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JCD editorial – December 2021
Michael H. Gold MD
doi : 10.1111/jocd.14619
Volume 20, Issue 12 p. 3721-3721
How has the pandemic lockdown changed our daily facial skincare habits?
Emilia ?cieszko,Emilian Budny,Helena Rotsztejn MD, PhD,Anna Erkiert-Polguj MD, PhD
doi : 10.1111/jocd.14059
Volume 20, Issue 12 p. 3722-3726
During the COVID-19 pandemic, Poland implemented widespread closure of beauty and cosmetic services to control the virus spread.
Alopecia areata after ChAdOx1 nCoV-19 vaccine (Oxford/AstraZeneca): a potential triggering factor?
Reham Essam MD,Rana Ehab MD,Radwa Al-Razzaz MSc,Maha W. Khater MD,Emad A. Moustafa MD
doi : 10.1111/jocd.14459
Volume 20, Issue 12 p. 3727-3729
The course of acne in healthcare workers during the COVID-19 pandemic and evaluation of possible risk factors
Birgül Özkesici Kurt MD
doi : 10.1111/jocd.14530
Volume 20, Issue 12 p. 3730-3738
There are a limited number of publications reporting an increase in acne in the COVID-19 outbreak.
Mental health and psychological resilience among acne vulgaris patients during the pandemic: A cross-sectional controlled study
Eser Sagaltici MD,Betul Tas MD
doi : 10.1111/jocd.14531
Volume 20, Issue 12 p. 3739-3746
The current literature has not yet addressed mental health among acne vulgaris (AV) patients during the COVID-19 pandemic.
New-onset cutaneous kaposi’s sarcoma following SARS-CoV-2 infection
Francesca Magri MD,Stefania Giordano MD,Alessandra Latini MD,Marta Muscianese MD
doi : 10.1111/jocd.14549
Volume 20, Issue 12 p. 3747-3750
COVID-19 is associated with several cutaneous manifestations, including chilbain-like lesions, urticaria, erythema multiforme, and maculopapular lesions. Dermatoses may be directly linked to the viral infection or also represent a consequence of systemic therapies administrated for COVID-19. A potential role of SARS-CoV-2 in triggering the reactivation of other viruses, such as HHV-6, HHV-7 and Epstein-Barr virus has been hypothesized.
Reaction to dermal filler following COVID-19 vaccination
Allison Osmond MD, MSc, FRCPC,Bret Kenny MEng
doi : 10.1111/jocd.14566
Volume 20, Issue 12 p. 3751-3752
Recurrence of alopecia areata after covid-19 vaccination: A report of three cases in Italy
Alfredo Rossi MD, PhD,Francesca Magri MD,Simone Michelini MD,Gemma Caro MD,Marco Di Fraia MD,Maria Caterina Fortuna MD,Giovanni Pellacani MD, PhD,Marta Carlesimo MD
doi : 10.1111/jocd.14581
Volume 20, Issue 12 p. 3753-3757
Common COVID-19 vaccines side effects are pain at the injection site, muscle pain, fever, headaches, fatigue. Possible immune-related side effects in predisposed individuals have not been established so far.
Impact of COVID-19 pandemic in dermatology outpatient clinics
Rujittika Mungmunpuntipantip,Viroj Wiwanitkit
doi : 10.1111/jocd.14427
Volume 20, Issue 12 p. 3758-3758
Androgenetic alopecia (AGA) is the most common form of hair loss consisting of a characteristic receding frontal hairline in men and diffuse hair thinning in women, with frontal hairline retention, and can impact an individual's quality of life. The condition is primarily mediated by 5-alpha-reductase and dihydrotestosterone (DHT) which causes hair follicles to undergo miniaturization and shortening of successive anagen cycles. Although a variety of medical, surgical, light-based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select appropriate therapies for this chronic condition.
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics
Mark S. Nestor MD, PhD,Glynis Ablon MD,Anita Gade DO,Haowei Han DO,Daniel L. Fischer DO, MA
doi : 10.1111/jocd.14537
Volume 20, Issue 12 p. 3759-3781
Androgenetic alopecia (AGA) is the most common form of hair loss consisting of a characteristic receding frontal hairline in men and diffuse hair thinning in women, with frontal hairline retention, and can impact an individual's quality of life. The condition is primarily mediated by 5-alpha-reductase and dihydrotestosterone (DHT) which causes hair follicles to undergo miniaturization and shortening of successive anagen cycles. Although a variety of medical, surgical, light-based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select appropriate therapies for this chronic condition.
