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The use of herbal medicines and conventional drugs by individuals with cerebral palsy and the risk of interactions
M.ClementeM.D.MiguelK.B.FelipeC.GribnerR.E.CidadeJ.F.G.DiasD.F.C.JuniorL.C.FernandezE.F.ClementeO.G.Miguel
doi : 10.1016/j.hermed.2021.100500
Volume 30, December 2021, 100500
The use of herbal medicine has been increasing in many parts of the world, despite safety issues. Cerebral palsy (CP) is traditionally considered a group of disorders, which include cognitive, communicative and epilepsy symptoms. Individuals with CP use conventional drugs in addition to herbal medicines, with the expectation of alleviating side effects. However, improper use of herbs may lead to treatment failure or pharmacokinetic interactions. This research investigated herbal medicines and conventional drugs; used by individuals with CP. In addition, individual assessments for each participant of this study was used to gather information in order to improve quality of life.
Lignosus rhinocerus TM02® sclerotia extract inhibits dengue virus replication and Infection
Ahmad SuhailKhazaliaNurshamimiNor RashidbShin-YeeFungbRohanaYusofb
doi : 10.1016/j.hermed.2021.100505
Volume 30, December 2021, 100505
Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom’s successful cultivation, a novel cultivar, named L.rhinocerus TM02®, was produced and has been tested for anti-inflammatory, anti-proliferative, antioxidant, and other medicinal properties. However, the antiviral effects of TM02® cultivar have not been demonstrated. In this study, the antiviral properties of cold-water extract (CWE) from the sclerotium of L.rhinocerus TM02® cultivar were investigated, in inhibiting dengue serotype 2 infection in Vero cells. The authors observed a dose-dependent inhibition on dengue virus replication, particularly during the early stage of dengue infection. The extract also exhibited a significant virucidal effect and displayed a mild prophylactic effect. Hence, in the absence of anti-dengue treatment and limited dengue vaccination, these results indicate that TM02® CWE may serve as an alternative medicine in reducing dengue infection. Further studies are required to identify and verify the bioactive compounds of TM02® CWE that mediate the antiviral activity.
Antimicrobial and antioxidant potential of a standardized Ayurvedic formulation explains its clinical efficacy as gargles in post-radiotherapy oral cancer patients
SandeepChavanaSushamaBhuvadaBhagyashriKumbhlakaraJyotiAutibTanhajiWalunjaShrideviPathakbRahulTanpurecShwetaGujardJagdishShindeeArvindKulkarnieVidyaGuptacVineetaDeshmukhdSadanandSardeshmukhd
doi : 10.1016/j.hermed.2021.100510
Volume 30, December 2021, 100510
Exploring the antioxidant and antimicrobial potential of a standardized proprietary poly-herbal powder and evaluating its clinical efficacy as an Ayurvedic gargle (Gandush) for reducing oral microbial load and side effects of radiotherapy in oral cavity cancer patients was the aim of this pilot study.
Antimicrobial activities of extract, fractions and isolated compounds from the fruits of Elaeocarpus floribundus growing in North-East India
Ayorinde VictorOgundeleabcArchanaYadavdSaikatHaldareArchana MoniDasab
doi : 10.1016/j.hermed.2021.100511
Volume 30, December 2021, 100511
The fruits of Elaeocarpus floribundus Blume are edible and used for the treatment of dysentery and diarrhoea, a claim of which no scientific studies have validated and whose bioactive principles are unknown. Therefore, the present study centres in the evaluation of the antimicrobial activity of the ethanolic crude extract, fractions and the identification of its active constituents.
Identification of medicinal herbs in Asteraceae and Polygonaceae using an electrochemical fingerprint recorded using screen-printed electrode
LiFua1YuhongZhengbc1AiwuWangdPengchongZhangeSuDingaWeihongWuaQingweiZhouaFeiChenaShichaoZhaoa
doi : 10.1016/j.hermed.2021.100512
Volume 30, December 2021, 100512
A quick and low-cost method for traditional medical herbs identification is essential for the plant resources and pharmaceutical industries. The electrochemical voltammetric profile of plant tissues can be considered as a unique fingerprint available for herbal traditional medical herbs identification. In this work, a chip-based portable method is proposed for measuring the electrochemical fingerprint of a series of medicinal herbs with the assistance of graphene. Fingerprints were converted into patterns, colors and pixels for easy identification. The results indicated that the proposed electrochemical fingerprint sensor can recognize medicinal herbs in fresh, dried and prepared forms. In addition, the taxonomic relationships of these species were studied based on the recorded fingerprints, since the degree of differences in electroactive compounds can reflect genetic differences. The results indicate that the electrochemical fingerprints recorded from fresh samples can effectively reflect the phylogenetic position of species.
