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Reflections on Our Editorship of The American Journal of Gastroenterology
Spiegel, Brennan MD, MSHS, FACG1; Lacy, Brian E. MD, PhD, FACG2
doi : 10.14309/ajg.0000000000001558
December 2021 - Volume 116 - Issue 12 - p 2313-2315
A Brighter Red Section
Karsan, Hetal A. MD, FACG, FASGE, FAASLD, FACP1; Saini, Sameer D. MD, MS, AGAF, FACP2,3
doi : 10.14309/ajg.0000000000001561
December 2021 - Volume 116 - Issue 12 - p 2316-2317
Endoscopy Teaching Competencies for Junior Faculty: Outstanding Endoscopy Teaching Is Within Your SCOPE
Kumar, Navin L. MD1,2; Sewell, Justin L. MD, PhD, MPH3,4
doi : 10.14309/ajg.0000000000001509
December 2021 - Volume 116 - Issue 12 - p 2318-2320
The Need for Allyship in Achieving Gender Equity in Gastroenterology
Bilal, Mohammad MD1; Balzora, Sophie MD, FACG2; Pochapin, Mark B. MD, FACP, FASGE, FACG2; Oxentenko, Amy S. MD, FACP, FACG, AGAF3
doi : 10.14309/ajg.0000000000001508
December 2021 - Volume 116 - Issue 12 - p 2321-2323
Metastatic Rectal Linitis Plastic From Bladder Cancer
Okamoto, Takeshi MD1; Yamamoto, Kazuki MD1; Kanomata, Naoki MD, PhD2
doi : 10.14309/ajg.0000000000001260
December 2021 - Volume 116 - Issue 12 - p 2324
Extensive Abdominal Wall Hematoma After Paracentesis
Medas, Renato MD1,2; Garrido, Isabel MD1,2; Coelho, Rosa MD1,2; Macedo, Guilherme MD, PhD1,2
doi : 10.14309/ajg.0000000000001365
December 2021 - Volume 116 - Issue 12 - p 2325
Dysphagia Secondary to Intraluminal Choriocarcinoma of the Gastroesophageal Junction
Benz, Cecilia MD1; Smith, John MD2; Mani, Ravi MD3; Musunuru, Tejo MD4; He, Jing MD5; Okereke, Ikenna MD6
doi : 10.14309/ajg.0000000000001379
December 2021 - Volume 116 - Issue 12 - p 2326
Multimodal Visualization of Small Bowel Granulomatosis With Polyangiitis
Grewal, Jasleen K. MD1; Baltayan, Armine MD2; Kovacs, Thomas O. G. MD1
doi : 10.14309/ajg.0000000000001404
December 2021 - Volume 116 - Issue 12 - p 2327
Acute Abdominal Pain in a Patient With COVID-19
Stuby, Johann MD1; Tschopp, Stefan MD2; Rudiger, Alain MD1
doi : 10.14309/ajg.0000000000001414
December 2021 - Volume 116 - Issue 12 - p 2328
Endoscopic Ultrasound–Guided Gastric Access to Facilitate Endoscopic Necrosectomy of a Large Walled-Off Necrosis in a Patient With Roux-en-Y Gastric Bypass Anatomy
Tejedor-Tejada, Javier MD1; Deshmukh, Ameya DO2; Elmeligui, Ahmed MBBS3; Parsa, Nasim MD4; Dawod, Enad MD5; Nieto, Jose DO6
doi : 10.14309/ajg.0000000000001410
December 2021 - Volume 116 - Issue 12 - p 2329
CME Information
doi : 10.14309/ajg.0000000000001123
December 2021 - Volume 116 - Issue 12 - p 2330-2331
Continuing Medical Education Questions: December 2021
Trikudanathan, Guru MD
doi : 10.14309/ajg.0000000000001560
December 2021 - Volume 116 - Issue 12 - p 2332
Continuing Medical Education Questions: December 2021
Bushyhead, Daniel MD
doi : 10.14309/ajg.0000000000001559
December 2021 - Volume 116 - Issue 12 - p 2333
Assisted Reproductive Technology in Crohn's Disease and Ulcerative Colitis: A Systematic Review and Meta-Analysis
Laube, Robyn BMed, MD, MPH, FRACP1,2; Tran, Yvonne BSc PhD3; Paramsothy, Sudarshan BSc, MBBS, MRCP, FRACP, PhD1,2,4; Leong, Rupert W. MBBS, FRACP, MD, AGAF1,2,4,5
doi : 10.14309/ajg.0000000000001537
December 2021 - Volume 116 - Issue 12 - p 2334-2344
Diagnostic Evaluation of Gastric Motor and Sensory Disorders
Lacy, Brian E. PhD, MD, FACG1; Crowell, Michael D. PhD, FACG2; Cangemi, David J. MD1; Lunsford, Tisha N. MD2; Simren, Magnus MD, PhD3,4; Tack, Jan MD5
doi : 10.14309/ajg.0000000000001562
December 2021 - Volume 116 - Issue 12 - p 2345-2356
