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The long-term use of tocilizumab in giant cell arteritis
Fiona Louise Coath, Chetan Mukhtyar
doi : 10.1093/rheumatology/keab418
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4447–4449
A systematic review and network meta-analysis of the safety of early interventional treatments in rheumatoid arthritis
Maryam A Adas, Victoria B Allen, Mark Yates, Katie Bechman, Benjamin D Clarke, Mark D Russell, Andrew I Rutherford, Andrew P Cope, Sam Norton, James B Galloway
doi : 10.1093/rheumatology/keab429
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4450–4462
Systematic searches of MEDLINE, EMBASE and PubMed were conducted up to September 2020. Double-blind randomized controlled trials (RCTs) of licensed treatments conducted on completely naïve or MTX-naïve RA patients were included. Long-term extension studies, post-hoc and pooled analyses and RCTs with no comparator arm were excluded. Serious adverse events, serious infections and non-serious adverse events were extracted from all RCTs, and event rates in intervention and comparator arms were compared using meta-analysis and network meta-analysis (NMA).
Glucocorticoids in spondyloarthritis—systematic review and real-world analysis
Varun Dhir, Debasish Mishra, Joydeep Samanta
doi : 10.1093/rheumatology/keab275
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4463–4475
The objective of this study was to identify and summarize the efficacy and safety of systemic glucocorticoids (GCs) and local injections of GC in SpA.
Central sensitization, illness perception and obesity should be considered when interpreting disease activity in axial spondyloarthritis
Stan C Kieskamp, Davy Paap, Marlies J G Carbo, Freke Wink, Reinhard Bos, Hendrika Bootsma, Suzanne Arends, Anneke Spoorenberg
doi : 10.1093/rheumatology/keab019
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4476–4485
Many patients with axial spondyloarthritis (axSpA) report persistent pain even when treated with anti-inflammatory agents. Our aim was to explore the presence of central sensitization (CS) and different types of illness perceptions in patients with axSpA, and to assess their associations with disease activity assessments.
Effect of ultrasound-detected synovitis on therapeutic efficacy of hyaluronic acid injection for symptomatic knee osteoarthritis
Chien-Chih Wang, Chin-Tien Wang, Kun-Ling Tsai, Chen-Liang Chou, Jian-Kang Chao, Hsin-Yi Huang, Chung-Lan Kao
doi : 10.1093/rheumatology/keab020
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4486–4494
To determine whether ultrasound (US)-detected synovitis affects the therapeutic efficacy of hyaluronic acid (HA) injection for treating knee OA.
Open-label phase 3 study of intravenous golimumab in patients with polyarticular juvenile idiopathic arthritis
Nicolino Ruperto, Hermine I Brunner, César Pacheco-Tena, Ingrid Louw, Gabriel Vega-Cornejo, Alberto J Spindler, Daniel J Kingsbury, Heinrike Schmeling, Arturo Borzutzky, Rubén Cuttica, C J Inman, Victor Malievskiy, Christiaan Scott, Vladimir Keltsev, Maria Teresa Terreri, Diego Oscar Viola, Ricardo M Xavier, Taciana A Pedrosa Fernandes, María del Rocío Maldonado Velázquez, Michael Henrickson, Michael B Clark, Karen A Bensley, Xiaoming Li, Kim Hung Lo, Jocelyn H Leu, Chyi-Hung Hsu, Elizabeth C Hsia, Zhenhua Xu, Alberto Martini, Daniel J Lovell, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and the Paediatric Rheumatology International Trials Organisation (PRINTO)
doi : 10.1093/rheumatology/keab021
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4495–4507
To assess efficacy, pharmacokinetics (PK) and safety of intravenous (i.v.) golimumab in patients with polyarticular-course JIA (pc-JIA).
Glycolysis-derived acidic microenvironment as a driver of endothelial dysfunction in systemic sclerosis
Elena Andreucci, Francesca Margheri, Silvia Peppicelli, Francesca Bianchini, Jessica Ruzzolini, Anna Laurenzana, Gabriella Fibbi, Cosimo Bruni, Silvia Bellando-Randone, Serena Guiducci, Eloisa Romano, Mirko Manetti, Marco Matucci-Cerinic, Lido Calorini
doi : 10.1093/rheumatology/keab022
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4508–4519
SSc is an autoimmune disease characterized by peripheral vasculopathy and skin and internal organ fibrosis. Accumulating evidence underlines a close association between a metabolic reprogramming of activated fibroblasts and fibrosis. This prompted us to determine the metabolism of SSc dermal fibroblasts and the effect on the vasculopathy characterizing the disease.
Characteristics and risk factors of relapses in patients with adult-onset Still's disease: a long-term cohort study
Jianfen Meng, Huihui Chi, Zhihong Wang, Hao Zhang, Yue Sun, Jialin Teng, Qiongyi Hu, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Xinyao Wu, Jincao Jia, Mengyan Wang, Yuning Ma, Zhuochao Zhou, Fan Wang, Tingting Liu, Liyan Wan, Xin Qiao, Xia Chen, Chengde Yang, Yutong Su
doi : 10.1093/rheumatology/keab023
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4520–4529
To describe the detailed characteristics and explore the potential risk factors of relapses in patients with adult-onset Still's disease (AOSD).
