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COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort
Paul D. Jewell, Kate Bramham, James Galloway, Frank Post, Sam Norton, James Teo, Richard Fisher, Rohit Saha, Sam Hutchings, Phil Hopkins, Priscilla Smith, Jennifer Joslin, Satish Jayawardene, Sarah Mackie, Ali Mudhaffer, Amelia Holloway, Henry Kibble, Mosammat Akter, Benjamin Zuckerman, Kieran Palmer, Ciara Murphy, Domniki Iatropoulou, Claire C. Sharpe & Eirini Lioudaki
doi : 10.1186/s12882-021-02557-x
BMC Nephrology volume 22, Article number: 359 (2021)
Acute kidney injury (AKI) is common among patients hospitalised with COVID-19 and associated with worse prognosis. The aim of this study was to investigate the epidemiology, risk factors and outcomes of AKI in patients with COVID-19 in a large UK tertiary centre.
Adrenal function testing in dialysis patients – a review of the literature
Lara Brotzer, Manuela Nickler, Min Jeong Kim, Beat Mueller & Claudine A. Blum
doi : 10.1186/s12882-021-02541-5
BMC Nephrology volume 22, Article number: 360 (2021)
Secondary adrenal insufficiency is a frequent issue in patients with renal replacement therapy. There are concerns about metabolism and clearance for adrenocorticotropic hormone (ACTH) and cortisol in addition to hemoconcentration as confounding factors during hemodialysis (HD). Therefore, ACTH testing is currently performed before or in between HD sessions. This review of the literature aims to evaluate the current evidence for validity of testing for adrenal insufficiency in patients on chronic renal replacement therapy.
Risk factors associated with albuminuria in Rwanda: results from a STEPS survey
Candide Tran Ngoc, Prebo Barango, Roger Harrison, Andrew Jones, Steven Velabo Shongwe, Albert Tuyishime, François Uwinkindi, Hongyi Xu & Stephanie Shoop-Worrall
doi : 10.1186/s12882-021-02574-w
BMC Nephrology volume 22, Article number: 361 (2021)
Non-communicable diseases (NCDs) are a growing burden which affects every part of the world, including developing countries. Chronic kidney disease (CKD) has varied etiology which can result from or complicate other NCDs such as diabetes and cardiovascular diseases. The growing prevalence of NCDs coupled with the increasing age in most developing countries, has seen a marked increase of CKD in these settings. CKD has been described as “the most neglected NCD” and greatly affects the quality of life of patients. It also places a huge economic burden on societies. However, few epidemiological data exist, particularly in sub-Saharan Africa. Assessment of the prevalence of albuminuria as a marker of kidney damage and CKD progression and its main risk factors was thus needed in Rwanda.
Kidney biopsy in very elderly patients: indications, therapeutic impact and complications
Mathilde Fedi, Mickaël Bobot, Julia Torrents, Pierre Gobert, Éric Magnant, Yannick Knefati, David Verhelst, Gaëtan Lebrun, Valérie Masson, Philippe Giaime, Julien Santini, Stanislas Bataille, Philippe Brunet, Bertrand Dussol, Stéphane Burtey, Julien Mancini, Laurent Daniel & Noémie Jourde-Chiche
doi : 10.1186/s12882-021-02559-9
BMC Nephrology volume 22, Article number: 362 (2021)
Few data is available on the risk/benefit balance of native kidney biopsy (KB) in very elderly patients.
Laxative use and mortality in patients on haemodialysis: a prospective cohort study
Yu Honda, Seiji Itano, Aiko Kugimiya, Eiji Kubo, Yosuke Yamada, Miho Kimachi, Yugo Shibagaki & Tatsuyoshi Ikenoue
doi : 10.1186/s12882-021-02572-y
BMC Nephrology volume 22, Article number: 363 (2021)
Patients on haemodialysis (HD) are often constipated. This study aimed to assess the relationship between constipation and mortality in such patients. In this study, constipation was defined as receiving prescription laxatives, based on the investigation results of “a need to take laxatives is the most common conception of constipation” reported by the World Gastroenterology Organization Global Guidelines.