Disorders of gastric motor and sensory function affect 10%-20% of the world’s population and adversely impact nutrition, quality of life, work productivity, and health care costs. Classifying these disorders can be challenging given the heterogeneity of symptom presentation, the presence of symptoms unexplained by endoscopic, radiographic and/or laboratory evaluation, and overlap with other luminal gastrointestinal disorders. Accurately diagnosing these highly prevalent disorders relies upon an understanding of epidemiology and risk factors, the ability to take a careful clinical history focused on symptoms, and the presence of predisposing medical, surgical, and psychological conditions. A variety of diagnostic studies are now available to assess gastric motor function and identify maladaptive relaxation, accommodation, and abnormal sensation. FDA-approved treatment options are limited and thus many patients undergo a series of empirical treatment trials that target individual symptoms, often without much benefit. This article provides updated recommendations for identifying and classifying the most common gastric motor and sensory disorders using currently accepted diagnostic tests, and provides a brief supplemental overview on treatment options. “Things sweet to taste prove in digestion sour.” –Shakespeare, Richard II, 1595.
Classifying Esophageal Motility by FLIP Panometry: A Study of 722 Subjects With Manometry
Carlson, Dustin A. MD, MS1; Gyawali, C. Prakash MD, MRCP2; Khan, Abraham MD3; Yadlapati, Rena MD, MS4; Chen, Joan MD, MS5; Chokshi, Reena V. MD6; Clarke, John O. MD7; Garza, Jose M. MD8; Jain, Anand S. MD9; Katz, Philip MD10; Konda, Vani MD11; Lynch, Kristle MD12; Schnoll-Sussman, Felice H. MD10; Spechler, Stuart J. MD11,13; Vela, Marcelo F. MD, MS14; Prescott, Jacqueline E. BS1; Baumann, Alexandra J. DO1; Donnan, Erica N. MD1; Kou, Wenjun PhD1; Kahrilas, Peter J. MD1; Pandolfino, John E. MD, MS1
doi : 10.14309/ajg.0000000000001532
December 2021 - Volume 116 - Issue 12 - p 2357-2366
Functional luminal imaging probe (FLIP) panometry can evaluate esophageal motility in response to sustained esophageal distension at the time of sedated endoscopy. This study aimed to describe a classification of esophageal motility using FLIP panometry and evaluate it against high-resolution manometry (HRM) and Chicago Classification v4.0 (CCv4.0).
Comparative Safety of Endoscopic vs Radiological Gastrostomy Tube Placement: Outcomes From a Large, Nationwide Veterans Affairs Database
Kohli, Divyanshoo R. MD1; Kennedy, Kevin F. MS2; Desai, Madhav MD1; Sharma, Prateek MD1
doi : 10.14309/ajg.0000000000001504
December 2021 - Volume 116 - Issue 12 - p 2367-2373
A gastrostomy is generally performed in patients who are unable to maintain volitional intake of food. We compared outcomes of percutaneous endoscopic gastrostomy (PEG) and interventional radiologist–guided gastrostomy (IRG) using an integrated nationwide database.
Mucocutaneous Manifestations in Autoimmune Gastritis: A Prospective Case-Control Study
Gonzalez, Agustin MD1; Latorre, Gonzalo MD2; Paredes, Loreto MD1; Montoya, Lorena MD1; Maquilon, Sara MD2; Shah, Shailja C. MD, MPH3,4; Espino, Alberto MD2; Sabatini, Natalia MD1; Torres, Javiera MD5; Roa, Juan Carlos MD5; Riquelme, Arnoldo MD, MMedEd2,6; Kolbach, Marianne MD1
doi : 10.14309/ajg.0000000000001501
December 2021 - Volume 116 - Issue 12 - p 2374-2384
Autoimmune gastritis (AIG) is associated with nutritional deficiencies, autoimmune diseases, and gastric malignancies. The aims of the study were to test the hypothesis that mucocutaneous (MC) manifestations occur more often in patients with vs without AIG and to delineate patterns of MC manifestations in AIG.
