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The Role of HIF1?-PFKFB3 Pathway in Diabetic Retinopathy
Jie Min, Tianshu Zeng, Margaretha Roux, David Lazar, Lulu Chen, Slavica Tudzarova
doi : 10.1210/clinem/dgab362
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2505–2519
Diabetic retinopathy (DR) is the leading cause of blindness for adults in developed countries. Both microvasculopathy and neurodegeneration are implicated in mechanisms of DR development, with neuronal impairment preceding microvascular abnormalities, which is often underappreciated in the clinic. Most current therapeutic strategies, including anti-vascular endothelial growth factor (anti-VEGF)-antibodies, aim at treating the advanced stages (diabetic macular edema and proliferative diabetic retinopathy) and fail to target the neuronal deterioration. Hence, new therapeutic approach(es) intended to address both vascular and neuronal impairment are urgently needed.
Changes in Regional Fat Distribution and Anthropometric Measures Across the Menopause Transition
Gail A Greendale, Weijuan Han, Joel S Finkelstein, Sherri-Ann M Burnett-Bowie, MeiHua Huang, Deborah Martin, Arun S Karlamangla
doi : 10.1210/clinem/dgab389
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2520–2534
The relation between the menopause transition (MT) and changes in regional fat distribution is uncertain.
Development and Evaluation of Deep Learning-based Automated Segmentation of Pituitary Adenoma in Clinical Task
He Wang, Wentai Zhang, Shuo Li, Yanghua Fan, Ming Feng, Renzhi Wang
doi : 10.1210/clinem/dgab371
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2535–2546
The resection plan of pituitary adenoma (PA) needs preoperative observation of the sellar region. Radiomics prediction requires high-quality segmentations. Manual delineation is time-consuming and subject to rater variability.
Poor Endometrial Proliferation After Clomiphene is Associated With Altered Estrogen Action
Leah Hawkins Bressler, Marc A Fritz, San-Pin Wu, Lingwen Yuan, Suzanna Kafer, Tianyuan Wang, Francesco J DeMayo, Steven L Young
doi : 10.1210/clinem/dgab381
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2547–2565
Suboptimal endometrial thickening is associated with lower pregnancy rates and occurs in some infertile women treated with clomiphene.
Effects of Synbiotic Supplementation and Lifestyle Modifications on Women With Polycystic Ovary Syndrome
Izabela Chudzicka-Struga?a, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J Duleba
doi : 10.1210/clinem/dgab369
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2566–2573
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age.
Joint Genome-Wide Association Analyses Identified 49 Novel Loci For Age at Natural Menopause
Lei Zhang, Xin-Tong Wei, Jun-Jie Niu, Zi-Xuan Lin, Qian Xu, Jing-Jing Ni, Wan-Lin Zhang, Bai-Xue Han, Shan-Shan Yan, Gui-Juan Feng, Hong Zhang, Xiao-Lin Yang, Zi-Jia Zhang, Rong Hai, Hai-Gang Ren, Feng Zhang, Yu-Fang Pei
doi : 10.1210/clinem/dgab377
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2574–2591
Age at natural menopause (ANM) is an important index for women’s health. Either early or late ANM is associated with a series of adverse outcomes later in life. Despite being an inheritable trait, its genetic determinant has not yet been fully understood.
Rate and Predictors of 30-day Readmission Following Diabetic Ketoacidosis in Type 1 Diabetes Mellitus: A US Analysis
Hafeez Shaka, Maria Aguilera, Maria Aucar, Zain El-Amir, Farah Wani, Chukwudi Charles Muojieje, Asim Kichloo
doi : 10.1210/clinem/dgab372
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2592–2599
Diabetic ketoacidosis (DKA) is a serious endocrine emergency, associated with morbidity and mortality. Readmissions play a significant but sometimes preventable role in healthcare cost burden on the US.
Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome
Burçin Gönül ?remli, Süleyman Nahit ?endur, U?ur Ünlütürk
doi : 10.1210/clinem/dgab373
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2600–2605
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome) can be seen as a postvaccination phenomenon that occurs after exposure to adjuvants in vaccines that increase the immune responses. There are very limited data regarding ASIA syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.
Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System
Lia Puder, Sophie Roth, Philipp Krabusch, Susanna Wiegand, Robert Opitz, Martin Bald, Christa Flück, Esther Schulz, Egbert Voss, Lajos Markó, Peter Linz, Felix Berger, Dominik N Müller, Titus Kuehne, Michael J Litt, Roger D Cone, Peter Kühnen, Marcus Kelm
doi : 10.1210/clinem/dgab368
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2606–2616
Pro-opiomelanocortin (POMC) and the melanocortin-4 receptor (MC4R) play a pivotal role in the leptin–melanocortin pathway. Mutations in these genes lead to monogenic types of obesity due to severe hyperphagia. In addition to dietary-induced obesity, a cardiac phenotype without hypertrophy has been identified in MC4R knockout mice.
Effect of Sitagliptin on Islet Function in Pancreatic Insufficient Cystic Fibrosis With Abnormal Glucose Tolerance
Andrea Kelly, Saba Sheikh, Darko Stefanovski, Amy J Peleckis, Sarah C Nyirjesy, Jack N Eiel, Aniket Sidhaye, Russell Localio, Robert Gallop, Diva D De Leon, Denis Hadjiliadis, Ronald C Rubenstein, Michael R Rickels
doi : 10.1210/clinem/dgab365
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2617–2634
Impaired incretin secretion may contribute to the defective insulin secretion and abnormal glucose tolerance (AGT) that associate with worse clinical outcomes in pancreatic insufficient cystic fibrosis (PI-CF). The study objective was to test the hypothesis that dipeptidyl peptidase-4 (DPP-4) inhibitor-induced increases in intact incretin hormone [glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)] concentrations augment insulin secretion and glucagon suppression and lower postprandial glycemia in PI-CF with AGT.
