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New Therapies for Corneal Endothelial Diseases: 2020 and Beyond
Soh, Yu Qiang MBBS, MMed, FRCOphth*; Poh, Stanley S. J. MBBS†; Peh, Gary S. L. PhD*; Mehta, Jodhbir S. MBBS, FRCOphth, FRCS(Ed), PhD*,†,‡,§
doi : 10.1097/ICO.0000000000002687
November 2021 - Volume 40 - Issue 11 - p 1365-1373
Penetrating keratoplasty used to be the only surgical technique for the treatment of end-stage corneal endothelial diseases. Improvements in surgical techniques over the past decade have now firmly established endothelial keratoplasty as a safe and effective modality for the treatment of corneal endothelial diseases. However, there is a worldwide shortage of corneal tissue, with more than 50% of the world having no access to cadaveric tissue. Cell injection therapy and tissue-engineered endothelial keratoplasty may potentially offer comparable results as endothelial keratoplasty while maximizing the use of cadaveric donor corneal tissue. Descemet stripping only, Descemet membrane transplantation, and selective endothelial removal are novel therapeutic modalities that take this a step further by relying on endogenous corneal endothelial cell regeneration, instead of allogenic corneal endothelial cell transfer. Gene therapy modalities, including antisense oligonucleotides and clustered regularly interspaced short palindromic repeats–based gene editing, offer the holy grail of potentially suppressing the phenotypic expression of genetically determined corneal endothelial diseases at the asymptomatic stage. We now stand at the crossroads of exciting developments in medical technologies that will likely revolutionize the way we treat corneal endothelial diseases over the next 2 decades.
Keratoplasty Rejection Risk Associated With Recent Vaccination—The Pragmatic Approach
Lockington, David MD, FRCOphth, PhD
doi : 10.1097/ICO.0000000000002818
November 2021 - Volume 40 - Issue 11 - p 1374-1376
Clinical Outcomes and Patient Satisfaction After Corneal Neurotization
Rafailov, Leon MD*; Kim, Jane S. MD†; Wisely, Clayton Ellis MD, MBA†; Espana, Edgar M. MD‡; Soifer, Matias MD§; Leyngold, Ilya M. MD*
doi : 10.1097/ICO.0000000000002759
November 2021 - Volume 40 - Issue 11 - p 1377-1386
The aim of this study was to assess clinical outcomes of corneal neurotization (CN) and determine patient perception of postoperative results.
Ocular Surface Squamous Neoplasia Managed With Primary Interferon ?2b: A Comparative Analysis of 212 Tumors in Smokers Versus Nonsmokers
Shields, Carol L. MD; Paulose, Sefy A. MD; Yaghy, Antonio MD; Dalvin, Lauren A. MD; Constantinescu, Alexandru B. MD; Lally, Sara E. MD; Shields, Jerry A. MD
doi : 10.1097/ICO.0000000000002615
November 2021 - Volume 40 - Issue 11 - p 1387-1394
To explore clinical features and outcomes of ocular surface squamous neoplasia (OSSN) treated with primary interferon (IFN)-?2b, based on patient cigarette smoking status.
Long-Term Safety and Efficacy of Tacrolimus 0.1% in Severe Pediatric Vernal Keratoconjunctivitis
Caputo, Roberto MD*; Marziali, Elisa MD*; de Libero, Cinzia MD*; Di Grande, Laura MD†; Danti, Gioia Orthoptist*; Virgili, Gianni MD‡,§; Villani, Edoardo MD¶; Mori, Francesca MD, PhD†; Bacci, Giacomo M. MD*; Lucenteforte, Ersilia PhD?; Pucci, Neri MD†
doi : 10.1097/ICO.0000000000002751
November 2021 - Volume 40 - Issue 11 - p 1395-1401
The aim of this study was to evaluate the safety and efficacy of tacrolimus 0.1% eye drops in a large population of pediatric patients affected by a severe form of vernal keratoconjunctivitis (VKC) who responded poorly to cyclosporine eye drops.
