmi,Charlie E. Chan Jr.,Worawit Louthrenoo
doi : 10.1111/1756-185X.14266
Volume 25, Issue 1 p. 7-20
Gout is the most prevalent inflammatory arthritis in the Asia-Pacific region and worldwide. This clinical practice guideline (CPG) aims to provide recommendations based on systematically obtained evidence and values and preferences tailored to the unique needs of patients with gout and hyperuricemia in Asia, Australasia, and the Middle East. The target users of these guidelines are general practitioners and specialists, including rheumatologists, in these regions.
Emerging role of TWEAK-Fn14 axis in lupus, a disease related to autoimmunity and fibrosis
Yuan Xu,Hui-Ting Wei,Hao-Yue Jing,Xiao-Yang Tan,Xiao-Tao Zhou,Yue-Rong Ma
doi : 10.1111/1756-185X.14232
Volume 25, Issue 1 p. 21-26
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder. Lupus nephritis (LN) is one of the severe clinical implications in SLE, and this was relates to fibrosis in the kidney. As an important marker in the tumor necrosis factor (TNF) superfamily, TNF-like weak inducer of apoptosis (TWEAK) has been given much attention with respect to its role in regulating pro-inflammatory immune response. Fibroblast growth factor-inducible 14 (Fn14), the sole receptor for TWEAK, has been found expressed in different immune and non-immune cells. TWEAK binds to Fn14, and then regulates inflammatory components production via downstream signaling pathways. To date, dysregulated expression of TWEAK, Fn14 has been reported in SLE, LN patients, and in vivo, in vitro studies have discussed the significant role of TWEAK-Fn14 axis in SLE, LN pathogenesis, partly through mediating the fibrosis process. In this review, we will discuss the association of TWEAK-Fn14 axis in lupus. Understanding the relationship will better realize the potential for making TWEAK-Fn14 as a marker for the diseases, and will help to give many clues for targeting them in treatment of lupus in the future.
A comparative study of IL-6, CRP and NT-proBNP levels in post-COVID multisystem inflammatory syndrome in children (MISC) and Kawasaki disease patients
Mimi Ganguly,Alolika Nandi,Paramita Banerjee,Purbasha Gupta,Subhajit Dey Sarkar,Surupa Basu,Priyankar Pal
doi : 10.1111/1756-185X.14236
Volume 25, Issue 1 p. 27-31
Post-COVID multisystem hyperinflammatory syndrome in children (MISC) has clinical and laboratory similarities with Kawasaki disease (KD). Inflammatory markers like C-reactive protein (CRP), interleukin 6 (IL6) as well as N-terminal probrain natriuretic peptide (NT-proBNP) are elevated in both. This study attempts a comparative analysis of the 3 markers in an attempt at early differentiation for planning appropriate management.
Increased serum AXL is associated with radiographic knee osteoarthritis severity
Shao Zhenghai
doi : 10.1111/1756-185X.14239
Volume 25, Issue 1 p. 32-37
To investigate the expression and clinical significance of serum soluble AXL in patients with radiographic knee osteoarthritis (KOA).
Associations between radiographic features, clinical features and ultrasound of thumb-base osteoarthritis: A secondary analysis of the COMBO study
Ying Shi,Kai Fu,Win Min Oo,Leticia A. Deveza,Xia Wang,Vicky Duong,Sarah R. Robbins,David J. Hunter
doi : 10.1111/1756-185X.14248
Volume 25, Issue 1 p. 38-46
To investigate the associations of ultrasound and radiographic features of thumb-base osteoarthritis (OA) with thumb-base pain and hand function at baseline and 12 weeks.
Effect of psoriatic arthritis on the strength, proprioception, skill, coordination, and functional condition of the hand
Busra Candiri,Burcu Talu,Dilan Demirtas Karaoba,Gulfem Ezgi Ozaltin,Servet Yolbas
doi : 10.1111/1756-185X.14241
Volume 25, Issue 1 p. 47-55
This study was planned to evaluate the strength, proprioception, skill, coordination, and functional condition of the hand in individuals with psoriatic arthritis and to correlate disease activity with these parameters.