Delineating phenotypes of Kawasaki disease and SARS-CoV-2-related inflammatory multisystem syndrome: a French study and literature review
Bilade Cherqaoui, Isabelle Koné-Paut, Hélène Yager, Fleur Le Bourgeois, Maryam Piram
doi : 10.1093/rheumatology/keab026
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4530–4537
To better define the clinical distinctions between the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related paediatric inflammatory multisystem syndrome (PIMS) and Kawasaki disease (KD).
Heart disease in eosinophilic granulomatosis with polyangiitis (EGPA) patients: a screening approach proposal
Eloi Garcia-Vives, J F Rodriguez-Palomares, Len Harty, Roser Solans-Laque, David Jayne
doi : 10.1093/rheumatology/keab027
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4538–4547
To define the pattern of cardiac involvement in eosinophilic granulomatosis and polyangiitis (EGPA) and propose an algorithm for heart disease screening.
Pain and fatigue are longitudinally and bi-directionally associated with more sedentary time and less standing time in rheumatoid arthritis
Ciara M O’Brien, Nikos Ntoumanis, Joan L Duda, George D Kitas, Jet J C S Veldhuijzen van Zanten, George S Metsios, Sally A M Fenton
doi : 10.1093/rheumatology/keab029
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4548–4557
The aims of this study were to examine the longitudinal and bi-directional associations of pain and fatigue with sedentary, standing and stepping time in RA.
Childhood-onset of primary Sjögren’s syndrome: phenotypic characterization at diagnosis of 158 children
Manuel Ramos-Casals, Nihan Acar-Denizli, Arjan Vissink, Pilar Brito-Zerón, Xiaomei Li, Francesco Carubbi, Roberta Priori, Nataša Toplak, Chiara Baldini, Enrique Faugier-Fuentes, Aike A Kruize, Thomas Mandl, Minako Tomiita, Saviana Gandolfo, Kunio Hashimoto, Gabriela Hernandez-Molina, Benedikt Hofauer, Samara Mendieta-Zerón, Astrid Rasmussen, Pulukool Sandhya, Damien Sene, Virginia Fernandes Moça Trevisani, David Isenberg, Erik Sundberg, Sandra G Pasoto, Agata Sebastian, Yasunori Suzuki, Soledad Retamozo, Bei Xu, Roberto Giacomelli, Angelica Gattamelata, Masa Bizjak, Stefano Bombardieri, Richard-Eduardo Loor-Chavez, Anneline Hinrichs, Peter Olsson, Hendrika Bootsma, Scott M Lieberman, and the Sjogren Big Data Consortium*
doi : 10.1093/rheumatology/keab032
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4558–4567
To characterize the phenotypic presentation at diagnosis of childhood-onset primary SS.
Subcutaneous dosing regimens of tocilizumab in children with systemic or polyarticular juvenile idiopathic arthritis
Nicolino Ruperto, Hermine I Brunner, Athimalaipet V Ramanan, Gerd Horneff, Rubén Cuttica, Michael Henrickson, Jordi Anton, Alina Lucica Boteanu, Inmaculada Calvo Penades, Kirsten Minden, Heinrike Schmeling, Markus Hufnagel, Jennifer E Weiss, Manuela Pardeo, Kabita Nanda, Johannes Roth, Nadina Rubio-Pérez, Joy C Hsu, Sunethra Wimalasundera, Chris Wells, Kamal Bharucha, Wendy Douglass, Min Bao, Navita L Mallalieu, Alberto Martini, Daniel Lovell, Fabrizio De Benedetti, for the Paediatric Rheumatology INternational Trials Organisation (PRINTO) and the Paediatric Rheumatology Collaborative Study Group (PRCSG)
doi : 10.1093/rheumatology/keab047
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4568–4580
To determine s.c. tocilizumab (s.c.-TCZ) dosing regimens for systemic JIA (sJIA) and polyarticular JIA (pJIA).
Serum uric acid and knee osteoarthritis in community residents without gout: a longitudinal study
Dong Jin Go, Dong Hyun Kim, Jie Young Kim, Ali Guermazi, Michel Daoud Crema, David J Hunter, Hyun Ah Kim
doi : 10.1093/rheumatology/keab048
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4581–4590
Emerging evidence suggests a potential link between OA and gout; however, the association between serum uric acid (UA) itself and knee OA remains uncertain due to a lack of longitudinal studies. Here, we investigated the association between serum UA and knee OA according to cartilage status in elderly community residents without gout.
Association between environmental air pollution and rheumatoid arthritis flares
Giovanni Adami, Ombretta Viapiana, Maurizio Rossini, Giovanni Orsolini, Eugenia Bertoldo, Alessandro Giollo, Davide Gatti, Angelo Fassio
doi : 10.1093/rheumatology/keab049
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4591–4597
Environmental air pollution has been linked to the pathogenesis of RA. Nevertheless, evidence linking higher concentrations of air pollutants with the risk of RA reactivations is missing. The objective of the present study was to determine the association between RA flares and air pollution.
