American Journal of Ophthalmology Case Reports




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Pre- and juxtapapillary arterial loops in eyes with tilted disc syndrome and inferior staphyloma

Salomon YvesCohenabSylviaNghiem-Buffetac

doi : 10.1016/j.ajoc.2021.101194

Volume 24, December 2021, 101194

To report and discuss the association between pre- or juxtapapillary arterial loops and tilted disc syndrome (TDS).

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Transient vision loss associated with paracentral acute middle maculopathy detected on multi-modal imaging

Jesse D.SengilloLilyZhangJayanthSridharHarry W.FlynnJr.Stephen G.Schwartz

doi : 10.1016/j.ajoc.2021.101195

Volume 24, December 2021, 101195

To report two patients with transient decreased vision and associated paracentral acute middle maculopathy (PAMM) lesions identified with multi-modal imaging, including what we believe to be the first documented patient of PAMM associated with iron deficiency anemia.

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Unilateral retinopathy post perilesional interferon ?2b injections for ocular surface squamous cell carcinoma

ShivDallaaMaryChampionbRadwanAjlanbJohn E.SutphinbJason A.Sokolb

doi : 10.1016/j.ajoc.2021.101196

Volume 24, December 2021, 101196

To describe the clinical course of a patient presenting with unilateral retinopathy after perilesional interferon alpha injections for treatment of ocular surface squamous cell carcinoma.

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Off-label intravitreal brolucizumab for recalcitrant diabetic macular edema: A real-world case series

DebdulalChakrabortyaJay U.ShethbSubhenduBoralaTushar K.Sinhaa

doi : 10.1016/j.ajoc.2021.101197

Volume 24, December 2021, 101197

To report the efficacy of intravitreal injection (IVI) of brolucizumab for recalcitrant diabetic macular edema (DME) in a real-world setting.

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Acute macular neuroretinopathy following Pfizer-BioNTech COVID-19 vaccination

Daniel A.ValenzuelaSylviaGrothKenneth J.TaubenslagSapnaGangaputra

doi : 10.1016/j.ajoc.2021.101200

Volume 24, December 2021, 101200

To describe a case of acute macular neuroretinopathy (AMN) in a patient immediately following administration of the Pfizer-BioNTech COVID-19 vaccine.

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Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak?

HaramayaGurungaRanjuKharel SitaulabPratapKarkibAnadiKhatricBhaiyaKhanaldSagun NarayanJoshieIndramanMaharjanaMadan PrasadUpadhyayf

doi : 10.1016/j.ajoc.2021.101198

Volume 24, December 2021, 101198

Seasonal Hyperacute Panuveitis (SHAPU), is a mysterious blinding disease seen only in Nepal with a higher prevalence among children usually seen in autumn every alternate odd year since 1975. This report highlights the sporadic summer outbreak in the even years with atypical presentation.

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Foveal neovascularization in combined branch retinal vein and artery occlusion

FrancescoRomanoChiaraPreziosaGiovanniStaurenghiMarcoPellegrini

doi : 10.1016/j.ajoc.2021.101199

Volume 24, December 2021, 101199

To describe a case of combined branch retinal vein and artery occlusion (CBRVAO) complicated by foveal neovascularization (FNV).

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Bilateral neuroretinits and exudative retinal detachment with multifocal subretinal deposits secondary to Bartonella henselae infection

EfratFleissigabFionaKimaDouglas KennethSigfordaCharles C.Barra

doi : 10.1016/j.ajoc.2021.101201

Volume 24, December 2021, 101201

to describe a case of bilateral neuroretinitis with bullous retinal detachment and multiple subretinal lesions, in a 10-year-old immunocompetent girl.

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Occlusive retinal vasculitis associated with systemic sclerosis and antiphospholipid antibodies

Caleb C.NgabSandipSureshcJames T.RosenbaumcdeH. RichardMcDonaldabEmmett T.CunninghamJr.abfg

doi : 10.1016/j.ajoc.2021.101206

Volume 24, December 2021, 101206

To report a series of patients with occlusive retinal vasculitis associated with systemic sclerosis (SSc) and elevated antiphospholipid antibody titers.

