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Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking CessationA Randomized Clinical Trial
Timothy B. Baker, PhD1,2; Megan E. Piper, PhD1,2; Stevens S. Smith, PhD1,2; Daniel M. Bolt, PhD3; James H. Stein, MD4; Michael C. Fiore, MD1,2
doi : 10.1001/jama.2021.15333
JAMA. 2021;326(15):1485-1493
Smoking cessation medications are routinely used in health care. Research suggests that combining varenicline with the nicotine patch, extending the duration of varenicline treatment, or both, may increase cessation effectiveness.
Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac ArrestThe CAPITAL CHILL Randomized Clinical Trial
Michel Le May, MD1; Christina Osborne, BSc1; Juan Russo, MD1; Derek So, MD1; Aun Yeong Chong, MD1; Alexander Dick, MD1; Michael Froeschl, MD1; Christopher Glover, MD1; Benjamin Hibbert, MD1; Jean-François Marquis, MD1; Sophie De Roock, MD1; Marino Labinaz, MD1; Jordan Bernick, MSc1; Shawn Marshall, MD2; Ronnen Maze, MD1; George Wells, PhD1,3
doi : 10.1001/jama.2021.15703
JAMA. 2021;326(15):1494-1503
Comatose survivors of out-of-hospital cardiac arrest experience high rates of death and severe neurologic injury. Current guidelines recommend targeted temperature management at 32 °C to 36 °C for 24 hours. However, small studies suggest a potential benefit of targeting lower body temperatures.
Association of Tramadol vs Codeine Prescription Dispensation With Mortality and Other Adverse Clinical Outcomes
Junqing Xie, BSMed, MSc1; Victoria Y. Strauss, PhD1; Daniel Martinez-Laguna, MD, PhD2,3,4,5; Cristina Carbonell-Abella, MD, PhD2,3,4,13; Adolfo Diez-Perez, MD, PhD2,3,4,5,6; Xavier Nogues, MD, PhD2,5,6,7; Gary S. Collins, PhD1,8; Sara Khalid, PhD1; Antonella Delmestri, PhD1; Aleksandra Turkiewicz, PhD, CStat9; Martin Englund, MD, PhD9; Mina Tadrous, PharmD, PhD10,11; Carlen Reyes, MD, PhD2,4; Daniel Prieto-Alhambra, MD, PhD1,12
doi : 10.1001/jama.2021.15255
JAMA. 2021;326(15):1504-1515
Although tramadol is increasingly used to manage chronic noncancer pain, few safety studies have compared it with other opioids.
Association of Remote vs In-Person Benefit Delivery With WIC Participation During the COVID-19 Pandemic
Aditi Vasan, MD, MSHP1; Chén C. Kenyon, MD, MSHP1; Christina A. Roberto, PhD2; Alexander G. Fiks, MD, MSCE1; Atheendar S. Venkataramani, MD, PhD2
doi : 10.1001/jama.2021.14356
JAMA. 2021;326(15):1531-1533
Comparison of SARS-CoV-2 Antibody Response Following Vaccination With BNT162b2 and mRNA-1273
Deborah Steensels, PharmD, PhD1; Noella Pierlet, MSc1; Joris Penders, MD, PhD1; Dieter Mesotten, MD, PhD1; Line Heylen, MD, PhD1
doi : 10.1001/jama.2021.15125
JAMA. 2021;326(15):1533-1535
The Supreme Court, the Texas Abortion Law (SB8), and the Beginning of the End of Roe v Wade?
I. Glenn Cohen, JD1; Eli Y. Adashi, MD, MS2; Lawrence O. Gostin, JD3
doi : 10.1001/jama.2021.17639
JAMA. 2021;326(15):1473-1474
Coverage of Dental, Vision, and Hearing Services in MedicareThe Window of Opportunity Is Open
Amber Willink, PhD1,2; Karen Davis, PhD2
doi : 10.1001/jama.2021.13291
JAMA. 2021;326(15):1475-1476
Policies to Promote Shared Responsibility for Safer Electronic Health Records
Dean F. Sittig, PhD1; Hardeep Singh, MD, MPH2
doi : 10.1001/jama.2021.13945
JAMA. 2021;326(15):1477-1478
Is There a Role for Combined Use of Varenicline and Nicotine Patch or Extended Treatment Duration to Enhance Smoking Cessation?