New diagnostic and imaging technologies in dermatology
Shishira R Jartarkar MD,Anant Patil MD,Uwe Wollina MD,Michael H. Gold MD,Henner Stege MD,Stephan Grabbe MD,Mohamad Goldust MD
doi : 10.1111/jocd.14499
Volume 20, Issue 12 p. 3782-3787
Diagnosis of dermatological disorders is primarily based on clinical examination in combination with histopathology. However, clinical findings alone may not be sufficient for accurate diagnosis and cutaneous biopsies are being associated with morbidity.
The use of light in the treatment of acne vulgaris—a review
Julita Zdrada MSc,Anna Stolecka-Warzecha PhD,Wiktoria Odrzywo?ek MSc,Anna Deda PhD,Barbara B?o?ska-Fajfrowska MD, PhD,S?awomir Wilczy?ski PhD
doi : 10.1111/jocd.14506
Volume 20, Issue 12 p. 3788-3792
Topical and oral antibiotic therapy is also a popular method of treatment. The effectiveness of this method is limited by the increasing resistance of bacteria to antibiotics. Over the decades since the introduction of antibiotics to treat acne, the resistance levels of bacteria have changed. This defense mechanism is developed evolutionarily. Modifications of antibiotic receptor sites, alteration of drug influx/efflux, or enzymatic degradation are common mechanisms used by bacteria to initiate and strengthen internal antibiotic resistance. The basic chromophores used in light therapy are hemoglobin, melanin, water bound to proteins, and porphyrins. Hemoglobin absorbs light mainly at 580 nm, while melanin absorbs the entire visible spectral range (400–750 nm). Porphyrins are aromatic compounds, classified as photosensitizing substances, intensively absorbing blue light, and to a lesser extent in long visible bands, such as orange and red light. Using IPL makes it possible to cover the maximum light absorption of porphyrins and hemoglobin, therefore it can be an effective tool in the treatment of inflammatory lesions in acne vulgaris. In view of the effectiveness of light therapy and its effect even on antibiotic-resistant bacteria, it is worth considering the possibility of using light therapy instead of antibiotic therapy. Due to the increasing resistance of bacteria to antimicrobials, they should be used with caution and as a last resort. The high-energy light treatment act only locally (unlike with antibiotics taken orally) and on a chromophore, such as melanin, hemoglobin, or porphyrins.
Mechanism and clinical applications of needle-free injectors in dermatology: Literature review
Hye Sung Han MD,Ji Yeon Hong MD, PhD,Tae Rin Kwon MD, PhD,Sung Eun Lee BS,Kwang Ho Yoo MD, PhD,Sun Young Choi MD, PhD,Beom Joon Kim MD, PhD
doi : 10.1111/jocd.14047
Volume 20, Issue 12 p. 3793-3801
Needle-free jet injectors are devices that deliver drugs using a high-speed jet without a needle. Recent studies have significantly increased our understanding of the mechanisms of needle-free jet injectors, and technical advancements have broadened the scope of application of the device.
Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis
Meng Wang MM,Yuan Zhou MM,Yan Yan PhD
doi : 10.1111/jocd.14057
Volume 20, Issue 12 p. 3802-3807
Acne vulgaris, a chronic inflammatory dermatosis, affects approximately 85% of adolescents and young adults.The level of vitamin D in acne patients and the effect on acne patients of a vitamin D supplementation have previously been documented; however, it remains to be disputed whether vitamin D deficiency is normal in acne patients.
