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Spotlight on the September 21 Issue
Merino, Jose G. MD, MPhil; Editor-in-Chief, Neurology(R)
doi : 10.1212/WNL.0000000000012579
Volume 97(12), 21 September 2021, p 565-566
Earliest Marker of Brain Injury in Repetitive Sports-Related Concussion: Canary in the Midline?
Bigler, Erin D. PhD; Allder, Steven MD
doi : 10.1212/WNL.0000000000012589
Volume 97(12), 21 September 2021, p 567-569
Modified Pediatric ASPECTS: Building Tools for Future Pediatric Stroke Studies
Lee, Sarah MD; Fox, Christine K. MD, MAS
doi : 10.1212/WNL.0000000000012543
Volume 97(12), 21 September 2021, p 570-571
Acute and Chronic Effects of Multiple Concussions on Midline Brain Structures
Churchill, Nathan W. PhD; Hutchison, Michael G. PhD; Graham, Simon J. PhD; Schweizer, Tom A. PhD
doi : 10.1212/WNL.0000000000012580
Volume 97(12), 21 September 2021, p e1170-e1181
To test the hypothesis that a history of concussion (HOC) causes greater disturbances in cerebral blood flow (CBF) and white matter microstructure of midline brain structures after subsequent concussions, during the acute and chronic phases of recovery.
Association Between Physical Activity and Mortality Among Community-Dwelling Stroke Survivors
Joundi, Raed A. MD, DPhil, FRCPC; Patten, Scott B. MD, PhD; Lukmanji, Aysha BASc; Williams, Jeanne V.A. MSc; Smith, Eric E. MD MPH
doi : 10.1212/WNL.0000000000012535
Volume 97(12), 21 September 2021, p e1182-e1191
To determine the relationship between physical activity (PA) and mortality in community-dwelling stroke survivors.
Incidence of Stroke in Immigrants to Canada: A Province-wide Retrospective Analysis
Vyas, Manav V. MBBS, PhD; Austin, Peter C. PhD; Pequeno, Priscila MSc; Fang, Jiming PhD; Silver, Frank L. MD, MSc; Laupacis, Andreas MD; Kapral, Moira K. MD, MSc
doi : 10.1212/WNL.0000000000012555
Volume 97(12), 21 September 2021, p e1192-e1201
To evaluate the association between immigration status and stroke incidence.
Association of Pediatric ASPECTS and NIH Stroke Scale, Hemorrhagic Transformation, and 12-Month Outcome in Children With Acute Ischemic Stroke
Beslow, Lauren A. MD, MSCE; Vossough, Arastoo MD, PhD; Ichord, Rebecca N. MD; Slavova, Nedelina MD; Yau, Maggie L.Y. MBBS; Gajera, Jay MD; Stojanovski, Belinda BSc; Adil, Malik M. MD; Breimann, Jake BA; Kimmel, Alexandra BA; Mackay, Mark T. MBBS, PhD
doi : 10.1212/WNL.0000000000012558
Volume 97(12), 21 September 2021, p e1202-e1209
We aimed to determine whether a modified pediatric Alberta Stroke Program Early CT Score (modASPECTS) is associated with clinical stroke severity, hemorrhagic transformation, and 12-month functional outcomes in children with acute arterial ischemic stroke (AIS).
Seizure Incidence Rates in Children and Adults With Familial Cerebral Cavernous Malformations
Fox, Christine K. MD, MAS; Nelson, Jeffrey MS; McCulloch, Charles E. PhD; Weinsheimer, Shantel PhD; Pawlikowska, Ludmila PhD; Hart, Blaine MD; Mabray, Marc C. MD; Zafar, Atif MD; Morrison, Leslie MD; Zabramski, Joseph M. MD; Akers, Amy PhD; Kim, Helen MPH, PhD
doi : 10.1212/WNL.0000000000012569
Volume 97(12), 21 September 2021, p e1210-e1216
Seizure incidence rates related to familial cerebral cavernous malformation (FCCM) are not well described, especially for children. To measure the seizure incidence rate, examine seizure predictors, and characterize epilepsy severity, we studied a cohort of children and adults with FCCM enrolled in the Brain Vascular Malformation Consortium (BVMC).
Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort
Grinspan, Zachary M. MD, MS; Knupp, Kelly G. MD; Patel, Anup D. MD; Yozawitz, Elissa G. MD; Wusthoff, Courtney J. MD; Wirrell, Elaine C. MD; Valencia, Ignacio MD; Singhal, Nilika S. MD; Nordli, Douglas R. MD; Mytinger, John R. MD; Mitchell, Wendy G. MD; Keator, Cynthia G. MD; Loddenkemper, Tobias MD; Hussain, Shaun A. MD; Harini, Chellamani MD; Gaillard, William D. MD; Fernandez, Ivan S. MD; Coryell, Jason MD; Chu, Catherine J. MD; Berg, Anne T. PhD; Shellhaas, Renee A. MD, MS
doi : 10.1212/WNL.0000000000012511
Volume 97(12), 21 September 2021, p e1217-e1228
To compare the effectiveness of initial treatment for infantile spasms.
Associations of Fully Automated CSF and Novel Plasma Biomarkers With Alzheimer Disease Neuropathology at Autopsy
Grothe, Michel J. PhD*; Moscoso, Alexis PhD*; Ashton, Nicholas J. PhD; Karikari, Thomas K. PhD; Lantero-Rodriguez, Juan MSc; Snellman, Anniina PhD; Zetterberg, Henrik MD, PhD; Blennow, Kaj MD, PhD+; Scholl, Michael PhD+; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000012513
Volume 97(12), 21 September 2021, p e1229-e1242
To study CSF biomarkers of Alzheimer disease (AD) analyzed by fully automated Elecsys immunoassays compared to neuropathologic gold standards and to compare their accuracy to plasma phosphorylated tau (p-tau181) measured with a novel single molecule array method.
Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous APOE [Latin Small Letter Open E]4 Carriers
Tao, Qiushan MD, MS; Alvin Ang, Ting Fang MD; Akhter-Khan, Samia C. MS; Itchapurapu, Indira Swetha MPH; Killiany, Ronald PhD; Zhang, Xiaoling MD, PhD; Budson, Andrew E. MD; Turk, Katherine W. MD; Goldstein, Lee MD, PhD; Mez, Jesse MS, MD; Alosco, Michael L. PhD; Qiu, Wei Qiao MD, PhD; for the Alzheimer's Disease Neuroimaging Initiative
doi : 10.1212/WNL.0000000000012512
Volume 97(12), 21 September 2021, p e1243-e1252
Previous research has shown that elevated blood C-reactive protein (CRP) is associated with increased Alzheimer disease (AD) risk only in APOE [epsilon]4 allele carriers; the objective of this study was to examine the interactive effects of plasma CRP and APOE genotype on cognition and AD biomarkers.
What Is the Role of GABA Transporters in Seizures?
Benarroch, Eduardo MD
doi : 10.1212/WNL.0000000000012574
Volume 97(12), 21 September 2021, p 580-584
Use of Social Media in Health Care-Opportunities, Challenges, and Ethical Considerations: A Position Statement of the American Academy of Neurology
Busl, Katharina M. MD, MS; Rubin, Michael A. MD, MA; Tolchin, Benjamin D. MD, MS; Larriviere, Dan MD, JD; Epstein, Leon MD; Kirschen, Matthew MD, PhD; Taylor, Lynne P. MD; on behalf of the Ethics, Law, and Humanities Committee, a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society; on behalf of the Ethics, Law, and Humanities Committee, a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society
doi : 10.1212/WNL.0000000000012557
Volume 97(12), 21 September 2021, p 585-594
Amnestic MCI in ADNI: Maybe Not Enough Memory Impairment?