Reproductive Hormone Concentrations and Associated Anatomical Responses: Does Soy Formula Affect Minipuberty in Boys?
Helen B Chin, Andrea Kelly, Margaret A Adgent, Stacy A Patchel, Kerry James, Hubert W Vesper, Julianne C Botelho, Donald Walt Chandler, Babette S Zemel, Joan I Schall, Eileen G Ford, Kassa Darge, Virginia A Stallings, Donna D Baird, Walter J Rogan, David M Umbach
doi : 10.1210/clinem/dgab354
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2635–2645
Soy formula feeding is common in infancy and is a source of high exposure to phytoestrogens, documented to influence vaginal cytology in female infants. Its influence on minipuberty in males has not been established.
A Life Course Approach to the Relationship Between Fetal Growth and Hypothalamic-Pituitary-Adrenal Axis Function
Wrivu N Martin, Carol A Wang, Stephen J Lye, Stephen G Matthews, Rebecca M Reynolds, Carly E McLaughlin, Roger Smith, Craig E Pennell
doi : 10.1210/clinem/dgab341
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2646–2659
Human and animal studies suggest that hypothalamic-pituitary-adrenal axis (HPA-A) function may be programmed in utero; however, these findings are inconsistent. Given the powerful metabolic actions of cortisol, it is important to clarify the influence of early life on adult HPA-A function.
Early Impairment of Insulin Sensitivity, ?-Cell Responsiveness, and Insulin Clearance in Youth with Stage 1 Type 1 Diabetes
Alfonso Galderisi, Antoinette Moran, Carmella Evans-Molina, Mariangela Martino, Nicola Santoro, Sonia Caprio, Claudio Cobelli
doi : 10.1210/clinem/dgab344
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2660–2669
Clinical onset of type 1 diabetes (Stage 3 T1D) is preceded by a presymptomatic phase characterized by multiple islet autoantibodies with normal glucose tolerance (Stage 1 T1D).
Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)—Rather a Bystander Than a Driver of Mortality
Georg Semmler, Sarah Wernly, Sebastian Bachmayer, Isabella Leitner, Bernhard Wernly, Matthias Egger, Lena Schwenoha, Leonora Datz, Lorenz Balcar, Marie Semmler, Felix Stickel, David Niederseer, Elmar Aigner, Christian Datz
doi : 10.1210/clinem/dgab339
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2670–2677
Recently, the novel metabolic dysfunction-associated fatty liver disease (MAFLD) definition has been introduced.
Sequencing Cell-free Fetal DNA in Pregnant Women With GCK-MODY
Soo Heon Kwak, Camille E Powe, Se Song Jang, Michael J Callahan, Sarah N Bernstein, Seung Mi Lee, Sunyoung Kang, Kyong Soo Park, Hak C Jang, Jose C Florez, Jong-Il Kim, Jong Hee Chae
doi : 10.1210/clinem/dgab265
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2678–2689
Individuals with monogenic diabetes due to inactivating glucokinase (GCK) variants typically do not require treatment, except potentially during pregnancy. In pregnancy, fetal GCK genotype determines whether treatment is indicated, but noninvasive methods are not clinically available.
Impaired Bone Microarchitecture in Premenopausal Women With Acromegaly: The Possible Role of Wnt Signaling
Paula P B Silva, Rosa M R Pereira, Liliam Takayama, Clarissa G Borba, Felipe H Duarte, Ericka B Trarbach, Regina Matsunaga Martin, Marcello D Bronstein, Nicholas A Tritos, Raquel S Jallad
doi : 10.1210/clinem/dgab260
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2690–2706
Acromegaly can impair bone integrity, increasing the risk of vertebral fractures (VFs).
Effectiveness and Safety of Thermal Ablation in the Treatment of Primary Hyperparathyroidism: A Multicenter Study
Ying Wei, Cheng-Zhong Peng, Shu-Rong Wang, Jun-Feng He, Li-Li Peng, Zhen-Long Zhao, Xiao-Jing Cao, Yan Li, Ming-An Yu
doi : 10.1210/clinem/dgab240
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2707–2717
Ultrasound (US)-guided thermal ablation has generated recent interest as minimally invasive treatments of primary hyperparathyroidism (pHPT). But definitive evidence for the efficacy of thermal ablation in treating pHPT is not well characterized.
Diminishing Value from Multiple Serial Bone Densitometry in Women Receiving Antiresorptive Medication for Osteoporosis
Gregory A Kline, Suzanne N Morin, Sidney Feldman, Lisa M Lix, William D Leslie
doi : 10.1210/clinem/dgab211
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2718–2725
The value of serial bone mineral density (BMD) monitoring while on osteoporosis therapy is controversial.
Recurrence-Free Survival Analysis in Locally Advanced Pheochromocytoma: First Appraisal
Sophie Moog, Frédéric Castinetti, Christine DoCao, Laurence Amar, Julien Hadoux, Charlotte Lussey-Lepoutre, Françoise Borson-Chazot, Delphine Vezzosi, Delphine Drui, Sandrine Laboureau, Marie-Laure Raffin Sanson, Livia Lamartina, Peggy Pierre, Marie Batisse Ligner, Ségolène Hescot, Abir Al Ghuzlan, Karine Renaudin, Rosella Libé, Suzanne Laroche, Gabrielle Deniziaut, Anne-Paule Gimenez-Roqueplo, Arnaud Jannin, Sophie Leboulleux, Carole Guerin, Matthieu Faron, Eric Baudin ENDOCAN-COMETE network and the French Group of Endocrine Tumors (GTE)
doi : 10.1210/clinem/dgab202
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2726–2737
The behavior of locally advanced pheochromocytoma (LAP) remains unknown.