Early Complications With Preloaded Descemet Membrane Endothelial Keratoplasty Are Not Dependent on Optisol-GS Washout or Trypan Blue Restaining
Greenwald, Miles F. MD*; Nanji, Afshan A. MD, MPH*; Clements, John L. MD*,†; Stutzman, Richard D. MD*; Stoeger, Christopher G. MBA, CEBT, CTBS‡; Chamberlain, Winston D. MD, PhD*
doi : 10.1097/ICO.0000000000002634
November 2021 - Volume 40 - Issue 11 - p 1402-1405
To describe the intraoperative and early postoperative complications using preloaded Descemet membrane endothelial keratoplasty (DMEK) grafts with intraocular injection of the graft in Optisol-GS and omission of trypan blue restaining.
Surgeon Preference for Keratoplasty Techniques and Barriers to Performing Deep Anterior Lamellar Keratoplasty
Thanitcul, Chanon BS; Mathews, Priya MD, MPH; Woreta, Fasika A. MD, MPH; Akpek, Esen K. MD; Varadaraj, Varshini MD, MPH; Srikumaran, Divya MD
doi : 10.1097/ICO.0000000000002644
November 2021 - Volume 40 - Issue 11 - p 1406-1412
To identify barriers and facilitators to adopting deep anterior lamellar keratoplasty (DALK) for nonendothelial corneal pathology.
Predisposing Factors, Clinical Presentations, and Outcomes of Contact Lens–Related Pythium Keratitis
Nonpassopon, Manachai MD*; Jongkhajornpong, Passara MD*; Aroonroch, Rangsima MD†; Koovisitsopit, Atit MD*; Lekhanont, Kaevalin MD*
doi : 10.1097/ICO.0000000000002651
November 2021 - Volume 40 - Issue 11 - p 1413-1419
To describe predisposing factors, clinical presentations, and treatment outcomes of contact lens (CL)–related Pythium keratitis.
Surgeon Preferences for Endothelial Keratoplasty in Canada
Kisilevsky, Eli MD*; Srikumaran, Divya MD†; Chew, Hall F. MD, FRCSC*
doi : 10.1097/ICO.0000000000002639
November 2021 - Volume 40 - Issue 11 - p 1420-1425
To quantify practice patterns and assess attitudes and barriers to performing Descemet membrane endothelial keratoplasty (DMEK) in Canada.
Agreement of Corrected Intraocular Pressure Values Between Corvis ST and Pentacam in Patients With Keratoconus, Subclinical Keratoconus, and Normal Cornea
Chen, Yanhui MD; Rong, Hua MD; Liu, Wei MD; Liu, Guihua MD; Du, Bei MD, PhD; Jin, Chengcheng MD; Wei, Ruihua MD, PhD
doi : 10.1097/ICO.0000000000002707
November 2021 - Volume 40 - Issue 11 - p 1426-1432
To analyze the agreement of corrected intraocular pressure (IOP) values between Corvis ST (?IOP1) and Pentacam (?IOP2) in patients with keratoconus (KC), subclinical KC (sub-KC), and normal cornea.
The Reliability of Successive Scheimpflug Imaging and Anterior Segment Optical Coherence Tomography Measurements Decreases With Increasing Keratoconus Severity
Flockerzi, Elias MD*; Elzer, Berit MD*; Daas, Loay MD*; Xanthopoulou, Kassandra MD*; Eppig, Timo PhD†; Langenbucher, Achim PhD†; Seitz, Berthold MD*
doi : 10.1097/ICO.0000000000002657
November 2021 - Volume 40 - Issue 11 - p 1433-1439
This study assesses the reliability of successive measurements of tomographic parameters in different keratoconus (KC) stages with 2 different devices.
Rituximab as an Adjuvant Rescue Treatment for Ocular Cicatricial Pemphigoid
Bevans, Stephanie L. MD*; Parker, John MD†; Ivey, Jordan M. MD‡; Pavlidakey, Peter MD§; Sami, Naveed MD¶
doi : 10.1097/ICO.0000000000002683
November 2021 - Volume 40 - Issue 11 - p 1440-1444
Ocular cicatricial pemphigoid (OCP) can lead to devastating ocular complications without prompt treatment. A number of immunomodulatory agents have been attempted with varying success. The objective of this study was to evaluate the use of rituximab as an adjuvant to immunomodulatory treatments (IMTs) in refractory OCP.