Comparison of the effect of Sedamin and aromatherapy with Lavender on fatigue severity of patients with heart failure: A three arm randomized controlled trial
MahtabHassanzadehaZahraFarsibSeyedeh AzamSajadic
doi : 10.1016/j.hermed.2021.100514
Volume 30, December 2021, 100514
Fatigue is one of the main symptoms of heart failure, which leads to activity intolerance and self-care impairment. Aromatherapy is one of the most popular and widely used methods among patients with chronic diseases. One reason for the popularity of complementary medicine methods is the ease of use and attention to patient preferences, so in this study, the effect of two herbal derivatives with two methods of consumption (oral and inhalation) was investigated. This study compared the effect of Lavender essence inhalation and oral Sedamin on fatigue severity in patients with heart failure.
Rationalistic approach in COVID-19 prevention through intervention of Unani medicine prevalent in epidemic – A review
FatimaKhanAbdul NasirAnsariMohdNayab
doi : 10.1016/j.hermed.2021.100515
Volume 30, December 2021, 100515
A novel coronavirus virus (2019-nCoV) emerged in China in December 2019 and achieved a high-risk category by the World Health Organization (WHO). The initial symptoms included fever, cough, dyspnea, and sore throat. The present review aims to evaluate the available evidence for the safety and efficacy of Unani herbal drugs and formulations in the prevention of Wabai Amraz (epidemic diseases) having resemblance to SARS-CoV-2.
Effects of Anethum graveolens (dill) and its derivatives on controlling cardiovascular risk factors: A systematic review and meta-analysis
CyrusJaliliaSajjadMoradibAtiehMirzababaeicHamedMohammadidFatimaHeydarzadehcMaryamMiraghajaniefAnastasia-ViktoriaLazaridif
doi : 10.1016/j.hermed.2021.100516
Volume 30, December 2021, 100516
Previous studies have demonstrated that the supplementation of Anethum graveolens (dill) could affect the metabolic indices. Thus, the present study summarizes all of the published clinical studies which evaluate the efficacy of dill administration on cardiovascular risk factors.
Effects of natural herb-containing dental toothpaste on periodontal pathogenic bacteria and clinical parameters: A randomized clinical trial
SatoshiShirakawaaYujiMatsushimaaSohtaroKajiyamaaTakumaSuzukiaTakatoshiNaganoaMasahikoNikaidoubKazuhiroGomia
doi : 10.1016/j.hermed.2021.100517
Volume 30, December 2021, 100517
Toothpastes containing natural herbs (NHs) have been commercially sold based on the claim that NHs possess anti-inflammatory, astringency, and antibacterial activities that reduce gingival inflammation. However, there have been few reports on the effects of such toothpastes on periodontitis or oral bacteria. The aim was to investigate the effects of a toothpaste containing NHs (Acess®) on clinical parameters and oral bacteria.
In vitro evaluation of the antiproliferative activity of Carpobrotus edulis on human neuroblastoma cells
Sylvester IfeanyiOmoruyiAdaze BijouEnogieruOkobi EkoEkpo
doi : 10.1016/j.hermed.2021.100519
Volume 30, December 2021, 100519
Neuroblastoma is a solid neuroendocrine tumour located outside the cranial cavity and contributes about 15% of all cancer?associated deaths in children. Treatment of neuroblastoma is quite challenging and involves the use of chemotherapy, surgery and radiotherapy. Despite treatment strategies, systemic toxicity are setbacks to patient well-being, hence the need for a new and affordable approach. Medicinal plants are of importance in the field of drug discovery for cancer as some notable anti-cancer agents have been isolated from them. In the present study, the anti-cancer activity of aqueous extract of Carpobrotus edulis (C. edulis), a ground-creeping edible medicinal plant was investigated in SK-N-BE(2) and SH-SY5Y neuroblastoma cells. The effect of C. edulis on cell viability and survival was determined using MTT (3-[4,5-dimethylthiazol-2-yl]?2,5 diphenyltetrazolium bromide) and clonogenic assays respectively. Apoptosis was determined using a Caspase-9 assay kit and flow cytometry was used to measure intracellular reactive oxygen species (ROS) and depolarization of mitochondrial membrane potential. The results show that C. edulis inhibits cell viability (IC50 of 0.86 mg/ml and 1.45 mg/ml for SK-N-BE(2) and SHSY5Y cells respectively) and colony formation in the neuroblastoma cells as well as induce apoptosis, which is evidenced by an increase in caspase-9 activity in the cells. C. edulis also led to a loss of mitochondrial membrane potential and increased production of ROS. Collectively, these results suggest that C. edulis induces cell death via induction of mitochondrial?mediated apoptosis and accumulation of intracellular ROS, thus providing a rationale for further investigations.
