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Imaging Fuchs Endothelial Corneal Dystrophy in Clinical Practice and Clinical Trials
Patel, Sanjay V. MD, FRCOphth
doi : 10.1097/ICO.0000000000002738
December 2021 - Volume 40 - Issue 12 - p 1505-1511
Corneal tomography has an emerging role in the assessment of Fuchs endothelial corneal dystrophy (FECD) in clinical practice and potentially for future clinical trials. Posterior elevation and pachymetry maps derived from elevation based Scheimpflug tomography can detect early corneal edema, even at a subclinical stage, enabling clinicians to better counsel patients about their vision and the risk of disease progression with and without cataract surgery. Tomographic imaging provides a functional assessment of corneal endothelial health, and could enable objective assessment of FECD progression, or regression, in response to novel therapeutic interventions. Clinicians and investigators should adopt Scheimpflug imaging for the assessment of FECD over traditional morphologic imaging modalities.
Cutting Edge: Novel Treatment Options Targeting Corneal Neovascularization to Improve High-Risk Corneal Graft Survival
Cursiefen, Claus MD, PhD*,†; Hos, Deniz MD, PhD*,†
doi : 10.1097/ICO.0000000000002736
December 2021 - Volume 40 - Issue 12 - p 1512-1518
Corneal neovascularization is an important risk factor for graft rejection after keratoplasty, although its role in posterior lamellar keratoplasty is not yet well defined. The aim of this work was to describe clinically available approaches that target corneal neovascularization preoperatively to improve graft survival after subsequent penetrating keratoplasty (PK) and to present findings on Descemet membrane endothelial keratoplasty (DMEK) in eyes with neovascularization.
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders
Palme, Christoph MD*; Wanner, Astrid*; Romano, Vito MD, PhD†; Franchi, Alexander MD*; Haas, Gertrud MD*; Kaye, Stephen B. MD, FRCS, FRCOphth†; Steger, Bernhard MD†
doi : 10.1097/ICO.0000000000002681
December 2021 - Volume 40 - Issue 12 - p 1519-1524
To investigate whether transvascular indocyanine green (ICG) dye leakage is associated with conjunctival malignancy.
Limbal Stem Cell Deficiency: Demographics and Clinical Characteristics of a Large Retrospective Series at a Single Tertiary Referral Center
Cheung, Albert Y. MD*; Sarnicola, Enrica MD†; Denny, Matthew R. MD‡; Sepsakos, Lorena MD§; Auteri, Nicholas J. BS‡; Holland, Edward J. MD‡
doi : 10.1097/ICO.0000000000002770
December 2021 - Volume 40 - Issue 12 - p 1525-1531
The aim of this study was to characterize a large cohort of patients presenting to a single referral center for limbal stem cell deficiency (LSCD).
Microsporidial Stromal Keratitis: Epidemiological Features, Slit-Lamp Biomicroscopic Characteristics, and Therapy
Matoba, Alice MD*; Goosey, John MD†; Chévez-Barrios, Patricia MD*,‡,§
doi : 10.1097/ICO.0000000000002704
December 2021 - Volume 40 - Issue 12 - p 1532-1540
Microsporidial stromal keratitis is a rare form of infectious keratitis, with only 7 cases reported in the United States to date. This study was performed to evaluate risk factors, clinical features, and response to therapy.
Survey of Corneal Surgeons' Attitudes Regarding Keratoplasty Rejection Risk Associated With Vaccinations
Lockington, David MD, FRCOphth, PhD*; Lee, Barry MD†; Jeng, Bennie H. MD‡; Larkin, Daniel F. P. MD, FRCOphth§; Hjortdal, Jesper MD, PhD¶
doi : 10.1097/ICO.0000000000002662
December 2021 - Volume 40 - Issue 12 - p 1541-1547
To investigate the attitudes and practice of corneal specialists if patients with keratoplasty sought advice regarding common vaccinations and risk for potential graft rejection.