Analysis of Immune Cells on Donor Corneal Endothelium After Corneal Transplantation Using the HRT-Rostock Cornea Module
Okumura, Naoki MD, PhD*; Velumani, Thenmozhi BOptom†; Hadiya, Farhath BOptom†; Padmanaban, Vasanthi BOptom†; Komori, Yuya BS, MS*; Hanada, Naoya BS*; Hirono, Taisuke PhD‡; Srinivas, Sangly P. PhD§; Koizumi, Noriko MD, PhD*; Padmanabhan, Prema MD†
doi : 10.1097/ICO.0000000000002706
November 2021 - Volume 40 - Issue 11 - p 1445-1452
The aim of this study was to investigate the immune cells on corneal endothelium of the graft in patients who underwent penetrating keratoplasty (PK), Descemet-stripping endothelial keratoplasty (DSEK), and Descemet membrane endothelial keratoplasty (DMEK).
Results From the German Fungal Keratitis Registry: Significant Differences Between Cases With and Without a History of Contact Lens Use
Roth, Mathias MD*; Holtmann, Christoph MD*; Daas, Loay MD†; Kakkassery, Vinodh MD‡; Kurzai, Oliver MD§,¶; Geerling, Gerd MD*; Bäurle, Sebastian MD?; Bayoudh, Wesal MD**; Brücher, Viktoria MD††; Cvetkova-Fischer, Nadezhda MD‡‡; Dias Blak, Matthias MD§§; Bornstein, Agnes MD¶¶; Fischer, Charlotte MD??; Fuest, Matthias MD***; Grisanti, Salvatore MD‡; Herwig-Carl, Martina C. MD†††; Kroll, Sandra MD‡‡‡; Lenk, Janine MD§§§; Lommatzsch, Claudia MD¶¶¶; MacKenzie, Colin R. MD???; Matthaei, Mario MD****; Mehlan, Juliane MD††††; Messmer, Elisabeth M. MD‡‡‡‡; Müller, Violetta MD§§§§; Pawlik, Vera MD‡; Ranjbar, Mahdy MD‡; Renner-Wilde, Anna MD‡‡‡‡; Rickmann, Annekatrin MD¶¶¶¶; Saeger, Mark MD????; Schargus, Marc MD*,*****; Schwarz, Luisa MD†††††; Seitz, Berthold MD†; Steindor, Friedrich MD*; Unterlauf, Jan Darius MD‡‡‡‡‡; Viestenz, Arne MD†,?; von Lilienfeld-Toal, Marie MD§§§§§,§; Walther, Grit PhD§
doi : 10.1097/ICO.0000000000002705
November 2021 - Volume 40 - Issue 11 - p 1453-1461
Fungal keratitis (FK) is a serious ophthalmic disease with a potentially devastating outcome that seems to be increasing in recent years. The use of contact lenses (CLs) was evaluated as a risk factor for FK to determine possible differences in course and outcome.
Primary Graft Failure, Infection, and Endothelial Cell Density in Corneal Transplants With Increased Death-to-Preservation Time
Sun, Michelle J. MD, MPH*; Duong, Andrew T. BA*; Tran, Khoa D. PhD†; Straiko, Megan M.W. PhD†; Stoeger, Christopher G. MBA, CEBT†; Sales, Christopher S. MD, MPH‡
doi : 10.1097/ICO.0000000000002697
November 2021 - Volume 40 - Issue 11 - p 1462-1465
To ascertain whether death-to-preservation time (DPT) is associated with donor endothelial cell density (ECD), primary graft failure (PGF), and infection.
Long-Term Results and Refractive Error After Cataract Surgery With a Scleral Incision in Eyes With Deep Anterior Lamellar Keratoplasty
Tourabaly, Moïse MD; Knoeri, Juliette MD; Georgeon, Cristina orthoptist; Borderie, Marie M2; Bouheraoua, Nacim MD, PhD; Borderie, Vincent MD, PhD
doi : 10.1097/ICO.0000000000002758
November 2021 - Volume 40 - Issue 11 - p 1466-1473
Phacoemulsification in eyes with deep anterior lamellar keratoplasty (DALK) is associated with possible decreased graft survival and difficult IOL power calculation. We assessed cataract surgery in eyes with previous DALK.