High Levels of Thyroid Hormone Impair Regulatory T Cell Function Via Reduced PD-1 Expression
Yi Zhong, Ting-Ting Lu, Xiao-Mei Liu, Bing-Li Liu, Yun Hu, Shu Liu, Jie Wang, Guo-Qing Li, Xiao-Ming Mao
doi : 10.1210/clinem/dgab191
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2738–2753
Regulatory T cell (Treg) dysfunction plays an important role in the development and progression of Graves’ disease (GD). Programmed cell death 1 (PD-1) prompts FoxP3 in Treg expression and enhances the suppressive activity of Tregs. Whether abnormal expression of PD-1 contributes to the breakdown of Tregs and the role of thyroid hormone in the PD-1 expression of Tregs in GD remain substantially undefined.
AMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age
Reshef Tal, David B Seifer, Renana Tal, Emily Granger, Ethan Wantman, Oded Tal
doi : 10.1210/clinem/dgab168
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2754–2766
Antimüllerian hormone (AMH) level is strongly associated with ovarian response in assisted reproductive technology (ART) cycles but is a poor predictor of live birth. It is unknown whether AMH is associated with cumulative live birth rates (CLBRs) in women with diminished ovarian reserve (DOR).
Vitamin D Supplementation for Prevention of Cancer: The D2d Cancer Outcomes (D2dCA) Ancillary Study
Ranee Chatterjee, Paul Fuss, Ellen M Vickery, Erin S LeBlanc, Patricia R Sheehan, Michael R Lewis, Rowena J Dolor, Karen C Johnson, Sangeeta R Kashyap, Jason Nelson, Anastassios G Pittas, D2d Research Group
doi : 10.1210/clinem/dgab153
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2767–2778
Observational studies suggest that low vitamin D status may be a risk factor for cancer.
A Novel Familial PHP1B Variant With Incomplete Loss of Methylation at GNAS-A/B and Enhanced Methylation at GNAS-AS2
Patrick Hanna, Bruno Francou, Brigitte Delemer, Harald Jüppner, Agnès Linglart
doi : 10.1210/clinem/dgab136
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2779–2787
Pseudohypoparathyroidism type 1B (PHP1B), also referred to as inactivating PTH/PTHrP signaling disorder (iPPSD), is characterized by proximal renal tubular resistance to parathyroid hormone (PTH) leading to hypocalcemia, hyperphosphatemia, and elevated PTH values. Autosomal dominant PHP1B (AD-PHP1B) with loss of methylation at the maternal GNAS A/B:TSS-DMR (transcription start site-differentially methylated region) alone can be caused by maternal deletions involving STX16.
Approach to Obesity in the Older Population
Assaf Buch, Yonit Marcus, Gabi Shefer, Paul Zimmet, Naftali Stern
doi : 10.1210/clinem/dgab359
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages 2788–2805
Until recently, weight loss in older obese people was feared because of ensuing muscle loss and frailty. Facing overall increasing longevity, high rates of obesity in older individuals (age ??65 years) and a growing recognition of the health and functional cost of the number of obesity years, abetted by evidence that intentional weight loss in older obese people is safe, this approach is gradually, but not unanimously, being replaced by more active principles. Lifestyle interventions that include reduced but sufficient energy intake, age-adequate protein and micronutrient intake, coupled with aerobic and resistance exercise tailored to personal limitations, can induce weight loss with improvement in frailty indices. Sustained weight loss at this age can prevent or ameliorate diabetes. More active steps are controversial. The use of weight loss medications, particularly glucagon-like peptide-1 analogs (liraglutide as the first example), provides an additional treatment tier. Its safety and cardiovascular health benefits have been convincingly shown in older obese patients with type 2 diabetes mellitus. In our opinion, this option should not be denied to obese individuals with prediabetes or other obesity-related comorbidities based on age. Finally, many reports now provide evidence that bariatric surgery can be safely performed in older people as the last treatment tier. Risk-benefit issues should be considered with extreme care and disclosed to candidates. The selection process requires good presurgical functional status, individualized consideration of the sequels of obesity, and reliance on centers that are highly experienced in the surgical procedure as well as short-term and long-term subsequent comprehensive care and support.
Outcome Squares Integrating Efficacy and Safety, as Applied to Functioning Pituitary Adenoma Surgery
Friso de Vries, Daniel J Lobatto, Marco J T Verstegen, Pieter J Schutte, Irene C Notting, Mark C Kruit, S Faisal Ahmed, Alberto M Pereira, Wouter R van Furth, Nienke R Biermasz
doi : 10.1210/clinem/dgab138
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3300–e3311
Transsphenoidal surgery is standard care in the treatment of hormone-secreting pituitary adenomas. Current clinician-reported surgical outcome measures are one-dimensional, typically focusing primarily on complete or partial resection, and secondarily on complication rates. However, outcomes are best reflected by the delicate balance of efficacy and complications at patient level.
