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Melanoma Screening—Time for a Reset?
Allan C. Halpern, MD1; Michael A. Marchetti, MD1
doi : 10.1001/jamadermatol.2021.3883
JAMA Dermatol. 2021;157(12):1409-1411
Novel Treatments for Chronic Erythema Multiforme Inform Translational Science and Disease Pathogenesis
Arturo R. Dominguez, MD1; Samantha N. Lopez, BS2
doi : 10.1001/jamadermatol.2021.4082
JAMA Dermatol. 2021;157(12):1411-1413
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis
Laura Maintz, MD1,2; Thomas Welchowski, PhD2,3; Nadine Herrmann, PhD1,2; Juliette Brauer, BA1,2; Anna Sophie Kläschen, MD1,2; Rolf Fimmers, PhD3; Matthias Schmid, PhD3; Thomas Bieber, MD, PhD, MDRA1,2; and the CK-CARE Study Group
doi : 10.1001/jamadermatol.2021.3668
JAMA Dermatol. 2021;157(12):1414-1424
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and is driven by a complex pathophysiology underlying highly heterogeneous phenotypes. Current advances in precision medicine emphasize the need for stratification.
Association Between Melanoma Detected During Routine Skin Checks and Mortality
Caroline G. Watts, PhD1,2; Kirstie McLoughlin, DPhil1,3; Chris Goumas, MPH1; Cathelijne H. van Kemenade, MPH1; Joanne F. Aitken, PhD4,5; H. Peter Soyer, MD6,7; Pablo Fernandez Peñas, MD8,9; Pascale Guitera, MD, PhD10,11,12; Richard A. Scolyer, MD10,11,13; Rachael L. Morton, PhD10,14; Scott W. Menzies, MBBS, PhD11,12; Michael Caruana, DPhil1,3; Yoon Jung Kang, PhD1,3; Graham J. Mann, MBBS, PhD10,15,16; Annette H. Chakera, MD, PhD17,18; Christine M. Madronio, MPhil, MPH19; Bruce K. Armstrong, MBBS, PhD20; John F. Thompson, MD10,11; Anne E. Cust, PhD1,10
doi : 10.1001/jamadermatol.2021.3884
JAMA Dermatol. 2021;157(12):1425-1436
Early melanoma diagnosis is associated with better health outcomes, but there is insufficient evidence that screening, such as having routine skin checks, reduces mortality.
Association of Sun-Protective Behaviors With Bone Mineral Density and Osteoporotic Bone Fractures in US Adults
Mohsen Afarideh, MD, MPH1; Julio C. Sartori-Valinotti, MD1; Megha M. Tollefson, MD1,2
doi : 10.1001/jamadermatol.2021.4143
JAMA Dermatol. 2021;157(12):1437-1446
Despite the reassuring emerging evidence on the lack of a causal relationship between sun protection and vitamin D deficiency, there is scarce data on whether multimodal sun protection is associated with reduced bone mineral density (BMD) and/or increased prevalence of osteoporotic bone fractures. This lack of data may lead to worry and decreased sun-protective behaviors on the part of patients.
Risks of Multiple Skin Cancers in Organ Transplant Recipients
Mackenzie R. Wehner, MD, MPhil1,2,3; Jiangong Niu, PhD2; Lee Wheless, MD, PhD4; Laura X. Baker, MD4; Olivia G. Cohen, MSPH5; David J. Margolis, MD, PhD1; Sharon H. Giordano, MD, MPH2; Thuzar M. Shin, MD, PhD1
doi : 10.1001/jamadermatol.2021.4148
JAMA Dermatol. 2021;157(12):1447-1455
There are limited reports on the risks of multiple primary skin cancers in organ transplant recipients (OTRs).