Laser in surgical scar clearance: An update review
Barnali Chowdhury MD,Martin Kassir MD,Julio Salas-Alanis MD,Steven Nistico MD,Hassan Galadari MD,Klaus Fritz MD,Carmen Salavastru MD,Leszek Blicharz MD,Mohamad Goldust MD
doi : 10.1111/jocd.14325
Volume 20, Issue 12 p. 3808-3811
Scar formation is a consequence of wound healing that developed from damaged tissue either from physical injury or surgical incision. A hypertrophic scar develops due to an abnormal healing response to trauma. It might lead to serious functional and cosmetic disability. There are numerous methods mentioned in the literature to treat such scars but to date, no single method has been known to cure them. In this review, we focused on differences between various types of nonsurgical management of hypertrophic scar focusing on the indication, mechanism of action, and efficacy of the pulsed dye laser (PDL), fractional carbon dioxide laser (fCO2), Er-YAG laser, and intense pulse light (IPL). The literature research included peer-reviewed articles (clinical trials or scientific reviews) which were identified by searching electronic databases like PubMed till January 2021 and reference lists of respective articles. Only articles published in the English language were included.
Stem cell-derived exosomes: A supernova in cosmetic dermatology
Xu Shen BSc,Shenghua Song BSc,Nian Chen BSc,Junlin Liao MD,Li Zeng MD
doi : 10.1111/jocd.14438
Volume 20, Issue 12 p. 3812-3817
Stem cell-derived exosomes are cell-free vesicles secreted by stem cells. Exosomes play a pivotal role in cell-to cell communication due to the functional proteins and genetic information which they carry. In addition, studies on cell migration, tumor invasion, tissue regeneration, myocardial repair after injury, and fracture healing have been widely reported.
The revolution of cosmeceuticals delivery by using nanotechnology: A narrative review of advantages and side effects
Maha N. Abu Hajleh PhD,Rana Abu-Huwaij PhD,Ali AL-Samydai PhD,Lidia Kamal Al-Halaseh PhD,Emad A. Al-Dujaili PhD
doi : 10.1111/jocd.14441
Volume 20, Issue 12 p. 3818-3828
The qualified and paradigm jump in the formulation and production of cosmeceuticals refer in some way to the great revolution in nanotechnology. Nowadays, the industry of nano-formulated cosmeceuticals plays a significant and essential role in the evolution and growth of the pharmaceutical industries. This review manuscript focuses on the use of nanocarriers in delivering the cosmetic agents into the target area such as skin, hair, and nails.
Acupuncture: A therapeutic approach against acne
Chen Chun-Yan MS,Xu Guang-yao MS,Shang Yan-yan MS,Xu Ming-Shu PhD,Liu Peng MS
doi : 10.1111/jocd.14487
Volume 20, Issue 12 p. 3829-3838
Acne is a common but chronic skin disease that influence large population especially juvenile. Acne can continue, begin, or grow into severe form in adult age, affecting face, back, and chest. It may be a serious issue if not cared or treated timely. Even if acne got treated it leaves a persistent scar, which is difficult to alleviate. These acne lesions are long-lasting and result in significant impact on mental and physical health of an individual. There are four mechanisms that are involved in acne lesion formation. However, the accurate series of events of the interaction among the factors in acne pathogenesis is still unsettled. Pubescent acne is due to increase hormone levels, when in fact adult acne is due to fluctuation in hormone levels. There are various approaches for the treatment of acne, including oral medications, creams or gels, acupuncture. Traditional Chinese Medicine stated acne as a infection that is associated with the pathogenic influence of damp heat and heat on specific meridians. As an ancient and integral part of Chinese medicine acupuncture therapy is employed in the treatment of many diseases including acne. It functions by ameliorating the deep-rooted mechanisms playing crucial role in acne development. In this review, we have explained the acne causes, pathogenesis, and its available treatment options. Additionally, we also discussed the acupuncture therapy methods, devices, different techniques. and its mechanism of action in treating acne. Furthermore, clinical trials studies motivated us to highlight the scope of acupuncture in the growing system of medicine.
Perioral dermatitis: Diagnosis, proposed etiologies, and management
Tamara Searle BSc,Faisal R. Ali MRCP, PhD,Firas Al-Niaimi MRCP
doi : 10.1111/jocd.14060
Volume 20, Issue 12 p. 3839-3848
Perioral dermatitis is a common cutaneous condition characterized by acneiform facial eruptions often with an eczematous appearance. A granulomatous subtype exists in addition to the classic variant. While topical corticosteroids have been largely implicated in this condition, its etiology is not completely understood.