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Audiology findings in patients with teprotumumab associated otologic symptoms

Caroline Y.YuaTatianaCorreabBrittany A.SimmonsaMarlan R.HansenbErin M.Shrivera

doi : 10.1016/j.ajoc.2021.101202

Volume 24, December 2021, 101202

To report a case series of subjective and objective hearing function changes associated with teprotumumab treatment for thyroid eye disease.

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Atezolizumab-induced bilateral anterior uveitis: A case report

TsuyoshiMitoaShunTakedaaNozomuMotonobHiroshiSasakia

doi : 10.1016/j.ajoc.2021.101205

Volume 24, December 2021, 101205

To report a case of bilateral anterior uveitis undergoing atezolizumab treatment for advanced non-small cell lung cancer (NSCLC).

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Intra-ocular lens extrusion in a patient with corneal graft melting

CharlotteErreraaGabrielleGomartaVeroniqueLindnerbTristanBourciera

doi : 10.1016/j.ajoc.2021.101204

Volume 24, December 2021, 101204

Postoperative extrusion of an intraocular lens at a site unrelated to the surgical incision is a very rare complication. We report the case of a posterior chamber intraocular lens extrusion through the cornea eight years after a penetrating keratoplasty in a patient with spontaneous aseptic stromal melting.

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Chronic recurrent multifocal osteomyelitis, central retinal artery occlusion and optic neuropathy: A new association

Michael S.VaphiadesabKevin E.LaicdeLanning B.KlineaBrendanGrondinesaEmilyRiserb

doi : 10.1016/j.ajoc.2021.101209

Volume 24, December 2021, 101209

To report a patient with chronic recurrent multifocal osteomyelitis (CRMO) complicated by optic neuropathy and central retinal artery occlusion (CRAO).

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Corneal thickness in the case of familial lecithin-cholesterol acyltransferase deficiency

ShinsukeKinoshitaacSeiichiroSugitabAkihiroYoshidac

doi : 10.1016/j.ajoc.2021.101211

Volume 24, December 2021, 101211

We report our findings of a patient with a definitive diagnosis of familial lecithin-cholesterol acyltransferase deficiency (FLD), whose corneal thickness was measured using swept-source optical coherence tomography (OCT) and who underwent an ophthalmologic therapeutic intervention.

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Fluorescence imaging of the ILM flap following MH surgery

HomayounTabandeh

doi : 10.1016/j.ajoc.2021.101203

Volume 24, December 2021, 101203

To report on the imaging of internal limiting membrane (ILM) flap following macular hole (MH) surgery.

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Traumatic central retinal vein occlusion following a hawk attack to the posterior cranium

Jake E.TenewitzaAndrew A.GirardaMont J.Cartwrightab

doi : 10.1016/j.ajoc.2021.101214

Volume 24, December 2021, 101214

We describe a patient who developed a central retinal vein oculsion following a diving hawk attack to her posterior cranium.

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Idiopathic intracranial hypertension in a pediatric transgender patient

TaylorNaymanaMélanieHébertbLuis H.Ospinaa

doi : 10.1016/j.ajoc.2021.101208

Volume 24, December 2021, 101208

Androgens given for gender affirmation have been implicated in the pathophysiology of idiopathic intracranial hypertension (IIH) in transgender patients. 10 cases of transgender adults with IIH have been published but this association has not been described in younger patients. Herein we describe the first case of IIH in an adolescent transgender patient.

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Invasive sino-orbital aspergillosis with brain invasion in an immunocompetent pregnant patient

Hamad M.AlsulaimanaSahar M.ElkhamarybMohammedAlrajehaOsamaAl-AlsheikhaHudaAl-Ghadeerc

doi : 10.1016/j.ajoc.2021.101210

Volume 24, December 2021, 101210

Invasive Fungal Sinusitis (IFS) is a potentially life-threatening condition that can progress rapidly to the orbit and the brain, especially if it goes on undetected for a long period. We report a case of a 28-year-old pregnant woman in her second trimester with sino-orbital Aspergillosis and subsequent brain involvement who tragically developed deterioration of her neurological status and a spontaneous abortion.

