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Diagnosis and Treatment of Latent Tuberculosis Infection
Chitnis, Amit S. MD, MPH1; Jaganath, Devan MD, MPH2,3; Gish, Robert G. MD4; Wong, Robert J. MD, MS5,6
doi : 10.14309/ajg.0000000000001398
November 2021 - Volume 116 - Issue 11 - p 2155-2158
Regulation of Artificial Intelligence-Based Applications in Gastroenterology
Chawla, Saurabh MD1; Schairer, Jason MD2; Kushnir, Vladimir MD3; Hernandez-Barco, Yasmin Genevieve MD4; ACG FDA-Related Matters Committee
doi : 10.14309/ajg.0000000000001401
November 2021 - Volume 116 - Issue 11 - p 2159-2162
Pyodermatitis-Pyostomatitis Vegetans in Active Inflammatory Bowel Disease
De Giorgi, Vincenzo MD1; Trane, Luciana MD1; Silvestri, Flavia MD1; Venturi, Federico MD1; Zuccaro, Biancamaria MD1; Scarfì, Federica MD1
doi : 10.14309/ajg.0000000000001324
November 2021 - Volume 116 - Issue 11 - p 2163
A Case of Malignant Atrophic Papulosis With Multiple Complications
Wang, Haiyan MD1; Zhang, Xiaoli MD, PhD2
doi : 10.14309/ajg.0000000000001322
November 2021 - Volume 116 - Issue 11 - p 2164
Isolated Gastric Amyloid Light Chain Amyloidosis Causing Upper Gastrointestinal Bleeding
Singh, Achintya D. MD1; Zhang, Xuefeng MD2; Anwer, Faiz MD3; Bhatt, Amit MD4
doi : 10.14309/ajg.0000000000001378
November 2021 - Volume 116 - Issue 11 - p 2165
Biliary Obstruction Caused by B-Cell Lymphoma Associated With IgG4-Related Disease
Ogawa, Kazuya MD1; Sato, Hiroki MD, PhD1; Ikarashi, Satoshi MD, PhD1; Hayashi, Kazunao MD, PhD1; Terai, Shuji MD, PhD1
doi : 10.14309/ajg.0000000000001367
November 2021 - Volume 116 - Issue 11 - p 2166
Clamping and Turning Method With Foreign Body Forceps to Assist Release of the Snare Trapped in a Gastric Bezoar
Peng, Xue MD1; Xie, Rui MD, PhD2; He, Wei MD1; Yang, Shiming MD, PhD1; Bai, Jianying MD, PhD1
doi : 10.14309/ajg.0000000000001304
November 2021 - Volume 116 - Issue 11 - p 2167-2168
CME Information
doi : 10.14309/ajg.0000000000001123
November 2021 - Volume 116 - Issue 11 - p 2169-2170
Continuing Medical Education Questions: November 2021
Chahal, Prabhleen MD, FACG; Saleh, Mohannad Abou MD
doi : 10.14309/ajg.0000000000001533
November 2021 - Volume 116 - Issue 11 - p 2171
Continuing Medical Education Questions: November 2021
Richter, Seth J. MD, FACG
doi : 10.14309/ajg.0000000000001530
November 2021 - Volume 116 - Issue 11 - p 2172
Association of Body Mass Index With Risk of Early-Onset Colorectal Cancer: Systematic Review and Meta-Analysis
Li, Hengjing MM1,2; Boakye, Daniel MPH, PhD1; Chen, Xuechen MM1,2; Hoffmeister, Michael MSc, PhD1; Brenner, Hermann MD, MPH1,3,4
doi : 10.14309/ajg.0000000000001393
November 2021 - Volume 116 - Issue 11 - p 2173-2183
Incidence of colorectal cancer (CRC) in young adults has been increasing in recent decades in many countries for still widely unclear reasons. Suspected candidates include increasing prevalence of overweight and obesity, but specific evidence on their role for early-onset CRC (EOCRC) is sparse. We conducted a systematic review and meta-analysis to summarize available evidence on the association of body mass index (BMI) with EOCRC.