Compromised Volumetric Bone Density and Microarchitecture in Men With Congenital Hypogonadotropic Hypogonadism
Agnès Ostertag, Georgios E Papadakis, Corinne Collet, Severine Trabado, Luigi Maione, Nelly Pitteloud, Jerome Bouligand, Marie Christine De Vernejoul, Martine Cohen-Solal, Jacques Young
doi : 10.1210/clinem/dgab169
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3312–e3326
Men with congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS) have both low circulating testosterone and estradiol levels. Whether bone structure is affected remains unknown.
The Role of Thyroid in Renovascular Function: Independent Association of Serum TSH With Renal Plasma Flow
Theodora Pappa, Mahyar Heydarpour, Jonathan Williams, Paul N Hopkins, Gail K Adler, Erik K Alexander, Gordon Williams
doi : 10.1210/clinem/dgab390
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3327–e3334
There are well-established interactions between the thyroid and the kidney. Thyroid hypofunction is associated with reduced renal plasma flow (RPF), and hypothyroidism is highly prevalent in chronic kidney disease; however, less is known about the thyroid-kidney axis in the euthyroid state.
PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche
Jussi Tennilä, Jarmo Jääskeläinen, Pauliina Utriainen, Raimo Voutilainen, Merja Häkkinen, Seppo Auriola, Laure Morin-Papunen, Jani Liimatta
doi : 10.1210/clinem/dgab385
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3335–e3345
Premature adrenarche (PA) may increase the risk for polycystic ovary syndrome (PCOS).
Two Distinctive POMC Promoters Modify Gene Expression in Cushing Disease
Takako Araki, Yukiko Tone, Masaaki Yamamoto, Hiraku Kameda, Anat Ben-Shlomo, Shozo Yamada, Akira Takeshita, Masato Yamamoto, Yasuhiko Kawakami, Masahide Tone, Shlomo Melmed
doi : 10.1210/clinem/dgab387
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3346–e3363
Mechanisms underlying pituitary corticotroph adenoma adrenocorticotropin (ACTH) production are poorly understood, yet circulating ACTH levels closely correlate with adenoma phenotype and clinical outcomes.
Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults
Marc Diedisheim, Etienne Dancoisne, Jean-François Gautier, Etienne Larger, Emmanuel Cosson, Bruno Fève, Philippe Chanson, Sébastien Czernichow, Sopio Tatulashvili, Marie-Laure Raffin-Sanson, Kankoé Sallah, Muriel Bourgeon, Christiane Ajzenberg, Agnès Hartemann, Christel Daniel, Thomas Moreau, Ronan Roussel, Louis Potier
doi : 10.1210/clinem/dgab393
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3364–e3368
Diabetes is reported as a risk factor for severe coronavirus disease 2019 (COVID-19), but whether this risk is similar in all categories of age remains unclear.
Women With Polycystic Ovary Syndrome Have an Increased Risk of Major Cardiovascular Events: a Population Study
Thomas R Berni, Christopher L Morgan, D Aled Rees
doi : 10.1210/clinem/dgab392
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3369–e3380
The effects of polycystic ovary syndrome (PCOS) on cardiovascular morbidity and mortality are unclear.
Characteristics of Patients with Type 1 Diabetes and Additional Autoimmune Disease in the DPV Registry
Nicole Prinz, Sascha R Tittel, Rainer Bachran, Robert Birnbacher, Joachim Brückel, Désirée Dunstheimer, Holger Haberland, Melanie Hess, Wolfram Karges, Rudolf Oeverink, Andreas Veigel, Reinhard W Holl
doi : 10.1210/clinem/dgab376
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3381–e3389
Autoimmune diseases affect ~8% of the population. Type 1 diabetes mellitus (T1DM) is linked to other autoimmune diseases (AIDs), such as autoimmune thyroid disease or Addison’s disease (AD), that may impact diabetes therapy and outcome.
Birth Weight– or Gestational Age–adjusted Second-tier LCMSMS Cutoffs Improve Newborn Screening for CAH in New Zealand
Mark R de Hora, Natasha L Heather, Dianne Webster, Benjamin B Albert, Paul L Hofman
doi : 10.1210/clinem/dgab383
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3390–e3399
The positive predictive value of newborn screening for congenital adrenal hyperplasia (CAH) in New Zealand is approximately 10%. The use of a second tier liquid chromatography-tandem mass spectrometry bloodspot steroid profile test with birth weight– or gestational age–adjusted screening cutoffs may result in further screening improvements.
Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood
Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
doi : 10.1210/clinem/dgab379
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3400–e3413
Biological stress is related to cardiovascular disease in adults. The associations of stress with cardiovascular and metabolic diseases may originate in childhood.
Insulin-Mediated Substrate Use in Women With Different Phenotypes of PCOS: the Role of Androgens
Flavia Tosi, Michela Villani, Matteo Migazzi, Giulia Faccin, Sabrina Garofalo, Tom Fiers, Jean-Marc Kaufman, Enzo Bonora, Paolo Moghetti
doi : 10.1210/clinem/dgab380
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3414–e3425
Few studies have explored in vivo insulin action on substrate use in women with PCOS. In particular, no data are available in women with different PCOS phenotypes.
Adolescent Thyroid Disorders and Risk for Type 2 Diabetes in Young Adulthood
Aya Bardugo, Estela Derazne, Inbar Zucker, Cole D Bendor, Gal Puris, Miri Lutski, Orit Pinhas-Hamiel, Tali Cukierman-Yaffe, Ofri Mosenzon, Meir Schechter, Dorit Tzur, Arnon Afek, Amir Tirosh, Hertzel C Gerstein, Itamar Raz, Gilad Twig
doi : 10.1210/clinem/dgab382
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3426–e3435
Thyroid hormones play a key role in systemic metabolism, yet the relationship between thyroid dysfunction and risk for type 2 diabetes is unclear.
