One-year access to more than 500 world journals available in the system
-
http://medilib.ir
- Duration of Time : 365 Day
Price : 300$- Special Price : 100$
Spotlight on the December 7 Issue
José G. Merino
doi : 10.1212/WNL.0000000000012961
vol. 97 no. 23 1055-1056
High BMI in Youths as a Modifiable Risk Factor for Multiple Sclerosis
Tomas Kalincik, Helen Tremlett, Alberto Ascherio
doi : 10.1212/WNL.0000000000012966
vol. 97 no. 23 1057-1058
Racial, Socioeconomic, and Geographic Disparities in Acute Stroke Care in the United States
Cumara B. O'Carroll, Bart M. Demaerschalk
doi : 10.1212/WNL.0000000000012940
vol. 97 no. 23 1059-1060
Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis
Rune A. Aa. Høglund, Haakon E. Meyer, Hein Stigum, Øivind Torkildsen, Nina Grytten, Trygve Holmøy, Ola Nakken
doi : 10.1212/WNL.0000000000012957
vol. 97 no. 23 e2253-e2261
To prospectively investigate the long-term relationship between body mass index (BMI) in adolescents and young adults and risk for multiple sclerosis (MS) at the population level.
Autoimmune Encephalitis After SARS-CoV-2 Infection
Cristina Valencia Sanchez, Elitza Theel, Matthew Binnicker, Michel Toledano, Andrew McKeon
doi : 10.1212/WNL.0000000000012931
vol. 97 no. 23 e2262-e2268
Autoimmune encephalitis (AE) cases after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported, but the frequency is unknown. We aimed to determine the frequency and diagnostic features of coronavirus disease 2019 (COVID-19)–related AE.
Frequency of Neurologic Manifestations in COVID-19
Shubham Misra, Kavitha Kolappa, Manya Prasad, Divya Radhakrishnan, Kiran T. Thakur, Tom Solomon, Benedict Daniel Michael, Andrea Sylvia Winkler, Ettore Beghi, Alla Guekht, Carlos A. Pardo, Greta Karen Wood, Sherry Hsiang-Yi Chou, Ericka L. Fink, Erich Schmutzhard, Amir Kheradmand, Fan Kee Hoo, Amit Kumar, Animesh Das, Achal K. Srivastava, Ayush Agarwal, Tarun Dua, Kameshwar Prasad
doi : 10.1212/WNL.0000000000012930
vol. 97 no. 23 e2269-e2281
One year after the onset of the coronavirus disease 2019 (COVID-19) pandemic, we aimed to summarize the frequency of neurologic manifestations reported in patients with COVID-19 and to investigate the association of these manifestations with disease severity and mortality.
Carotid Plaque Inflammation Imaged by PET and Prediction of Recurrent Stroke at 5 Years
John Joseph McCabe, Pol Camps-Renom, Nicola Giannotti, Jonathan P. McNulty, Sarah Coveney, Seán Murphy, Mary Barry, Joseph Harbison, Simon Cronin, David Williams, Gillian Horgan, Eamon Dolan, Tim Cassidy, Ciaran McDonnell, Eoin Kavanagh, Shane Foley, Seán Collins, Martin O'Connell, Alejandro Fernández-León, Raquel Delgado-Mederos, Michael Marnane, Joan Martí-Fàbregas, Peter J. Kelly
doi : 10.1212/WNL.0000000000012909
vol. 97 no. 23 e2282-e2291
To determine whether carotid plaque inflammation identified by 18F-fluorodeoxyglucose (18FDG)-PET is associated with late (5-year) recurrent stroke.
Acute Ischemic Stroke Interventions in the United States and Racial, Socioeconomic, and Geographic Disparities
Adam de Havenon, Kevin Sheth, Karen C. Johnston, Alen Delic, Eric Stulberg, Jennifer Majersik, Mohammad Anadani, Shadi Yaghi, David Tirschwell, John Ney
doi : 10.1212/WNL.0000000000012943
vol. 97 no. 23 e2292-e2303
In patients with ischemic stroke (IS), IV alteplase (tissue plasminogen activator [tPA]) and endovascular thrombectomy (EVT) reduce long-term disability, but their utilization has not been fully optimized. Prior research has also demonstrated disparities in the use of tPA and EVT specific to sex, race/ethnicity, socioeconomic status, and geographic location. We sought to determine the utilization of tPA and EVT in the United States from 2016–2018 and if disparities in utilization persist.
Life Expectancy in Duchenne Muscular Dystrophy
Jonathan Broomfield, Micki Hill, Michela Guglieri, Michael Crowther, Keith Abrams
doi : 10.1212/WNL.0000000000012910
vol. 97 no. 23 e2304-e2314
Duchenne muscular dystrophy (DMD) is a rare progressive disease that is often diagnosed in early childhood and leads to considerably reduced life expectancy; because of its rarity, research literature and patient numbers are limited. To fully characterize the natural history, it is crucial to obtain appropriate estimates of the life expectancy and mortality rates of patients with DMD.
Assessment of Sacsin Turnover in Patients With ARSACS
Fabiana Longo, Daniele De Ritis, Annarita Miluzio, Davide Fraticelli, Jonathan Baets, Marina Scarlato, Filippo M. Santorelli, Stefano Biffo, Francesca Maltecca
doi : 10.1212/WNL.0000000000012962
vol. 97 no. 23 e2315-e2327
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is caused by variations in SACS gene encoding sacsin, a huge multimodular protein of unknown function. More than 200 SACS variations have been described worldwide to date. Because ARSACS presents phenotypic variability, previous empirical studies attempted to correlate the nature and position of SACS variations with the age at onset or with disease severity, although not considering the effect of the various variations on protein stability. In this work, we studied genotype-phenotype correlation in ARSACS at a functional level.
Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife
Eva Schelbaum, Lacey Loughlin, Steven Jett, Cenai Zhang, Grace Jang, Niharika Malviya, Hollie Hristov, Silky Pahlajani, Richard Isaacson, Jonathan P. Dyke, Hooman Kamel, Roberta Diaz Brinton, Lisa Mosconi
doi : 10.1212/WNL.0000000000012941
vol. 97 no. 23 e2328-e2339
To examine associations between indicators of estrogen exposure from women's reproductive history and brain MRI biomarkers of Alzheimer disease (AD) in midlife.
DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging
Eleanor L.S. Conole, Anna J. Stevenson, Susana Muñoz Maniega, Sarah E. Harris, Claire Green, Maria del C. Valdés Hernández, Mathew A. Harris, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary, Veronique E. Miron, Heather C. Whalley, Riccardo E. Marioni, Simon R. Cox
doi : 10.1212/WNL.0000000000012997
vol. 97 no. 23 e2340-e2352
To investigate chronic inflammation in relation to cognitive aging by comparison of an epigenetic and serum biomarker of C-reactive protein and their associations with neuroimaging and cognitive outcomes.
Shoulder-Tap Test for Functional Gait Disorders
Jan Coebergh, Ioanna Zimianiti, Diego Kaski
doi : 10.1212/WNL.0000000000012886
vol. 97 no. 23 1070-1071
Antiseizure Medication Withdrawal in Seizure-Free Patients: Practice Advisory Update Summary
David Gloss, Kimberly Pargeon, Alison Pack, Jay Varma, Jacqueline A. French, Benjamin Tolchin, Dennis J. Dlugos, Mohamad A. Mikati, Cynthia Harden, on behalf of the AAN Guideline Subcommittee
doi : 10.1212/WNL.0000000000012944
vol. 97 no. 23 1072-1081
To update a 1996 American Academy of Neurology practice parameter.
Continuous Unilateral Eye Blinking Related to Cerebellar Epilepsy in a Neonate
Bernardo Corrêa de Almeida Teixeira, Rafaela Grochoski, Carlos Alberto Mattozo, Gilliatt Hauer Queiroz Telles, Raul Martins Filho, Mara Lucia Schmitz Ferreira Santos
doi : 10.1212/WNL.0000000000012949
vol. 97 no. 23 1082-1083
Clinical Reasoning: An Unexpected Response to Therapy in a Patient With HIV and Focal Seizures
Lorraine Chishimba, Mashina Chomba, Stanley Zimba, Tilele Mwansa, Wilmot Sinyangwe, Humphrey Kunda, Lottie Hachaambwa, Deanna Saylor
doi : 10.1212/WNL.0000000000012536
vol. 97 no. 23 1084-1089
We present the case of a 23-year-old right-handed man who presented to an emergency department in Lusaka, Zambia, with new-onset headaches and focal seizures. He was on combination antiretroviral therapy (cART) for HIV and had been started on antituberculous therapy at his local clinic 2 weeks before presentation, based on chest X-ray findings. On examination, he had subtle weakness and hyperreflexia in his left upper extremity. The remainder of the neurologic examination was normal. Brain CT scan revealed a single, ring-enhancing, heterogenous mass in the right posterior parietal lobe with marked vasogenic edema. His laboratory results revealed severe virologic and immunologic failure, and CSF analysis was unremarkable. He was empirically managed as CNS tuberculosis (TB). Two months later, his symptoms worsened, and he developed new neurologic deficits, despite adherence to cART and TB treatment. Repeat imaging subsequently revealed progression of his underlying CNS process with multiple brain abscesses present, and subsequent investigations revealed an unusual cause of these lesions. In this case, we review the differential diagnosis for space-occupying lesions in the context of poorly controlled HIV infection. In particular, we highlight the approach to these patients in resource-limited settings in the context of diagnostic limitations and highlight the importance of considering the local epidemiology of neurologic infections. Finally, this case demonstrates the need to maintain a wide differential diagnosis and a close monitoring plan for prompt reevaluation of empiric diagnoses when response to empiric therapy is unexpected.
Clinical Reasoning: A 55-Year-Old Man With Odd Behavior and Abnormal Movements
Paul McIntosh, Burton Scott
doi : 10.1212/WNL.0000000000012663
vol. 97 no. 23 1090-1093
Teaching NeuroImage: Starch-Iodine Test
Govert Dwarshuis, Bastiaan Ter Meulen, Cyra Leurs, Harold Suliman
doi : 10.1212/WNL.0000000000012597
vol. 97 no. 23 e2353-e2354
Teaching Video NeuroImage: Spontaneous Upbeat-Torsional Nystagmus From Medial Medullary Infarction
David Edward Hale, Kemar Earl Green
doi : 10.1212/WNL.0000000000012659
vol. 97 no. 23 e2355-e2356
Editors' Note: Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women
James E. Siegler, Steven Galetta
doi : 10.1212/WNL.0000000000012958
vol. 97 no. 23 1094
Reader Response: Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women
Kazuo Abe
doi : 10.1212/WNL.0000000000012959
vol. 97 no. 23 1094-1095
Author Response: Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women
Tian-Shin Yeh, Changzheng Yuan, Alberto Ascherio, Bernard A. Rosner, Walter C. Willett, Deborah Blacker
doi : 10.1212/WNL.0000000000012963
vol. 97 no. 23 1095
[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease
doi : 10.1212/WNL.0000000000012559
vol. 97 no. 23 1096
American Academy of Neurology Code of Professional Conduct
doi : 10.1212/WNL.0000000000012889
vol. 97 no. 23 1096
Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women
doi : 10.1212/WNL.0000000000012933
vol. 97 no. 23 1096
