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Safety, clinical and laboratory characteristics of donors with thalassemia minor in living donor kidney transplant: a case series
Nhan Hieu Dinh & Suzanne Monivong Cheanh Beaupha
doi : 10.1186/s12882-021-02609-2
BMC Nephrology volume 22, Article number: 397 (2021)
Due to the increasing demand for kidney transplants, sometimes donors with underlying medical conditions can be considered for living kidney donor transplant. Thalassemia is amongst the most common inherited disorders of hemoglobin globally, which is not restricted as an exclusion criterion. However, there is currently no study examine the safety and characteristics of kidney donors with thalassemia minor.
Higher one-year achievement rate of serum phosphate associated with lower cardiovascular mortality in hemodialysis patients
Weichen Zhang, Guoxin Ye, Zhaori Bi, Weisheng Chen, Jing Qian, Minmin Zhang, Ding Ding, Mengjing Wang & Jing Chen
doi : 10.1186/s12882-021-02547-z
BMC Nephrology volume 22, Article number: 398 (2021)
Estimation of phosphate load in hemodialysis patients is always controversial in clinical practice. The aim of this study was to verify individual achievement rate of serum phosphate as the evaluation of phosphate load through investigating its impact on cardiovascular mortality in hemodialysis patients.
Cost-effectiveness and value of information analysis of NephroCheck and NGAL tests compared to standard care for the diagnosis of acute kidney injury
Elisabet Jacobsen, Simon Sawhney, Miriam Brazzelli, Lorna Aucott, Graham Scotland, Magaly Aceves-Martins, Clare Robertson, Mari Imamura, Amudha Poobalan, Paul Manson, Callum Kaye & Dwayne Boyers
doi : 10.1186/s12882-021-02610-9
BMC Nephrology volume 22, Article number: 399 (2021)
Early and accurate acute kidney injury (AKI) detection may improve patient outcomes and reduce health service costs. This study evaluates the diagnostic accuracy and cost-effectiveness of NephroCheck and NGAL (urine and plasma) biomarker tests used alongside standard care, compared with standard care to detect AKI in hospitalised UK adults.
Treatment persistence to tolvaptan in patients with autosomal dominant polycystic kidney disease: a secondary use of data analysis of patients in the IMADJIN® dataset
Mark Thomas, Pedro Henrique Franca Gois, Belinda E. Butcher, Michelle H. T. Ta & Greg W. Van Wyk
doi : 10.1186/s12882-021-02607-4
BMC Nephrology volume 22, Article number: 400 (2021)
Tolvaptan is the only available disease-modifying treatment for autosomal dominant polycystic kidney disease (ADPKD). Prior to October 2020 access to tolvaptan in Australia was restricted by a controlled monitoring and distribution program called IMADJIN®. Focusing on hepatic safety, the IMADJIN® program collected real-world data on patients with ADPKD. A retrospective, secondary data analysis of the IMADJIN® dataset was undertaken to determine the time to all-cause discontinuation of tolvaptan in Australia.
Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study
Tahira Scott, Isabelle Ethier, Carmel Hawley, Elaine M. Pascoe, Andrea K. Viecelli, Arnold Ng, Yeoungjee Cho & David W. Johnson
doi : 10.1186/s12882-021-02604-7
BMC Nephrology volume 22, Article number: 401 (2021)
Cardiovascular disease is a leading cause of mortality in kidney failure (KF). Patients with KF from atheroembolic disease are at higher risk of cardiovascular disease than other causes of KF. This study aimed to determine survival on dialysis for patients with KF from atheroembolic disease compared with other causes of KF.
Association of meteorological factors and ambient air pollution on medical care utilization for urolithiasis: a population-based time-series study
Tae Il Noh, Jinwook Hong, Seok Ho Kang & Jaehun Jung
doi : 10.1186/s12882-021-02614-5
BMC Nephrology volume 22, Article number: 402 (2021)
To identify the association of meteorological factors/ambient air pollutants with medical care utilization for urolithiasis and estimate the effect size/time lags.
Correction to: COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort
Paul D. Jewell, Kate Bramham, James Galloway, Frank Post, Sam Norton, James Teo, Richard Fisher, Rohit Saha, Sam Hutchings, Phil Hopkins, Priscilla Smith, Jennifer Joslin, Satish Jayawardene, Sarah Mackie, Ali Mudhaffer, Amelia Holloway, Henry Kibble, Mosammat Akter, Benjamin Zuckerman, Kieran Palmer, Ciara Murphy, Domniki Iatropoulou, Claire C. Sharpe & Eirini Lioudaki
doi : 10.1186/s12882-021-02617-2
BMC Nephrology volume 22, Article number: 403 (2021)
?-Thalassemia minor & renal tubular dysfunction: is there any association?