Clinical efficacy and safety of full-dose versus half-dose corticosteroids plus leflunomide for IgA nephropathy
Yebei Li, Yi Xiong, Tianlun Huang, Xin Liu & Gaosi Xu
doi : 10.1186/s12882-021-02555-z
BMC Nephrology volume 22, Article number: 364 (2021)
The results of leflunomide (LEF) in patients with IgA nephropathy (IgAN) were inconsistent.
Mortality and cardiovascular events in adults with kidney failure after major non-cardiac surgery: a population-based cohort study
Tyrone G. Harrison, Paul E. Ronksley, Matthew T. James, Shannon M. Ruzycki, Marcello Tonelli, Braden J. Manns, Kelly B. Zarnke, Deirdre McCaughey, Prism Schneider, James Wick & Brenda R. Hemmelgarn
doi : 10.1186/s12882-021-02577-7
BMC Nephrology volume 22, Article number: 365 (2021)
People with kidney failure have a high incidence of major surgery, though the risk of perioperative outcomes at a population-level is unknown. Our objective was to estimate the proportion of people with kidney failure that experience acute myocardial infarction (AMI) or death within 30?days of major non-cardiac surgery, based on surgery type.
Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
Yuzhuo Zhang, Ying Zhao, Chenglu Wei, Yongrong Li, Hira Aslam, Qingmin Feng, Qing Huang, Yu Zheng, Feifen Lv, Wei Hao & Jike Li
doi : 10.1186/s12882-021-02576-8
BMC Nephrology volume 22, Article number: 366 (2021)
Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the association of common medical comorbidities with ERD, and find independent risk factors to ERD in Chinese tropics with essential hypertension.
Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study
Shunta Hori, Nobumichi Tanaka, Tatsuo Yoneda, Nobutaka Nishimura, Mitsuru Tomizawa, Tomonori Nakahama, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Kiyoyuki Minamiguchi & Kiyohide Fujimoto
doi : 10.1186/s12882-021-02568-8
BMC Nephrology volume 22, Article number: 367 (2021)
Safety and survival during and after donor nephrectomy (DN) are one of the main concerns in living kidney donors (LKDs). Therefore, kidney (left/right) to be procured should be determined after considering the difficulty of DN, as well as the preservation of remnant renal function (RRF). In this prospective study, we investigated the roles of computed tomography volumetry (CTV) in split renal function (SRF) and established a predictive model for RRF in LKDs.
LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4
Zhuang Geng, Xiang Wang, Shiyuan Hao, Bingzi Dong, Yajing Huang, Yangang Wang & Lili Xu
doi : 10.1186/s12882-021-02580-y
BMC Nephrology volume 22, Article number: 368 (2021)
LncRNA NNT-AS1 (NNT-AS1) has been extensively studied as the causative agent in propagation and progression of lung and bladder cancers, and cholangiocarcinoma. However, its significance in proliferation and inflammation of diabetic nephropathy is enigmatic. This study focuses on the molecular mechanisms followed by NNT-AS1 to establish diabetic nephropathy (DN) and its potential miRNA target.
Evaluating kidney function using a point-of-care creatinine test in Ugandan children with severe malaria: a prospective cohort study
Anthony Batte, Kristin J. Murphy, Ruth Namazzi, Katrina Co, Robert O. Opoka, John M. Ssenkusu, Chandy C. John & Andrea L. Conroy
doi : 10.1186/s12882-021-02573-x
BMC Nephrology volume 22, Article number: 369 (2021)
Acute kidney injury (AKI) disproportionately affects individuals in low-and middle-income countries (LMIC). However, LMIC—particularly countries in sub-Saharan Africa— are under-represented in global AKI research. A critical barrier in diagnosing AKI is access to reliable serum creatinine results. We evaluated the utility of a point-of-care test to measure creatinine and diagnose AKI in Ugandan children with malaria.
