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Is a fat thumb another sign of psoriatic arthritis?
Kevin Pile
doi : 10.1111/1756-185X.14237
Volume 24, Issue 12 p. 1447-1448
Prevalence and risk factors of systemic sclerosis-associated interstitial lung disease in East Asia: A systematic review and meta-analysis
Meihua Qiu,Xueyuan Nian,Lingling Pang,Pengfei Yu,Shenchun Zou
doi : 10.1111/1756-185X.14206
Volume 24, Issue 12 p. 1449-1459
Interstitial lung disease (ILD) is a common and potentially life-threatening complication for individuals with systemic sclerosis (SSc). The purpose of this study was to complete a systematic review and meta-analysis on prevalence and risk factors of SSc-ILD in East Asia.
Myeloperoxidase and associated lung disease: Review of the latest developments
Hannah Hu,Karuna Keat
doi : 10.1111/1756-185X.14213
Volume 24, Issue 12 p. 1460-1466
Myeloperoxidase (MPO) anti-neutrophil cytoplasmic antibodies (ANCA) are often detected in association with a variety of lung pathologies, the most common being interstitial lung disease (ILD). A growing cohort of patients are being diagnosed with MPO-ANCA in the context of ILD without ANCA-associated vasculitis. Clinically and radiologically, there is little to differentiate this cohort from MPO-ANCA-negative ILD patients; however, the pathophysiology is likely different and different treatments are likely required. We present here a brief summary of the proposed pathophysiology of MPO-ANCA-positive ILD, and a more detailed review of the latest evidence on management, including monitoring for development of ANCA-associated vasculitis, immunosuppression, anti-fibrotics, and novel agents that have yet to be trialled in human experiments.
Magnetic Resonance Imaging evidence of Inflammation at Interphalangeal joint of Thumb — A distinct entity in psoriatic arthritis
Ashish J Mathew,Arvind Ganapati,Jyoti Panwar,Varghese Koshy,Anu Desai,Debashish Danda
doi : 10.1111/1756-185X.14156
Volume 24, Issue 12 p. 1467-1472
This study aimed to compare inflammation at the interphalangeal (IP) joint of thumb in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA), undifferentiated inflammatory arthritis (UIA), and in psoriasis patients without clinical arthritis (PsO) using low-field magnetic resonance imaging (MRI).
Acceptance and image quality of high-resolution peripheral quantitative computed tomography of the metacarpophalangeal joints in rheumatoid arthritis
Rasmus Klose-Jensen,Kresten Krarup Keller,Bente Langdahl,Ellen-Margrethe Hauge
doi : 10.1111/1756-185X.14169
Volume 24, Issue 12 p. 1473-1481
High-resolution peripheral quantitative computed tomography (HR-pQCT) requires longer immobilization time than conventional radiography, which challenges patient acceptance and image quality. Therefore, the aim was to investigate the acceptance of HR-pQCT in patients with rheumatoid arthritis (RA), and secondly the effect of an inflatable hand immobilization device on motion artefacts of the metacarpophalangeal (MCP) joints.
Asymptomatic myocardial dysfunction was revealed by feature tracking cardiac magnetic resonance imaging in patients with primary Sjögren’s syndrome
Isamu Yokoe,Hitomi Kobayashi,Atsuma Nishiwaki,Yosuke Nagasawa,Noboru Kitamura,Masaki Haraoka,Yasuyuki Kobayashi,Masami Takei,Hideki Nakamura
doi : 10.1111/1756-185X.14227
Volume 24, Issue 12 p. 1482-1490
To evaluate subclinical left ventricular (LV) regional dysfunction in patients with primary Sjögren's syndrome (pSS) using feature tracking cardiac magnetic resonance (FT-CMR) imaging and to identify pSS characteristics independently associated with LV regional dysfunction.
Trajectory mapping of primary Sjögren's syndrome via transcriptome learning demonstrates limitations of peripheral blood sequencing
Bing Zhong,Yaqiong Wang,Qinghua Zou,Chen Xuemeng,Can Qian,Chengshun Chen,Jie Xiong,Zihan Zheng,Liyun Zou,Jingyi Li
doi : 10.1111/1756-185X.14229
Volume 24, Issue 12 p. 1491-1499
Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterized by aberrant immune cell action against secretory glands throughout the body. A number of studies have previously identified unique characteristics in the circulating expression profile of white blood cells of pSS patients. However, the molecular progression pattern of pSS is unclear. Through a systematic analysis of pSS transcriptome information, we found that pSS transcriptomes display broad heterogeneity, but cannot be distinguished from the broad range of possible profiles of healthy controls. Instead, only sample learning using a subset of pre-identified signature genes could achieve partial separation through a trajectory governed by interferon activity. Interestingly, this trajectory is correlated with a decrease in dendritic cell counts. Our study thus highlights a major limitation to the utility of broad blood transcriptome analysis in the context of pSS, while also identifying several factors that influence the divergence between patient samples.