Mohsen Vakili Sadeghi, Maryam Mirghorbani & Roghayeh Akbari
doi : 10.1186/s12882-021-02602-9
BMC Nephrology volume 22, Article number: 404 (2021)
Beta(?)-thalassemia is one of the most common hereditary hematologic disorders. Patients with thalassemia minor (TM) are often asymptomatic and the rate of renal dysfunction is unknown in these patients. Due to the high prevalence of renal dysfunction in Iran, the current study aimed to determine renal tubular dysfunction in patients with beta-TM.
Tacrolimus trough levels in kidney transplant recipients
Young Hui Hwang, Hyunjung Kim, Kyungok Min & Jaeseok Yang
doi : 10.1186/s12882-021-02622-5
BMC Nephrology volume 22, Article number: 405 (2021)
It is very important that kidney transplant recipients (KTRs) take immunosuppressive drugs to prevent graft rejection. This study aimed to identify the tacrolimus trough levels (TTL)-mean, TTL-standard deviation (SD), and TTL- coefficient of variation (CV) as well as factors affecting these values over a 2-year period in clinically stable patients >?5?years after kidney transplantation (KT).
Blood and urinary cytokine balance and renal outcomes at cardiac surgery
William T. McBride, Mary Jo Kurth, Anna Domanska, Joanne Watt, Gavin McLean, Jijin Joseph, John V. Lamont, Peter Fitzgerald & Mark W. Ruddock
doi : 10.1186/s12882-021-02621-6
BMC Nephrology volume 22, Article number: 406 (2021)
Increased perioperative pro-inflammatory biomarkers, renal hypoperfusion and ischemia reperfusion injury (IRI) heighten cardiac surgery acute kidney injury (CS-AKI) risk. Increased urinary anti-inflammatory cytokines attenuate risk. We evaluated whether blood and urinary anti-inflammatory biomarkers, when expressed as ratios with biomarkers of inflammation, hypoperfusion and IRI are increased in CS-AKI patients.
Clinical factors associated with severe hypophosphataemia after kidney transplant
Maximilian R. Ralston, Karen S. Stevenson, Patrick B. Mark & Colin C. Geddes
doi : 10.1186/s12882-021-02624-3
BMC Nephrology volume 22, Article number: 407 (2021)
The mechanism by which hypophosphataemia develops following kidney transplantation remains debated, and limited research is available regarding risk factors. This study aimed to assess the association between recipient and donor variables, and the severity of post-transplantation hypophosphataemia.
A novel MAGED2 variant in a Chinese preterm newborn with transient antenatal Bartter’s syndrome with 4?years follow-up
Mingsheng Ma, Mengqi Zhang, Yu Zhou, Fengxia Yao, Min Wei, Zhenghong Li & Zhengqing Qiu
doi : 10.1186/s12882-021-02553-1
BMC Nephrology volume 22, Article number: 408 (2021)
Transient antenatal Bartter’s syndrome caused by MAGED2 mutation is a rare X-linked recessive renal tubular disorder. Cases reported are mostly infants, and the long-term prognosis of the disease is still under investigation.
Citrate dose for continuous hemofiltration: effect on calcium and magnesium balance, parathormone and vitamin D status, a randomized controlled trial
Willem Boer, Tom Fivez, Margot Vander Laenen, Liesbeth Bruckers, Hans Jurgen Grön, Miet Schetz & Heleen Oudemans-van Straaten
doi : 10.1186/s12882-021-02598-2
BMC Nephrology volume 22, Article number: 409 (2021)
Regional citrate anticoagulation may cause a negative calcium balance, systemic hypocalcemia and parathormone (PTH) activation but randomzed studies are not available. Aim was to determine the effect of citrate dose on calcium (Ca) and magnesium (Mg) balance, PTH and Vitamin D.
A case of Podocytic Infolding Glomerulopathy with SLE and literature review
Xi Liu, Jieli Huang, Kun Zhang, Yangyang Niu, Yuting Liu, Chunli Cui & Chen Yu
doi : 10.1186/s12882-021-02615-4
BMC Nephrology volume 22, Article number: 410 (2021)
Podocytic infolding glomerulopathy (PIG) is a rare pathological change which was characterized by the microspheres or microtubular structures in the thickened glomerular basement membrane (GBM). Only a few dozen cases have been reported worldwide so far. Here we present a case of PIG with systemic lupus erythematosus.