The mobility of the superficial and deep midfacial fat compartments: An ultrasound-based investigation
Leonie Schelke MD, PhD,Peter J. Velthuis MD, PhD,Natalia Lowry MD, PhD,Rod J. Rohrich MD,Arthur Swift MD,Robert H. Gotkin MD,Nicholas Moellhoff MD,Konstantin Frank MD,Mihai Dumbrava BA,Sebastian Cotofana MD, PhD
doi : 10.1111/jocd.14374
Volume 20, Issue 12 p. 3849-3856
Understanding the mobility of the midface and the separate contributions of the superficial and deep fat compartments is essential for natural esthetic outcomes following soft tissue filler or fat grafting procedures. A study was designed that used ultrasound imaging to demonstrate in vivo visualization and quantification of distances and movements in the midface.
After the Temporal Lifting Technique—What comes next?
Claudia A. Hernandez MD,Carolina Schneider MD,Michael H. Gold D,Mariana Muniz MD,Jeremy B. Green MD,Michael Alfertshofer,Konstantin Frank MD,Sebastian Cotofana MD, PhD
doi : 10.1111/jocd.14247
Volume 20, Issue 12 p. 3857-3862
The temporal lifting technique can provide lateral facial lifting when administering hyaluronic acid (HA)-based soft tissue fillers into the subdermal plane of the temple. However, the central facial oval is not influenced by this technique.
Evaluation of safety and efficacy of a new device for muscle toning and body shaping
Alessandro Leone MD,Domenico Piccolo MD,Claudio Conforti MD,Laura Pieri PhD,Irene Fusco PhD
doi : 10.1111/jocd.14579
Volume 20, Issue 12 p. 3863-3870
The spread of non-invasive procedures for fat deposits removal has increased rapidly in recent years. In the field of esthetic medicine, high-intensity focused electromagnetic field (HIFEM) technology has recently been introduced, as a tool for toning and strengthening muscles, which goes far beyond normal physical exercise.
Effectiveness of combined microfocused ultrasound with visualization and subdermal calcium hydroxyapatite injections for the management of brachial skin laxity
Sylvia Ramirez MD, MPH, MBA, Dip Derm, MSc,Ivan Boon Kwang Puah MBBS, GDFD, GDA, GDSM
doi : 10.1111/jocd.14573
Volume 20, Issue 12 p. 3871-3879
There is no publication to date on the combined use of microfocused ultrasound with visualization (MFU-V) and calcium hydroxylapatite (CaHA) for brachial skin laxity.
Efficacy and safety of Resveratrol combined with Ablative Fractional CO2 laser system in the treatment of skin photoaging
Yi-Mei Du MD,Jing Zeng MD,Meng Li MD,Yang-Bin Wang MD,Yan Wu MD, PhD,Rui-Qun Qi MD, PhD,Xing-Hua Gao MD, PhD,Hong-Duo Chen MD
doi : 10.1111/jocd.14569
Volume 20, Issue 12 p. 3880-3888
To evaluate the efficacy and safety of resveratrol combined with ablative fractional CO2 laser system (AFL) treating skin photoaging.
Treating melasma with the 1064 nm Nd:YAG laser with a 650-microsecond pulse duration: A clinical evaluation
Tanya Greywal MD,Arisa Ortiz MD
doi : 10.1111/jocd.14558
Volume 20, Issue 12 p. 3889-3892
The effective treatment of melasma remains a challenge that necessitates a multifaceted approach that includes strict sun protection, bleaching creams, chemical peels, and laser therapy. The 1064 nm Nd:YAG laser with a 650-microsecond pulse duration provides a safe option for all skin types.
Combination treatment for buttock and abdominal remodeling and skin improvement using HIFEM procedure and simultaneous delivery of radiofrequency and targeted pressure energy
Diane Irvine Duncan MD, FACS
doi : 10.1111/jocd.14554
Volume 20, Issue 12 p. 3893-3898
High-intensity electromagnetic field procedure (HIFEM) is an effective tool for body shaping and muscle toning. Radiofrequency (RF) combined with targeted pressure energy (TPE) provides the solution for skin laxity and cellulite.