Predictive value of anti-CarP and anti-PAD3 antibodies alone or in combination with RF and ACPA for the severity of rheumatoid arthritis
Celine Lamacchia, Delphine S Courvoisier, Matthias Jarlborg, Sylvette Bas, Pascale Roux-Lombard, Burkhard Möller, Adrian Ciurea, Axel Finckh, Chelsea Bentow, Laura Martinez-Prat, Michael Mahler, Cem Gabay, Michael J Nissen, the SCQM Rheumatologists
doi : 10.1093/rheumatology/keab050
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4598–4608
The objective of this study was to analyse the predictive value of anti-carbamylated protein (anti-CarP) and anti-peptidyl-arginine deiminase type-3 (anti-PAD3) antibodies, alone or in combination with RF and ACPA, to identify patients at high risk of developing severe RA outcomes.
Focal vasculitic myositis as a primary manifestation of Behçet’s disease: a case series of 10 Korean patients in a locomotive medicine clinic
Du Hwan Kim, Sun Woong Kim, Seung Mi Yeo, Min-Soo Kang, Young Cheol Yoon, Duk Hyun Sung
doi : 10.1093/rheumatology/keab053
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4609–4615
Muscle involvement in Behçet’s disease (BD) is rare, and several cases have been reported in the literature. Therefore, this study aimed to describe the clinical, laboratory and imaging findings in adult patients presenting with BD-associated myositis before the diagnosis of BD.
Venous thromboembolism in ANCA-associated vasculitis: a population-based cohort study
Matina Liapi, David Jayne, Peter A Merkel, Mårten Segelmark, Aladdin J Mohammad
doi : 10.1093/rheumatology/keab057
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4616–4623
To determine incidence rate and predictors of venous thromboembolic events (VTE) in a population-based cohort with ANCA-associated vasculitis (AAV).
Association between current medication use and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative
Thomas A Perry, Xia Wang, Michael Nevitt, Christina Abdelshaheed, Nigel Arden, David J Hunter
doi : 10.1093/rheumatology/keab059
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4624–4632
Use of specific medications may accelerate the progression of radiographic knee OA (RKOA). Our aim was to examine the effect of medication use on the progression of RKOA.
Do people with rheumatoid arthritis maintain their physical activity level at treatment onset over the first year of methotrexate therapy?
James M Gwinnutt, Husain Alsafar, Kimme L Hyrich, Mark Lunt, Anne Barton, Suzanne M M Verstappen, the RAMS co-investigators
doi : 10.1093/rheumatology/keab060
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4633–4642
To describe how many people with RA reduce their baseline physical activity level over the first year of MTX treatment, and which factors predict this.
CCL2 produced by CD68+/CD163+ macrophages as a promising clinical biomarker of microscopic polyangiitis-interstitial lung disease
Shogo Matsuda, Takuya Kotani, Hiroko Kuwabara, Takayasu Suzuka, Takao Kiboshi, Keisuke Fukui, Takaaki Ishida, Youhei Fujiki, Hideyuki Shiba, Kenichiro Hata, Takeshi Shoda, Yoshinobu Hirose, Tohru Takeuchi
doi : 10.1093/rheumatology/keab064
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4643–4653
Microscopic polyangiitis (MPA) is often complicated by interstitial lung disease (ILD); however, biomarkers that can be used to diagnose and predict the progression of MPA-ILD have not been identified. In this study, we evaluated various serum biomarkers in MPA-ILD to assess their diagnostic and predictive performance.
Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis: a multinational study
Sergey Moiseev, Andreas Kronbichler, Egor Makarov, Nikolay Bulanov, Matija Crnogorac, Haner Direskeneli, Kresimir Galesic, Ummugulsum Gazel, Duvuru Geetha, Loic Guillevin, Zdenka Hrušková, Mark A Little, Adeel Ahmed, Stephen P McAdoo, Aladdin J Mohammad, Sarah Moran, Pavel Novikov, Charles D Pusey, Chinar Rahmattulla, Veronika Satrapová, Joana Silva, Benjamin Terrier, Vladimír Tesa?, Kerstin Westman, David R W Jayne
doi : 10.1093/rheumatology/keab071
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4654–4661
To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America.