First diagnosis of thrombotic thrombocytopenic purpura after SARS-CoV-2 vaccine – case report
Bilgin Osmanodja, Adrian Schreiber, Eva Schrezenmeier & Evelyn Seelow
doi : 10.1186/s12882-021-02616-3
BMC Nephrology volume 22, Article number: 411 (2021)
We report a case of a 25-year-old male patient, who developed acquired thrombotic thrombocytopenic purpura (aTTP) after receiving a first dose of mRNA-based SARS-CoV-2 vaccine Spikevax (mRNA-1273, Moderna Biotech, USA). While this is the first case in literature describing a case of aTTP after receiving the Spikevax vaccine, there are two other cases after mRNA-based Covid-19 vaccine and two after adenoviral SARS-CoV-2 vaccine.
Mesangial sclerosis in a patient with type 1 diabetes following simultaneous pancreas-kidney transplantation despite maintenance of normoglycemia: a case report
Boonphiphop Boonpheng, Jonathan E. Zuckerman, Gerald S. Lipshutz, Gabriel M. Danovitch, Angela Phelps, Michele Pena & Julie M. Yabu
doi : 10.1186/s12882-021-02620-7
BMC Nephrology volume 22, Article number: 412 (2021)
Simultaneous pancreas-kidney transplantation is considered a curative treatment for type 1 diabetes complicated by end-stage kidney disease. We report herein a case of mesangial sclerosis in a patient who underwent successful kidney-pancreas transplantation despite well-controlled glucose and excellent pancreatic allograft function.
Evaluation of recombinant human erythropoietin responsiveness by measuring erythrocyte creatine content in haemodialysis patients
Shun Hasegawa, Seishi Nakamura, Tetsuro Sugiura, Yoshiaki Tsuka, Nobuyuki Takahashi, Koichiro Matsumura, Toshika Okumiya, Masato Baden & Ichiro Shiojima
doi : 10.1186/s12882-021-02623-4
BMC Nephrology volume 22, Article number: 413 (2021)
One of the main causes of anaemia in patients with end-stage renal disease is relative deficiency in erythropoietin production. Eythropoiesis stimulating agent (ESA), a potent haematopoietic growth factor, is used to treat anaemia in haemodialysis patients. The effect of ESA is usually assessed by haematological indices such as red blood cell count, haemoglobin concentration and haematocrit, but erythrocyte indices do not provide information of the rapid change in erythropoietic activity. As erythrocyte creatine directly assess erythropoiesis, the aim of this study was to evaluate the effect of ESA in haemodialysis patients by measuring the erythrocyte creatine content.
The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil
Gustavo Gomes Thomé, Talissa Bianchini, Rafael Nazario Bringhenti, Pedro Guilherme Schaefer, Elvino José Guardão Barros & Francisco Veríssimo Veronese
doi : 10.1186/s12882-021-02603-8
BMC Nephrology volume 22, Article number: 414 (2021)
The prevalence and distribution of glomerular diseases differ among countries, and the indication to perform a kidney biopsy varies among centres. In this study, we assessed the prevalence of primary and secondary glomerulopathies based on histological diagnoses, and the correlation between glomerulopathies and demographic and clinical data was evaluated.
Combining renal cell arrest and damage biomarkers to predict progressive AKI in patient with sepsis
Xiaolei Tao, Chunbo Chen, Weihong Luo, Jing Zhou, Jianwei Tian, Xiaobing Yang & Fan Fan Hou
doi : 10.1186/s12882-021-02611-8
BMC Nephrology volume 22, Article number: 415 (2021)
Sepsis is the most common trigger for AKI and up to 40% of mild or moderate septic AKI would progress to more severe AKI, which is associated with significantly increased risk for death and later CKD/ESRD. Early identifying high risk patients for AKI progression is a major challenge in patients with septic AKI.