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Ultra-widefield and anterior-segment optical coherence tomography in Alagille syndrome

NobuhiroKatoaMasatoshiHarutaaRyutaTakasebYorikoWatanabebShigeoYoshidaa

doi : 10.1016/j.ajoc.2021.101213

Volume 24, December 2021, 101213

We describe the ocular findings in a patient with Alagille syndrome, included those obtained with ultra-widefield and anterior-segment optical coherence tomography (AS-OCT) imaging.

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Acute macular neuroretinopathy (AMN) following COVID-19 vaccination

DanielaDrükeaUwePleyerbHansHoeraufaNicolasFeltgenaSebastianBemmea

doi : 10.1016/j.ajoc.2021.101207

Volume 24, December 2021, 101207

To describe a case of acute macular neuroretinopathy (AMN) in a 23-year-old Caucasian female after a COVID-19 vaccination (Vaxzevira).

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Novel surgical approach for removing intraretinal loculated foveal hemorrhage in a patient with hypertensive retinopathy

HassanKhojasteha1AmirAkhavanrezayatb1HashemGhorababQuan DongNguyenb

doi : 10.1016/j.ajoc.2021.101217

Volume 24, December 2021, 101217

To present a surgical approach for removing intra-retinal loculated foveal hemorrhage due to hypertensive retinopathy (HR) in a patient with uncontrolled hypertension (HTN).

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The role of vitreous cortex remnants in proliferative vitreoretinopathy formation demonstrated by histopathology: A case report

Koen A.van OverdamaEelco M.BuschbRobert M.VerdijkcClaire W.A.Pennekampa

doi : 10.1016/j.ajoc.2021.101219

Volume 24, December 2021, 101219

The pathogenesis of proliferative vitreoretinopathy (PVR), the most important cause of retinal detachment surgery failure, is still not fully understood. We previously hypothesized a causal link between vitreoschisis-induced vitreous cortex remnants (VCR) and PVR formation. The purpose of this case report is to demonstrate this association by showing the clinical occurrence of PVR in the presence of VCR across the retinal surface, illustrated by histopathological analysis.

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Transient visual field loss after COVID-19 vaccination: Experienced by ophthalmologist, case report

ChaisiriJumroendararasameaSomboonPanyakornaRittirakOthongbAurayaJumroendararasamecWorapotSrimananaKunTipparuta

doi : 10.1016/j.ajoc.2021.101212

Volume 24, December 2021, 101212

The first reported case of bilateral transient visual field defect, experienced by an ophthalmologist, which developed shortly after COVID-19 vaccination (CoronaVac, Sinovac Biotech Ltd., Beijing, China) and confirmed by computerized automated perimetry.

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Vitreoretinal lymphoma following primary testicular lymphoma: Report of two cases and review of the literature

Joseph B.AlsbergeaRobert N.Johnsonb

doi : 10.1016/j.ajoc.2021.101218

Volume 24, December 2021, 101218

To report two cases of vitreoretinal lymphoma that developed following primary testicular lymphoma and review the literature.

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Exacerbation of pigment epithelial detachment following aflibercept: A case of bevacizumab rescue?

SamanehDavoudiaRamakRoohipourmoallaiabCynthia M.GuerinaSiva S.R.Iyera

doi : 10.1016/j.ajoc.2021.101216

Volume 24, December 2021, 101216

We describe a 61-year-old female patient with a retinal pigment epithelial detachment (PED) of the left eye in the setting of neovascular aged-macular degeneration (nAMD) with unanticipated responses to aflibercept and bevacizumab.

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Cogan syndrome masquerading as corneal ectasia

Leanne M.LittleJ. BradleyRandleman

doi : 10.1016/j.ajoc.2021.101215

Volume 24, December 2021, 101215

To report a case of Cogan syndrome that presented with the appearance of bilateral asymmetric corneal ectasia on Scheimpflug tomography.