Liver-Unrelated Comorbid Conditions Do Not Affect Cognitive Performance or Hepatic Encephalopathy Progression in Cirrhosis
Acharya, Chathur MD1; Nadhem, Omar MD1; Shaw, Jawaid MD1; Hassouneh, Ramzi MD1; Fagan, Andrew BS1; McGeorge, Sara BS1; Sterling, Richard K. MD1; Puri, Puneet MD1; Fuchs, Michael MD1; Luketic, Velimir MD1; Sanyal, Arun J. MD1; Wade, James B. PhD2; Gilles, HoChong S. FNP3; Heuman, Douglas M. MD1; Tinsley, Felicia RN1; Matherly, Scott MD1; Lee, Hannah MD1; Siddiqui, Mohammad S. MD1; Thacker, Leroy R. PhD3; Bajaj, Jasmohan S. MD1
doi : 10.14309/ajg.0000000000001346
December 2021 - Volume 116 - Issue 12 - p 2385-2389
We aimed to determine the effect of comorbidities on covert hepatic encephalopathy (CHE) diagnosis and overt hepatic encephalopathy (OHE) development.
Impact of Alcohol Abstinence on the Risk of Hepatocellular Carcinoma in Patients With Alcohol-Related Liver Cirrhosis
Rodríguez, Manuel MD1,2; González-Diéguez, María Luisa MD1; Varela, María MD1,2,3; Cadahía, Valle MD1; Andrés-Vizán, Sara María PhD4; Mesa, Alicia MD5; Castaño, Andrés MD1; Alvarez-Navascués, Carmen MD1
doi : 10.14309/ajg.0000000000001399
December 2021 - Volume 116 - Issue 12 - p 2390-2398
Although alcohol cessation is the only effective treatment for alcohol-related liver disease, few data exist concerning its influence on the risk of hepatocellular carcinoma (HCC). We aimed to evaluate the effect of alcohol abstinence on the incidence of HCC in patients with alcohol-related cirrhosis.
Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease
Harrison, Stephen A. MD1; Baum, Seth J. MD2; Gunn, Nadege T. MD3; Younes, Ziad H. MD4; Kohli, Anita MD5; Patil, Rashmee MD6; Koziel, Margaret J. MD7; Chera, Harinder BS7; Zhao, Jeff PhD7; Chakravarthy, Manu V. MD, PhD7
doi : 10.14309/ajg.0000000000001375
December 2021 - Volume 116 - Issue 12 - p 2399-2409
AXA1125 and AXA1957 are novel, orally administered endogenous metabolic modulator compositions, specifically designed to simultaneously support multiple metabolic and fibroinflammatory pathways associated with nonalcoholic fatty liver disease (NAFLD). This study assessed safety, tolerability, and biologic activity of AXA1125 and AXA1957 in NAFLD.
Quality of Care Program Reduces Unplanned Health Care Utilization in Patients With Inflammatory Bowel Disease
Melmed, Gil Y. MD, MS1; Oliver, Brant PhD, MS, MPH, FNP2; Hou, Jason K. MD3; Lum, Donald MD4; Singh, Siddharth MD5; Crate, Damara RN6; Almario, Christopher MD, MSHPM1,7; Bray, Harry MD4; Bresee, Catherine MS8; Gerich, Mark MD9; Gerner, Donna RN10; Heagy, Erica FNP-C4; Holthoff, Megan MSHS2; Hudesman, David MD11; McCutcheon Adams, Kelly LICSW12; Mattar, Mark C. MD13; Metwally, Mark MD10; Nelson, Eugene DSc, MPH2; Ostrov, Arthur MD10; Rubin, David T. MD14; Scott, Frank MD, MSCE9; Samir, Shah MD15; van Deen, Welmoed PhD, MD7; Younes, Ziad MD16; Oberai, Ridhima BS17; Weaver, Alandra MPH17; Siegel, Corey A. MD, MS6, on behalf of IBD Qorus
doi : 10.14309/ajg.0000000000001547
December 2021 - Volume 116 - Issue 12 - p 2410-2418
There is significant variation in processes and outcomes of care for patients with inflammatory bowel disease (IBD), suggesting opportunities to improve quality of care. We aimed to determine whether a structured quality of care program can improve IBD outcomes, including the need for unplanned health care utilization.