Development and Validation of a Natural Language Processing Algorithm to Extract Descriptors of Microbial Keratitis From the Electronic Health Record
Woodward, Maria A. MD, MSc*,†; Maganti, Nenita MD*,‡; Niziol, Leslie M. MS*; Amin, Sejal MD§; Hou, Andrew MD§; Singh, Karandeep MD†,¶
doi : 10.1097/ICO.0000000000002755
December 2021 - Volume 40 - Issue 12 - p 1548-1553
The purpose of this article was to develop and validate a natural language processing (NLP) algorithm to extract qualitative descriptors of microbial keratitis (MK) from electronic health records.
Medication Adherence Among Patients With Corneal Diseases
Khan, Mariam MHSA*; Michelson, Sarah MD*; Newman-Casey, Paula Anne MD, MS*,†; Woodward, Maria A. MD, MSc*,†
doi : 10.1097/ICO.0000000000002680
December 2021 - Volume 40 - Issue 12 - p 1554-1560
Bowman Layer Onlay Grafting: Proof-of-Concept of a New Technique to Flatten Corneal Curvature and Reduce Progression in Keratoconus
Dapena, Isabel MD, PhD*,†; van der Star, Lydia BOptom*,†; Groeneveld-van Beek, Esther A. MSc*,‡; Quilendrino, Ruth MD*,†; van Dijk, Korine BOptom, PhD*,†; Parker, Jack S. MD, PhD§,¶; Oellerich, Silke PhD*; Melles, Gerrit R. J. MD, PhD*,†,‡,¶
doi : 10.1097/ICO.0000000000002740
December 2021 - Volume 40 - Issue 12 - p 1561-1566
The aim of this study was to describe a new surgical technique for flattening the corneal curvature and to reduce progression in eyes with advanced progressive keratoconus (KC) by using Bowman layer (BL) onlay grafting and to report on the preliminary outcomes of this procedure.
Relationship of Body Mass Index With Fuchs Endothelial Corneal Dystrophy Severity and TCF4 CTG18.1 Trinucleotide Repeat Expansion
Kinariwala, Bhumi B. MD*; Xu, Timothy T. BS†; Baratz, Keith H. MD‡; Aleff, Ross A. BS§; Patel, Sanjay V. MD, FRCOphth‡; Maguire, Leo J. MD‡; Fautsch, Michael P. PhD‡; Wieben, Eric D. PhD§; Millen, Amy E. PhD¶; Patel, Sangita P. MD, PhD*,?
doi : 10.1097/ICO.0000000000002689
December 2021 - Volume 40 - Issue 12 - p 1567-1570
To investigate the association of body mass index (BMI) with Fuchs endothelial corneal dystrophy (FECD) severity and TCF4 CTG18.1 expansion.
Descemet Stripping Automated Endothelial Keratoplasty in Pediatric Age Group: A Decade of Our Experience
Ramappa, Muralidhar MBBS, MS*,†,‡; Mohamed, Ashik MBBS, MTech, PhD, MAMS*,§; Achanta, Divya S. Ramya BS*,†,‡; Tumati, Chaitanya S. Kiran BS‡; Chaurasia, Sunita MBBS, MS*,†,‡,¶; Edward, Deepak P. MD?
doi : 10.1097/ICO.0000000000002811
December 2021 - Volume 40 - Issue 12 - p 1571-1580
This study was to report the outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) in managing corneal endothelial disorders in children less than 14 years of age.
Comparative Efficacy and Safety of Standard Versus Accelerated Corneal Crosslinking for Keratoconus: 1-Year Outcomes From the Save Sight Keratoconus Registry Study
Kandel, Himal PhD*; Nguyen, Vuong PhD*; Ferdi, Alex C. MBBS, MA*; Gupta, Aanchal MBBS, MMed†,‡; Abbondanza, Marco MD§; Sullivan, Laurence MBBS¶; Apel, Andrew MBBS?; Watson, Stephanie L. MBBS, PhD*
doi : 10.1097/ICO.0000000000002747
December 2021 - Volume 40 - Issue 12 - p 1581-1589
The aim of this study was to compare the efficacy and safety of standard [Ultraviolet (UV) light power: 3 mW/cm2, duration: 30 minutes] versus accelerated (UV power: 9 mW/cm2, duration: 10 minutes) corneal crosslinking (CXL) for stabilizing keratoconus.