The ratio of measured to estimated glomerular filtration rate may be a marker of early mortality and dialysis requirement
James G. Heaf, Rafal Yahya & Morten Dahl
doi : 10.1186/s12882-021-02561-1
BMC Nephrology volume 22, Article number: 370 (2021)
It has been suggested that, in patients with CKD stage 5, measured GFR (mGFR), defined as the mean of urea and creatinine clearance, as measured by a 24-h urine collection, is a better measure of renal function than estimated GFR (eGFR), based on the CKD-EPI formula. This could be due to reduced muscle mass in this group. Its use is recommended in the ERBP guidelines. Unplanned dialysis initiation (DI) is associated with increased morbidity, mortality, and reduced modality choice and is generally considered undesirable. We hypothesized that the ratio mGFR/eGFR (M/E) aids prediction of death and DI.
Ambiguous definitions for baseline serum creatinine affect acute kidney diagnosis at the emergency department
Michael Niemantsverdriet, Meriem Khairoun, Ayman El Idrissi, Romy Koopsen, Imo Hoefer, Wouter van Solinge, Jan Willem Uffen, Domenico Bellomo, Wouter Tiel Groenestege, Karin Kaasjager & Saskia Haitjema
doi : 10.1186/s12882-021-02581-x
BMC Nephrology volume 22, Article number: 371 (2021)
Acute kidney injury (AKI) incidence is increasing, however AKI is often missed at the emergency department (ED). AKI diagnosis depends on changes in kidney function by comparing a serum creatinine (SCr) measurement to a baseline value. However, it remains unclear to what extent different baseline values may affect AKI diagnosis at ED.
The ensemble learning model is not better than the Asian modified CKD-EPI equation for glomerular filtration rate estimation in Chinese CKD patients in the external validation study
Li Zhao, Jing-jing Zhang, Xin Tian, Jian-min Huang, Peng Xie & Xiang-zhou Li
doi : 10.1186/s12882-021-02595-5
BMC Nephrology volume 22, Article number: 372 (2021)
To assess the clinical practicability of the ensemble learning model established by Liu et al. in estimating glomerular filtration rate (GFR) and validate whether it is a better model than the Asian modified Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in a cohort of Chinese chronic kidney disease (CKD) patients in an external validation study.
Perceptions of physical activity and technology enabled exercise interventions among people with advanced chronic kidney disease: a qualitative study
Mary Beth Weber, Susan Ziolkowski, Ahad Bootwala, Alan Bienvenida, Shuchi Anand & Felipe Lobelo
doi : 10.1186/s12882-021-02591-9
BMC Nephrology volume 22, Article number: 373 (2021)
Exercise improves health outcomes and quality of life in persons with chronic kidney disease (CKD). The numbers of persons with advanced CKD meeting physical activity guidelines however is low. We undertook a qualitative study of men and women aged 36–74 from various race/ethnic populations with advanced CKD not requiring dialysis to describe their experiences and opinions around prior physical activity, motivating factors for and barriers to exercise, and perceptions of exercise-promoting technology and group-based programming designed to improve physical activity levels.
Association of fibroblast growth factor 23 and ?-klotho in hemodialysis patients during administration of ferric citrate hydrate: post hoc analysis of ASTRIO study
Kyoko Ito, Keitaro Yokoyama, Masaaki Nakayama, Masafumi Fukagawa & Hideki Hirakata
doi : 10.1186/s12882-021-02575-9
BMC Nephrology volume 22, Article number: 374 (2021)
Fibroblast growth factor-23 (FGF23) and ?-klotho are associated with anemia in patients with chronic kidney disease. In this post hoc analysis of the ASTRIO study (UMIN000019176), we investigated the relationship between FGF23 and ?-klotho during treatment with an iron-based phosphate binder, ferric citrate hydrate (FC), compared with non-iron-based phosphate binders in hemodialysis (HD) patients. We examined the effect of iron absorption by FC on the relationship between FGF23 and ?-klotho. There have been few clinical studies evaluating these biomarkers simultaneously in HD patients.
