JAMA - Journal of the American Medical Association




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Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell CarcinomaThe ESCORT-1st Randomized Clinical Trial

Huiyan Luo, MD, PhD1,2; Jin Lu, BS3; Yuxian Bai, MD4; Teng Mao, MM5; Jun Wang, MD6; Qingxia Fan, BS7; Yiping Zhang, MB8; Kuaile Zhao, MD9; Zhendong Chen, MB10; Shegan Gao, MD11; Jiancheng Li, MD12; Zhichao Fu, MD13; Kangsheng Gu, MD14; Zhihua Liu, MD15; Lin Wu, MD16; Xiaodong Zhang, MD17; Jifeng Feng, PhD18; Zuoxing Niu, MM19; Yi Ba, MD20; Helong Zhang, MD21; Ying Liu, MD22; Li Zhang, MB23; Xuhong Min, BS24; Jing Huang, MD25; Ying Cheng, MD26; Dong Wang, MD27; Yu Shen, PhD28; Qing Yang, MD28; Jianjun Zou, MD28; Rui-Hua Xu, MD, PhD1,2; for the ESCORT-1st Investigators

doi : 10.1001/jama.2021.12836

JAMA. 2021;326(10):916-925

Standard first-line therapy for advanced or metastatic esophageal carcinoma is chemotherapy, but the prognosis remains poor. Camrelizumab (an anti–programmed death receptor 1 [PD-1] antibody) showed antitumor activity in previously treated advanced or metastatic esophageal squamous cell carcinoma.

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Effect of Urate-Elevating Inosine on Early Parkinson Disease ProgressionThe SURE-PD3 Randomized Clinical Trial

The Parkinson Study Group SURE-PD3 Investigators

doi : 10.1001/jama.2021.10207

JAMA. 2021;326(10):926-939

Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, and clinical data.

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Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill PatientsA Randomized Clinical Trial

Harry Gelissen, MD, MBA1; Harm-Jan de Grooth, MD, PhD1,2; Yvo Smulders, MD, PhD3; Evert-Jan Wils, MD, PhD4; Wouter de Ruijter, MD, PhD5; Roel Vink, MD, PhD6; Bob Smit, PhD1,7; Jantine Röttgering, MD1; Leila Atmowihardjo, MD1; Armand Girbes, MD, PhD1; Paul Elbers, MD, PhD1; Pieter-Roel Tuinman, MD, PhD1; Heleen Oudemans-van Straaten, MD, PhD1; Angelique de Man, MD, PhD1

doi : 10.1001/jama.2021.13011

JAMA. 2021;326(10):940-948

Hyperoxemia may increase organ dysfunction in critically ill patients, but optimal oxygenation targets are unknown.

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Trends in Mortality From COVID-19 and Other Leading Causes of Death Among Latino vs White Individuals in Los Angeles County, 2011-2020

Paul Simon, MD1; Alex Ho, MD1; Megha D. Shah, MD1; Rashmi Shetgiri, MD1

doi : 10.1001/jama.2021.11945

JAMA. 2021;326(10):973-974

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Screening for Chlamydia and GonorrheaUS Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force

doi : 10.1001/jama.2021.14081

JAMA. 2021;326(10):949-956

Chlamydia and gonorrhea are among the most common sexually transmitted infections in the US. Infection rates are highest among adolescents and young adults of both sexes. Chlamydial and gonococcal infections in women are usually asymptomatic and may lead to pelvic inflammatory disease and its associated complications. Newborns of pregnant persons with untreated infection may develop neonatal chlamydial pneumonia or gonococcal or chlamydial ophthalmia. Infection in men may lead to urethritis and epididymitis. Both types of infection can increase risk of acquiring or transmitting HIV.

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Screening for Chlamydial and Gonococcal InfectionsUpdated Evidence Report and Systematic Review for the US Preventive Services Task Force

Amy Cantor, MD, MPH1,2,3; Tracy Dana, MLS1; Jessica C. Griffin, MS1; Heidi D. Nelson, MD, MPH4; Chandler Weeks, MPH1; Kevin L. Winthrop, MD, MPH5; Roger Chou, MD1

doi : 10.1001/jama.2021.10577

JAMA. 2021;326(10):957-966

The 2014 US Preventive Services Task Force (USPSTF) recommendation statement supported the effectiveness of screening for chlamydia and gonorrhea in asymptomatic, sexually active women 24 years or younger and in older women at increased risk for infection, although evidence for screening in men was insufficient.

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Making Vaccines Available to Other Countries Before Offering Domestic Booster Vaccinations

G. Owen Schaefer, DPhil1; R. J. Leland, PhD2; Ezekiel J. Emanuel, MD, PhD3

doi : 10.1001/jama.2021.13226

JAMA. 2021;326(10):903-904

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Setting the Stage for the Next 10 Years of Health Care Payment Innovation

Bob Kocher, MD1,2,3; Rahul Rajkumar, MD4,5

doi : 10.1001/jama.2021.13153

JAMA. 2021;326(10):905-906

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Private Equity and Health Care DeliveryValue-Based Payment as a Guardrail?