Volumetric Rectal Perception Testing: Is It Clinically Relevant? Results From a Large Patient Cohort
Mazor, Yoav MD, PhD1,2; Trieu, Rose Qizhengyan MD3,4; Prott, Gillian CNS3; Jones, Michael PhD5; Ejova, Anastasia PhD5,6; Kellow, John MD3,4; Malcolm, Allison MD3,4
doi : 10.14309/ajg.0000000000001526
December 2021 - Volume 116 - Issue 12 - p 2419-2429
Rectal perception testing is a recommended component of anorectal physiology testing. Although recent consensus (London) guidelines suggested criteria for categorizing hyporectal and hyper-rectal sensitivity, these were based on scant evidence. Moreover, data regarding diagnostic capabilities and clinical utility of rectal perception testing are lacking. The aims of this study were to determine the association between rectal perception testing and both clinical and physiological variables to enhance the analysis and interpretation of real-life test results.
Age-Specific Rates and Time-Courses of Gastrointestinal and Nongastrointestinal Complications Associated With Screening/Surveillance Colonoscopy
Ladabaum, Uri MD, MS1; Mannalithara, Ajitha PhD1; Desai, Manisha PhD2; Sehgal, Maanek3; Singh, Gurkirpal MD1,4
doi : 10.14309/ajg.0000000000001531
December 2021 - Volume 116 - Issue 12 - p 2430-2445
The rates of serious cardiac, neurologic, and pulmonary events attributable to colonoscopy are poorly characterized, and background event rates are usually not accounted for.
Cystic Fibrosis Transmembrane Conductance Regulator Modulator Use Is Associated With Reduced Pancreatitis Hospitalizations in Patients With Cystic Fibrosis
Ramsey, Mitchell L. MD1; Gokun, Yevgeniya MS2; Sobotka, Lindsay A. DO1; Wellner, Michael R. MD1; Porter, Kyle MAS2; Kirkby, Stephen E. MD3; Li, Susan S. MD4; Papachristou, Georgios I. MD, PhD1; Krishna, Somashekar G. MD, MPH1; Stanich, Peter P. MD1; Hart, Phil A. MD1; Conwell, Darwin L. MD, MSc1; Lara, Luis F. MD1
doi : 10.14309/ajg.0000000000001527
December 2021 - Volume 116 - Issue 12 - p 2446-2454
Acute pancreatitis (AP) occurs among patients with pancreas-sufficient cystic fibrosis (PS-CF) but is reportedly less common among patients with pancreas-insufficient cystic fibrosis (PI-CF). The incidence of AP may be influenced by cystic fibrosis transmembrane conductance regulator (CFTR) modulator use. We hypothesized that CFTR modulators would reduce AP hospitalizations, with the greatest benefit in PS-CF.
Association of Terry Nails With Liver Cirrhosis
Sack, Jordan S. MD, MPH1; Liu, Anne F. MD1; Gray, Meagan MD2; Roat, James MD3; Zucker, Stephen D. MD1,3
doi : 10.14309/ajg.0000000000001492
December 2021 - Volume 116 - Issue 12 - p 2455-2458
We looked at the association between Terry nails and liver cirrhosis in an ambulatory population from hepatology and gastroenterology clinics.
Health Economic Impact of a Multicenter Quality-of-Care Initiative for Reducing Unplanned Healthcare Utilization Among Patients With Inflammatory Bowel Disease
Almario, Christopher V. MD, MSHPM1,2; Kogan, Lawrence MD3; van Deen, Welmoed K. PhD, MD4; Scott, Frank I. MD, MSCE5; Singh, Siddharth MD6; Hou, Jason K. MD, MS7; Lum, Donald MD8; Aguilar, Humberto MD9; Betteridge, John MD10; Flynn, Ann MD11; Gerich, Mark MD5; Kaufman, Lia MD12; Mattar, Mark C. MD13; Mize, Carrie LPN14; Ostrov, Arthur MD15; Shah, Samir A. MD16; Younes, Ziad MD14; Weaver, S. Alandra MPH17; Heller, Caren MD17; Siegel, Corey A. MD, MS18; Melmed, Gil Y. MD, MS1,19
doi : 10.14309/ajg.0000000000001540
December 2021 - Volume 116 - Issue 12 - p 2459-2464
A multicenter adult inflammatory bowel disease learning health system (IBD Qorus) implemented clinical care process changes for reducing unplanned emergency department visits and hospitalizations using a Breakthrough Series Collaborative approach.