Duff, Kevin PhD; on behalf of the ADNI investigators
doi : 10.1212/WNL.0000000000012587
Volume 97(12), 21 September 2021, p 595-596
MCI Criteria in ADNI: Meeting Biological Expectations
Petersen, Ronald C. MD, PhD
doi : 10.1212/WNL.0000000000012588
Volume 97(12), 21 September 2021, p 597-599
Garcin Syndrome in a Patient With Neurolymphomatosis
Nishida, Katsuya MD; Takenaka, Yu MD; Yamasaki, Hiroshi MD, PhD; Futamura, Naonobu MD, PhD
doi : 10.1212/WNL.0000000000012485
Volume 97(12), 21 September 2021, p 600-601
Pearls & Oy-sters: Adult-Onset Alexander Disease With Transient Swelling of the Medulla Oblongata
Oshima, Yuki MD; Takahashi-Iwata, Ikuko MD, PhD; Sato, Shoki MD; Harada, Taisuke MD, PhD; Yoshida, Tomokatsu MD, PhD; Yabe, Ichiro MD, PhD
doi : 10.1212/WNL.0000000000012268
Volume 97(12), 21 September 2021, p 602-605
Child Neurology: RNA Sequencing for the Diagnosis of Lissencephaly
Qashqari, Hebah MBBS, FRCPC; Ramani, Arun PhD; Gonorazky, Hernan MD; Amburgey, Kimberly MSc; Ghahramani Seno, Mohammad M. DVM, PhD; Brudno, Michael PhD; Naumenko, Sergey PhD; Das, Soma PhD; Dowling, James J. MD, PhD
doi : 10.1212/WNL.0000000000012265
Volume 97(12), 21 September 2021, p e1253-e1256
Clinical Reasoning: A 65-Year-Old Woman With Tremor
Ye, Jing MD*; Cao, Hua MD*; Chen, Lizhang MD; Lei, Song MD; Liu, Mei MD; Long, Xiuying MD; Li, Guangzong MD; Zheng, Hongbo MD
doi : 10.1212/WNL.0000000000012262
Volume 97(12), 21 September 2021, p e1257-e1261
Teaching NeuroImage: CAR-T-Induced Nonconvulsive Status Epilepticus
Rodriguez, Yvo MD; AlGaeed, Mohanad MD; Dolbec, Katelyn MD; Pang, Trudy MD
doi : 10.1212/WNL.0000000000012182
Volume 97(12), 21 September 2021, p e1262-e1263
Teaching NeuroImage: Palindromic Rheumatoid Meningitis: A Tale of 2 Hemispheres
doi : 10.1212/WNL.0000000000012365
Volume 97(12), 21 September 2021, p e1264-e1265
Editors' Note: Association of Time of Day When Endovascular Therapy for Stroke Starts and Functional Outcome
Siegler, James E. MD; Galetta, Steven MD
doi : 10.1212/WNL.0000000000012581
Volume 97(12), 21 September 2021, p 606
Reader Response: Association of Time of Day When Endovascular Therapy for Stroke Starts and Functional Outcome
Aristizabal-Carmona, Brayan; Lozada-Martinez, Ivan; Picon-Jaimes, Yelson; Moscote-Salazar, Luis; Pacheco-Hernandez, Alfonso
doi : 10.1212/WNL.0000000000012582
Volume 97(12), 21 September 2021, p 606-607
Author Response: Association of Time of Day When Endovascular Therapy for Stroke Starts and Functional Outcome
Hajdu, Steven D.; Kaesmacher, Johannes; Gralla, Jan; Fischer, Urs; Saliou, Guillaume
doi : 10.1212/WNL.0000000000012583
Volume 97(12), 21 September 2021, p 607
Editors' Note: Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE [epsilon]4, and Cognitive Impairment
Siegler, James E. MD; Galetta, Steven MD
doi : 10.1212/WNL.0000000000012584
Volume 97(12), 21 September 2021, p 607-608
Reader Response: Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE [epsilon]4, and Cognitive Impairment
Garnier-Crussard, Antoine; Krolak-Salmon, Pierre
doi : 10.1212/WNL.0000000000012585
Volume 97(12), 21 September 2021, p 608
Author Response: Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE [epsilon]4, and Cognitive Impairment
Therriault, Joseph; Pascoal, Tharick; Gauthier, Serge; Rosa-Neto, Pedro
doi : 10.1212/WNL.0000000000012586
Volume 97(12), 21 September 2021, p 609