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Late-onset granular intra-amniotic infection following amniotic membrane transplantation

Shaker O.AlreshidiabSamar A.Al-Swailema

doi : 10.1016/j.ajoc.2021.101221

Volume 24, December 2021, 101221

The amniotic membrane (AM) is used in ocular surface reconstruction and is effective at promoting epithelialization and preventing corneal perforation in cases of acute microbial keratitis. Here, we report a case of isolated AM infection after AM transplantation for a persistent epithelial defect following tectonic penetrating keratoplasty.

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Unilateral acute anterior uveitis with macular edema following the use of sildenafil citrate in a patient with HLA-B27 positivity

JonathanRegenoldaHashemGhorabaaAmirAkhavanrezayataWataruMatsumiyaabAzadehMobasserianaIrmakKaracaaMoosaZaidiaBrandonPhamaQuan DongNguyena

doi : 10.1016/j.ajoc.2021.101228

Volume 24, December 2021, 101228

To present a case of acute anterior uveitis with macular edema associated with sildenafil citrate use in an HLA-B27 positive patient.

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Acute cataract development in a 43-year-old woman after an ultrasound eyelid-tightening procedure

NadavLevingerabIrinaBarequetacEliyaLevingeradShalhevet GoldfeatherBen ZakenaeShmuelLevingera

doi : 10.1016/j.ajoc.2021.101226

Volume 24, December 2021, 101226

The purpose of this article is to describe a severe side effect presentation of a bilateral cataract after treatment with intense focused ultrasound (IFUS) and subsequent uneventful cataract surgery.

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Propionibacterium acnes endophthalmitis following transplantation of contaminated Descemet's membrane endothelial keratoplasty graft

Grayson W.ArmstrongaShawn R.LinaAviramAssidonbSarkisSoukiasianaDeanEliottaUlaJurkunasa

doi : 10.1016/j.ajoc.2021.101227

Volume 24, December 2021, 101227

To report the clinical outcomes of a case of Propionibacterium acnes (P. acnes) endophthalmitis following Descemet's membrane endothelial keratoplasty (DMEK) surgery.

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How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes

Gonzalez-ArochaCarlaRodriguez-MartinezAna-CatalinaMohamed-NoriegaJibran

doi : 10.1016/j.ajoc.2021.101225

Volume 24, December 2021, 101225

To describe the clinical symptoms, anatomical location of the injury and different etiologies of one-and-a-half syndrome and its variants.

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Neurotrophic corneal ulcer and iridocyclitis directly preceding Ramsay-Hunt Syndrome

Farzan M.GorganiMS, DO.abcTodd L.BeyerDO, FAAO, FASOPRS.ab

doi : 10.1016/j.ajoc.2021.101220

Volume 24, December 2021, 101220

To present to and inform the practitioner of an unusual presentation of Varicella zoster virus and Ramsay-Hunt Syndrome.

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Bilateral nummular infiltrates: An uncommon presentation of Candida keratitis

DeenaDahshanaCharles D.FrancisaMaya S.Bitarb

doi : 10.1016/j.ajoc.2021.101233

Volume 24, December 2021, 101233

We present a case of misdiagnosed fungal keratitis due to a bilateral nummular presentation.

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Bilateral endogenous Trichoderma endophthalmitis in an immunocompromised host

AbdulazizAl-ShehriabSaudAljohaniacValmore A.Semideya

doi : 10.1016/j.ajoc.2021.101234

Volume 24, December 2021, 101234

To report a case of bilateral endogenous endophthalmitis, caused by the Trichoderma species, in a severely immunocompromised patient.

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Idiopathic lenticular surface neovascularization: An unusual presentation

ManojSomanabIndu J.NairaRamya R.NadigaJay U.ShethabUnnikrishnanNairab

doi : 10.1016/j.ajoc.2021.101231

Volume 24, December 2021, 101231

To present a case of posterior lenticular surface neovascularization in the absence of any ocular or systemic pathology.

