One-year access to more than 500 world journals available in the system
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State Public Option Plans — Too Modest to Improve Affordability?
Erin C. Fuse Brown, M.P.H., J.D., Katherine L. Gudiksen, Ph.D., and Jaime S. King, J.D., Ph.D.
doi : 10.1056/NEJMp2111356
N Engl J Med 2021; 385:1057-1059
Medicare for More — Why We Still Need a Public Option and How to Get There
Jacob S. Hacker, Ph.D.
doi : 10.1056/NEJMp2111494
N Engl J Med 2021; 385:1060-1062
Treatment of Older Adults with Cancer — Addressing Gaps in Evidence
Monica M. Bertagnolli, M.D., and Harpreet Singh, M.D.
doi : 10.1056/NEJMp2106089
N Engl J Med 2021; 385:1062-1065
Effect of Salt Substitution on Cardiovascular Events and Death
Bruce Neal, M.B., Ch.B., Ph.D., Yangfeng Wu, M.D., Ph.D., Xiangxian Feng, Ph.D., Ruijuan Zhang, M.Sc., Yuhong Zhang, M.Med., Jingpu Shi, Ph.D., Jianxin Zhang, Ph.D., Maoyi Tian, Ph.D., Liping Huang, Ph.D., Zhifang Li, M.Sc., Yan Yu, Ph.D., Yi Zhao, Ph.D., Bo Zhou, Ph.D., Jixin Sun, M.Sc., Yishu Liu, M.Sc., Xuejun Yin, M.P.H., Zhixin Hao, M.D., Jie Yu, M.D., Ph.D., Ka-Chun Li, M.Sc., Xinyi Zhang, M.P.H., Peifen Duan, M.Sc., Faxuan Wang, Ph.D., Bing Ma, M.Sc., Weiwei Shi, Ph.D., Gian Luca Di Tanna, Ph.D., Sandrine Stepien, M.Sc., Sana Shan, M.Sc., Sallie-Anne Pearson, Ph.D., Nicole Li, M.D., Ph.D., Lijing L. Yan, Ph.D., Darwin Labarthe, Ph.D., and Paul Elliott, M.B., B.S., Ph.D.
doi : 10.1056/NEJMoa2105675
N Engl J Med 2021; 385:1067-1077
Salt substitutes with reduced sodium levels and increased potassium levels have been shown to lower blood pressure, but their effects on cardiovascular and safety outcomes are uncertain.
Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting
Noam Barda, M.D., Noa Dagan, M.D., Yatir Ben-Shlomo, B.Sc., Eldad Kepten, Ph.D., Jacob Waxman, M.D., Reut Ohana, M.Sc., Miguel A. Hernán, M.D., Marc Lipsitch, D.Phil., Isaac Kohane, M.D., Doron Netzer, M.D., Ben Y. Reis, Ph.D., and Ran D. Balicer, M.D.
doi : 10.1056/NEJMoa2110475
N Engl J Med 2021; 385:1078-1090
Preapproval trials showed that messenger RNA (mRNA)–based vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had a good safety profile, yet these trials were subject to size and patient-mix limitations. An evaluation of the safety of the BNT162b2 mRNA vaccine with respect to a broad range of potential adverse events is needed.
Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer
Oliver Sartor, M.D., Johann de Bono, M.B., Ch.B., Ph.D., Kim N. Chi, M.D., Karim Fizazi, M.D., Ph.D., Ken Herrmann, M.D., Kambiz Rahbar, M.D., Scott T. Tagawa, M.D., Luke T. Nordquist, M.D., Nitin Vaishampayan, M.D., Ghassan El-Haddad, M.D., Chandler H. Park, M.D., Tomasz M. Beer, M.D., Alison Armour, M.B., Ch.B., M.D., Wendy J. Pérez-Contreras, M.P.A., Michelle DeSilvio, Ph.D., Euloge Kpamegan, Ph.D., Germo Gericke, M.D., Ph.D., Richard A. Messmann, M.D., M.H.S., Michael J. Morris, M.D., and Bernd J. Krause, M.D. for the VISION Investigators*
doi : 10.1056/NEJMoa2107322
N Engl J Med 2021; 385:1091-1103
Metastatic castration-resistant prostate cancer remains fatal despite recent advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic castration-resistant prostate cancer. Lutetium-177 (177Lu)–PSMA-617 is a radioligand therapy that delivers beta-particle radiation to PSMA-expressing cells and the surrounding microenvironment.
Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children
Priyanka D. Patel, M.B., B.S., Pratiksha Patel, M.B., B.S., Yuanyuan Liang, Ph.D., James E. Meiring, Ph.D., Theresa Misiri, M.P.H., Felistas Mwakiseghile, M.Sc., J. Kathleen Tracy, Ph.D., Clemens Masesa, M.Sc., Harrison Msuku, B.Sc., David Banda, B.Sc., Maurice Mbewe, B.Sc., Marc Henrion, Ph.D., Fiyinfolu Adetunji, M.P.H., Kenneth Simiyu, Ph.D., Elizabeth Rotrosen, A.B., Megan Birkhold, M.D., Nginache Nampota, M.B., B.S., Osward M. Nyirenda, B.Sc., Karen Kotloff, M.D., Markus Gmeiner, M.Sc., Queen Dube, Ph.D., Gift Kawalazira, M.B., B.S., Matthew B. Laurens, M.D., Robert S. Heyderman, Ph.D., Melita A. Gordon, M.D., and Kathleen M. Neuzil, M.D. for the TyVAC Malawi Team
doi : 10.1056/NEJMoa2035916
N Engl J Med 2021; 385:1104-1115
Typhoid fever caused by multidrug-resistant H58 Salmonella Typhi is an increasing public health threat in sub-Saharan Africa.
Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine
Pablo Tebas, M.D., Christine C. Roberts, Ph.D., Kar Muthumani, Ph.D., Emma L. Reuschel, Ph.D., Sagar B. Kudchodkar, Ph.D., Faraz I. Zaidi, M.S., Scott White, M.D., Amir S. Khan, Ph.D., Trina Racine, Ph.D., Hyeree Choi, B.S., Jean Boyer, Ph.D., Young K. Park, J.D., Sylvie Trottier, M.D., Celine Remigio, D.P.T., R.N., Diane Krieger, M.D., Susan E. Spruill, M.S., Mark Bagarazzi, M.D., Gary P. Kobinger, Ph.D., David B. Weiner, Ph.D., and Joel N. Maslow, M.D., Ph.D.
doi : 10.1056/NEJMoa1708120
N Engl J Med 2021; 385:e35
Although Zika virus (ZIKV) infection is typically self-limiting, other associated complications such as congenital birth defects and the Guillain–Barré syndrome are well described. There are no approved vaccines against ZIKV infection.
Treatment of Acute Uncomplicated Appendicitis
David A. Talan, M.D., and Salomone Di Saverio, M.D., Ph.D.
doi : 10.1056/NEJMcp2107675
N Engl J Med 2021; 385:1116-1123
Placenta Increta
Carlos A. Zapata-Caballero, M.D., and Victor H. Ramirez-Santes, M.D.
doi : 10.1056/NEJMicm2109363
N Engl J Med 2021; 385:1124
Conjunctival Kaposi’s Sarcoma
Filipe Gouveia-Moraes, M.D., and Nuno Campos, M.D.
doi : 10.1056/NEJMicm2105217
N Engl J Med 2021; 385:e36
Case 28-2021: A 37-Year-Old Woman with Covid-19 and Suicidal Ideation
Carol S. North, M.D., M.P.E., Emily M. Sorg, M.D., SooJeong Youn, Ph.D., and Jacqueline T. Chu, M.D.
doi : 10.1056/NEJMcpc2107350
N Engl J Med 2021; 385:1125-1132
Call for Emergency Action to Limit Global Temperature Increases, Restore Biodiversity, and Protect Health
Lukoye Atwoli, Abdullah H. Baqui, Thomas Benfield, Raffaella Bosurgi, Fiona Godlee, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Carlos Augusto Monteiro, Ian Norman, Kirsten Patrick, Nigel Praities, Marcel G.M. Olde Rikkert, Eric J. Rubin, Peush Sahni, Richard Smith, Nick Talley, Sue Turale, and Damián Vázquez
doi : 10.1056/NEJMe2113200
N Engl J Med 2021; 385:1134-1137
Can Salt Substitution Save At-Risk Persons from Stroke?
Julie R. Ingelfinger, M.D.
doi : 10.1056/NEJMe2112857
N Engl J Med 2021; 385:1137-1138
The Importance of Context in Covid-19 Vaccine Safety
Grace M. Lee, M.D., M.P.H.
doi : 10.1056/NEJMe2112543
N Engl J Med 2021; 385:1138-1140
Audio Interview: New Evidence on SARS-CoV-2 Vaccine Boosters
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2115200
N Engl J Med 2021; 385:e48
Oral versus Intravenous Antibiotics for Endocarditis
Jehan Chowdhury, D.O., Robin Patel, M.D., and Henry Chambers, M.D.
doi : 10.1056/NEJMclde2108866
N Engl J Med 2021; 385:1141-1143
High Congenital Syphilis Case Counts among U.S. Infants Born in 2020
doi : 10.1056/NEJMc2111103
N Engl J Med 2021; 385:1144-1145
Breakthrough Infections in BNT162b2-Vaccinated Health Care Workers
doi : 10.1056/NEJMc2108076
N Engl J Med 2021; 385:1145-1146
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
doi : 10.1056/NEJMc2108482
N Engl J Med 2021; 385:1147-1149
Bimekizumab versus Adalimumab in Plaque Psoriasis
doi : 10.1056/NEJMc2113092
N Engl J Med 2021; 385:1149-1150
The Evolving Challenge of Infections in Cirrhosis
doi : 10.1056/NEJMc2111760
N Engl J Med 2021; 385:1150-1152