Comparison of renal remission and relapse-free rate in initial- and delayed-onset lupus nephritis
Eiji Suzuki,Makiko Yashiro-Furuya,Jumpei Temmoku,Yuya Fujita,Naoki Matsuoka,Momoko Hazama,Tomoyuki Asano,Shuzo Sato,Hiroko Kobayashi,Hiroshi Watanabe,Takashi Kanno,Kiyoshi Migita
doi : 10.1111/1756-185X.14228
Volume 24, Issue 12 p. 1500-1509
Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE) which contributes to significant morbidity and mortality. It is unclear whether the timing of LN onset influences renal outcome. This study aimed to investigate differences in clinical features—particularly the relapse-free rate—in remission duration from induction therapies for LN and the onset timing of LN after the development of SLE.
Thrombotic risk assessment in patients with systemic lupus erythematosus: Validation of the adjusted-Global Antiphospholipid Syndrome Score (aGAPSS) in Thai patients
Wanitcha Chanloung,Nuntana Kasitanon,Ramjai Wichainun,Worawit Louthrenoo
doi : 10.1111/1756-185X.14230
Volume 24, Issue 12 p. 1510-1519
The adjusted-Global Antiphospholipid Syndrome Score (aGAPSS) has been validated and used to predict antiphospholipid antibodies (aPL) related to vascular thrombosis (VT).
Pain catastrophizing hinders Disease Activity Score 28 – erythrocyte sedimentation rate remission of rheumatoid arthritis in patients with normal C-reactive protein levels
Tamami Yoshida,Motomu Hashimoto,Go Horiguchi,Kosaku Murakami,Koichi Murata,Kohei Nishitani,Ryu Watanabe,Wataru Yamamoto,Masao Tanaka,Akio Morinobu,Hiromu Ito,Shuichi Matsuda,Ritei Uehara
doi : 10.1111/1756-185X.14231
Volume 24, Issue 12 p. 1520-1529
This study aimed to assess the relationship between pain catastrophizing and achievement of 28-joint Disease Activity Score-defined remission of rheumatoid arthritis (RA), considering the presence or absence of systemic inflammation, and to evaluate associated factors for pain catastrophizing.
Upadacitinib in patients from China, Brazil, and South Korea with rheumatoid arthritis and an inadequate response to conventional therapy
Xiaofeng Zeng,Dongbao Zhao,Sebastiao C. Radominski,Mauro Keiserman,Chang K. Lee,Sebastian Meerwein,Jeffrey Enejosa,Yunxia Sui,Mohamed-Eslam F. Mohamed,Won Park
doi : 10.1111/1756-185X.14235
Volume 24, Issue 12 p. 1530-1539
This study assessed the efficacy and safety of upadacitinib (UPA), in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), in Chinese, Brazilian, and South Korean patients with active rheumatoid arthritis (RA) and an inadequate response (IR) to csDMARDs.
Which interventions are effective for cutaneous disease in systemic lupus erythematosus? A Cochrane Review summary with commentary
Alessandro de Sire
doi : 10.1111/1756-185X.14215
Volume 24, Issue 12 p. 1540-1542
Scientific critique on the effects of supervised exercise program and home exercise program in patients with systemic sclerosis: A randomized controlled trial
Alexandros Mitropoulos,Markos Klonizakis
doi : 10.1111/1756-185X.14234
Volume 24, Issue 12 p. 1543-1544
Response to “Scientific critique on the effects of supervised exercise program and home exercise program in patients with systemic sclerosis: A randomized controlled trial”
Hazal Yakut,Sevgi Özalevli
doi : 10.1111/1756-185X.14233
Volume 24, Issue 12 p. 1545-1546
Your help is needed in the fight against COVID-19: Please contribute to the COVID-19 Global rheumatology alliance registry
doi : 10.1111/1756-185X.14192
Volume 24, Issue 12 p. 1547-1547