Defining the optimal disease duration of early diffuse systemic sclerosis for clinical trial design
Robyn T Domsic, Shiyao Gao, Maureen Laffoon, Steven Wisniewski, Yuqing Zhang, Virginia Steen, Robert Lafyatis, Thomas A Medsger, Jr
doi : 10.1093/rheumatology/keab075
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4662–4670
Clinical trials in early diffuse cutaneous systemic sclerosis (SSc) using the modified Rodnan skin score (mRSS) as the primary outcome measure have most often been negative. We wanted to assess how the definition of disease onset (first SSc manifestation vs first non-Raynaud manifestation) and varying lengths of disease duration at trial entry as an inclusion criteria functioned. Our objective was to optimize trial inclusion criteria
Patient perceptions of health-related quality of life in giant cell arteritis: international development of a disease-specific patient-reported outcome measure
Joanna C Robson, Celia Almeida, Jill Dawson, Alison Bromhead, Emma Dures, Catherine Guly, Elizabeth Hoon, Sarah Mackie, Mwidimi Ndosi, John Pauling, Catherine Hill
doi : 10.1093/rheumatology/keab076
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4671–4680
GCA is a large vessel vasculitis (LVV) presenting with headache, jaw claudication, musculoskeletal and visual involvement. Current treatment is glucocorticoids and anti-IL-6 tocilizumab in refractory disease. The objective of this study was to explore the impact of GCA and its treatment on people’s health-related quality of life (HRQoL), to inform the development of a disease-specific patient-reported outcome measure (PROM) for use in clinical trials and practice.
Healthcare utilization and economic burden of difficult-to-treat rheumatoid arthritis: a cost-of-illness study
Nadia M T Roodenrijs, Paco M J Welsing, Marlies C van der Goes, Janneke Tekstra, Floris P J G Lafeber, Johannes W G Jacobs, Jacob M van Laar
doi : 10.1093/rheumatology/keab078
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4681–4690
To determine the impact of difficult-to-treat rheumatoid arthritis (D2T RA) on (costs related to) healthcare utilization, other resource use and work productivity.
Causal pathways to health-related quality of life in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort
Kiem Oen, Jiahao Tian, Thomas M Loughin, Natalie J Shiff, Lori B Tucker, Adam M Huber, Roberta A Berard, Deborah M Levy, Dax G Rumsey, Shirley M Tse, Mercedes Chan, Brian M Feldman, Ciaran M Duffy, Jaime Guzman, for the ReACCh-Out Investigators
doi : 10.1093/rheumatology/keab079
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4691–4702
Structural equation modelling was applied to data from the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort to help elucidate causal pathways to decreased health-related quality of life (HRQoL) in children with JIA.
EQ-5D-3L full health state discriminates between drug and placebo in clinical trials of systemic lupus erythematosus
Julius Lindblom, Alvaro Gomez, Alexander Borg, Sharzad Emamikia, Dimitris Ladakis, Joaquin Matilla, Martin Pehr, Flordelyn Cobar, Yvonne Enman, Emelie Heintz, Malin Regardt, Ioannis Parodis
doi : 10.1093/rheumatology/keab080
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4703–4716
The objectives of this study were to investigate the discriminative ability of EQ-5D-3L full health state (FHS) in clinical trials of SLE, and to identify factors associated with FHS after treatment.
Happiness, quality of life and their determinants among people with systemic sclerosis: a structural equation modelling approach
Tânia Santiago, Eduardo Santos, Ana Catarina Duarte, Patrícia Martins, Marlene Sousa, Francisca Guimarães, Soraia Azevedo, Raquel Miriam Ferreira, Miguel Guerra, Ana Cordeiro, Inês Cordeiro, Sofia Pimenta, Patrícia Pinto, Ana Margarida Pinto, Maria João Salvador, José António P da Silva
doi : 10.1093/rheumatology/keab083
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4717–4727
Patients’ objectives and experiences must be core to the study and management of chronic diseases, such as SSc. Although patient-reported outcomes are attracting increasing attention, evaluation of the impact of disease on the overall subjective well-being, equivalent to ‘happiness’, is remarkably lacking.
Behçet’s syndrome in children and young people in the United Kingdom and the Republic of Ireland: a prospective epidemiological study
Clare E Pain, Michael W Beresford, Farida Fortune, Eric T C Lai, Ruth Murphy, David Taylor-Robinson, Paul A Brogan, Robert J Moots
doi : 10.1093/rheumatology/keab084
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4728–4736
To define the incidence and prevalence of Behçet’s syndrome (BS) in children and young people (CYP) up to the age of 16?years in the United Kingdom (UK) and Republic of Ireland (ROI).
Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort
Christine Chew, John A Reynolds, Apinya Lertratanakul, Peggy Wu, Murray Urowitz, Dafna D Gladman, Paul R Fortin, Sang-Cheol Bae, Caroline Gordon, Ann E Clarke, Sasha Bernatsky, John G Hanly, David Isenberg, Anisur Rahman, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Joan Merrill, Daniel Wallace, Ellen Ginzler, Munther Khamashta, Ola Nived, Andreas Jönsen, Kristjan Steinsson, Susan Manzi, Ken Kalunian, Mary Anne Dooley, Michelle Petri, Cynthia Aranow, Ronald van Vollenhoven, Thomas Stoll, Graciela S Alarcón, S Sam Lim, Guillermo Ruiz-Irastorza, Christine A Peschken, Anca D Askanase, Diane L Kamen, Murat ?nanç, Rosalind Ramsey-Goldman, Ian N Bruce
doi : 10.1093/rheumatology/keab090
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4737–4747
Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance.
Associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee osteoarthritis
Yuanyuan Wang, Tao Meng, Guangfeng Ruan, Shuang Zheng, Jimin Zhu, Han Cen, Benny Antony, Anita E Wluka, Flavia Cicuttini, Tania Winzenberg, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Changhai Ding
doi : 10.1093/rheumatology/keab092
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4748–4754
To describe the associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee OA.
Associations between serum antibodies to periodontal pathogens and preclinical phases of rheumatoid arthritis
Daniel Manoil, Delphine S Courvoisier, Benoit Gilbert, Burkhard Möller, Ulrich A Walker, Ines Von Muehlenen, Andrea Rubbert-Roth, Axel Finckh, Nagihan Bostanci
doi : 10.1093/rheumatology/keab097
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4755–4764
To examine whether serum antibodies against selected periodontal pathogens are associated with early symptoms of RA development in healthy individuals at risk of developing the disease.
A distinguishing profile of chemokines, cytokines and biomarkers in the saliva of children with Sjögren’s syndrome
M Paula Gomez Hernandez, Emily E Starman, Andrew B Davis, Miyuraj Harishchandra Hikkaduwa Withanage, Erliang Zeng, Scott M Lieberman, Kim A Brogden, Emily A Lanzel
doi : 10.1093/rheumatology/keab098
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4765–4777
SS is an autoimmune disease most commonly diagnosed in adults but can occur in children. Our objective was to assess the presence of chemokines, cytokines and biomarkers (CCBMs) in saliva from these children that were associated with lymphocyte and mononuclear cell functions.
Data-driven definitions for active and structural MRI lesions in the sacroiliac joint in spondyloarthritis and their predictive utility
Walter P Maksymowych, Robert G Lambert, Xenofon Baraliakos, Ulrich Weber, Pedro M Machado, Susanne J Pedersen, Manouk de Hooge, Joachim Sieper, Stephanie Wichuk, Denis Poddubnyy, Martin Rudwaleit, Désirée van der Heijde, Robert Landewe, Iris Eshed, Mikkel Ostergaard
doi : 10.1093/rheumatology/keab099
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4778–4789
To determine quantitative SI joint MRI lesion cut-offs that optimally define a positive MRI for inflammatory and structural lesions typical of axial SpA (axSpA) and that predict clinical diagnosis.
Female hormonal exposures and risk of rheumatoid arthritis in the French E3N-EPIC cohort study
Carine Salliot, Yann Nguyen, Gaëlle Gusto, Amandine Gelot, Juliette Gambaretti, Xavier Mariette, Marie-Christine Boutron-Ruault, Raphaèle Seror
doi : 10.1093/rheumatology/keab101
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4790–4800
To assess the relationships between female hormonal exposures and risk of RA in a prospective cohort of French women.
Phenotype and treatment of elderly onset compared with younger?onset rheumatoid arthritis patients in international daily practice
Johanna M Maassen, Sytske Anne Bergstra, Arvind Chopra, Nimmisha Govind, Elizabeth A Murphy, David Vega-Morales, Tom W J Huizinga, Cornelia F Allaart
doi : 10.1093/rheumatology/keab102
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4801–4810
To identify possible differences in baseline characteristics, initial treatment and treatment response between RA patient subgroups based on age at disease onset.
Disease activity and its predictors in early inflammatory arthritis: findings from a national cohort
Mark Yates, Joanna M Ledingham, Paul Amlani Hatcher, Maryam Adas, Sasha Hewitt, Sam Bartlett-Pestell, Sanketh Rampes, Sam Norton, James B Galloway
doi : 10.1093/rheumatology/keab107
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4811–4820
We set out to characterize patient factors that predict disease activity during the first year of treatment for early inflammatory arthritis (EIA).
Clinical impact of myositis-specific autoantibodies on long-term prognosis of juvenile idiopathic inflammatory myopathies: multicentre study
Yuichi Yamasaki, Norimoto Kobayashi, Shinji Akioka, Kazuko Yamazaki, Shunichiro Takezaki, Haruna Nakaseko, Asami Ohara, Kenichi Nishimura, Yutaka Nishida, Satoshi Sato, Takayuki Kishi, Motomu Hashimoto, Masaaki Mori, Yuka Okazaki, Masataka Kuwana, Akiko Ohta
doi : 10.1093/rheumatology/keab108
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4821–4831
This study aimed to investigate the clinical characteristics, treatment and prognosis of juvenile idiopathic inflammatory myopathies (JIIM) in Japan for each myositis-specific autoantibody (MSA) profile.