Clamping Cortisol and Testosterone Mitigates the Development of Insulin Resistance during Sleep Restriction in Men
Peter Y Liu, Darian Lawrence-Sidebottom, Katarzyna Piotrowska, Wenyi Zhang, Ali Iranmanesh, Richard J Auchus, Johannes D Veldhuis, Hans P A Van Dongen
doi : 10.1210/clinem/dgab375
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3436–e3448
Sleep loss in men increases cortisol and decreases testosterone, and sleep restriction by 3 to 4 hours/night induces insulin resistance.
Association Between Visit-to-Visit Fasting Plasma Glucose Variability and Osteoporotic Fractures in Nondiabetic Subjects
Jung A Kim, Ji Sung Lee, Eyun Song, Eun Roh, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
doi : 10.1210/clinem/dgab370
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3449–e3460
Although long-term glucose variability has been reported to be a risk factor associated with osteoporosis, there have been no previous studies between the relationship of glucose variability and fractures in people without diabetes.
Maternal Plasma Lipids During Pregnancy, Insulin-like Growth Factor-1, and Excess Fetal Growth
Kuan-Yu Chen, Shin-Yu Lin, Chien-Nan Lee, Hung-Tsung Wu, Ching-Hua Kuo, Han-Chun Kuo, Chia-Chi Chuang, Chun-Heng Kuo, Szu-Chi Chen, Kang-Chih Fan, Ming-Wei Lin, Chi-Tai Fang, Hung-Yuan Li
doi : 10.1210/clinem/dgab364
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3461–e3472
Maternal lipids during pregnancy and placental growth factors are associated with excess fetal growth. However, how these factors interact to increase the risk of delivering large-for-gestational-age (LGA) neonates remains unclear. In this study, we investigated the relationship between maternal plasma triglycerides (TGs) and free fatty acids (FFAs) during pregnancy, cord blood insulin-like growth factors (IGF), and LGA.
Rare Variants in Triglycerides-Related Genes Increase Pancreatitis Risk in Multifactorial Chylomicronemia Syndrome
Martine Paquette, Julie Amyot, Manon Fantino, Alexis Baass, Sophie Bernard
doi : 10.1210/clinem/dgab360
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3473–e3482
Severe hypertriglyceridemia (fasting triglycerides [TG] concentration ?10 mmol/L) can be caused by multifactorial chylomicronemia syndrome (MCS) or familial chylomicronemia syndrome (FCS). Both conditions are associated with an increased risk of acute pancreatitis. The clinical differences between MCS patients with or without a rare variant in TG-related genes have never been studied.
Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort
Charles D Nicoli, April P Carson, Timothy B Plante, D Leann Long, Leslie A McClure, Janin Schulte, Mary Cushman
doi : 10.1210/clinem/dgab355
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3483–e3494
The peptide neurotensin is implicated in insulin resistance, diabetes mellitus (DM), and cardiovascular disease.
FSH-stimulated Inhibin B (FSH-iB): A Novel Marker for the Accurate Prediction of Pubertal Outcome in Delayed Puberty
Shakun Chaudhary, Rama Walia, Anil Bhansali, Devi Dayal, Naresh Sachdeva, Tulika Singh, Sanjay Kumar Bhadada
doi : 10.1210/clinem/dgab357
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3495–e3505
Clinicians have long been struggling to find an effective tool to predict onset of puberty.
Associations of Osteocalcin Forms With Metabolic Syndrome and Its Individual Components in Older Men: The Health In Men Study
Xiaoying Liu, Bu B Yeap, Kaye E Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C Brennan-Speranza
doi : 10.1210/clinem/dgab358
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3506–e3518
The osteoblast-derived polypeptide, osteocalcin (OC), has been associated with lower risk of type 2 diabetes and metabolic syndrome (MetS) in several epidemiological studies. Animal studies have indicated the undercarboxylated form of OC (ucOC) drives its association with metabolic outcomes.
Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome
Graeme L Fraser, Barbara Obermayer-Pietsch, Joop Laven, Georg Griesinger, Axelle Pintiaux, Dirk Timmerman, Bart C J M Fauser, Christopher Lademacher, Jean Combalbert, Hamid R Hoveyda, Steven Ramael
doi : 10.1210/clinem/dgab320
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3519–e3532
Polycystic ovary syndrome (PCOS), a highly prevalent endocrine disorder characterized by hyperandrogenism, is the leading cause of anovulatory infertility.
Effect of Orlistat on Live Birth Rate in Overweight or Obese Women Undergoing IVF-ET: A Randomized Clinical Trial
Ze Wang, Junli Zhao, Xiang Ma, Yun Sun, Guimin Hao, Aijun Yang, Wenchao Ren, Lei Jin, Qun Lu, Gengxiang Wu, Xiufeng Ling, Cuifang Hao, Bo Zhang, Xinyu Liu, Dongzi Yang, Yimin Zhu, Jing Li, Hongchu Bao, Ancong Wang, Jianqiao Liu, Zi-Jiang Chen, Jichun Tan, Yuhua Shi
doi : 10.1210/clinem/dgab340
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3533–e3545
Obesity management prior to infertility treatment remains a challenge. To date, results from randomized clinical trials involving weight loss by lifestyle interventions have shown no evidence of improved live birth rate.
Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-Modified Association
Shaoping Zhang, Kamaira H Philips, Kevin Moss, Di Wu, Hamdi S Adam, Elizabeth Selvin, Ryan T Demmer, Faye L Norby, Indra Z Mustapha, James D Beck
doi : 10.1210/clinem/dgab337
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3546–e3558
To determine whether periodontal disease is positively associated with incident diabetes across the continuum of body mass levels (BMI) and test the hypothesis that the periodontal risk for incident diabetes is modified by BMI.