The effectiveness of long Pulsed Nd:YAG Laser alone for treatment of keloids and hypertrophic scars versus its combination with bleomycin
Heba Ramadan MD of dermatology,Mahmoud Saber MD of dermatology,Manal Salah MD of dermatology,Nevien Samy MD of dermatology
doi : 10.1111/jocd.14509
Volume 20, Issue 12 p. 3899-3906
Pathological scars are benign hyper-proliferative growths of dermal collagen that causes severe psychological and physical problems. This study was performed to assess and compare safety and clinical efficiency of combined pulsed Nd-YAG laser and intralesional bleomycin versus pulsed Nd-YAG laser alone to treat the hypertrophic scars and keloids.
Acne scar treatment using high-energy fractional nanosecond Q-switched 1064 nm laser
Nasrin Mani MD,Anže Zorman
doi : 10.1111/jocd.14534
Volume 20, Issue 12 p. 3907-3912
The objective of this study was to evaluate the effectiveness and safety of high-energy ablative fractional nanosecond Q-switched 1064 nm laser therapy for acne scars.
Using blend wavelengths in order to improve the safety and efficacy of laser hair removal
Yehonatan Noyman MD,Assi Levi MD,Ofer Reiter MD,Moshe Lapidoth MD MPH
doi : 10.1111/jocd.14535
Volume 20, Issue 12 p. 3913-3916
As the pursuit for a safe and effective device for laser hair removal continues, the use of simultaneous multiple wavelengths in a single device requires further exploration.
Fractional carbon dioxide laser versus carbon-assisted Q-switched Nd: YAG laser in the treatment of dilated facial pores
Fatma Eldeeb MD,Reham M. Wahid MD,Rania Alakad MD
doi : 10.1111/jocd.14311
Volume 20, Issue 12 p. 3917-3923
The treatment of dilated facial pores is difficult, and the ideal modality is not established yet. Different ablative and nonablative lasers have been used in the treatment of dilated pores with variable outcomes.
A split-face clinical trial of conventional red-light photodynamic therapy versus daylight photodynamic therapy for acne vulgaris
Evgenia Slutsky-Bank MD,Ofir Artzi MD,Eli Sprecher MD,Amir Koren MD
doi : 10.1111/jocd.14359
Volume 20, Issue 12 p. 3924-3930
Photodynamic therapy (PDT) is considered an effective treatment for acne vulgaris. A significant drawback is pain during illumination. Daylight PDT (DL-PDT) is more tolerable.
An alternative for the treatment of vulvar syringoma: 577 nm pro-yellow laser
Gulhan Aksoy Sarac MD,Meltem Onder MD
doi : 10.1111/jocd.14186
Volume 20, Issue 12 p. 3931-3933
Syringoma is a benign sweat gland tumor.
Facial skin esthetic treatments with plasma radiofrequency ablation
Adone Baroni MD, PhD
doi : 10.1111/jocd.14045
Volume 20, Issue 12 p. 3934-3939
The field of esthetic dermatology continues to evolve rapidly, and esthetic procedures for facial skin play a key role in it. During recent years, patients have been demanding more non-invasive and safe technology characterized by satisfactory results and minimal downtime as compared to traditional surgical procedures. In the panorama of facial skin treatments, many options have different indications and limitations.
High-power blue laser as a versatile tool in dermatology
Jacek Szyma?czyk MD, PhD,Agata Ma?kowska PhD,Karol Szyma?ski MD, PhD,Tadeusz Pó?ch?opek MD,Witold Trzeciakowski PhD,Janusz Szyma?czyk MD
doi : 10.1111/jocd.14432
Volume 20, Issue 12 p. 3940-3942
Efficacy of topical tacrolimus 0.03% monotherapy in the treatment of non-segmental vitiligo: a randomized, controlled trial
Ramadan Saleh MD,Aml Abd-Elaziz Ahmed MSc,Wafaa M Abd-Elmagid MD
doi : 10.1111/jocd.14041
Volume 20, Issue 12 p. 3943-3952
Topical tacrolimus is increasingly used nowadays in the treatment of vitiligo.