Psychosocial determinants of cardiovascular events among black Americans with chronic kidney disease or associated risk factors in the Jackson heart study
Nrupen A. Bhavsar, Clemontina A. Davenport, Lexie Zidanyue Yang, Sarah Peskoe, Julia J. Scialla, Rasheeda K. Hall, Crystal C. Tyson, Tara Strigo, Mario Sims, Jane Pendergast, Lesley H. Curtis, L. Ebony Boulware & Clarissa J. Diamantidis
doi : 10.1186/s12882-021-02594-6
BMC Nephrology volume 22, Article number: 375 (2021)
Individuals with chronic kidney disease (CKD), hypertension (HTN), or diabetes mellitus (DM) are at increased risk for cardiovascular disease (CVD). The extent to which psychosocial factors are associated with increased CVD risk within these individuals is unclear. Black individuals experience a high degree of psychosocial stressors due to socioeconomic factors, environment, racism, and discrimination. We examined the association between psychosocial factors and risk of CVD events among Black men and women with CKD and CKD risk factors in the Jackson Heart Study.
Minimal change disease following the Moderna COVID-19 vaccine: first case report
Shaefiq Thappy, Sherin R. Thalappil, Shahem Abbarh, Abdulrahman Al-Mashdali, Mohammed Akhtar & Mohamad M. Alkadi
doi : 10.1186/s12882-021-02583-9
BMC Nephrology volume 22, Article number: 376 (2021)
There have been cases of minimal change disease (MCD) reported following previous vaccines. During the COVID-19 era, only 3 cases of new-onset MCD and a case of MCD relapse were reported following the Pfizer-BioNTech COVID-19 vaccine. We herein report the first case of MCD after receiving the Moderna COVID-19 vaccine.
The effectiveness of intervention based on the transactional model on improving coping efforts and stress moderators in hemodialysis patients in Tehran: a randomized controlled trial
Mohtasham Ghaffari, Mohammad Ali Morowatisharifabad, Mohammad Saeed Jadgal, Yadollah Mehrabi & Somayeh Alizadeh
doi : 10.1186/s12882-021-02592-8
BMC Nephrology volume 22, Article number: 377 (2021)
Present study was conducted to determine the effect of training on coping efforts and stress moderators, based on transactional model of Lazarus and Folkman, in hemodialysis patients.
Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study
Kenichi Kono, Yoshifumi Moriyama, Hiroki Yabe, Ayaka Hara, Takeki Ishida, Tetsuya Yamada & Yusuke Nishida
doi : 10.1186/s12882-021-02566-w
BMC Nephrology volume 22, Article number: 378 (2021)
The first objective of this study was to determine the relationship between muscle strength or physical performance and mortality, and the second objective was to show the relationship of Geriatric Nutritional Risk Index (GNRI) to muscle strength and physical performance decline.
Components of quality of life in hemodialysis patients from family caregivers’ perspective: a qualitative study
Sima Sadat Hejazi, Meimanat Hosseini, Abbas Ebadi & Hamid Alavi Majd
doi : 10.1186/s12882-021-02584-8
BMC Nephrology volume 22, Article number: 379 (2021)
Patients with end-stage kidney disease experience serious complications which affect their lives. Few studies have investigated the patients’ quality of life qualitatively from the perspective of family caregivers as the closest individuals to the patients. The family caregivers are directly involved in the patients’ disease progression and observe the changes, problems, and complications of disease and hemodialysis. This study aimed to explain the components of quality of life in hemodialysis patients from the family caregivers’ perspective.
A disease-causing variant of COL4A5 in a Chinese family with Alport syndrome: a case series
Jing Wu, Jun Zhang, Li Liu, Bo Zhang, Tomohiko Yamamura, Kandai Nozu, Masafumi Matsuo & Jinghong Zhao
doi : 10.1186/s12882-021-02585-7
BMC Nephrology volume 22, Article number: 380 (2021)
Alport syndrome (AS), which is a rare hereditary disease caused by mutations of genes including COL4A3, COL4A4 and COL4A5, has a wide spectrum of phenotypes. Most disease-causing variants of AS are located in the exons or the conservative splicing sites of these genes, while little is known about the intronic disease-causing variants.
Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study
Jie V. Zhao & C. Mary Schooling
doi : 10.1186/s12882-021-02586-6
BMC Nephrology volume 22, Article number: 381 (2021)
Kidney dysfunction occurs in severe COVID-19, and is a predictor of COVID-19 mortality. Whether kidney dysfunction causes severe COVID-19, and hence is a target of intervention, or whether it is a symptom, is unclear because conventional observational studies are open to confounding. To obtain unconfounded estimates, we used Mendelian randomization to examine the role of kidney function in severe COVID-19.
Understand the difference between clinical measured ultrafiltrationand real ultrafiltration in peritoneal dialysis
Zanzhe Yu, Zhuqing Wang, Qin Wang, Minfang Zhang, Haijiao Jin, Li Ding, Hao Yan, Jiaying Huang, Yan Jin, Simon Davies, Wei Fang & Zhaohui Ni
doi : 10.1186/s12882-021-02589-3
BMC Nephrology volume 22, Article number: 382 (2021)
It has been noticed for years that ultrafiltration (UF) is important for survival in peritoneal dialysis. On the other hand, precise and convenient UF measurement suitable for patient daily practice is not as straight forward as it is to measure UF in the lab. Both overfill and flush before fill used to be source of measurement error for clinical practice. However, controversy finding around UF in peritoneal dialysis still exists in some situation. The current study was to understand the difference between clinical measured UF and real UF. The effect of evaporation and specific gravity in clinical UF measurement were tested in the study.
Investigating the relationship between quality of life and hope in family caregivers of hemodialysis patients and related factors
Seyedeh Azam Sajadi, Zahra Farsi, Roghayeh Akbari, Atefeh Sadeghi & Abazar Akbarzadeh Pasha
doi : 10.1186/s12882-021-02578-6
BMC Nephrology volume 22, Article number: 383 (2021)
Family caregivers of hemodialysis patients are the first and most crucial source of care at home. They experience many problems in the care of hemodialysis patients, which can affect their quality of life and hope, affecting the quality of care provided to patients. This study aimed to determine the relationship between quality of life and hope in family caregivers of hemodialysis patients.
Prevalence of SARS-CoV-2 antibodies in hemodialysis patients in Senegal: a multicenter cross-sectional study
Sidy Mohamed Seck, Moustapha Mbow, Yaya Kane, Mouhamadou Moustapha Cisse, Gnagna Faye, Adama Kama, Moussa Sarr, Pamela Nitcheu, Mohamed Dahaba, Ibrahima Mbemba Diallo, Mame Selly Diawara, Lotingo Nehemie Motoula Latou, Yacine Dia & Souleymane Mboup
doi : 10.1186/s12882-021-02582-w
BMC Nephrology volume 22, Article number: 384 (2021)
Hemodialysis patients are among high-risk groups for COVID-19. Africa is the continent with the lowest number of cases in the general population but we have little information about the disease burden in dialysis patients.
Association between metabolic parameters and risks of anemia and electrolyte disturbances among stages 3–5 chronic kidney disease patients in Taiwan
Adi Lukas Kurniawan, Ya-Lan Yang, Chien-Yeh Hsu, Rathi Paramastri, Hsiu-An Lee, Po-Yuan Ni, Mei-Yun Chin & Jane C.-J. Chao
doi : 10.1186/s12882-021-02590-w
BMC Nephrology volume 22, Article number: 385 (2021)
Anemia and electrolyte disturbances are adverse outcomes of chronic kidney disease (CKD). This study explored the association between metabolic parameters with anemia and electrolyte and mineral disorders among CKD patients in Taiwan.