Estimating the population health burden of musculoskeletal conditions using primary care electronic health records
Dahai Yu, George Peat, Kelvin P Jordan, James Bailey, Daniel Prieto-Alhambra, Danielle E Robinson, Victoria Y Strauss, Karen Walker-Bone, Alan Silman, Mamas Mamas, Steven Blackburn, Stephen Dent, Kate Dunn, Andrew Judge, Joanne Protheroe, Ross Wilkie
doi : 10.1093/rheumatology/keab109
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4832–4843
Better indicators from affordable, sustainable data sources are needed to monitor population burden of musculoskeletal conditions. We propose five indicators of musculoskeletal health and assessed if routinely available primary care electronic health records (EHR) can estimate population levels in musculoskeletal consulters.
Dissecting the clinical heterogeneity of adult-onset Still’s disease: results from a multi-dimensional characterization and stratification
Onorina Berardicurti, Alessandro Conforti, Daniela Iacono, Ilenia Pantano, Francesco Caso, Giacomo Emmi, Rosa Daniela Grembiale, Francesco Paolo Cantatore, Fabiola Atzeni, Federico Perosa, Raffaele Scarpa, Giuliana Guggino, Francesco Ciccia, Roberto Giacomelli, Paola Cipriani, Piero Ruscitti
doi : 10.1093/rheumatology/keaa904
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4844–4849
To stratify adult-onset Still’s disease (AOSD) patients in distinct clinical subsets to be differently managed, by using a multi-dimensional characterization.
Haploidentical ?/? T-cell and B-cell depleted stem cell transplantation in severe mevalonate kinase deficiency
Maura Faraci, Stefano Giardino, Marina Podestà, Filomena Pierri, Gianluca Dell’Orso, Andrea Beccaria, João Farela Neves, Stefano Volpi, Marco Gattorno
doi : 10.1093/rheumatology/keaa912
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4850–4854
Mevalonic aciduria represents the most severe form of mevalonate kinase deficiency (MKD). Patients with mevalonic aciduria have an incomplete response even to high doses of anti-cytokine drugs such as anakinra or canakinumab and stem cell transplantation (SCT) represents a possible therapy for this severe disease.
Crystal deposition measured with dual-energy computed tomography: association with mortality and cardiovascular risks in gout
Anne Marty-Ané, Laurène Norberciak, Mariano Andrès, Eric Houvenagel, Vincent Ducoulombier, Julie Legrand, Jean-François Budzik, Tristan Pascart
doi : 10.1093/rheumatology/keaa920
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4855–4860
To determine whether the volume of monosodium urate (MSU) crystal deposition measured with dual-energy CT (DECT) is predictive of short-term mortality and development of cardiovascular comorbidities and diabetes mellitus.
Dual-energy computed tomography vs ultrasound, alone or combined, for the diagnosis of gout: a prospective study of accuracy
Jasvinder A Singh, Jean-François Budzik, Fabio Becce, Tristan Pascart
doi : 10.1093/rheumatology/keaa923
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4861–4867
To examine the accuracy of dual-energy CT (DECT) vs ultrasound or their combination for the diagnosis of gout.
New insights into the epidemiology of ANCA-associated vasculitides in Germany: results from a claims data study
Bernhard Hellmich, Peter Lamprecht, Philip Spearpoint, Dieter Götte, Angelika Deichmann, Ina Buchholz, Matthias P Schönermark, Peter Rutherford
doi : 10.1093/rheumatology/keaa924
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4868–4873
ANCA-associated vasculitides (AAV) are rare, potentially life-threatening autoimmune diseases characterized by systemic inflammation and organ damage. AAV prevalence rates reported in Europe vary considerably and robust data sources are often lacking. This study aimed to examine the feasibility of claims data analysis as a complementary method to registry-based studies to assess the epidemiology of AAV.
Are musculoskeletal conditions neglected in national health surveys?
Giovanni E Ferreira, Rachelle Buchbinder, Joshua R Zadro, Mary O’Keeffe, Priti Kharel, Lidia Carballo-Costa, Juliana S Oliveira, Christopher G Maher
doi : 10.1093/rheumatology/keab025
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4874–4879
To describe the proportion of national health surveys that contain questions on the prevalence and consequences of musculoskeletal conditions.
TNFi-induced sustained clinical remission in peripheral spondyloarthritis patients cannot be maintained with a step-down strategy based on methotrexate
Philippe Carron, Ann-Sophie De Craemer, Thomas Renson, Roos Colman, , Dirk Elewaut, Filip Van den Bosch
doi : 10.1093/rheumatology/keab056
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4880–4883
Treatment with golimumab monotherapy in early peripheral SpA (pSpA) results in higher rates of clinical remission compared with treatment in more longstanding disease. When reaching remission, treat-to-target recommendations suggest tapering of treatment. We therefore explored whether addition of MTX would permit discontinuation of golimumab in patients with pSpA in sustained clinical remission.
Combination rituximab and intravenous immunoglobulin for treatment of refractory vasculitic neuropathy: a case series
Kaitlin Lima, Jinny Tavee, Anisha Dua
doi : 10.1093/rheumatology/keab069
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4884–4887
Limited evidence exists to guide treatment of refractory vasculitic neuropathy. While rituximab (RTX) and IVIG have both been proposed as individual treatment options for these patients, combination therapy has never been reported.