Comparison of 2% deoxyarbutin and 4% hydroquinone as a depigmenting agent in healthy individuals: A double-blind randomized controlled clinical trial
Anis Irawan Anwar MD, PhD,Yulia Asmarani MD,Asnawi Madjid MD,Ilhamjaya Patellongi MD, PhD,Anni Adriani MD, PhD,Suryani As’ad MD, PhD,Ivan Kurniadi MD, BMedSci (Hons)
doi : 10.1111/jocd.14050
Volume 20, Issue 12 p. 3953-3959
Hydroquinone, which is considered the gold standard skin depigmenting agent, has been associated with multiple side effects. Lately, deoxyarbutin has been suggested to be an alternative of hydroquinone with better safety profile.
The efficacy and safety of an antiaging topical serum containing hesperetin and sodium cyclic lysophosphatidic acid: A single-center clinical trial
Yi-Shaun Sheen MD, PhD,Hsin-Yi Huang MD, PhD,Yi-Hua Liao MD, PhD
doi : 10.1111/jocd.14063
Volume 20, Issue 12 p. 3960-3967
Skin aging is characterized by dehydration and degradation of the structural components in the dermis. It has been demonstrated that hesperetin possesses collagen synthesis and antioxidant properties and sodium cyclic lysophosphatidic acid (NcPA) increases skin moisture through upregulating the synthesis of hyaluronic acid.
A randomized, controlled, split-face study of topical timolol maleate 0.5% eye drops for the treatment of erythematotelangiectatic rosacea
Danfeng Wei,Michael R. Hamblin,Xiang Wen
doi : 10.1111/jocd.14347
Volume 20, Issue 12 p. 3968-3973
Centrofacial erythema associated with telangiectasis is the most common presentation of rosacea, known as erythematotelangiectatic rosacea (ETR). However, successful management of these symptoms remains challenging.
The safety and efficacy of a cosmetic camouflaging agent for post-procedural bruising
Michael H. Gold MD, FAAD,Suneel Chilukuri MD,Doris Day MD, MA,Kaitlyn M. Enright MSc
doi : 10.1111/jocd.14588
Volume 20, Issue 12 p. 3974-3981
A challenge of minimally invasive esthetic procedures (eg, injectables and threads) is managing adverse events (AEs), such as post-procedural bruising. Implementation of post-procedural camouflage therapy may minimize the appearance of bruising and mitigate AEs.
The importance of palpation in the skin cancer screening examination
Benjamin G. Gorman BA,Jennifer Hanson MD,Nahid Y. Vidal MD
doi : 10.1111/jocd.14054
Volume 20, Issue 12 p. 3982-3985
With the recent unprecedented shift toward contactless healthcare solutions, providers should recall the value that proper palpation adds to dermatologic practice. We present a case that demonstrates the limitations of touchless care and how proper palpation during skin cancer examinations may impact cosmetic outcomes. Our patient is an 86-year-old male patient with Sezary syndrome and monoclonal B-cell lymphocytosis whose squamous cell carcinoma invasion was missed by visual inspection alone. He delayed treatment of his biopsy-proven squamous cell carcinoma for 15 months. On follow-up, visual examination only showed a well-healed biopsy scar, and treatment was delayed another 2 months. Finally, thorough physical examination found perineural invasion. This helped guide the Mohs approach, but due to the delays resulted in a larger final defect and poorer cosmetic outcomes. Proper, deep palpation of skin lesions, especially prior biopsy sites, is imperative to the treatment of skin cancer in cosmetically sensitive areas. Biopsy scars on the face often heal well, and visual only inspection may miss crucial details. This case also reminds dermatologists of the importance of patient education in the prompt treatment of skin cancer for the best cosmetic outcomes.
Effectiveness and safety of the improved mini-incision surgery for osmidrosis treatment
Pan Zhang MD,Dashuai Li MM,Liqun Li MD,Shengsheng Pan MD
doi : 10.1111/jocd.14061
Volume 20, Issue 12 p. 3986-3990
As the mainstream treatment of axillary osmidrosis, surgical treatment is still limited by various complications, such as paresthesia, scars, local infection, hematoma, flap necrosis, and long recovery time. In this study, we tried to adopt the improved mini-incision surgery for osmidrosis treatment.