Meta-Analysis: Placebo Response and Its Determinants in Functional Dyspepsia
Huang, Xinyi MBBS1; Oshima, Tadayuki MD, PhD1; Tomita, Toshihiko MD, PhD1; Fukui, Hirokazu MD, PhD1; Miwa, Hiroto MD, PhD1
doi : 10.14309/ajg.0000000000001397
November 2021 - Volume 116 - Issue 11 - p 2184-2196
Placebo response rates are relatively higher in clinical trials of disorders of brain-gut interaction. However, placebo response in functional dyspepsia (FD) has not been well described. Minimizing placebo response is important in drug development. We therefore conducted a meta-analysis to determine placebo response in trials for FD and to identify factors affecting placebo response rates.
Statins and Liver Cancer in Cirrhosis: The Most Relevant Questions Are Still Unanswered
Moctezuma-Velazquez, Carlos MD1; Abraldes, Juan G. MD2
doi : 10.14309/ajg.0000000000001385
November 2021 - Volume 116 - Issue 11 - p 2197-2198
Several observational studies have shown an association between statin use and lower incidence of liver cancer. However, several potential biases limit a causal interpretation that could lead to a recommendation of statin prescription to patients with cirrhosis in the absence of a cardiovascular indication. Ongoing randomized trials will soon provide a clearer picture on the efficacy and safety of statins for preventing liver cancer and other complications of cirrhosis.
The Results From Up-Front Esophageal Testing Predict Proton Pump Inhibitor Response in Patients With Chronic Cough
Ribolsi, Mentore MD, PhD1; Luca Guarino, Michele Pier MD, PhD1; Balestrieri, Paola MD, PhD1; Altomare, Annamaria MD, PhD1; Tullio, Alessandro MD1; Petitti, Tommasangelo MD1; Cicala, Michele MD, PhD, AGAF1
doi : 10.14309/ajg.0000000000001389
November 2021 - Volume 116 - Issue 11 - p 2199-2206
The clinical management of chronic cough patients is challenging, and their response to proton pump inhibitors (PPIs) is considered as unsatisfactory. Few data concerning the association between impedance-pH variables and PPI response in these patients are available. Mean nocturnal baseline impedance (MNBI) and postreflux swallow-induced peristaltic wave (PSPW) index increase the diagnostic yield of impedance-pH in gastroesophageal reflux disease.
Feasibility and Accuracy of Artificial Intelligence–Assisted Sponge Cytology for Community-Based Esophageal Squamous Cell Carcinoma Screening in China
Gao, Ye MD1; Xin, Lei MD1; Feng, Ya-Dong MD2; Yao, Bin PhD3,4; Lin, Han PhD1; Sun, Chang MD1; An, Wei MD1; Li, Zhao-Shen MD1; Shi, Rui-Hua MD2; Wang, Luo-Wei MD1
doi : 10.14309/ajg.0000000000001499
November 2021 - Volume 116 - Issue 11 - p 2207-2215
Screening is the pivotal strategy to relieve the burden of esophageal squamous cell carcinoma (ESCC) in high-risk areas. The cost, invasiveness, and accessibility of esophagogastroduodenoscopy (EGD) necessitate the development of preliminary screening methods.
Validity of Secretin Stimulation Testing on Proton Pump Inhibitor Therapy for Diagnosis of Zollinger-Ellison Syndrome
Bhattacharya, Sumona MD1; Blau, Jenny E. MD2,3; Cochran, Craig RN2; Auh, Sungyoung PhD4; Weinstein, Lee S. MD2; Jensen, Robert T. MD1; Wank, Stephen MD1
doi : 10.14309/ajg.0000000000001487
November 2021 - Volume 116 - Issue 11 - p 2216-2221
Zollinger-Ellison syndrome (ZES) is characterized by gastrinoma-induced hypergastrinemia causing excessive gastric acid secretion. Secretin stimulation tests (SSTs) are required for diagnosis in the majority of patients. Two case reports suggest that proton pump inhibitors (PPIs) cause false SST results. Consequently, PPIs are discontinued to allow hyperchlorhydria to recur; however, uncontrolled acidity can cause life-threatening complications in those with underlying undiagnosed ZES. The aim of this study was to determine whether PPIs influence the validity of SSTs for the diagnosis of ZES.
