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Toward a New Era for the Indian Health System
Jessica Leston, M.P.H., and Brigg Reilley, M.P.H.
doi : 10.1056/NEJMp2108894
N Engl J Med 2021; 385:1249-1251
Marking the 40th Anniversary of the AIDS Epidemic — American Physicians Look Back
Ronald Bayer, Ph.D., Gerald M. Oppenheimer, Ph.D., M.P.H., and Valentina Parisi, M.P.H.
doi : 10.1056/NEJMp2106933
N Engl J Med 2021; 385:1251-1253
Maintenance or Discontinuation of Antidepressants in Primary Care
Gemma Lewis, Ph.D., Louise Marston, Ph.D., Larisa Duffy, B.Sc., Nick Freemantle, Ph.D., Simon Gilbody, Ph.D., Rachael Hunter, M.Sc., Tony Kendrick, M.D., David Kessler, M.D., Dee Mangin, F.R.N.Z.C.G.P., Michael King, Ph.D., Paul Lanham, B.A., Michael Moore, F.R.C.G.P., Irwin Nazareth, Ph.D., Nicola Wiles, Ph.D., Faye Bacon, B.Sc., Molly Bird, M.Sc., Sally Brabyn, M.Sc., Alison Burns, B.Sc., Caroline S. Clarke, Ph.D., Anna Hunt, M.Sc., Jodi Pervin, B.Sc., and Glyn Lewis, Ph.D.
doi : 10.1056/NEJMoa2106356
N Engl J Med 2021; 385:1257-1267
Patients with depression who are treated in primary care practices may receive antidepressants for prolonged periods. Data are limited on the effects of maintaining or discontinuing antidepressant therapy in this setting.
Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension
Weili Zhang, M.D., Ph.D., Shuyuan Zhang, Ph.D., Yue Deng, Ph.D., Shouling Wu, M.D., Jie Ren, M.D., Gang Sun, M.D., Jinfeng Yang, M.D., Yinong Jiang, M.D., Xinjuan Xu, M.D., Tzung-Dau Wang, M.D., Ph.D., Youren Chen, M.D., Yufeng Li, M.D., Lianchen Yao, M.D., Dianfang Li, M.D., Lixin Wang, M.D., Xiaomei Shen, M.D., Xinhua Yin, M.D., Wei Liu, M.D., Xiaoyang Zhou, M.D., Bingpo Zhu, M.D., Zihong Guo, M.D., Hualing Liu, M.D., Xiaoping Chen, M.D., Yingqing Feng, M.D., Gang Tian, M.D., Xiuyin Gao, B.Sc., Kazuomi Kario, M.D., Ph.D., and Jun Cai, M.D., Ph.D. for the STEP Study Group*
doi : 10.1056/NEJMoa2111437
N Engl J Med 2021; 385:1268-1279
The appropriate target for systolic blood pressure to reduce cardiovascular risk in older patients with hypertension remains unclear.
Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis
William J. Sandborn, M.D., Brian G. Feagan, M.D., Geert D’Haens, M.D., Douglas C. Wolf, M.D., Igor Jovanovic, M.D., Stephen B. Hanauer, M.D., Subrata Ghosh, M.D., AnnKatrin Petersen, M.D., Steven Y. Hua, Ph.D., Ji Hwan Lee, M.S., Lorna Charles, M.D., Denesh Chitkara, M.D., Keith Usiskin, M.D., Jean-Frederic Colombel, M.D., Loren Laine, M.D., and Silvio Danese, M.D. for the True North Study Group*
doi : 10.1056/NEJMoa2033617
N Engl J Med 2021; 385:1280-1291
Ozanimod, a selective sphingosine-1-phosphate receptor modulator, is under investigation for the treatment of inflammatory bowel disease.