Clinical outcomes and temporal trends of immunological and non-immunological rare diseases in adult kidney transplant
Ester Gallo, Silvia Mingozzi, Alberto Mella, Fabrizio Fop, Roberto Presta, Manuel Burdese, Elena Boaglio, Maria Cristina Torazza, Roberta Giraudi, Gianluca Leonardi, Antonio Lavacca, Paolo Gontero, Omidreza Sedigh, Andrea Bosio, Aldo Verri, Caterina Dolla & Luigi Biancone
doi : 10.1186/s12882-021-02571-z
BMC Nephrology volume 22, Article number: 386 (2021)
Rare diseases (RDs) encompass many difficult-to-treat conditions with different characteristics often associated with end-stage renal disease (ESRD). However, data about transplant outcomes in adult patients are still lacking and limited to case reports/case series without differentiation between immunological/non-immunological RDs.
High dose intravenous vitamin C treatment in Sepsis: associations with acute kidney injury and mortality
Thomas R. McCune, Angela J. Toepp, Brynn E. Sheehan, Muhammad Shaheer K. Sherani, Stephen T. Petr & Sunita Dodani
doi : 10.1186/s12882-021-02599-1
BMC Nephrology volume 22, Article number: 387 (2021)
The effects of vitamin C on clinical outcomes in critically ill patients remain controversial due to inconclusive studies. This retrospective observational cohort study evaluated the effects of vitamin C therapy on acute kidney injury (AKI) and mortality among septic patients.
The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)
Tess E. Cooper, Amy Dalton, Anh Kieu, Martin Howell, Sumedh Jayanti, Rabia Khalid, Wai H. Lim, Nicole Scholes-Robertson, Jonathan C. Craig, Armando Teixeira-Pinto, Michael J. Bourke, Allison Tong & Germaine Wong
doi : 10.1186/s12882-021-02600-x
BMC Nephrology volume 22, Article number: 388 (2021)
Gastro-intestinal (GI) intolerance is a frequently reported outcome in patients with kidney failure receiving maintenance dialysis and those who have received kidney transplants. Symptoms of GI intolerance (diarrhoea, constipation, bloating, abdominal pain, heart burn, and reflux) are associated with significant reduction in quality of life, morbidity, and increased used of healthcare resources. Having chronic kidney disease (CKD), together with related changes in diet and medication, may alter the gut microbiota and the microbial-derived uraemic metabolites that accumulate in kidney failure, and contribute to various complications including chronic diarrhoea, opportunistic infections, and drug-related colitis. Despite the high disease burden among patients with kidney replacement therapies, GI symptoms are often under-recognised and, consequently limited resources and strategies are devoted to the management of gastrointestinal complications in patients with CKD.
Evaluation and enhancement of standard equations for renal function estimation in individuals with components of metabolic disease
Luigi Brunetti, Hyunmoon Back, Sijia Yu, Urma Jalil & Leonid Kagan
doi : 10.1186/s12882-021-02588-4
BMC Nephrology volume 22, Article number: 389 (2021)
The primary objective of this study aims to test patient factors, with a focus on cardiometabolic disease, influencing the performance of the Cockcroft-Gault equation in estimating glomerular filtration rate.
The prognostic role of heart rate recovery after exercise and metabolic syndrome in IgA nephropathy
Balázs Sági, István Kés?i, Tibor Vas, Botond Csiky, Judit Nagy & Tibor Kovács
doi : 10.1186/s12882-021-02596-4
BMC Nephrology volume 22, Article number: 390 (2021)
Cardiovascular (CV) morbidity and mortality are higher in chronic kidney disease (CKD) than in the general population. Reduced heart rate recovery (HRR) is an independent risk factor for CV disease. The aim of the study was to determine the prognostic role of HRR in a homogenous group of CKD patients.
