New England Journal of Medicine

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SARS-CoV-2 Human Challenge Studies — Establishing the Model during an Evolving Pandemic

Garth Rapeport, M.B., B.Ch., Emma Smith, Ph.D., Anthony Gilbert, M.B., B.Ch., Andrew Catchpole, D.Phil., Helen McShane, F.Med.Sci., and Christopher Chiu, B.M., B.Ch., Ph.D.

doi : 10.1056/NEJMp2106970

N Engl J Med 2021; 385:961-964

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Supporting Value-Based Health Care — Aligning Financial and Legal Accountability

Mark M. Zaki, M.D., M.B.A., Anupam B. Jena, M.D., Ph.D., and Amitabh Chandra, Ph.D.

doi : 10.1056/NEJMp2105625

N Engl J Med 2021; 385:965-967

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Environmental Racism and Climate Change — Missed Diagnoses

Renee N. Salas, M.D., M.P.H.

doi : 10.1056/NEJMp2109160

N Engl J Med 2021; 385:967-969

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“Vaccine Passport” Certification — Policy and Ethical Considerations

Mark A. Hall, J.D., and David M. Studdert, Sc.D., L.L.B., M.P.H.

doi : 10.1056/NEJMp2104289

N Engl J Med 2021; 385:e32

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Prospective, Multicenter, Controlled Trial of Mobile Stroke Units

James C. Grotta, M.D., Jose-Miguel Yamal, Ph.D., Stephanie A. Parker, M.H.A., Suja S. Rajan, Ph.D., Nicole R. Gonzales, M.D., William J. Jones, M.D., Anne W. Alexandrov, Ph.D., Babak B. Navi, M.D., May Nour, M.D., Ph.D., Ilana Spokoyny, M.D., Jason Mackey, M.D., David Persse, M.D., Asha P. Jacob, M.D., Mengxi Wang, Ph.D., Noopur Singh, M.P.H., Andrei V. Alexandrov, M.D., Matthew E. Fink, M.D., Jeffrey L. Saver, M.D., Joey English, M.D., Ph.D., Nobl Barazangi, M.D., Ph.D., Patti L. Bratina, R.N., Michael Gonzalez, M.S., Brandi D. Schimpf, R.N., Kim Ackerson, R.N., Carla Sherman, R.N., Mackenzie Lerario, M.D., Saad Mir, M.D., Jenny Im, R.N., Josh Z. Willey, M.D., David Chiu, M.D., Michael Eisshofer, R.N., Janice Miller, M.D., David Ornelas, R.N., James P. Rhudy, Ph.D., Kevin M. Brown, R.T.R., Bryan M. Villareal, R.N., Marianne Gausche-Hill, M.D., Nichole Bosson, M.D., Greg Gilbert, M.D., Sarah Q. Collins, R.N., Kelly Silnes, M.S., Jay Volpi, M.D., Vivek Misra, M.D., James McCarthy, M.D., Tom Flanagan, M.A., Chethan P.V. Rao, M.D., Joseph S. Kass, M.D., Laura Griffin, D.N.P., Nicole Rangel-Gutierrez, A.C.N.P., Edgar Lechuga, R.N., Jonathan Stephenson, R.N., Kenny Phan, R.T.R., Yvette Sanders, Elizabeth A. Noser, M.D., and Ritvij Bowry, M.D.

doi : 10.1056/NEJMoa2103879

N Engl J Med 2021; 385:971-981

Mobile stroke units (MSUs) are ambulances with staff and a computed tomographic scanner that may enable faster treatment with tissue plasminogen activator (t-PA) than standard management by emergency medical services (EMS). Whether and how much MSUs alter outcomes has not been extensively studied.

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Benefits and Risks of Iron Interventions in Infants in Rural Bangladesh

Sant-Rayn Pasricha, M.B., B.S., Ph.D., M. Imrul Hasan, M.B., B.S., M.P.H., Sabine Braat, M.Sc., Leila M. Larson, Ph.D., S.M. Mulk-Uddin Tipu, M.B.A., Sheikh J. Hossain, M.P.H., Shamima Shiraji, M.Sc., Andrew Baldi, M.B., B.S., Mohammad S.A. Bhuiyan, M.B., B.S., Fahmida Tofail, Ph.D., Jane Fisher, Ph.D., Sally Grantham-McGregor, F.R.C.P., Julie A. Simpson, Ph.D., Jena D. Hamadani, M.B., B.S., Ph.D., and Beverley-Ann Biggs, M.B., B.S., Ph.D.

doi : 10.1056/NEJMoa2034187

N Engl J Med 2021; 385:982-995

Universal provision of iron supplements (drops or syrup) or multiple micronutrient powders to young children in low-to-middle-income countries where anemia is prevalent is recommended by the World Health Organization and widely implemented. The functional benefits and safety of these interventions are unclear.

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Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous Malformations

Matthieu Peyre, M.D., Ph.D., Danielle Miyagishima, Ph.D., Franck Bielle, M.D., Ph.D., Françoise Chapon, M.D., Ph.D., Michael Sierant, Ph.D., Quitterie Venot, Ph.D., Julie Lerond, M.Sc., Pauline Marijon, M.D., Samiya Abi-Jaoude, M.D., Tuan Le Van, M.D., Karim Labreche, Ph.D., Richard Houlston, Ph.D., Maxime Faisant, M.D., Ph.D., Stéphane Clémenceau, M.D., Anne-Laure Boch, M.D., Aurelien Nouet, M.D., Alexandre Carpentier, M.D., Ph.D., Julien Boetto, M.D., Angeliki Louvi, Ph.D., and Michel Kalamarides, M.D., Ph.D.

doi : 10.1056/NEJMoa2100440

N Engl J Med 2021; 385:996-1004

Cerebral cavernous malformations (CCMs) are common sporadic and inherited vascular malformations of the central nervous system. Although familial CCMs are linked to loss-of-function mutations in KRIT1 (CCM1), CCM2, or PDCD10 (CCM3), the genetic cause of sporadic CCMs, representing 80% of cases, remains incompletely understood.

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Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention

Daniel Chandramohan, Ph.D., Issaka Zongo, Ph.D., Issaka Sagara, M.D., Matthew Cairns, Ph.D., Rakiswendé-Serge Yerbanga, Ph.D., Modibo Diarra, M.D., Frédéric Nikièma, M.D., Amadou Tapily, M.D., Frédéric Sompougdou, M.D., Djibrilla Issiaka, M.D., Charles Zoungrana, M.D., Koualy Sanogo, M.D., Alassane Haro, M.Sc., Mahamadou Kaya, M.D., Abdoul-Aziz Sienou, M.Sc., Seydou Traore, M.D., Almahamoudou Mahamar, Pharm.D., Ismaila Thera, M.P.H., Kalifa Diarra, Pharm.D., Amagana Dolo, Ph.D., Irene Kuepfer, Ph.D., Paul Snell, Ph.D., Paul Milligan, Ph.D., Christian Ockenhouse, Ph.D., Opokua Ofori-Anyinam, Ph.D., Halidou Tinto, Ph.D., Abdoulaye Djimde, Ph.D., Jean-Bosco Ouédraogo, Ph.D., Alassane Dicko, M.D., and Brian Greenwood, M.D.

doi : 10.1056/NEJMoa2026330

N Engl J Med 2021; 385:1005-1017

Malaria control remains a challenge in many parts of the Sahel and sub-Sahel regions of Africa.

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