The Validity of Serum Alkaline Phosphatase to Identify Nutritional Rickets in Nigerian Children on a Calcium-Deprived Diet
Tom D Thacher, Christopher T Sempos, Ramon A Durazo-Arvizu, Philip R Fischer, Craig F Munns, John M Pettifor
doi : 10.1210/clinem/dgab328
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3559–e3564
Nutritional rickets results from the interaction of low vitamin D status and limited calcium intake. Serum alkaline phosphatase (AP) activity is a biomarker of impaired mineralization in rickets.
Causal Effects of N-6 Polyunsaturated Fatty Acids on Age-related Macular Degeneration: A Mendelian Randomization Study
Kai Wang, Yueyang Zhong, Fangkun Yang, Chenyang Hu, Xin Liu, Yanan Zhu, Ke Yao
doi : 10.1210/clinem/dgab338
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3565–e3572
Although the role of n-6 polyunsaturated fatty acids (PUFAs) in age-related macular degeneration (AMD) has been studied in previous observational studies, the precise manner in which 1 or more n-6 PUFAs account for this relationship remains unclear.
ALDH2 rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men
Kageumi Takeno, Yoshifumi Tamura, Saori Kakehi, Hideyoshi Kaga, Ryuzo Kawamori, Hirotaka Watada
doi : 10.1210/clinem/dgab324
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3573–e3581
A recent meta-analysis of genome-wide association studies data from East Asians identified aldehyde dehydrogenase 2 (ALDH2) rs671 as a susceptibility variant for type 2 diabetes in males.
Similar Stage-dependent Survival and Outcome in Sporadic and Hereditary Medullary Thyroid Carcinoma
Friedhelm Raue, Thomas Bruckner, Karin Frank-Raue
doi : 10.1210/clinem/dgab326
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3582–e3591
Long-term data are scarce on large cohorts with sporadic (sMTC) and hereditary medullary thyroid carcinoma (hMTC).
Bone Marrow Adiposity in Premenopausal Women With Type 2 Diabetes With Observations on Peri-Trabecular Adipocytes
Vicente F C Andrade, Débora Besen, Domingos C Chula, Victória Z C Borba, David Dempster, Carolina Aguiar Moreira
doi : 10.1210/clinem/dgab322
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3592–e3602
No study has yet evaluated the relationships among bone marrow adiposity (BMA), bone histomorphometry (BH), and glycemic control in premenopausal women with type 2 diabetes (T2DM).
Increasing Incidence of Primary Aldosteronism in Western Sweden During 3 Decades – Yet An Underdiagnosed Disorder
Eleftheria Gkaniatsa, Eva Ekerstad, Manuela Gavric, Andreas Muth, Penelope Trimpou, Daniel S Olsson, Gudmundur Johannsson, Oskar Ragnarsson
doi : 10.1210/clinem/dgab327
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3603–e3610
Primary aldosteronism (PA) is the most common cause of secondary hypertension. Yet, the incidence of PA in the general population has not been studied.
Additional Insulin Is Required in Both the Early and Late Postprandial Periods for Meals High in Protein and Fat: A Randomized Trial
Barbara Keating, Carmel E M Smart, Amelia J Harray, Nirubasini Paramalingam, Grant Smith, Timothy W Jones, Bruce R King, Elizabeth A Davis
doi : 10.1210/clinem/dgab318
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3611–e3618
The pattern and quantity of insulin required for high-protein high-fat (HPHF) meals is not well understood.
Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity
Jie Hong, Tingting Bo, Liuqing Xi, Xiaoqiang Xu, Naying He, Yafeng Zhan, Wanyu Li, Peiwen Liang, Yufei Chen, Juan Shi, Danjie Li, Fuhua Yan, Weiqiong Gu, Weiqing Wang, Ruixin Liu, Jiqiu Wang, Zheng Wang, Guang Ning
doi : 10.1210/clinem/dgab297
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3619–e3633
Vertical sleeve gastrectomy (VSG) is becoming a prioritized surgical intervention for obese individuals; however, the brain circuits that mediate its effective control of food intake and predict surgical outcome remain largely unclear.
Effects of Growth Hormone Treatment on Sleep-Related Parameters in Adults With Prader-Willi Syndrome
Hasanain Hamid Shukur, Laith Hussain-Alkhateeb, Stense Farholt, Ole Nørregaard, Anders Palmstrøm Jørgensen, Charlotte Hoybye
doi : 10.1210/clinem/dgab300
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3634–e3643
Prader-Willi syndrome (PWS) is a rare, genetic, multisymptom, neurodevelopmental disease due to lack of the expression of the paternal genes in the q11 to q13 region of chromosome 15. The main characteristics of PWS are muscular hypotonia, hyperphagia, obesity, behavioral problems, cognitive disabilities, and endocrine deficiencies, including growth hormone (GH) deficiency. Sleep apnea and abnormal sleep patterns are common in PWS. GH treatment might theoretically have a negative impact on respiration.
Vitamin D3 Dose Requirement That Raises 25-Hydroxyvitamin D to Desirable Level in Overweight and Obese Elderly
Dania S Bacha, Maya Rahme, Laila Al-Shaar, Rafic Baddoura, Georges Halaby, Ravinder J Singh, Ziyad R Mahfoud, Robert Habib, Asma Arabi, Ghada El-Hajj Fuleihan
doi : 10.1210/clinem/dgab296
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3644–e3654
Guidelines for the dosage of vitamin D supplementation vary widely globally.