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A case series from a single family of familial retinal arteriolar tortuosity with common history of sudden visual loss

TomohiroObayashiaAkiKatoaHarumitsuSuzukibKeiOhashicMunenoriYoshidaaYuShibataaYuichiroOguraaTsutomuYasukawaa

doi : 10.1016/j.ajoc.2021.101230

Volume 24, December 2021, 101230

To report family members with familial retinal arteriolar tortuosity (FRAT) identified after sudden visual loss.

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Purtscher-like retinopathy in a patient with COVID-19 and disseminated intravascular coagulation

Effie Z.RahmanaPoojaShahaJeremy E.OngbMortonGoldbergcSally S.Ongac

doi : 10.1016/j.ajoc.2021.101229

Volume 24, December 2021, 101229

To describe a unique case of Purtscher-like retinopathy after a severe, complicated COVID-19 course which included development of disseminated intravascular coagulation (DIC).

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Acute macular neuroretinopathy associated with COVID-19 infection

James A.DavidaGeorge D.Fivgasab

doi : 10.1016/j.ajoc.2021.101232

Volume 24, December 2021, 101232

To report a case of bilateral acute macular neuroretinopathy (AMN) associated with a COVID-19 infection.

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Choroidal neovascularization complicating sclerochoroidal calcifications

MaurizioBattaglia ParodiaAlessandroArrigoaAdelaidePinaaFrancescaCalcagnoaAlessioAntropoliaRashidHassan FarahaFrancescoBandelloaAhmad M.Mansourb

doi : 10.1016/j.ajoc.2021.101235

Volume 24, December 2021, 101235

Sclerochoroidal calcifications (SCC) are rare conditions characterized by unifocal or multifocal well-defined scleral deposits of calcium. The present study describes two cases of SCC complicated by the onset of choroidal neovascularization (CNV).

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Lichen simplex chronicus of the eyelid: A case report and literature review

Steven H.AdamsaNatalie T.HuangbThomasBersanicSamuelAlpertb

doi : 10.1016/j.ajoc.2021.101237

Volume 24, December 2021, 101237

To report a case of lichen simplex chronicus (LSC) of the eyelid and to perform a literature review on this topic.

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Patient specific implants in orbital reconstruction: A pilot study?

Larissa A.HabibaMichael K.Yoonbc

doi : 10.1016/j.ajoc.2021.101222

Volume 24, December 2021, 101222

Successful repair of the orbital skeleton restores function and cosmesis by normalizing globe position and allowing full motility of the extraocular muscles. Routine repairs are successful with standard implants. However, defects that are irregular or cause volume deficiency can be challenging to repair. The development of patient specific implants (PSI) offers an additional tool in complex cases. Herein, we report our experience using PSI for orbital reconstruction.

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Anterior chamber infiltration of CAR T-cells

EladJacobyabOfiraZlotobcVicktoriaVishnevskia Daibc

doi : 10.1016/j.ajoc.2021.101223

Volume 24, December 2021, 101223

A unique image of anterior chamber infiltration in a 2-year-infant with leukemia, treated with CD19 CAR T cells. Despite significant lymphopenia and resemblance of fungal infection initially, biopsy and cytologic analysis from anterior chamber fluid confirmed that this was CAR T-cell infiltration, likely targeting microscopic leukemia, unknown to us treating physicians. This is a unique case in 2 aspects: first, to state the high quality of CAR T-cell trafficking; and second – given the wide use of these cells currently, this image may help educate clinicians regarding this potential diagnosis.

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Corneal perforation in ocular graft-versus-host disease

Cathy Y.ZhangaAsim V.FarooqbGeorge J.HarocoposacEric L.SollenbergeraJoshua H.HoudCharles S.BouchardeChristineShiehfUyen L.TranfAnthony J.LubniewskiaAndrew J.W.HuangaGrace L.Paleya

doi : 10.1016/j.ajoc.2021.101224

Volume 24, December 2021, 101224

Corneal perforation is a rare, vision-threatening complication of ocular graft-versus-host disease (GVHD) and is not well understood. Our objective was to examine the clinical disease course and histopathologic correlation in patients who progressed to this outcome.

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