A novel loss-of-function mutation in LACC1 underlies hereditary juvenile arthritis with extended intra-familial phenotypic heterogeneity
Yonatan Butbul Aviel, Ayala Ofir, Ofer Ben-Izhak, Euvgeni Vlodavsky, Netanel Karbian, Riva Brik, Dror Mevorach, Daniella Magen
doi : 10.1093/rheumatology/keab017
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4888–4898
To investigate phenotypic and molecular characteristics of a consanguineous family with autosomal-recessive, polyarticular, juvenile isiopathic arthriris (JIA) with extra-articular manifestations, including renal amyloidosis and Crohn’s disease, associated with a novel homozygous truncating variant in LACC1.
Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarization
Hao Wang, Haiyan Zhang, Kai Fan, Danyang Zhang, Aihau Hu, Xiangzhou Zeng, Yan li Liu, Guanghong Tan, Hua Wang
doi : 10.1093/rheumatology/keab018
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4899–4909
Direct inhibition of M1 polarization of synovial macrophages may be a useful therapeutic treatment for OA and OA-associated synovitis. Frugoside (FGS) is a cardiac glycoside compound isolated and extracted from Calotropis gigantea. Cardiac glycosides possess interesting anti-inflammatory potential. However, the corresponding activity of FGS has not been reported. Therefore, our aim was to find direct evidence of the effects of FGS on synovial macrophage M1 polarization and OA control.
Distinct transcriptional profile of blood mononuclear cells in Behçet’s disease: insights into the central role of neutrophil chemotaxis
Kleio-Maria Verrou, Nikolaos I Vlachogiannis, Giannis Ampatziadis-Michailidis, Panagiotis Moulos, Georgios A Pavlopoulos, Pantelis Hatzis, George Kollias, Petros P Sfikakis
doi : 10.1093/rheumatology/keab052
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4910–4919
Both innate and adaptive immune responses are reportedly increased in Behçet’s disease (BD), a chronic, relapsing systemic vasculitis lying at the intersection between autoinflammation and autoimmunity. To further study pathophysiologic molecular mechanisms operating in BD, we searched for transcriptome-wide changes in blood mononuclear cells from these patients.
Neutrophil extracellular traps release in gout and pseudogout depends on the number of crystals regardless of leukocyte count
Estrella Garcia-Gonzalez, Alessandra Gamberucci, Orso-Maria Lucherini, Alessandra Alì, Antonella Simpatico, Sauro Lorenzini, Pietro-Enea Lazzerini, Sergio Tripodi, Bruno Frediani, Enrico Selvi
doi : 10.1093/rheumatology/keab087
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4920–4928
Microcrystal-induced arthritis is still an unresolved paradigm for medicine. Overt inflammation may be absent even when crystals occur in SF. Recently, the production of neutrophil extracellular traps (NETs) embedding MSU crystals has been proposed as a possible mechanism of the auto-resolution of the inflammatory phase during gout. We aimed to verify and quantify the release of NETs in SFs during gout and pseudogout attacks and to compare any differences with respect to crystals and neutrophils number, and to analyse activation of necroptosis pathway in SF from crystal-induced arthritis.
Mer tyrosine kinase?as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease
Lucrezia Rovati, Naoki Kaneko, Federica Pedica, Antonella Monno, Takashi Maehara, Cory Perugino, Marco Lanzillotta, Simone Pecetta, John H Stone, Claudio Doglioni, Angelo A Manfredi, Shiv Pillai, Emanuel Della-Torre
doi : 10.1093/rheumatology/keab096
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4929–4941
IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory disorder characterized by a dysregulated resolution of inflammation and wound healing response that might develop after an apoptotic insult induced by cytotoxic T lymphocytes (CTLs). Mer receptor tyrosine kinase (MerTK) and its ligand, protein S (ProS1), have a pivotal role in the resolution of inflammation, being implicated in the clearance of apoptotic cells, quenching of the immune response and development of tissue fibrosis. In the present work we aimed to investigate a possible involvement of the MerTK signalling pathway in the pathogenesis of IgG4-RD and development of tissue fibrosis.