Mineralocorticoid Receptor Antagonist Effect on Aldosterone to Renin Ratio in Patients With Primary Aldosteronism
Alessio Pecori, Fabrizio Buffolo, Jacopo Burrello, Giulio Mengozzi, Francesca Rumbolo, Valeria Avataneo, Antonio D’Avolio, Franco Rabbia, Chiara Bertello, Franco Veglio, Paolo Mulatero, Silvia Monticone
doi : 10.1210/clinem/dgab290
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3655–e3664
Although current international guidelines recommend to avoid mineralocortcoid receptor antagonists in patients undergoing screening test for primary aldosteronism, a recent report suggested that mineralocorticoid receptor antagonist treatment can be continued without significant influence on screening results.
Peptide Receptor Radionuclide Therapy With 177Lu-DOTATATE for Symptomatic Control of Refractory Carcinoid Syndrome
Wouter T Zandee, Tessa Brabander, Anela Blaževi?, Noémie S Minczeles, Richard A Feelders, Wouter W de Herder, Johannes Hofland
doi : 10.1210/clinem/dgab289
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3665–e3672
Peptide receptor radionuclide therapy (PRRT) with [Lutetium-177-DOTA0-Tyr3]octreotate (177Lu-DOTATATE) results in an increase of progression-free survival and quality of life in patients with progressive, well-differentiated neuroendocrine neoplasms (NENs).
FTO Obesity Variant–Exercise Interaction on Changes in Body Weight and BMI: The Taiwan Biobank Study
Yuta Hiraike, Chao-Tung Yang, Wei-Ju Liu, Tomohide Yamada, Chia-Lin Lee
doi : 10.1210/clinem/dgab295
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3673–e3681
Gene–exercise interaction on cross-sectional body mass index (BMI) has been extensively studied and is well established. However, gene–exercise interaction on changes in body weight/BMI remains controversial.
Incidence of Complications in 25 Adult Patients With X-linked Hypophosphatemia
Hajime Kato, Minae Koga, Yuka Kinoshita, Yuki Taniguchi, Hiroshi Kobayashi, Seiji Fukumoto, Masaomi Nangaku, Noriko Makita, Nobuaki Ito
doi : 10.1210/clinem/dgab282
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3682–e3692
Adults with X-linked hypophosphatemia (XLH) present complications other than osteomalacia.
Timing of Pubertal Onset in Girls and Boys With Constitutional Delay
Elfa Jonsdottir-Lewis, Amalia Feld, Ryan Ciarlo, Erica Denhoff, Henry A Feldman, Yee-Ming Chan
doi : 10.1210/clinem/dgab270
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3693–e3703
The decision whether to treat a child with delayed puberty with sex steroids is primarily based on patient, family, and provider preference. Knowing when children with constitutional delay eventually enter puberty would inform this decision.
Thyroid Immune-related Adverse Events Following Immune Checkpoint Inhibitor Treatment
Christopher A Muir, Roderick J Clifton-Bligh, Georgina V Long, Richard A Scolyer, Serigne N Lo, Matteo S Carlino, Venessa H M Tsang, Alexander M Menzies
doi : 10.1210/clinem/dgab263
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3704–e3713
Thyroid dysfunction occurs commonly following immune checkpoint inhibition. The etiology of thyroid immune-related adverse events (irAEs) remains unclear and clinical presentation can be variable.
Clinical and Hormonal Profiles Correlate With Molecular Characteristics in Patients With 11?-Hydroxylase Deficiency
Melek Yildiz, Emregul Isik, Zehra Yavas Abali, Mehmet Keskin, Mehmet Nuri Ozbek, Firdevs Bas, Seyit Ahmet Ucakturk, Muammer Buyukinan, Hasan Onal, Cengiz Kara, Karl-Heinz Storbeck, Feyza Darendeliler, Atilla Cayir, Edip Unal, Ahmet Anik, Huseyin Demirbilek, Tugba Cetin, Fatma Dursun, Gonul Catli, Serap Turan, Henrik Falhammar, Tugba Baris, Ali Yaman, Goncagul Haklar, Abdullah Bereket, Tulay Guran
doi : 10.1210/clinem/dgab225
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3714–e3724
Given the rarity of 11?-hydroxylase deficiency (11?OHD), there is a paucity of data about the differences in clinical and biochemical characteristics of classic (C-11?OHD) and nonclassic 11?OHD (NC-11?OHD).
Impact of Gestational and Postmenstrual Age on Excretion of Fetal Zone Steroids in Preterm Infants Determined by Gas Chromatography-Mass Spectrometry
Johanna Ruhnau, Stephanie Hübner, Donna Sunny, Till Ittermann, Michaela F Hartmann, Jan De Lafollie, Stefan A Wudy, Matthias Heckmann
doi : 10.1210/clinem/dgab194
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3725–e3738
Fetal zone steroids (FZSs) are excreted in high concentrations in preterm infants. Experimental data suggest protective effects of FZSs in models of neonatal disease.
Sex-Dependent Association of Vitamin D With Insulin Resistance in Humans
Xin Chen, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
doi : 10.1210/clinem/dgab213
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3739–e3747
Animal studies suggested that vitamin D might decrease insulin resistance. Estrogen increased insulin sensitivity and glucose tolerance in rodents. However, sex-specific association of vitamin D with insulin resistance in humans remains unclear.