Preference of eyebrow apex positions on different facial shapes in Malaysian population: An inter-ethnic study
Vasanthakumar Packirisamy PhD,Chakravarthy Marx Sadacharan PhD
doi : 10.1111/jocd.14062
Volume 20, Issue 12 p. 3991-4000
Eyebrows are an important esthetic feature of the face. In cosmetic surgery, knowledge about the patient's preference of eyebrow apex position is important to achieve agreeable esthetic results.
Corrective strategies for poor appearance after tissue expansion for temporal and sideburn cicatricial alopecia
Wenjie Jiang PhD,Lulu Chen PhD,Lingling Jia MD,Meng Wang PhD,Bo Wang BS
doi : 10.1111/jocd.14067
Volume 20, Issue 12 p. 4001-4004
The expanded scalps are usually used to repair the scalp defects. However, hair growth direction and hair density of the expanded scalps may be inconsistent with those of the defective sites, resulting in unsatisfactory results.
Randomized, double-blind, placebo-controlled split-face trial of the efficacy of tranexamic acid by drug delivery through microneedling in the treatment of melasma
Dâmia Kuster Kaminski Arida MD,Priscila Regina Orso Rebellato MD,Giovana Liz Marioto de Campos MD,Adriane Costa MD,Juliano Vilaverde Schmitt MD, PhD,Thelma Larocca Skare MD, PhD,Luciana Rodrigues Lisboa Faucz MD, PhD
doi : 10.1111/jocd.14257
Volume 20, Issue 12 p. 4005-4010
Melasma is a prevalent skin pigmentation disorder that is difficult to treat. Tranexamic acid (TA) is a potential agent, but there are few studies on its effectiveness under the transdermal route (drug delivery—Dd). One of these Dd pathways is through microneedling, which seems to be effective itself.
Microneedling-assisted topical tranexamic acid solution versus 4% hydroquinone for treating melasma: A split-face randomized study
Mohamed S. Zaky MD,Zakaria M. Obaid MD,Eman A. Khalil MD,Mohamed L. Elsaie MD
doi : 10.1111/jocd.14440
Volume 20, Issue 12 p. 4011-4016
Melasma, also known as chloasma or mask of pregnancy, is a common, acquired, hyperpigmentary disorder usually affecting females. Tranexamic acid (TA), a derivative of amino acid lysine, has shown promising results over the past few years when used along with other therapies and when used as a stand-alone therapy.
Quality of life in young adults with acne: Results of a cross-sectional study
Inder Pal Singh MD,Kavita Poonia MD,Kanika Bajaj MBBS
doi : 10.1111/jocd.14540
Volume 20, Issue 12 p. 4017-4023
The impact of acne on quality of life (QoL) may vary between patients from different age groups. There are limited data in the literature on QoL of young adults with acne and acne scars.
Pilot study of histology aspect of cellulite in seventy patients who differ in BMI and cellulite grading
Antonio Scarano MD, DDS,Morena Petrini D.D.S.,Andrea Sbarbati MD,Roberto Amore MD,Eugenio Luigi Iorio MD,Marco Marchetti MD,Domenico Amuso MD
doi : 10.1111/jocd.14584
Volume 20, Issue 12 p. 4024-4031
Cellulite is a topographic alteration of the skin with unknown etiology and is characterized by the presence of a dimpled or puckered aspect, as resembling an orange peel and cottage cheese or as having mattress-like appearance.
Development and validation of a global photonumeric scale for evaluating skin quality of aged female facial skin
Christine Eiben-Nielson PhD,Martina Kerscher MD
doi : 10.1111/jocd.14058
Volume 20, Issue 12 p. 4032-4039
Skin quality plays an important role in overall attractiveness. However, so far, no visual grading scales have been published while their development seems to be an essential key step to provide validated grading scales for the evaluation of efficacy of minimally invasive procedures and cosmeceuticals aims on the improvement of skin quality, esthetic research, and clinical application.
Effect of dermal fibroblasts and mesenchymal stem cells seeded on an amniotic membrane scaffold in skin regeneration: A case series
Seyedeh-Sara Hashemi PhD,Ali Akbar Mohammadi MD,Kasra Moshirabadi MD,Mitra Zardosht MS
doi : 10.1111/jocd.14043
Volume 20, Issue 12 p. 4040-4047
Skin wound healing has always been a challenging subject as it involves the coordinated functioning of various cells and molecules. Any disorder in wound healing can cause healing failure and result in chronic wounds. In this study, we hypothesized that co-cultured dermal fibroblasts (DFs) and Wharton's jelly mesenchymal stem cells (WJ-MSCs) seeded on an acellular amniotic membrane scaffold could be used to promote skin regeneration in chronic ulcers.