Impact of COVID-19 Pandemic on Infectious Keratitis Outcomes: A Retrospective Multicenter Study in Tertiary Eye Hospitals of South India
Christy, Josephine S. MS*; Mathews, Priya MD†; Rhagavan, Anita DO‡; Venugopal, Anitha DNB§; Manohar, Divya MS¶; Janakiraman, Anuja MS?; Gandhi, Preethika MS**; Nallobolu, Srujana MS*; Akpek, Esen K. MD†
doi : 10.1097/ICO.0000000000002829
November 2021 - Volume 40 - Issue 11 - p 1474-1481
The purpose of this study was to report the adverse effects of the COVID-19 pandemic on the clinical outcomes of infectious keratitis in South India.
Successful Ocular Surface Reconstruction in Complete Ankyloblepharon With the Simple Oral Mucosal Epithelial Transplantation Technique: A Case Report
Ngowyutagon, Panotsom MD*; Prabhasawat, Pinnita MD*; Chirapapaisan, Chareenun MD*; Jaru-ampornpan, Pimkwan MD*; Pornpanich, Kanograt MD*; Ekpo, Pattama PhD†; Sukon, Nutchaya MD*; Matamnan, Sutthicha MSc‡
doi : 10.1097/ICO.0000000000002638
November 2021 - Volume 40 - Issue 11 - p 1482-1486
To report an outcome of a patient with complete ankyloblepharon successfully managed with simple oral mucosal epithelial transplantation (SOMET).
Peters Anomaly in Nail-Patella Syndrome: A Case Report and Clinico-Genetic Correlation
Ramappa, Muralidhar MD*,†,‡; Gandhi, Uppal MD‡; Chaurasia, Sunita MD*,†,‡; Kabra, Meha PhD§; Kaur, Inderjeet PhD*,§; Mittal, Ruchi MD¶; Mishra, Dilip Kumar MD¶; Chakrabarti, Subhabrata PhD*,§; Edward, Deepak P. MD?,**
doi : 10.1097/ICO.0000000000002731
November 2021 - Volume 40 - Issue 11 - p 1487-1490
The purpose of this study was to report the clinicopathological features of Peters anomaly in a child with nail-patella syndrome.
Development of Cytomegalovirus Corneal Endotheliitis During Long-Term Topical Tacrolimus and Steroid Treatment for Chronic Ocular Surface Inflammatory Diseases
Yokogawa, Hideaki MD, PhD*; Kobayashi, Akira MD, PhD*; Takemoto, Yuko MD, PhD*; Mori, Natsuko MD, PhD*,†; Wajima, Ryotaro MD*; Nishino, Tsubasa MD, PhD*,‡; Sugiyama, Kazuhisa MD, PhD*
doi : 10.1097/ICO.0000000000002674
November 2021 - Volume 40 - Issue 11 - p 1491-1497
We report 3 cases of patients with chronic ocular surface inflammatory disease who developed cytomegalovirus (CMV) corneal endotheliitis during immunosuppressant and steroid treatment.
Surgical Treatment of a Corneal Epithelial Cyst
Wasilewski, Daniel MD, PhD
doi : 10.1097/ICO.0000000000002677
November 2021 - Volume 40 - Issue 11 - p 1498-1501
To describe a case of intracorneal epithelial cyst and present a surgical technique successfully used to treat this patient.
Phlyctenular Keratoconjunctivitis in a Patient With COVID-19 Infection
Eleiwa, Taher K. MD*; Elmaghrabi, Ayman MD*; Helal, Hend G. MD*; Abdelrahman, Samar N. MD†; ElSheikh, Reem H. MD‡; Elhusseiny, Abdelrahman M. MD‡,§
doi : 10.1097/ICO.0000000000002789
November 2021 - Volume 40 - Issue 11 - p 1502-1504
The coronavirus disease 2019 global pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several ophthalmic manifestations have been reported to be associated with SARS-CoV-2 infection, including conjunctivitis, acute sixth nerve palsy, and multiple cranial neuropathies. We present a unique case of unilateral phlyctenular keratoconjunctivitis in a 5-year-old boy in the setting of SARS-CoV-2 infection.