Identifying Bleeding Etiologies by Endoscopy Affected Outcomes in 10,342 Cases With Hematochezia: CODE BLUE-J Study
Nagata, Naoyoshi MD, PhD1,2; Kobayashi, Katsumasa MD3; Yamauchi, Atsushi MD4; Yamada, Atsuo MD, PhD5; Omori, Jun MD6; Ikeya, Takashi MD7; Aoyama, Taiki MD, PhD8; Tominaga, Naoyuki MD, PhD9; Sato, Yoshinori MD, PhD10; Kishino, Takaaki MD11; Ishii, Naoki MD, PhD12; Sawada, Tsunaki MD, PhD13; Murata, Masaki MD14; Takao, Akinari MD, PhD15; Mizukami, Kazuhiro MD, PhD16; Kinjo, Ken MD, PhD17; Fujimori, Shunji MD, PhD18; Uotani, Takahiro MD, PhD19; Fujita, Minoru MD, PhD20; Sato, Hiroki MD, PhD21; Suzuki, Sho MD22; Narasaka, Toshiaki MD, PhD23,24; Hayasaka, Junnosuke MD25; Funabiki, Tomohiro MD, PhD26,27; Kinjo, Yuzuru MD, PhD28; Mizuki, Akira MD, PhD29; Kiyotoki, Shu MD, PhD30; Mikami, Tatsuya MD, PhD31; Gushima, Ryosuke MD, PhD32; Fujii, Hiroyuki MD, PhD33; Fuyuno, Yuta MD, PhD34; Gunji, Naohiko MD, PhD35; Toya, Yosuke MD, PhD36; Narimatsu, Kazuyuki MD, PhD37; Manabe, Noriaki MD, PhD38; Nagaike, Koji MD39; Kinjo, Tetsu MD, PhD40; Sumida, Yorinobu MD, PhD41; Funakoshi, Sadahiro MD42; Kawagishi, Kana MD43; Matsuhashi, Tamotsu MD, PhD44; Komaki, Yuga MD, PhD45; Miki, Kuniko MS1; Watanabe, Kazuhiro MD, PhD2; Fukuzawa, Masakatsu MD, PhD46; Itoi, Takao MD, PhD46; Uemura, Naomi MD, PhD1,47; Kawai, Takashi MD, PhD1; Kaise, Mitsuru MD, PhD6
doi : 10.14309/ajg.0000000000001413
November 2021 - Volume 116 - Issue 11 - p 2222-2234
The bleeding source of hematochezia is unknown without performing colonoscopy. We sought to identify whether colonoscopy is a risk-stratifying tool to identify etiology and predict outcomes and whether presenting symptoms can differentiate the etiologies in patients with hematochezia.
Comparison of Cap-Assisted vs Conventional Endoscopic Technique for Management of Food Bolus Impaction in the Esophagus: Results of a Multicenter Randomized Controlled Trial
Ooi, Marie MBBS, FRACP1; Duong, Tuan MbChB1; Holman, Richard MBBS, FRACP1; Huynh, Dep MBBS, FRACP2; Lafta, Abdulnasser MBBS, FRACP3; Grimpen, Florian MD, FRACP3; Appleyard, Mark MBBS, FRACP3; Rayner, Chris K. MBBS, PhD, FRACP1,4; Nguyen, Nam Q. MBBS, FRACP, PhD1,4
doi : 10.14309/ajg.0000000000001484
November 2021 - Volume 116 - Issue 11 - p 2235-2240
“Push” or “pull” techniques with the use of snares, forceps, baskets, and grasping devices are conventionally used to manage esophageal food bolus impaction (FBI). A novel cap-assisted technique has recently been advocated to reduce time taken for food bolus (FB) removal. This study aimed to compare the effectiveness of the cap-assisted technique against conventional methods of esophageal FB removal in a randomized controlled trial.