Rajat S. Barua, MD, PhD1,2; Mohinder Vindhyal, MD, MEd2
doi : 10.1001/jama.2021.14994
JAMA. 2021;326(15):1481-1482
Tramadol, Codeine, and Risk of Adverse Outcomes
Howard S. Kim, MD, MS1,2,3; Danielle M. McCarthy, MD, MS1,2; Patrick M. Lank, MD, MS1,4
doi : 10.1001/jama.2021.14306
JAMA. 2021;326(15):1483-1484
How to Interpret and Use a Clinical Practice Guideline or RecommendationUsers’ Guides to the Medical Literature
Romina Brignardello-Petersen, DDS, MSc, PhD1; Alonso Carrasco-Labra, DDS, MSc, PhD2,3; Gordon H. Guyatt, MD, MSc1
doi : 10.1001/jama.2021.15319
JAMA. 2021;326(15):1516-1523
Clinicians may rely on recommendations from clinical practice guidelines for management of patients.
Interim Analyses During Group Sequential Clinical Trials
William J. Meurer, MD, MS1,2; Juliana Tolles, MD, MHS3,4
doi : 10.1001/jama.2021.10174
JAMA. 2021;326(15):1524-1525
Retinal Artery Thrombosis and Aortic Valve Vegetations
Shree K. Kurup, MD1; Miroslav Sekulic, MD, MA2; Alan H. Markowitz, MD3
doi : 10.1001/jama.2021.11949
JAMA. 2021;326(15):1526-1527
Interpreting SARS-CoV-2 Test Results
KC Coffey, MD, MPH1; Daniel J. Diekema, MD, MS2; Daniel J. Morgan, MD, MS1
doi : 10.1001/jama.2021.16146
JAMA. 2021;326(15):1528-1529
The Lingua Franca of Addiction—Stigmatizing Words That Wound
Anita Slomski
doi : 10.1001/jama.2021.16186
JAMA. 2021;326(15):1468-1470
Supplement Marketers Are Warned About Diabetes Claims
Rebecca Voelker, MSJ
doi : 10.1001/jama.2021.18267
JAMA. 2021;326(15):1472
Biosimilar Approved for Wet AMD
Rebecca Voelker, MSJ
doi : 10.1001/jama.2021.17342
JAMA. 2021;326(15):1472
Progress in FDA’s Review of Millions of Tobacco Products
Rebecca Voelker, MSJ
doi : 10.1001/jama.2021.18268
JAMA. 2021;326(15):1472
WHO: Need for Global Dementia Care Planning Is Urgent
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.17456
JAMA. 2021;326(15):1471
Higher Mortality Risk Among Transgender People
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.18251
JAMA. 2021;326(15):1471
COVID-19 Rolls Back Progress Against HIV, TB, and Malaria
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.18252
JAMA. 2021;326(15):1471
Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab and Remission Induction in ANCA-Associated Vasculitis
Kunal Chandwar, MD1; Puneet Kumar, MD1; Urmila Dhakad, MD1
doi : 10.1001/jama.2021.13863
JAMA. 2021;326(15):1535
Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab and Remission Induction in ANCA-Associated Vasculitis
Zhijuan Kang, MD1; Zhihui Li, MD1
doi : 10.1001/jama.2021.13867
JAMA. 2021;326(15):1535-1536
Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab and Remission Induction in ANCA-Associated Vasculitis
David R. W. Jayne, MD1; Peter A. Merkel, MD, MPH2; Pirow Bekker, MD, PhD3
doi : 10.1001/jama.2021.13873
JAMA. 2021;326(15):1536
Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab and Remission Induction in ANCA-Associated Vasculitis—Reply
Shunsuke Furuta, MD, PhD1; Kei Ikeda, MD, PhD1; Hiroshi Nakajima, MD, PhD1
doi : 10.1001/jama.2021.13879
JAMA. 2021;326(15):1536-1537
Continuous Infusion of Hypertonic Saline vs Standard Care and 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury
Randall M. Chesnut, MD1
doi : 10.1001/jama.2021.13860
JAMA. 2021;326(15):1537
Continuous Infusion of Hypertonic Saline vs Standard Care and 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury—Reply
Antoine Roquilly, MD, PhD1; Karim Asehnoune, MD, PhD1; for the Atlanrea Study Group and the Société Française d’Anesthésie Réanimation (SFAR) Research Network
doi : 10.1001/jama.2021.13876
JAMA. 2021;326(15):1537-1538