Effect of Body Refrigeration Time on Cornea Donor Tissue
Munir, Wuqaas M. MD*; Brown, Clayton H. PhD†; Munir, Saleha Z. OD*; Hoover, Caroline K. CEBT‡
doi : 10.1097/ICO.0000000000002665
December 2021 - Volume 40 - Issue 12 - p 1590-1593
To determine how early body refrigeration affects corneal donor transplant suitability and endothelial cell density.
Effects of Vectored Thermal Pulsation on Objective Tear Film Measures
Fallah, Shamis DO*; Loer, Christopher J. BA†
doi : 10.1097/ICO.0000000000002714
December 2021 - Volume 40 - Issue 12 - p 1594-1599
To assess the effect of vectored thermal pulsation treatment for meibomian gland dysfunction on objective measures of lipid layer thickness (LLT) and tear osmolarity.
Associated Neurotrophic Keratopathy in Complex Regional Pain Syndrome
Soifer, Matias MD*,†; Gomez-Caraballo, Maria BA*; Venkateswaran, Nandini MD*,†,‡; Jay, Gary W. MD§; Perez, Victor L. MD*,†
doi : 10.1097/ICO.0000000000002684
December 2021 - Volume 40 - Issue 12 - p 1600-1603
To report a case of neurotrophic keratopathy (NK) in a patient with complex regional pain syndrome (CRPS) with ipsilateral facial involvement.
Radial Endothelial Striae Over 360 Degrees in Fuchs Corneal Endothelial Dystrophy: New Pathophysiological Findings
Thuret, Gilles MD, PhD*,†; Ain, Anthony*; Koizumi, Noriko MD, PhD‡; Okumura, Naoki MD, PhD‡; Gain, Philippe MD, PhD*,†; He, Zhiguo PhD*
doi : 10.1097/ICO.0000000000002666
December 2021 - Volume 40 - Issue 12 - p 1604-1606
To report evidences that the abnormal endothelium of some Fuchs endothelial corneal dystrophy (FECD) present centripetal radial lines over 360 degrees
Corneal Toxicity Secondary to Latex From Asclepias curassavica in a Pediatric Patient
Yang, Jessica F. MD; Beal, Casey J. MD
doi : 10.1097/ICO.0000000000002708
December 2021 - Volume 40 - Issue 12 - p 1607-1609
To report a case of corneal milkweed toxicity on the corneal endothelium with epithelial damage in a pediatric patient.
Congenital Insensitivity to Pain: A Case Report With Corneal Esthesiometry and In Vivo Confocal Microscopy
Keenan, Jeremy D. MD, MPH*,†; Gonzales, John A. MD*,†; Waxman, Stephen G. MD, PhD‡,§; Delwig, Anton PhD¶
doi : 10.1097/ICO.0000000000002650
December 2021 - Volume 40 - Issue 12 - p 1610-1613
To report the findings of a comprehensive eye examination from an individual with congenital insensitivity to pain because of loss-of-function mutations in the SCN9A gene.
Spontaneous Deflation of the Big Bubble: A New Complication in Big Bubble Deep Anterior Lamellar Keratoplasty
Fogla, Rajesh DNB, FRCSEd, FRCOphth, FACS*; Gujar, Prateek MS†
doi : 10.1097/ICO.0000000000002720
December 2021 - Volume 40 - Issue 12 - p 1614-1616
To report a new complication of spontaneous deflation of type 1 big bubble (BB) in deep anterior lamellar keratoplasty (DALK).
Fungal Necrotizing Scleritis After Intravitreal Injection Therapy
Hernández-Pons, Antonio MD*; Ortiz-Seller, Amparo MD*; López-Cruz, Ian MD†; Camarena, Juan J. MD, PhD‡; Comín-Pérez, Alberto MD*; Ferrández-Pérez, María A. MD*; Martínez-Costa, Lucía MD, PhD*
doi : 10.1097/ICO.0000000000002670
December 2021 - Volume 40 - Issue 12 - p 1617-1619
To report a case of infectious necrotizing scleritis secondary to Aspergillus terreus after intravitreal injection therapy.
