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Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac ArrestA Randomized Clinical Trial
Lars W. Andersen, MD, MPH, PhD, DMSc1,2,3; Dan Isbye, MD, PhD4; Jesper Kjærgaard, MD, PhD, DMSc5; Camilla M. Kristensen, BS4; Søren Darling, MD6; Stine T. Zwisler, MD, PhD6; Stine Fisker, CRNA6; Jens Christian Schmidt, MD6; Hans Kirkegaard, MD, PhD, DMSc1,3; Anders M. Grejs, MD, PhD2; Jørgen R. G. Rossau, MD2; Jacob M. Larsen, MD, PhD7,8; Bodil S. Rasmussen, MD, PhD8,9; Signe Riddersholm, MD, PhD7,8,10; Kasper Iversen, MD, DMSc11,12; Martin Schultz, MD, PhD13; Jakob L. Nielsen, CRNA14; Bo Løfgren, MD, PhD1,10; Kasper G. Lauridsen, MD, PhD1,10,15; Christoffer Sølling, MD, PhD16; Kim Pælestik, MD16; Anders G. Kjærgaard, MD, PhD17; Dorte Due-Rasmussen, MD17; Fredrik Folke, MD, PhD12,18,19; Mette G. Charlot, MD, PhD18; Rikke Malene H. G. Jepsen, MD, PhD20; Sebastian Wiberg, MD, PhD20; Michael Donnino, MD21,22; Tobias Kurth, MD, PhD23; Maria Høybye, BS1; Birthe Sindberg, RN1; Mathias J. Holmberg, MD, MPH, PhD1,24; Asger Granfeldt, MD, PhD, DMSc2
doi : 10.1001/jama.2021.16628
JAMA. 2021;326(16):1586-1594
Previous trials have suggested that vasopressin and methylprednisolone administered during in-hospital cardiac arrest might improve outcomes.
Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle OsteoarthritisA Randomized Clinical Trial
Liam D. A. Paget, MD1,2,3; Gustaaf Reurink, PhD1,2,3,4; Robert-Jan de Vos, PhD5; Adam Weir, PhD5,6,7; Maarten H. Moen, PhD4,8; Sita M. A. Bierma-Zeinstra, PhD5,9; Sjoerd A. S. Stufkens, PhD1,2,3; Gino M. M. J. Kerkhoffs, PhD1,2,3; Johannes L. Tol, PhD2,3,10; for the PRIMA Study Group
doi : 10.1001/jama.2021.16602
JAMA. 2021;326(16):1595-1605
Approximately 3.4% of adults have ankle (tibiotalar) osteoarthritis and, among younger patients, ankle osteoarthritis is more common than knee and hip osteoarthritis. Few effective nonsurgical interventions exist, but platelet-rich plasma (PRP) injections are widely used, with some evidence of efficacy in knee osteoarthritis.
Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021
Emily Jane Woo, MD, MPH1; Adamma Mba-Jonas, MD, MPH1; Rositsa B. Dimova, PhD1; Meghna Alimchandani, MD1; Craig E. Zinderman, MD, MPH1; Narayan Nair, MD1
doi : 10.1001/jama.2021.16496
JAMA. 2021;326(16):1606-1613
As part of postauthorization safety surveillance, the US Food and Drug Administration (FDA) has identified a potential safety concern for Guillain-Barré syndrome (GBS) following receipt of the Ad26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccine.
Representativeness of Participants Eligible to Be Enrolled in Clinical Trials of Aducanumab for Alzheimer Disease Compared With Medicare Beneficiaries With Alzheimer Disease and Mild Cognitive Impairment
Timothy S. Anderson, MD, MAS1; John Z. Ayanian, MD, MPP2,3; Jeffrey Souza, MA4; Bruce E. Landon, MD, MBA4
doi : 10.1001/jama.2021.15286
JAMA. 2021;326(16):1627-1629
Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy
Elyse O. Kharbanda, MD, MPH1; Jacob Haapala, MPH1; Malini DeSilva, MD, MPH1; Gabriela Vazquez-Benitez, PhD1; Kimberly K. Vesco, MD, MPH2; Allison L. Naleway, PhD2; Heather S. Lipkind, MD, MS3
doi : 10.1001/jama.2021.15494
JAMA. 2021;326(16):1629-1631
Trends in Mortality Among Pregnant and Recently Pregnant Women in the US, 2015-2019
Jeffrey T. Howard, PhD1; Corey S. Sparks, PhD2; Alexis R. Santos-Lozada, PhD3; Samson A. Olowolaju, MPH2; Jud C. Janak, PhD4; Krista J. Howard, PhD5
doi : 10.1001/jama.2021.13971
JAMA. 2021;326(16):1631-1633
Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian RandomizationThe STROBE-MR Statement
Veronika W. Skrivankova, PhD1; Rebecca C. Richmond, PhD2,3; Benjamin A. R. Woolf, MSc2,4; James Yarmolinsky, PhD2,3; Neil M. Davies, PhD2,3,5; Sonja A. Swanson, ScD6; Tyler J. VanderWeele, PhD7; Julian P. T. Higgins, PhD3,8; Nicholas J. Timpson, PhD2,3; Niki Dimou, PhD9; Claudia Langenberg, PhD10,11; Robert M. Golub, MD12,13; Elizabeth W. Loder, MD14,15,16; Valentina Gallo, PhD17,18,19; Anne Tybjaerg-Hansen, MD, DMSc20; George Davey Smith, MD, DSc2,3,8; Matthias Egger, MD1,3,21; J. Brent Richards, MD22,23
doi : 10.1001/jama.2021.18236
JAMA. 2021;326(16):1614-1621
Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and aim to reduce potential bias from confounding and reverse causation.