Adding Branched-Chain Amino Acids to an Enhanced Standard-of-Care Treatment Improves Muscle Mass of Cirrhotic Patients With Sarcopenia: A Placebo-Controlled Trial
Hernández-Conde, Marta MD, PhD1; Llop, Elba MD, PhD1,2; Gómez-Pimpollo, Lucía MD, PhD3; Fernández Carrillo, Carlos MD, PhD1,2; Rodríguez, Luís RN1; Van Den Brule, Enrique MD, PhD3; Perelló, Christie MD, PhD1; López-Gómez, Marta MD, PhD1; Abad, Javier PhD1; Martínez-Porras, José Luís MD, PhD1; Fernández-Puga, Natalia MD, PhD1; Ferre, Carlos PhD1; Trapero, María MD, PhD1,2; Fraga, Enrique MD, PhD1,2; Calleja, José Luis MD, PhD1,2,4
doi : 10.14309/ajg.0000000000001301
November 2021 - Volume 116 - Issue 11 - p 2241-2249
The effect of branched-chain amino acid (BCAA) supplementation on muscle mass in patients with cirrhosis and sarcopenia is unknown.
Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study
Reig, Anna MD1,2; Álvarez-Navascués, Carmen MD, PhD3; Vergara, Mercedes MD, PhD2,4; Gómez-Domínguez, Elena MD, PhD5; Gallego-Moya, Adolfo MD6; Pérez-Medrano, Indhira M. MD7; Fábrega, Emilio MD, PhD8; Hernández-Guerra, Manuel MD, PhD9; Berenguer, Marina MD, PhD2,10,11; Estevez, Pamela MD12; Arencibia, Ana MD, PhD13; Morillas, Rosa M. MD, PhD2,14; Horta, Diana MD15; Albillos, Agustín MD, PhD2,16; Casado, Marta MD, PhD17; De la Cruz, Gema MD18; Fernandez-Bonilla, Eva MD19; Molina, Esther MD, PhD20; Hijona, Lander MD, PhD21; Diago, Moises MD, PhD22; Fernández-Rodriguez, Conrado M. MD23; González-Santiago, Jesús M. MD24; Sala, Margarita MD, PhD2,25; Gómez-Camarero, Judith MD, PhD26; Romero-Gomez, Manuel MD, PhD2,27; Suárez, Francisco MD, PhD28; Vargas, Victor MD, PhD2,29; Ferre-Aracil, Carlos MD30; Andrade, Raúl J. MD, PhD2,31; Chahri, Nadia MD32; Parés, Albert MD, PhD1,2
doi : 10.14309/ajg.0000000000001343
November 2021 - Volume 116 - Issue 11 - p 2250-2257
Obeticholic acid (OCA) and fibrates therapy results in biochemical improvement in placebo-controlled trials in patients with primary biliary cholangitis and insufficient response to ursodeoxycholic acid. There is scarce information outside of clinical trials. Therefore, we have assessed the effectiveness and adverse events of these treatments.
Chemopreventive Effect of Statin on Hepatocellular Carcinoma in Patients With Nonalcoholic Steatohepatitis Cirrhosis
Pinyopornpanish, Kanokwan MD1,2; Al-Yaman, Wael MD1; Butler, Robert S. MS3; Carey, William MD1; McCullough, Arthur MD1,4; Romero-Marrero, Carlos MD1
doi : 10.14309/ajg.0000000000001347
November 2021 - Volume 116 - Issue 11 - p 2258-2269
To estimate the annual incidence of hepatocellular carcinoma (HCC) in patients with nonalcoholic steatohepatitis (NASH) with advanced liver fibrosis, to determine the risk factors for the development of HCC, and to evaluate the chemoprotective effect of statin use stratified by fibrosis stage.