The association between elevated serum interleukin-22 and the clinical diagnosis of axial spondyloarthritis: A retrospective study
Michal Sagiv,Mohammad Adawi,Abid Awisat,Aniela Shouval,Regina Peri,Firas Sabbah,Itzhak Rosner,Aharon Kessel,Gleb Slobodin
doi : 10.1111/1756-185X.14246
Volume 25, Issue 1 p. 56-60
There is an unmet need for a reliable biomarker for the differentiation of axial spondyloarthritis (AxSpA) from its mimickers. Serum levels of interleukin-22 (IL-22) have previously been found to be significantly elevated in patients with AxSpA compared with healthy individuals or persons with osteoarthritis.
Salivary free light chains and salivary immunoglobulins as potential non-invasive biomarkers in primary Sjögren's syndrome
Pulukool Sandhya,Jayakanthan Kabeerdoss,Pamela Christudoss,Roy Arulraj,Santosh Kumar Mandal,Ramya Janardana,Pramod Prahlad Chebbi,Maya Pavalasseril Ganesan,Gowri Mahasampath,Debashish Danda
doi : 10.1111/1756-185X.14242
Volume 25, Issue 1 p. 61-69
B cells contribute significantly to the pathogenesis of primary Sjögren's syndrome (pSS). Free light chains (FLCs) are generated during the production of immunoglobulins (Igs) and are surrogates of B cell activity. We hypothesized that salivary FLCs and salivary Igs could represent salivary gland inflammation and therefore, serve as biomarkers in pSS.
Anti-ribosomal P protein antibodies in patients with systemic lupus erythematosus is associated with hyperferritinemia
Yoshiyuki Arinuma,Shunsei Hirohata,Takuya Isayama,Yasuhiro Hasegawa,Takumi Muramatsu,Junichi Kondo,Yoshiro Kanayama,Kazuma Ino,Yu Matsueda,Kenji Oku,Kunihiro Yamaoka
doi : 10.1111/1756-185X.14245
Volume 25, Issue 1 p. 70-75
Anti-ribosomal P protein antibodies (anti-ribo P) have been reported as one of the specific autoantibodies in patients with systemic lupus erythematosus (SLE) and has been demonstrated to bind and activate macrophages in vitro. Clinically, hyperferritinemia has been known to be a biomarker for macrophage activation. The aim of this study is to clarify the relationship of anti-ribo P and clinical characteristics and biomarkers including serum ferritin in patients with SLE.
Predictive factors for concomitant pulmonary arterial hypertension at diagnosis of systemic lupus erythematosus in a Chinese population
Ying Pan,Yining Sun,Lan He
doi : 10.1111/1756-185X.14251
Volume 25, Issue 1 p. 76-82
To investigate the predictive factors of pulmonary arterial hypertension (PAH) in systemic lupus erythematosus (SLE) patients.
COVID-19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age-associated B cells
Athanasios Sachinidis,Alexandros Garyfallos
doi : 10.1111/1756-185X.14238
Volume 25, Issue 1 p. 83-85
Recent advances in Pediatric Rheumatology: July to September 2021
Pallavi L. Nadig,Reva Tyagi,Surjit Singh
doi : 10.1111/1756-185X.14252
Volume 25, Issue 1 p. 86-89
Increased malignancies in systemic sclerosis
Jaime A. Vondenberg,Maheswari Muruganandam,Sharon E. Nunez,Nicole Suzanne Emil,Wilmer L. Sibbitt Jr.
doi : 10.1111/1756-185X.14244
Volume 25, Issue 1 p. 90-92
Correspondence reply to authors J A Vondenberg et: RE: Increased malignancies in systemic sclerosis (IJRD: IJRD-2021-0787)
Monique S. Rees,Chris Frampton,Douglas H. N. White,Kamal K. Solanki
doi : 10.1111/1756-185X.14271
Volume 25, Issue 1 p. 93-94
Successful treatment of children with juvenile systemic sclerosis using mycophenolate mofetil after methylprednisolone pulse therapy: A 3-year follow-up
Akinori Furusawa,Hiroyuki Wakiguchi,Fumiko Okazaki,Yuno Korenaga,Yoshihiro Azuma,Hiroki Yasudo,Shunji Hasegawa
doi : 10.1111/1756-185X.14260
Volume 25, Issue 1 p. 95-96