Importance of Supplemental Patch Testing Beyond a Screening Series for Patients With Dermatitis
Erin M. Warshaw, MD, MS1,2,3; Michele Buonomo, BA1,3,4; Joel G. DeKoven, MD5; Melanie D. Pratt, MD6; Margo J. Reeder, MD7; Jonathan I. Silverberg, MD8; Donald V. Belsito, MD9; Howard I. Maibach, MD10; Amber R. Atwater, MD11; Marie-Claude Houle, MDCM12; James S. Taylor, MD13; Kathryn A. Zug, MD14; Vincent A. DeLeo, MD15; Cory A. Dunnick, MD16
doi : 10.1001/jamadermatol.2021.4314
JAMA Dermatol. 2021;157(12):1456-1465
Patch test screening series for patients with dermatitis are limited and may miss clinically relevant contact allergens.
Homozygous MEFV Gene Variant and Pyrin-Associated Autoinflammation With Neutrophilic Dermatosis
Hassan Vahidnezhad, PhD1,2; Leila Youssefian, PhD1,2; Amir Hossein Saeidian, MSc1,2,3; Vahid Ziaee, MD4,5; Hamidreza Mahmoudi, MD6; Nima Parvaneh, MD7,8; Bahar Ashjaei, MD9; Soroush Shahrokh, MSc10; Kambiz Kamyab Hesari, MD11; Mohammadsadegh Soltani Zangbar, MSc12; Mehdi Yousefi, PhD12,13; Sirous Zeinali, PhD14,15; Jouni Uitto, MD, PhD1,2
doi : 10.1001/jamadermatol.2021.3899
JAMA Dermatol. 2021;157(12):1466-1471
Pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND) is a monogenic autoinflammatory disorder with autosomal dominant inheritance and has been associated with monoallelic p.Ser242Arg and p.Glu244Lys variations in the MEFV gene. This dermatosis shares clinical features and pathogenesis with familial Mediterranean fever, although it is a clinically distinct entity.
Evaluation of Thalidomide Treatment of Patients With Chronic Erythema Multiforme
Camille Roux, MD1; Emilie Sbidian, MD, PhD1,2; Jean-David Bouaziz, MD, PhD3; Diane Kottler, MD4,5; Pascal Joly, MD, PhD6; Vincent Descamps, MD, PhD4,5; Catherine Prost, MD, PhD7; Mahtab Samimi, MD, PhD8; Julien Seneschal, MD, PhD9; Nicolas Dupin, MD, PhD10; Céline Girard, MD11; Muriel Paul, MD2,12; Laurence Le Cleach, MD, PhD1,2; Saskia Ingen-Housz-Oro, MD1,2,13
doi : 10.1001/jamadermatol.2021.4083
JAMA Dermatol. 2021;157(12):1472-1476
Erythema multiforme (EM) may become long term, with a recurrent or persistent course. First-line treatment for chronic EM is valaciclovir. There is no consensus for selection of second-line treatment of chronic EM.
Treatment of Persistent Erythema Multiforme With Janus Kinase Inhibition and the Role of Interferon Gamma and Interleukin 15 in Its Pathogenesis
Michael J. Murphy, BS1; Diana Gruenstein, BA2; Alice Wang, BS1; Danielle Peterson, MD1; Jacob Levitt, MD2; Brett King, MD, PhD1; William Damsky, MD, PhD1,3
doi : 10.1001/jamadermatol.2021.4084
JAMA Dermatol. 2021;157(12):1477-1482
Persistent erythema multiforme (PEM) is poorly understood and lacks effective therapies other than glucocorticoids.
Bullous Dermatoses and Depression
Sarah P. Pourali, BS1; Yasmin Gutierrez, BS2; Alison H. Kohn, BS3; Jeffrey R. Rajkumar, BS4; Madison E. Jones, BA5; Isabela Ortiz, BS5; Michelle David, BA5; April W. Armstrong, MD, MPH5
doi : 10.1001/jamadermatol.2021.4055
JAMA Dermatol. 2021;157(12):1487-1495
There is a lack of evidence synthesis on the association between bullous skin disease and depression.