Changes in National Google Trends and Local Healthcare Utilization After High-Impact Gastroenterology Publications
Kamboj, Amrit K. MD1; Agarwal, Siddharth MBBS1; Chedid, Victor G. MD1; Iyer, Prasad G. MD, MS1; Bailey, Kent R. PhD2; Harmsen, William S. MS2; Katzka, David A. MD1
doi : 10.14309/ajg.0000000000001516
December 2021 - Volume 116 - Issue 12 - p 2465-2469
We examined national Google Trends and local healthcare utilization after 3 high-impact gastroenterology publications.
Question on Databases Used to Examine the Association Between Gastric Cancer and Heavy Alcohol Use
Wang, Yanfei MD1; Jiang, Yiqian MD1; Zhu, Zhongxin PhD2
doi : 10.14309/ajg.0000000000001392
December 2021 - Volume 116 - Issue 12 - p 2470
The Association Between Heavy Alcohol Use and Gastric Cancer
Wu, Hua BS1; Chen, Hong-Lin MD2
doi : 10.14309/ajg.0000000000001325
December 2021 - Volume 116 - Issue 12 - p 2470-2471
Responses to Wu et al. and Wang et al.
Laszkowska, Monika MD, MS1; Rodriguez, Steven MD2; Kim, Judith MD, MS3; Hur, Chin MD, MPH2,3,4
doi : 10.14309/ajg.0000000000001523
December 2021 - Volume 116 - Issue 12 - p 2472-2474
Response to “Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy”
Cheng, Yung-Yin MD1,2; Tsai, Ming-Che MD, MPH, PhD3,4,5; Wei, James Cheng-Chung MD, PhD5,6,7
doi : 10.14309/ajg.0000000000001495
December 2021 - Volume 116 - Issue 12 - p 2474
Response to Cheng et al.
Liu, Julia J. MD1; Owings, Anna H. DO2; Claggett, Brian PhD3; Robinson, Tanya PhD2; Glover, Sarah C. DO2
doi : 10.14309/ajg.0000000000001513
December 2021 - Volume 116 - Issue 12 - p 2474-2475
Acute Liver Failure due to Manufactured Alkaline Water: A Case Series of “Real Water”-Induced Liver Injury
Berk, Corrie DNP1; Ammar, Tarek MD2; Lee, Brian T. MD3
doi : 10.14309/ajg.0000000000001353
December 2021 - Volume 116 - Issue 12 - p 2476-2477
COVID-19 Vaccine for Chronic Gastroenterology and Hepatology Patients: A Need for Better Evidence
Fu, Xue-Lei MM1; Chen, Hong-Lin MD2
doi : 10.14309/ajg.0000000000001405
December 2021 - Volume 116 - Issue 12 - p 2478
Immunotherapy as a Downstaging Tool for Liver Transplantation in Hepatocellular Carcinoma
Lizaola-Mayo, Blanca C. MD1,2; Mathur, Amit K. MD2,3; Borad, Mitesh-J. MD4; Jadlowiec, Caroline C. MD2,3; Lam-Himlin, Dora M. MD5; Corey, Rebecca L. BCPS2,6; Iqbal, Sara MD1,2; Okubo, Keita MD, PhD2,3; Byrne, Thomas J. MD1,2; Moss, Adyr A. MD2,3; Aqel, Bashar A. MD1,2; Chascsa, David M. MD1,2
doi : 10.14309/ajg.0000000000001391
December 2021 - Volume 116 - Issue 12 - p 2478-2480
SARS-CoV-2 Immunization in Patients With Inflammatory Bowel Disease May Result in Disease Flares
Sangha, Maheep MD1; Roitman, Isabel NP1; Sultan, Keith MD2; Swaminath, Arun MD1
doi : 10.14309/ajg.0000000000001416
December 2021 - Volume 116 - Issue 12 - p 2480-2481
The Association Between Serum Infliximab Concentrations and Clinical Outcomes in Fistulizing Crohn's Disease
Dai, Cong PhD1; Jiang, Min PhD1; Huang, Yu-hong PhD1
doi : 10.14309/ajg.0000000000001505
December 2021 - Volume 116 - Issue 12 - p 2481-2482
Are We Ready to Give up Prophylactic Antibiotics for Endoscopic Ultrasonography –Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions?
Ashhab, Ashraf A. MD1; Pandol, Stephen J. MD1; Lo, Simon K. MD1
doi : 10.14309/ajg.0000000000001518
December 2021 - Volume 116 - Issue 12 - p 2482-2483
Calendar of Courses, Symposiums and Conferences
doi : 10.14309/ajg.0000000000001563
December 2021 - Volume 116 - Issue 12 - p 2484