Fasting Ketonuria and the Risk of Incident Nonalcoholic Fatty Liver Disease With and Without Liver Fibrosis in Nondiabetic Adults
Kim, Yejin MHS1; Chang, Yoosoo MD, PhD1,2,3; Kwon, Min-Jung MD, PhD1,4; Hong, Yun Soo MD, MHS5; Kim, Mi Kyung PhD6; Sohn, Won MD, PhD7; Cho, Yong Kyun MD, PhD7; Shin, Hocheol MD, PhD1,8; Wild, Sarah H. PhD9; Byrne, Christopher D. MB BCh, PhD10,11; Ryu, Seungho MD, PhD1,2,3
doi : 10.14309/ajg.0000000000001344
November 2021 - Volume 116 - Issue 11 - p 2270-2278
Dietary carbohydrate restriction or ketogenic diets are known to be beneficial in preventing liver fat accumulation. However, the effect of ketonemia on the risk of nonalcoholic fatty liver disease (NAFLD) in nondiabetic population is largely unknown. We investigated the association between fasting ketonuria and the risk of incident NAFLD in healthy adults.
Peppermint Oil Treatment for Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial
Nee, Judy MD1; Ballou, Sarah PhD1; Kelley, John M. PhD2,3; Kaptchuk, Ted J.2; Hirsch, William BS1; Katon, Jesse BS1; Cheng, Vivian MS, MPH1; Rangan, Vikram MD1; Lembo, Anthony MD1; Iturrino, Johanna MD1
doi : 10.14309/ajg.0000000000001395
November 2021 - Volume 116 - Issue 11 - p 2279-2285
Peppermint oil is often used to treat irritable bowel syndrome (IBS); however, the overall quality of previous studies is low, and findings have been heterogeneous. This study aimed to compare the effects of peppermint oil vs placebo in relieving IBS symptoms.
No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants
He, Qiangsheng MM1,2,#; Xia, Bin PhD1,2,#; Meng, Wenbo MD, PhD3,#; Fan, Die MM2; Kuo, Zi-Chong MD Student4; Huang, Junjie PhD5; Qin, Xiwen PhD6,7,8; Zou, Huachun PhD9,10; He, Yulong MD1,4; Zhang, Changhua MD4; Fang, Shuo MD11; Pan, Yihang MD, PhD1,4; Yang, Man MD3,4; Yuan, Jinqiu PhD1,2,4
doi : 10.14309/ajg.0000000000001377
November 2021 - Volume 116 - Issue 11 - p 2286-2291
The association between proton pump inhibitors' (PPIs) use and mortality remains unclear.
Targeted Albumin Therapy Does Not Improve Short-Term Outcome in Hyponatremic Patients Hospitalized With Complications of Cirrhosis: Data From the ATTIRE Trial
China, Louise MD, PhD1; Freemantle, Nick PhD2; Forrest, Ewan MD3; Kallis, Yiannis MD, PhD4; Ryder, Stephen D. DM5; Wright, Gavin MD, PhD6; O'Brien, Alastair MD, PhD1
doi : 10.14309/ajg.0000000000001488
November 2021 - Volume 116 - Issue 11 - p 2292-2295
Patients with decompensated cirrhosis and hyponatremia have a poor prognosis. We investigated Albumin to Prevent Infection in Chronic Liver Failure trial data to determine whether targeted albumin infusions improved outcome in patients with hyponatremia at baseline.
Vulvar Crohn's Disease: Clinical Features and Outcomes
Cho, Janice M. MD1; Loftus, Edward V. Jr MD2; Bruining, David H. MD2; Chedid, Victor G. MD2; Farraye, Francis A. MD, MS3; Faubion, William A. Jr MD2; Johnson, Amanda M. MD2; Kane, Sunanda V. MD, MSPH2; Kisiel, John B. MD2; Malik, Talha A. MD4; Papadakis, Konstantinos A. MD2; Pardi, Darrell S. MD2; Picco, Michael F. MD, PhD3; Raffals, Laura E. MD2; Schroeder, Kenneth W. MD, PhD2; Tremaine, William J. MD2; Coelho-Prabhu, Nayantara MBBS2
doi : 10.14309/ajg.0000000000001502
November 2021 - Volume 116 - Issue 11 - p 2296-2299
Vulvar involvement is a rare complication of Crohn's disease (CD). The optimal treatment of vulvar CD is unknown.