What’s Wrong With Advance Care Planning?
R. Sean Morrison, MD1,2; Diane E. Meier, MD1; Robert M. Arnold, MD3
doi : 10.1001/jama.2021.16430
JAMA. 2021;326(16):1575-1576
Health Care Professionals’ Spirituality and COVID-19Meaning, Compassion, Relationship
Anne L. Dalle Ave, MD, MS1,2; Daniel P. Sulmasy, MD, PhD2,3
doi : 10.1001/jama.2021.16769
JAMA. 2021;326(16):1577-1578
Paying for Cancer Drugs That Prove Their Benefit
Richard G. Frank, PhD1; Ezekiel J. Emanuel, MD, PhD2
doi : 10.1001/jama.2021.18308
JAMA. 2021;326(16):1579-1580
Marketing Medicine's Diversity: Issuing Promissory Notes for Health Care Equity
Michael O. Mensah, MD, MPH1
doi : 10.1001/jama.2021.17995
JAMA. 2021;326(16):1581-1582
Vasopressin and Steroids as Adjunctive Treatment for In-Hospital Cardiac Arrest
Jason Haukoos, MD, MSc1,2; Ivor S. Douglas, MD3; Comilla Sasson, MD, PhD4
doi : 10.1001/jama.2021.15460
JAMA. 2021;326(16):1583-1585
Serial Bone Density Measurement for Osteoporosis Screening
William D. Leslie, MD, MSc1; Carolyn J. Crandall, MD, MS2,3
doi : 10.1001/jama.2021.9858
JAMA. 2021;326(16):1622-1623
Gastrointestinal Evaluation of Iron Deficiency Anemia
Nabil M. Abou Baker, MD1; Andrew M. Davis, MD, MPH1
doi : 10.1001/jama.2021.11604
JAMA. 2021;326(16):1624-1625
COVID-19 Crisis Advances Efforts to Reimagine Nursing Homes
Jennifer Abbasi
doi : 10.1001/jama.2021.13326
JAMA. 2021;326(16):1568-1570
Assessing a Veterinary Sedative’s Role in Drug Overdose Deaths
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.18416
JAMA. 2021;326(16):1573
Aspergillosis Is Common Among COVID-19 Patients in the ICU
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.17973
JAMA. 2021;326(16):1573
Salt Substitute Cut Disease and Death Rates in Large Trial
Anita Slomski
doi : 10.1001/jama.2021.17441
JAMA. 2021;326(16):1572
Prompting Outpatients to Complete Advance Care Planning
Anita Slomski
doi : 10.1001/jama.2021.18589
JAMA. 2021;326(16):1572
Polypill for Initial Hypertension Treatment Is Promising
Anita Slomski
doi : 10.1001/jama.2021.18590
JAMA. 2021;326(16):1572
Bacterial Immunotherapy Reduced Kids’ Wheezing
Anita Slomski
doi : 10.1001/jama.2021.18591
JAMA. 2021;326(16):1572
Improving Contact Tracing Phone Apps
Rita Rubin, MA
doi : 10.1001/jama.2021.17661
JAMA. 2021;326(16):1571
Studying How Genomic Variation Affects Human Health
Rita Rubin, MA
doi : 10.1001/jama.2021.18645
JAMA. 2021;326(16):1571
Coordinating Diet-Related Efforts to Reduce Obesity
Rita Rubin, MA
doi : 10.1001/jama.2021.18646
JAMA. 2021;326(16):1571
The Recording and Reproduction of Cardiac and Respiratory Sounds
doi : 10.1001/jama.2021.15202
JAMA. 2021;326(16):1639
Durable Power of Attorney for Health Care
Kristin Walter, MD, MS1
doi : 10.1001/jama.2021.15882
JAMA. 2021;326(16):1642
A Review of General Health Checks in Adult Primary Care
Jeremy S. Faust, MD, MS1
doi : 10.1001/jama.2021.13870
JAMA. 2021;326(16):1633-1634
A Review of General Health Checks in Adult Primary Care—Reply
David T. Liss, PhD1; Cheryl L. Wilkes, MD1; Jeffrey A. Linder, MD, MPH1
doi : 10.1001/jama.2021.13882
JAMA. 2021;326(16):1634
Systematic Review of Counseling and Behavioral Interventions for Healthy Weight and Weight Gain in Pregnancy From the US Preventive Services Task Force
Jodie M. Dodd, PhD1; Kathryn Dalrymple, PhD2; Jennie Louise, PhD1
doi : 10.1001/jama.2021.13992
JAMA. 2021;326(16):1634-1635
Systematic Review of Counseling and Behavioral Interventions for Healthy Weight and Weight Gain in Pregnancy From the US Preventive Services Task Force—Reply
Amy G. Cantor, MD, MPH1; Rebecca M. Jungbauer, DrPH1; Roger Chou, MD1
doi : 10.1001/jama.2021.13995
JAMA. 2021;326(16):1635-1636
Systematic Review and Meta-analysis of Acute Treatments for Episodic Migraine in Adults
John C. Hagan III, MD1
doi : 10.1001/jama.2021.14060
JAMA. 2021;326(16):1636
Systematic Review and Meta-analysis of Acute Treatments for Episodic Migraine in Adults
Xavier Moisset, MD, PhD1; Geneviève Demarquay, MD, PhD2; Anne Ducros, MD, PhD3
doi : 10.1001/jama.2021.14063
JAMA. 2021;326(16):1636-1637
Systematic Review and Meta-analysis of Acute Treatments for Episodic Migraine in Adults—Reply
Zhen Wang, PhD1; Juliana H. VanderPluym, MD2; Mohammad Hassan Murad, MD, MPH1
doi : 10.1001/jama.2021.14069
JAMA. 2021;326(16):1637