Brian W. Powers, MD, MBA1,2; William H. Shrank, MD, MSHS1; Amol S. Navathe, MD, PhD3,4

doi : 10.1001/jama.2021.13197

JAMA. 2021;326(10):907-908

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Preventing a Pandemic's Toll—We've Been Here Before

Abigail Zuger, MD1

doi : 10.1001/jama.2021.14402

JAMA. 2021;326(10):909-910

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Titrating Oxygen Therapy in Critically Ill Patients

Martin Urner, MD1; Carolyn S. Calfee, MD, MAS2; Eddy Fan, MD, PhD1

doi : 10.1001/jama.2021.9843

JAMA. 2021;326(10):911-913

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Screening for Chlamydia and Gonorrhea

Jeanne Marrazzo, MD, MPH1; Jodie Dionne-Odom, MD, MSPH1

doi : 10.1001/jama.2021.14773

JAMA. 2021;326(10):913-915

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Estimands, Estimators, and Estimates

Roderick J. Little, PhD1; Roger J. Lewis, MD, PhD2,3,4

doi : 10.1001/jama.2021.2886

JAMA. 2021;326(10):967-968

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Pulmonary Rehabilitation in 2021

Carolyn L. Rochester, MD1,2; Martijn A. Spruit, PT, PhD3,4,5; Anne E. Holland, PT, PhD6,7,8

doi : 10.1001/jama.2021.6560

JAMA. 2021;326(10):969-970

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Influenza’s Unprecedented Low Profile During COVID-19 Pandemic Leaves Experts Wondering What This Flu Season Has in Store

Rita Rubin, MA

doi : 10.1001/jama.2021.14131

JAMA. 2021;326(10):899-900

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Adolescent Myocarditis After COVID-19 Vaccination Is Rare

Bridget M. Kuehn, MSJ

doi : 10.1001/jama.2021.14237

JAMA. 2021;326(10):902

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Severe Tuberculosis Surged After Shelter-in-Place Lifted

Bridget M. Kuehn, MSJ

doi : 10.1001/jama.2021.14683

JAMA. 2021;326(10):902

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SARS-CoV-2 Variant Antibodies Wane 6 Months After Vaccination

Jennifer Abbasi

doi : 10.1001/jama.2021.15115

JAMA. 2021;326(10):901

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Potential New Immune-Checkpoint Inhibitor Partner for Lung Cancer

Jennifer Abbasi

doi : 10.1001/jama.2021.14765

JAMA. 2021;326(10):901

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Point-of-Care SARS-CoV-2 Variant Diagnostic in Development

Jennifer Abbasi

doi : 10.1001/jama.2021.15116

JAMA. 2021;326(10):901

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Taxonomy of the Oaks

Matthew Joel Goodman, MD1

doi : 10.1001/jama.2021.10293

JAMA. 2021;326(10):980

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The Fad for Pseudoscience: Pertinent Queries and Musings

doi : 10.1001/jama.2020.18122

JAMA. 2021;326(10):981

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Screening for Chlamydia and Gonorrhea

Jill Jin, MD, MPH1

doi : 10.1001/jama.2021.14770

JAMA. 2021;326(10):984

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Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease

Marcel J. H. Kenter, PhD1; Adam F. Cohen, MD, PhD2

doi : 10.1001/jama.2021.11097

JAMA. 2021;326(10):974-975

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Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease

Umut A. Gurkan, PhD1

doi : 10.1001/jama.2021.11100

JAMA. 2021;326(10):975

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Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease—Reply

James F. Casella, MD1; Shari S. Kronsberg, MS2; Rebecca T. Gorney, MS1

doi : 10.1001/jama.2021.11103

JAMA. 2021;326(10):975-976

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A Review of the Diagnosis and Management of Headache

James T. Langland, MD1

doi : 10.1001/jama.2021.11373

JAMA. 2021;326(10):976

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A Review of the Diagnosis and Management of Headache

Adam G. Evans, MD1; Patrick E. Assi, MD1; Salam Al Kassis, MD1

doi : 10.1001/jama.2021.11376

JAMA. 2021;326(10):977

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A Review of the Diagnosis and Management of Headache

Alexandre Valotta da Silva, MD, PhD1

doi : 10.1001/jama.2021.11370

JAMA. 2021;326(10):977

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A Review of the Diagnosis and Management of Headache—Reply

Matthew S. Robbins, MD1

doi : 10.1001/jama.2021.11379

JAMA. 2021;326(10):977-978

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Percentage Incorrect in 2 Places

doi : 10.1001/jama.2021.13853

JAMA. 2021;326(10):978

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Disclosures Added to Medical News Story

doi : 10.1001/jama.2021.14538

JAMA. 2021;326(10):978

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