Gastroparesis After Pfizer-BioNTech COVID-19 Vaccination
Scott, Jaime MD1; Anderson, Jenna MD2; Mallak, Nadine MD3; Beitinjaneh, Bassel MD4; Wei, Kevin MD4; Otaki, Fouad MD2
doi : 10.14309/ajg.0000000000001354
November 2021 - Volume 116 - Issue 11 - p 2300
Baby Steps in the Right Direction: Toward a Parental Leave Policy for Gastroenterology Fellows
Uchida, Amiko M. MD1,2,3; Rabinowitz, Loren G. MD4; Harris, Courtney E. MD5; Clark, Varina R. BS6; Duma, Narjust MD7; Willers, Henning MD8
doi : 10.14309/ajg.0000000000001331
November 2021 - Volume 116 - Issue 11 - p 2300
Response to Uchida and Rabinowitz, et al.
Feld, Lauren Deborah MD1
doi : 10.14309/ajg.0000000000001370
November 2021 - Volume 116 - Issue 11 - p 2302
Advanced Gastroenterology Trainees Should Be Included in National Trainee Parental Leave Policies
Davis, Jessica P.E. MD, MSCR1; Miller, Jennifer B. MD, MSCR2; Argo, Curtis K. MD, MSCR2
doi : 10.14309/ajg.0000000000001338
November 2021 - Volume 116 - Issue 11 - p 2302
Response to Davis, et al.
Feld, Lauren D. MD1
doi : 10.14309/ajg.0000000000001381
November 2021 - Volume 116 - Issue 11 - p 2303
Proton Pump Inhibitors in Patients With Liver Cirrhosis: Evidence to Improve Their Battered Reputation
Labenz, Christian MD1,2; Labenz, Joachim MD3
doi : 10.14309/ajg.0000000000001394
November 2021 - Volume 116 - Issue 11 - p 2304
Response to Labenz and Labenz
Acharya, Chathur MD1; Bajaj, Jasmohan S. MD1
doi : 10.14309/ajg.0000000000001406
November 2021 - Volume 116 - Issue 11 - p 2304
Management of Portal Vein Thrombosis in Cirrhosis—Need a Closer Look!
Jindal, Ankur MD, DM1; Mukund, Amar MD1
doi : 10.14309/ajg.0000000000001363
November 2021 - Volume 116 - Issue 11 - p 2305
Response to Jindal and Mukund
Lv, Yong MD, PhD1; Han, Guohong MD, PhD1,2
doi : 10.14309/ajg.0000000000001496
November 2021 - Volume 116 - Issue 11 - p 2306
Paraneoplastic Achalasia Associated With Neuroendocrine Tumor
Sarvepalli, Shashank MD, MS1; Husain, Nisreen S. MD1
doi : 10.14309/ajg.0000000000001352
November 2021 - Volume 116 - Issue 11 - p 2306
Correction to: ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding
Laine, Loren MD, FACG1,2; Barkun, Alan N. MD, FACG3; Saltzman, John R. MD, FACG4; Martel, Myriam MSc2; Leontiadis, Grigorios I. MD, PhD5
doi : 10.14309/ajg.0000000000001506
November 2021 - Volume 116 - Issue 11 - p 2309
Correction to: Combined Use of Aspirin and Selective Serotonin Reuptake Inhibitors Is Associated With Lower Risk of Colorectal Cancer: A Nested Case-Control Study
Zhang, Naiqi MPhil1; Sundquist, Jan MD, PhD1,2,3; Sundquist, Kristina MD, PhD1,2,3; Zhang, Zhi-Gang PhD4; Ji, Jianguang MD, PhD1
doi : 10.14309/ajg.0000000000001520
November 2021 - Volume 116 - Issue 11 - p 2310
Calendar of Courses, Symposiums and Conferences
doi : 10.14309/ajg.0000000000001528
November 2021 - Volume 116 - Issue 11 - p 2311