Cross-reactive anti-CENP-A autoantibodies induce analytic interference in anti-TIF1? detection using line-dot immunoassay
Noémie Gensous, Laura Zanardo, Guillaume Martinroche, Judith Victor, Nicole Fabien, Pierre Duffau, Cécile Contin-Bordes
doi : 10.1093/rheumatology/keab451
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4942–4944
Band acro-osteolysis in systemic sclerosis
Matthew Colquhoun, Henry Penn
doi : 10.1093/rheumatology/keab031
Rheumatology, Volume 60, Issue 10, October 2021, Page 4945
Occlusion of both inferior and superior vena cava: an atypical presentation of Behçet’s disease
Matyas Kovacs, Denis Tack, Frédéric Vandergheynst
doi : 10.1093/rheumatology/keab055
Rheumatology, Volume 60, Issue 10, October 2021, Page 4946
Suntan sign as a clinical diagnostic key in dermatomyositis
Jessica Carolina Martinez-Rico, Giselle Rodriguez-Tamez, Maira Elizabeth Herz-Ruelas, Jesus Alberto Cardenas-de la Garza, Ivan de Jesus Hernandes-Galarza, Jorge Ocampo-Candiani, Sonia Chavez-Alvarez
doi : 10.1093/rheumatology/keab068
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4947–4948
Bilateral combined retinal vascular occlusion as a presenting feature in a case of systemic lupus erythematosus
Subina Narang, Mannat Giran, Sarabmeet Singh Lehl, Sanjay D’Cruz, Aman Sharma
doi : 10.1093/rheumatology/keab086
Rheumatology, Volume 60, Issue 10, October 2021, Pages 4949–4950
An autopsy case of anti-hydroxy-3-methylglutaryl-coenzyme A reductase myopathy with involvement of the heart, lungs and respiratory muscles
Hirohisa Fujikawa, Masahiro Minoda, Yusuke Owada, Keisuke Watanabe
doi : 10.1093/rheumatology/keab296
Rheumatology, Volume 60, Issue 10, October 2021, Pages e348–e350
Retinal vasculopathy in STING-associated vasculitis of infancy (SAVI)
Samantha Cooray, Robert Henderson, Ameenat Lola Solebo, Phil Ancliffe, Despina Eleftheriou, Paul A Brogan
doi : 10.1093/rheumatology/keab297
Rheumatology, Volume 60, Issue 10, October 2021, Pages e351–e353
Segmental arterial mediolysis: a rare cause of abdominal pain masquerading as vasculitis
Caoilfhionn M Connolly, Alice Yu, Philip Seo, Julie J Paik
doi : 10.1093/rheumatology/keab326
Rheumatology, Volume 60, Issue 10, October 2021, Pages e354–e355
A Case of polychondritis-onset refractory organizing pneumonia with cytopaenia diagnosed as VEXAS syndrome: the disease course of 7 years
Maki Sakuma, Akira Tanimura, Satsuki Yasui, Kenji Ishiguro, Toshiaki Kobayashi, Yusuke Ohshiro, Hideki Miyazaki, Ryogo Minamimoto, Takashi Okafuji, Katsuyoshi Shimozawa, Go Ogura, Akiyoshi Miwa, Hiroyuki Yamashita, Hiroshi Kaneko
doi : 10.1093/rheumatology/keab349
Rheumatology, Volume 60, Issue 10, October 2021, Pages e356–e359
Acquired haemophilia A in a patient with limited cutaneous systemic sclerosis
Herman K Glas, Wing-Yee Kwok, Paula F Ypma, Robbert J Goekoop
doi : 10.1093/rheumatology/keab351
Rheumatology, Volume 60, Issue 10, October 2021, Pages e360–e361
A case of anti-PL-7 antibody-positive anti-synthetase syndrome with dermatomyositis-associated erythema induced sclerodermatous changes
Maki Fukuzono, Katsuhito Sasaki, Yuki Ichimura, Sae Inoue, Riko Iwasaki, Hidemi Imai, Akimasa Saito, Noriko Kubota, Ryota Tanaka, Yoshiyuki Nakamura, Yasuhiro Fujisawa, Manabu Fujimoto, Toshifumi Nomura, Naoko Okiyama
doi : 10.1093/rheumatology/keab370
Rheumatology, Volume 60, Issue 10, October 2021, Pages e362–e364
Severe breast ulceration in Behçet’s treated with cyclophosphamide: a case report
Elisabeth Ball, Donal O’Kane, Collette McCourt, Maura McCarron, Claire Riddell
doi : 10.1093/rheumatology/keab379
Rheumatology, Volume 60, Issue 10, October 2021, Pages e365–e366
Comment on: Dual-energy computed tomography vs ultrasound, alone or combined, for the diagnosis of gout: a prospective study of accuracy
Sara Nysom Christiansen, Hilde B Hammer, Søren Torp-Pedersen, Lene Terslev
doi : 10.1093/rheumatology/keab243
Rheumatology, Volume 60, Issue 10, October 2021, Pages e367–e368
Comment on: Refining myositis associated with primary Sjögren’s syndrome: data from the prospective cohort ASSESS
Maria I Zervou, George N Goulielmos
doi : 10.1093/rheumatology/keab455
Rheumatology, Volume 60, Issue 10, October 2021, Pages e369–e370
Comment on: Gudu T, Stober C, Cope AP et al. Baricitinib set to join the Covid-19 therapeutic arsenal?
Sujoy Khan
doi : 10.1093/rheumatology/keab386
Rheumatology, Volume 60, Issue 10, October 2021, Page e371
Comment on: Dual-energy computed tomography versus ultrasound, alone or combined, for the diagnosis of gout: a prospective study of accuracy: reply
Jasvinder A Singh, Jean-François Budzik, Fabio Becce, Tristan Pascart
doi : 10.1093/rheumatology/keab320
Rheumatology, Volume 60, Issue 10, October 2021, Pages e372–e374