A multicentre, multi-national, double-blind, randomised, active-controlled, parallel-group clinical study to assess the safety and efficacy of PDA10 (Epoetin-alpha) vs. Eprex® in patients with anaemia of chronic renal failure
Soo Kun Lim, Bak Leong Goh, Ravindran Visvanathan, Su Hyun Kim, Jin Seok Jeon, Sung Gyun Kim, Jae Hyun Chang, Chun Soo Lim & Zaki Morad
doi : 10.1186/s12882-021-02601-w
BMC Nephrology volume 22, Article number: 391 (2021)
Erythropoietin stimulating agent (ESA) has been standard of care in treating renal anaemia for the past 20?years. Many patients have limited access to ESA in view of long-term costs leading to suboptimal ESA dosage. Biosimilar epoetin is a potential cost-effective alternative to originator for optimal renal anaemia management.
Identification of miRNA-mRNA network and immune-related gene signatures in IgA nephropathy by integrated bioinformatics analysis
Shi-Yao Wei, Shuang Guo, Bei Feng, Shang-Wei Ning & Xuan-Yi Du
doi : 10.1186/s12882-021-02606-5
BMC Nephrology volume 22, Article number: 392 (2021)
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, and its diagnosis depends mainly on renal biopsy. However, there is no specific treatment for IgAN. Moreover, its causes and underlying molecular events require further exploration.
Primary hyperoxaluria diagnosed after kidney transplantation: a case report and literature review
Zhitao Cai, Mao Ding, Rengui Chen, Jiefu Zhu, Lian Li & Xiongfei Wu
doi : 10.1186/s12882-021-02546-0
BMC Nephrology volume 22, Article number: 393 (2021)
Primary hyperoxaluria (PH) is a rare inherited autosomal recessive disease caused by disturbed glyoxylate metabolism. The disease is characterized by calcium oxalate crystal deposition in various organs, especially in the kidney. Due to the lack of current understanding of PH, nearly all patients are only initially diagnosed with PH when recurrent lithiasis and progressive end-stage renal disease occur. Many cases are not diagnosed in patients until renal allograft insufficiency occurs after renal transplantation. This case report and literature review aim to emphasize the need for careful pre-transplant PH screening of patients with bilateral nephrocalcinosis or nephrolithiasis.
Association between the psoas muscle index and hospitalization for pneumonia in patients undergoing hemodialysis
Kosei Yamaguchi, Mineaki Kitamura, Takahiro Takazono, Shuntaro Sato, Kazuko Yamamoto, Satoko Notomi, Kenji Sawase, Takashi Harada, Satoshi Funakoshi, Hiroshi Mukae & Tomoya Nishino
doi : 10.1186/s12882-021-02612-7
BMC Nephrology volume 22, Article number: 394 (2021)
Although muscle mass loss and pneumonia are common and crucial issues in hemodialysis (HD) patients, few reports have focused on their association, which remains unclear. This study assessed the association between skeletal muscle mass and the incidence of pneumonia in HD patients using the psoas muscle index (PMI).
Intravenous cyclophosphamide induces remission in children with difficult to treat steroid resistant nephrotic syndrome from minimal change disease
Maha Haddad, Arundhati Kale & Lavjay Butani
doi : 10.1186/s12882-021-02605-6
BMC Nephrology volume 22, Article number: 395 (2021)
Steroid resistant nephrotic syndrome (SRNS), while uncommon in children, is associated with significant morbidity. Calcineurin inhibitors (CNIs) remain the first line recommended therapy for children with non-genetic forms of SRNS, but some children fail to respond to them. Intravenous (IV) cyclophosphamide (CTX) has been shown to be effective in Asian-Indian children with difficult to treat SRNS (SRNS-DTT). Our study evaluated the outcome of IV CTX treatment in North American children with SRNS-DTT.
Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
Jieshan Lin, Bin Tang, Zhanwu Feng, Wenke Hao & Wenxue Hu
doi : 10.1186/s12882-021-02613-6
BMC Nephrology volume 22, Article number: 396 (2021)
Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function. This study aims to investigate the potential roles of B lymphocyte populations in subclinical atherosclerosis (measured by intima-media thickness, IMT) and prognosis in elderly patients with moderate-to-severe CKD.