Investigation of the relationship between alopecia areata and inflammatory blood parameters
Göktürk Dere MD,Mustafa Gündo?du MD
doi : 10.1111/jocd.14048
Volume 20, Issue 12 p. 4048-4051
Alopecia areata (AA) is an inflammatory condition that causes regional shedding without scarring on the hair or eyebrows, eyelashes, and beard. In studies conducted, it has been concluded that platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and mean platelet volume (MPV) are significant indicators of systemic inflammation in various diseases. In the present study, our aim was to examine these parameters in AA patients and to investigate their relationship with the disease.
Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways
Hao Fu MS,ShiQuan You MS,Dan Zhao PhD,Quan An PhD,Jiachan Zhang PhD,Changtao Wang PhD,Dongdong Wang PhD,Meng Li PhD
doi : 10.1111/jocd.14051
Volume 20, Issue 12 p. 4052-4059
UVA radiation can cause skin oxidative stress. Tremella fuciformis polysaccharides (TFPS) are the main active ingredient in Tremella. Previous studies have shown that TFPS have protective effects on UVA-induced oxidative stress cells, but the specific protective mechanism has not been clarified.
Lysophosphatidylcholine exerts an anti-skin photoaging effect via heat shock protein 70 induction
Hyunmin Hwang MD,Hyeyeon Chun PhD,Daehyun Kim MD,Munju Shin MD,Yun-Sun Kim PhD,Sohyun In MD,Taeyoon Kim MD,Nae-Gyu Kang PhD
doi : 10.1111/jocd.14068
Volume 20, Issue 12 p. 4060-4067
Skin-brightening agents prevent melanogenesis and reduce melanin production. However, a lower melanin content leads to weaker protection against sunlight. In this study, we evaluated the effect of lysophosphatidylcholine (LPC) and its commercial-grade product, Lysofix Dry™ (LD), on heat shock protein 70 (HSP70) expression in epidermal cells and their anti-skin photoaging effect against ultraviolet B (UVB) and blue light.
The potential of microfluidic devices in dermatology
Nithin Tom Mathew MS, PhD,Sinu Rose Mathachan MD, DNB, MRCP(SCE)
doi : 10.1111/jocd.14526
Volume 20, Issue 12 p. 4068-4069
Facial rejuvenation: A safe and effective treatment with a fractional non-ablative 675 nm laser in Asian population
Paolo Bonan MD,Alice Verdelli PhD,Laura Pieri PhD,Irene Fusco PhD,Rumpa Linpiyawan MD
doi : 10.1111/jocd.14529
Volume 20, Issue 12 p. 4070-4072
Letter to the editor regarding article “Yalici-Armagan B, Tabak GH, Dogan-Gunaydin S, Gulseren D, Akdogan N, Atakan N. Treatment of psoriasis with biologics in the early COVID-19 pandemic: A study examining patient attitudes toward the treatment and disease course. J Cosmet Dermatol. 2021;00:1–5”
Luca Potestio,Elisa Camela,Gabriella Fabbrocini,Matteo Megna
doi : 10.1111/jocd.14550
Volume 20, Issue 12 p. 4073-4075
Letter to the editor regarding the article ‘‘Patil S, Patil A. Systemic lupus erythematosus after COVID-19 vaccination: A case report. J Cosmet Dermatol. 2021 Aug 21. 10.1111/jocd.14386”
Lina Abdullah BS,Bassem Awada MD,Mazen Kurban MD,Ossama Abbas MD
doi : 10.1111/jocd.14572
Volume 20, Issue 12 p. 4076-4077
Comparing QS Nd:YAG laser alone with its combination with fractional ablative Er:YAG in tattoo removal
Vahideh Lajevardi MD,Hamidreza Mahmoudi MD,Fereshte Karimi MD,Yasamin Kalantari MD,Ifa Etesami MD
doi : 10.1111/jocd.14076
Volume 20, Issue 12 p. 4078-4080