Improve in-depth immunological risk assessment to optimize genetic-compatibility and clinical outcomes in child and adolescent recipients of parental donor kidney transplants: protocol for the INCEPTION study
Wai H. Lim, Brigitte Adams, Stephen Alexander, Antonia H. M. Bouts, Frans Claas, Michael Collins, Elisabeth Cornelissen, Heather Dunckley, Huib de Jong, Lloyd D’Orsogna, Anna Francis, Sebastiaan Heidt, Jean Herman, Rhonda Holdsworth, Joshua Kausman, Rabia Khalid, Jon Jin Kim, Siah Kim, Noël Knops, Vasilis Kosmoliaptsis, Cynthia Kramer, Dirk Kuypers, Nicholas Larkins, Suetonia C. Palmer, Chanel Prestidge, Agnieszka Prytula, Ankit Sharma, Meena Shingde, Anne Taverniti, Armando Teixeira-Pinto, Peter Trnka, Francis Willis, Daniel Wong & Germaine Wong
doi : 10.1186/s12882-021-02619-0
BMC Nephrology volume 22, Article number: 416 (2021)
Parental donor kidney transplantation is the most common treatment option for children and adolescents with kidney failure. Emerging data from observational studies have reported improved short- and medium-term allograft outcomes in recipients of paternal compared to maternal donors. The INCEPTION study aims to identify potential differences in immunological compatibility between maternal and paternal donor kidneys and ascertain how this affects kidney allograft outcomes in children and adolescents with kidney failure.
A novel de novo truncating TRIM8 variant associated with childhood-onset focal segmental glomerulosclerosis without epileptic encephalopathy: a case report
Yoko Shirai, Kenichiro Miura, Naoto Kaneko, Kiyonobu Ishizuka, Amane Endo, Taeko Hashimoto, Shoichiro Kanda, Yutaka Harita & Motoshi Hattori
doi : 10.1186/s12882-021-02626-1
BMC Nephrology volume 22, Article number: 417 (2021)
Heterozygous truncating variants in the Tripartite motif containing 8 (TRIM8) gene have been reported to cause epileptic encephalopathy, both with and without proteinuria. A recent study showed a lack of TRIM8 protein expression, with suppressor of cytokine signaling 1 (SOCS1) overexpression, in podocytes and tubules from a patient with a TRIM8 variant, who presented with epileptic encephalopathy and focal segmental glomerulosclerosis (FSGS). To date, no patients with TRIM8 variants who presented with nephrotic syndrome but without neurological manifestations have been described.
Renal function in ?-thalassemia major patients treated with two different iron-chelation regimes
Osama Tanous, Yossi Azulay, Raphael Halevy, Tal Dujovny, Neta Swartz, Raul Colodner, Ariel Koren & Carina Levin
doi : 10.1186/s12882-021-02630-5
BMC Nephrology volume 22, Article number: 418 (2021)
Renal injury in transfusion dependent ? thalassemia patients (TDT) has been attributed to iron overload, chronic anemia and iron-chelation therapy (ICT) toxicity. We studied renal function in TDT patients treated with two different ICT regimes.
Fetal and maternal outcome in patients with active lupus nephritis: comparison between new-onset and pre-existing lupus nephritis
Xing-Ji Lian, Li Fan, Xi Xia, Xia-Min Huang, Hong-Jian Ye, Xue-Qing Yu, Hai-Tian Chen & Wei Chen
doi : 10.1186/s12882-021-02633-2
BMC Nephrology volume 22, Article number: 419 (2021)
This study aimed to investigate fetal and maternal outcomes in women with active lupus nephritis (LN). Specifically, we compared women who had new-onset LN and those with pre-existing LN during pregnancy.
Splanchnic venous thrombosis in a nephrotic patient following COVID-19 infection: a case report
Maged H. Hussein, Mohamad S. Alabdaljabar, Noorah Alfagyh, Mohammad Badran & Khalid Alamiri
doi : 10.1186/s12882-021-02643-0
BMC Nephrology volume 22, Article number: 420 (2021)
As the COVID-19 pandemic spread worldwide, case reports and small series identified its association with an increasing number of medical conditions including a propensity for thrombotic complications. And since the nephrotic syndrome is also a thrombophilic state, its co-occurrence with the SARS-CoV-2 infection is likely to be associated with an even higher risk of thrombosis, particularly in the presence of known or unknown additional risk factors. Lower extremity deep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of COVID-19-associated hypercoagulable state with other venous or arterial sites being much less frequently involved. Although splanchnic vein thrombosis (SVT) has been reported to be 25 times less common than usual site venous thromboembolism (VTE) and rarely occurs in nephrotic patients, it can have catastrophic consequences. A small number of SVT cases have been reported in COVID-19 infected patients in spite of their number exceeding 180 million worldwide.