Ovarian Reserve Biomarkers and Menstrual Cycle Length in a Prospective Cohort Study
Benjamin S Harris, Anne Z Steiner, Anne Marie Jukic
doi : 10.1210/clinem/dgab204
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3748–e3759
While age-related changes in menstrual cycle length are well known, it is unclear whether anti-Müllerian (AMH) or other ovarian reserve biomarkers have a direct association with cycle length.
Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Body Composition From Mid-Childhood to Early Adolescence
Jaclyn A Janis, Sheryl L Rifas-Shiman, Shravanthi M Seshasayee, Sharon Sagiv, Antonia M Calafat, Diane R Gold, Brent A Coull, Clifford J Rosen, Emily Oken, Abby F Fleisch
doi : 10.1210/clinem/dgab187
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3760–e3770
Per- and polyfluoroalkyl substances (PFAS) may alter body composition by lowering anabolic hormones and increasing inflammation, but data are limited, particularly in adolescence when body composition is rapidly changing.
The Importance of Recognizing a Locally Advanced Pheochromocytoma
Eugenie S Lim, Scott A Akker
doi : 10.1210/clinem/dgab366
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3771–e3772
Galectin-3 in NAFLD: Therapeutic Target or Noncausal Biomarker?
Raymond E Soccio
doi : 10.1210/clinem/dgab363
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3773–e3774
Hypertension in Young Women: Implications of the Polycystic Ovary Syndrome and Opportunities for Prevention and Further Research
Lara C Kovell, Stephen P Juraschek, Erin D Michos
doi : 10.1210/clinem/dgab345
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3775–e3777
Elevation of Fasting GLP-1 Levels in Child and Adolescent Obesity: Friend or Foe?
Sodai Kubota, Daisuke Yabe
doi : 10.1210/clinem/dgab301
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3778–e3780
Glucagon-like peptide-1 (GLP-1) receptor agonists have been gaining much attention as a therapeutic approach to type 2 diabetes and obesity. Stinson et al recently reported that fasting GLP-1 is higher in children and adolescents with overweight/obesity and that it associates with cardiometabolic risk factors in a cross-sectional study comprising more than 4000 subjects. Obvious questions include why fasting GLP-1 is significantly increased in children and adolescents with overweight/obesity and why this is correlated with cardiometabolic risks. It has been shown that the inflammatory cytokine interleukin-6 (IL-6) stimulates GLP-1 secretion from pancreatic ?-cells. IL-6-induced GLP-1 secretion could therefore play a role in expanding the ?-cell reservoir in compensation for increased insulin needs due to exacerbation of insulin resistance. On the other hand, augmented GLP-1 secretion leads to increased insulin secretion, thereby enhancing hepatic lipogenesis and stimulating adipogenesis, which might underlie the associations of fasting GLP-1 with % body fat, triglycerides, and alanine aminotransferase. It is also possible that GLP-1 levels are naturally increased to oppose body weight gain to maintain body weight. However, it is important to note the differing biological effects of GLP-1 at physiological and pharmacological levels, which are evident in body weight reduction by GLP-1 receptor agonists and DPP-4 inhibitors. The Stinson study clearly demonstrated that fasting GLP-1 associates with overweight/obesity and cardiometabolic risk factors in children and adolescents. However, additional experiments need to be carried out to fully understand the relevance of these observations to human disease and health.
Letter to the Editor from Varady et al.: “Metabolic Impact of Intermittent Fasting in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Interventional Studies”
Krista A Varady, Kelsey Gabel, Sofia Cienfuegos, Mark Ezpeleta, Shuhao Lin, Kate Cares
doi : 10.1210/clinem/dgab298
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3781–e3782
Letter to the Editor from Blasdel et al: “No Venous Thromboembolism Increase Among Transgender Female Patients Remaining on Estrogen for Gender-affirming Surgery”
Gaines Blasdel, Nabeel Shakir, Augustus Parker, Rachel Bluebond-Langner, Lee Zhao
doi : 10.1210/clinem/dgab243
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3783–e3784
Letter to the Editor from Idrees and Bianco: “Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis”
Thaer Idrees, Antonio C Bianco
doi : 10.1210/clinem/dgab227
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3785–e3786
Letter to the Editor from Pöllänen et al: “Birth Cohorts in Type 1 Diabetes: Preparing for the Payoff”
Petra M Pöllänen, Mikael Knip
doi : 10.1210/clinem/dgab109
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3787–e3788
Response to Letter to the Editor from Brunerova et al: “Association of Cognitive Function and Retinal Neural and Vascular Structure in Type 1 Diabetes”
Ward Fickweiler, Emily A Wolfson, Samantha M Paniagua, Marc Gregory Yu, Atif Adam, Vanessa Bahnam, Konstantina Sampani, I-Hsien Wu, Gail Musen, Lloyd P Aiello, Hetal Shah, Jennifer K Sun, George L King
doi : 10.1210/clinem/dgab351
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3789–e3790
Response to Letter to the Editor from Blasdel et al: “No Venous Thromboembolism Increase Among Transgender Female Patients Remaining on Estrogen for Gender Affirming Surgery”
Aki Kozato, Joshua D Safer, John Henry Pang
doi : 10.1210/clinem/dgab245
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Page e3791
Response to Letter to the Editor From Idrees and Bianco: “Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-Analysis”
Anupam Kotwal, M Hassan Murad, Fares Alahdab
doi : 10.1210/clinem/dgab228
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3792–e3793
Response to Letter to the Editor from Pöllänen et al: “Birth Cohorts in Type 1 Diabetes: Preparing for the Payoff”
Kristina Cossen, Andrew Muir
doi : 10.1210/clinem/dgab110
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 9, September 2021, Pages e3794–e3795