Perianal Chancres of Primary Syphilis
Herbert Castillo Valladares, MD1; Errol Craig, MD2; Kenneth A. Katz, MD, MSc, MSCE3,4
doi : 10.1001/jamadermatol.2021.3763
JAMA Dermatol. 2021;157(12):1496
Gustatory Hyperhidrosis
Marlous L. Grijsen, PhD1,2,3; Esther J. van Zuuren, MD1
doi : 10.1001/jamadermatol.2021.3303
JAMA Dermatol. 2021;157(12):1497
Violaceous Plaques on the Left Lower Extremity
Bianca Uzoma, BS1; Paige Hoyer, MD2; Kathleen Kroger, MD2
doi : 10.1001/jamadermatol.2021.4295
JAMA Dermatol. 2021;157(12):1498-1499
Multiple Painless Subcutaneous Nodules on the Cheek of an Immunocompetent Man
Soufila Kudukkil Thazhathuveettil, MD1; Hitaishi Mehta, MD, DNB1; Keshavamurthy Vinay, MD, DNB1
doi : 10.1001/jamadermatol.2021.4579
JAMA Dermatol. 2021;157(12):1500-1501
Stasis Dermatitis
Ritesh Agnihothri, MD1; Kanade Shinkai, MD, PhD1
doi : 10.1001/jamadermatol.2021.3475
JAMA Dermatol. 2021;157(12):1524
Characteristics and Outcomes of Eosinophilic Fasciitis–Associated Monoclonal Gammopathy
Daniel R. Mazori, MD1,2,3; Bina Kassamali, BA1,2; Michelle S. Min, MD, MS1,2,4; Morgan Schaefer, BA1; Avery H. LaChance, MD, MPH1,2; Adam S. Sperling, MD, PhD2,5,6; Ruth Ann Vleugels, MD, MPH, MBA1,2
doi : 10.1001/jamadermatol.2021.4302
JAMA Dermatol. 2021;157(12):1508-1509
Content Analysis of Patient-Reported Outcome Measures Used in Patients With Nail Conditions
Khizar Abid, BHSc1; Leah Algu, BHSc2; Rakhshan Kamran, BSc3; Cameron F. Leveille, MD3; Charlene Rae, MSc4; Shari R. Lipner, MD, PhD5; Anne F. Klassen, DPhil4
doi : 10.1001/jamadermatol.2021.4539
JAMA Dermatol. 2021;157(12):1509-1511
Lesbian, Gay, Bisexual, and Transgender Identity and Disclosure Among Dermatologists in the US
Matthew D. Mansh, MD1; Erica Dommasch, MD, MPH2; J. Klint Peebles, MD3; Kara Sternhell-Blackwell, MD4; Howa Yeung, MD, MSc5
doi : 10.1001/jamadermatol.2021.4544
JAMA Dermatol. 2021;157(12):1512-1514
Reduction of Disease Burden With Early Sirolimus Treatment in a Child With Proteus Syndrome
Lisa Weibel, MD1; Martin Theiler, MD1; Ralph Gnannt, MD2; Kathrin Neuhaus, MD3; Jan Schellenberg Han, MD4; Hanspeter Huber, MD5; Thierry M. Nordmann, MD, PhD1,6
doi : 10.1001/jamadermatol.2021.4305
JAMA Dermatol. 2021;157(12):1514-1516
Incorporating Structural Competency Into Dermatologic Curricula
Erica Ogwumike, BA1; Donald A. Glass II, MD, PhD1; Rebecca Vasquez, MD1
doi : 10.1001/jamadermatol.2021.4560
JAMA Dermatol. 2021;157(12):1516-1517
Incorporating Structural Competency Into Dermatologic Curricula—Reply
Jenna C. Lester, MD1; Susan C. Taylor, MD2
doi : 10.1001/jamadermatol.2021.1899
JAMA Dermatol. 2021;157(12):1517