A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion
Guoliang Chai, Ph.D., Emmanuelle Szenker-Ravi, Ph.D., Changuk Chung, Ph.D., Zhen Li, Ph.D., Lu Wang, Ph.D., Muznah Khatoo, B.S., Trevor Marshall, B.S., Nan Jiang, Ph.D., Xiaoxu Yang, Ph.D., Jennifer McEvoy-Venneri, B.S., Valentina Stanley, B.S., Paula Anzenberg, B.S., Nhi Lang, B.S., Vanessa Wazny, B.S., Jia Yu, Ph.D., David M. Virshup, M.D., Rie Nygaard, Ph.D., Filippo Mancia, Ph.D., Rijad Merdzanic, M.D., Maria B.P. Toralles, M.D., Paula M.L. Pitanga, M.Sc., Ratna D. Puri, M.D., Rebecca Hernan, M.Sc., Wendy K. Chung, M.D., Ph.D., Aida M. Bertoli-Avella, M.D., Ph.D., Nouriya Al-Sannaa, M.D., Maha S. Zaki, M.D., Ph.D., Karl Willert, Ph.D., Bruno Reversade, Ph.D., and Joseph G. Gleeson, M.D.
doi : 10.1056/NEJMoa2033911
N Engl J Med 2021; 385:1292-1301
Structural birth defects occur in approximately 3% of live births; most such defects lack defined genetic or environmental causes. Despite advances in surgical approaches, pharmacologic prevention remains largely out of reach.
Newer Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease
Daniel C. Baumgart, M.D., Ph.D., and Catherine Le Berre, M.D.
doi : 10.1056/NEJMra1907607
N Engl J Med 2021; 385:1302-1315
Leukemia Cutis
Denise Barry, M.D., and Astrid Schmieder, M.D.
doi : 10.1056/NEJMicm2103771
N Engl J Med 2021; 385:1316
Kayser–Fleischer Rings in Wilson’s Disease
Atanu Chandra, M.D., and Moni S. Bhattacharjee, M.B., B.S.
doi : 10.1056/NEJMicm2103029
N Engl J Med 2021; 385:e46
Case 30-2021: A 47-Year-Old Man with Recurrent Unilateral Head and Neck Pain
Mark E. Lindsay, M.D., Ph.D., David M. Dudzinski, M.D., Byung C. Yoon, M.D., Ph.D., Michael R. Jaff, D.O., and Joseph V. Thakuria, M.D.
doi : 10.1056/NEJMcpc2107347
N Engl J Med 2021; 385:1317-1325
The Pursuit and Maintenance of Happiness
Jeffrey L. Jackson, M.D., M.P.H.
doi : 10.1056/NEJMe2111447
N Engl J Med 2021; 385:1327-1328
Moving the Goalposts for Blood Pressure — Time to Act
Mark R. Nelson, M.B., B.S., M.F.M., Ph.D.
doi : 10.1056/NEJMe2112992
N Engl J Med 2021; 385:1328-1329
Audio Interview: Covid-19 and the Media
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Richard Tofel, and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2115825
N Engl J Med 2021; 385:e59
Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce
doi : 10.1056/NEJMc2112981
N Engl J Med 2021; 385:1330-1332
Myocarditis after Covid-19 mRNA Vaccination
doi : 10.1056/NEJMc2109975
N Engl J Med 2021; 385:1332-1334
No Correlation between Anti-PF4 and Anti–SARS-CoV-2 Antibodies after ChAdOx1 nCoV-19 Vaccination
doi : 10.1056/NEJMc2111305
N Engl J Med 2021; 385:1334-1336
Effectiveness of an Inactivated SARS-CoV-2 Vaccine
doi : 10.1056/NEJMc2112423
N Engl J Med 2021; 385:1336-1339
Physical Rehabilitation in Patients with Heart Failure
doi : 10.1056/NEJMc2113494
N Engl J Med 2021; 385:1339-1341
Targeted Temperature Management after Cardiac Arrest
doi : 10.1056/NEJMc2112370
N Engl J Med 2021; 385:1341-1342
BNT162b2 Covid-19 Vaccine in Adolescents
doi : 10.1056/NEJMc2113394
N Engl J Med 2021; 385:1342-1343
HIV Infection — Screening, Diagnosis, and Treatment
doi : 10.1056/NEJMc2110946
N Engl J Med 2021; 385:1343-1344