Partial-Thickness Intrastromal Lamellar Keratoplasty for Corneal Pellucid Marginal Degeneration
Gonçalves, Thiago B. MD; Nosé, Angela F. B. MD; Pereira, Nicolas C. MD, PhD; Forseto, Adriana dos S. MD, PhD
doi : 10.1097/ICO.0000000000002671
December 2021 - Volume 40 - Issue 12 - p 1620-1623
Pellucid marginal degeneration (PMD) is a bilateral corneal ectatic disorder, characterized by thinning of the inferior cornea. Numerous surgical procedures have been described in the literature, and there is a lack of consensus regarding the best available surgical management. Recently, full-thickness intrastromal lamellar keratoplasty (ILK) was described as an option for treating PMD and emerged as a promising technique. However, ILK results in an irregular surface, leading to a significant residual against-therule (ATR) astigmatism.
Application of Trypan Blue Stain in the Microbiological Diagnosis of Infectious Keratitis—A Case Series
Sharma, Supriya DNB*; Rathi, Varsha M. DO*; Murthy, Somasheila I. MS†; Garg, Prashant MS†; Sharma, Savitri MD‡
doi : 10.1097/ICO.0000000000002725
December 2021 - Volume 40 - Issue 12 - p 1624-1628
The purpose of this study was to report 3 cases of microbial keratitis, wherein trypan blue staining was used to aid the microbiological diagnosis of fungal keratitis and Pythium keratitis in a rural setup.
Bilateral Immune-Mediated Keratolysis After Immunization With SARS-CoV-2 Recombinant Viral Vector Vaccine
Khan, Tanveer Alam MD*; Sidhu, Navneet MD*; Khan, Livia MBBS*; Sen, Seema MD†; Hussain, Nishat MD‡; Tandon, Radhika MD, DNB, FRCOphth*; Gupta, Noopur MS, DNB, PhD*
doi : 10.1097/ICO.0000000000002844
December 2021 - Volume 40 - Issue 12 - p 1629-1632
The purpose of this study was to report an unusual case of bilateral immune-mediated corneal melting and necrosis after ChAdOx1 nCoV-19 (Covishield) vaccination.
Implantation of an Artificial Endothelial Layer for Treatment of Chronic Corneal Edema
Auffarth, Gerd U. MD, PhD*; Son, Hyeck-Soo MD*; Koch, Matthias MD*; Weindler, Jan MD*; Merz, Patrick PhD*; Daphna, Ofer MD†; Marcovich, Arie L. MD†,‡,§; Augustin, Victor A. MD*
doi : 10.1097/ICO.0000000000002806
December 2021 - Volume 40 - Issue 12 - p 1633-1638
The purpose of this study was to describe a novel device that may serve as an alternative to Descemet membrane endothelial keratoplasty (DMEK) for the treatment of chronic corneal edema.
A Novel Virtual Wet Lab–Using a Smartphone Camera Adapter and a Video Conference Platform to Provide Real-Time Surgical Instruction
Cervantes, Lorenzo J. MD*; Tallo, Christian A. BS†; Lopes, Caithlin A. BA‡; Hellier, Erik A. MBA, CEBT‡; Chu, David S. MD§,¶
doi : 10.1097/ICO.0000000000002763
December 2021 - Volume 40 - Issue 12 - p 1639-1643
Proctored surgical instruction has traditionally been taught through in-person interactions in either the operating room or an improvised wet lab. Because of the COVID-19 pandemic, live in-person instruction was not feasible owing to social distancing protocols, so a virtual wet lab (VWL) was proposed and implemented. The purpose of this article is to describe our experience with a VWL as a Descemet membrane endothelial keratoplasty (DMEK) skills-transfer course. This is the first time that a VWL environment has been described for the instruction of ophthalmic surgery.
