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Online academic community in the Asia-Pacific countries: The paragon of a metamorphic world
Prithvi Sanjeevkumar Gaur,Sreoshy Saha,Himantha Atukorale,Irwin Lim,Cheng Yew Kuang,Priscilla Wong,Ghita Harifi,Babur Salim,Debashish Danda,Atiq Ul Haq,Latika Gupta
doi : 10.1111/1756-185X.14196
Volume 24, Issue 10 p. 1229-1234
Will rheumatologists ever pick up the arthroscope again?
Robert W. Ike,Kenneth C. Kalunian
doi : 10.1111/1756-185X.14184
Volume 24, Issue 10 p. 1235-1246
Conditions prompting physicians and surgeons first adapting endoscopes to peer into joints were mainly the sort of synovial conditions that would concern today's rheumatologists. Rheumatologists were among the pre-World War II pioneers developing and documenting arthroscopy. The post-War father of modern arthroscopy, Watanabe, found rheumatologists among his early students, who took back the technique to their home countries, teaching orthopedists and rheumatologists alike. Rheumatologists described and analyzed the intra-articular features of their common diseases in the ’60s and ’70s. A groundswell of interest from academic rheumatologists in adapting arthroscopy grew considerably in the ’90s with development of “needle scopes” that could be used in an office setting. Rheumatologists helped conduct the very trials the findings of which reduced demand for their arthroscopic services by questioning the efficacy of arthroscopic debridement in osteoarthritis (OA) and also developing biological compounds that greatly reduced the call for any resective intervention in inflammatory arthropathies. The arthroscope has proven an excellent tool for viewing and sampling synovium and continues to serve this purpose at several international research centers. While cartilage is now imaged mainly by magnetic resonance imaging, some OA features – such as a high prevalence of visible calcinosis – beg further arthroscopy-directed investigation. A new generation of “needle scopes” with far superior optics awaits future investigators, should they develop interest.
Epidemiology of Takayasu arteritis in Shanghai: A hospital-based study and systematic review
Ying Sun,Meng-meng Yin,Li-li Ma,Xiao-min Dai,Liang-jing Lv,Xiao-xiang Chen,Shuang Ye,Ting Li,Jie Chen,Dong-bao Zhao,Rui-na Kong,Qiang-hua Wei,Guang-hui Yang,Su-gang Gong,Cheng-de Yang,Hong-lei Liu,Yu Xue,Jian-ping Tang,Run Feng,Ai Peng,Ling Qin,Hua Liu,Xiao Su,Hui-ping Huang,Jian-long Guan,Dan Luo,Sheng-Ming Dai,Fu-tao Zhao,Zhen-Hang Zhu,Xiao-yan Zhang,Jie Han,Jia-yi Wang,Chun-yuan Xiao,Hu-ji Xu,Xin Wu,Dong-yi He,Jian-chun Mao,Zhu-jing Zhu,Luan Xue,Ben Li,Jiang Lin,Jian-zhou Zou,Xiao-ning Sun,Jing Ding,Zhi-hui Dong,Xiang-fei Wang,Jun-Ying,Lin-di Jiang
doi : 10.1111/1756-185X.14183
Volume 24, Issue 10 p. 1247-1256
Takayasu arteritis (TAK) is a rare large vessel vasculitis, and epidemiological data on TAK are lacking in China. Thus, we designed this study to estimate the TAK prevalence and incidence in residential Shanghai, China.
The current role of NLRP3 inflammasome polymorphism in gout susceptibility
Denise Clavijo-Cornejo,Olivia Hernández-González,Marwin Gutierrez
doi : 10.1111/1756-185X.14205
Volume 24, Issue 10 p. 1257-1265
The NLR family pyrin domain containing 3 (NLRP3) signaling pathway has an important role in inflammation mediated by monosodium urate crystals in gout, and the characterization of single nucleotide polymorphisms (SNPs) have helped to recognize disease susceptibility.
Serial administration of rhBMP-2 and alendronate enhances the differentiation of osteoblasts
Sang-Hyon Kim,Hye-Jung Choi,Dae Sung Yoon,Chang-Nam Son
doi : 10.1111/1756-185X.14189
Volume 24, Issue 10 p. 1266-1272
The incorporation of growth factors is an effective strategy to accelerate bone induction. Bone morphogenetic protein-2 (BMP-2) promotes osteoblast differentiation and induces bone formation. Alendronate (ALN) is an osteoclast deactivation drug. We investigated the effect of serial administration of recombinant human BMP-2 (rhBMP-2) and ALN on osteoblast differentiation.
Fibromyalgia in HIV-positive patients in Nigeria: A cross-sectional prospective study
Airenakho Emorinken,Mercy Ofunami Dic-Ijiewere,Cyril Oshomah Erameh,Asuwemhe Johnson Ugheoke,Folasade Ojuolape Agbebaku,Oluwaseun Remi Agbadaola
doi : 10.1111/1756-185X.14195
Volume 24, Issue 10 p. 1273-1281
Fibromyalgia is a chronic pain syndrome of unknown etiology characterized by chronic widespread musculoskeletal pain and tenderness. It affects the quality of life of patients and has been associated with the human immunodeficiency virus (HIV). The study aimed to determine the prevalence of fibromyalgia in HIV-positive patients and assess the effect of fibromyalgia on their functional status.
Handling missing data in a rheumatoid arthritis registry using random forest approach
Ahmad Alsaber,Adeeba Al-Herz,Jiazhu Pan,Ahmad T. AL-Sultan,Divya Mishra,KRRD Group
doi : 10.1111/1756-185X.14203
Volume 24, Issue 10 p. 1282-1293
Missing data in clinical epidemiological research violate the intention-to-treat principle, reduce the power of statistical analysis, and can introduce bias if the cause of missing data is related to a patient's response to treatment. Multiple imputation provides a solution to predict the values of missing data. The main objective of this study is to estimate and impute missing values in patient records. The data from the Kuwait Registry for Rheumatic Diseases was used to deal with missing values among patient records. A number of methods were implemented to deal with missing data; however, choosing the best imputation method was judged by the lowest root mean square error (RMSE). Among 1735 rheumatoid arthritis patients, we found missing values vary from 5% to 65.5% of the total observations. The results show that sequential random forest method can estimate these missing values with a high level of accuracy. The RMSE varied between 2.5 and 5.0. missForest had the lowest imputation error for both continuous and categorical variables under each missing data rate (10%, 20%, and 30%) and had the smallest prediction error difference when the models used the imputed laboratory values.
Assessing methotrexate intolerance and its prevalence in rheumatoid arthritis: Development and validation of the MISA questionnaire
Deeksha Vijaykumar,Varun Dhir,Siddharth Jain,Venkatesh Pai,Jaswinder Kaur,Godasi SRSNK Naidu,Aman Sharma,Shefali Khanna Sharma,Sanjay Jain
doi : 10.1111/1756-185X.14207
Volume 24, Issue 10 p. 1294-1301
Methotrexate (MTX) intolerance refers to unpleasant symptoms that accompany use of MTX. Although a validated questionnaire on MTX intolerance exists for children with juvenile idiopathic arthritis, it is lacking for adult rheumatoid arthritis (RA) patients.
Infliximab therapy in parenchymal neuro-Behçet’s disease: A single-center experience
Demet Yalcin Kehribar,Serkan Gunaydin,Metin Ozgen
doi : 10.1111/1756-185X.14209
Volume 24, Issue 10 p. 1302-1307
Parenchymal neuro-Behçet’s disease involvement is the most serious complication of Behçet's disease, and no sufficient data on its treatment exists. This study aims to investigate the efficacy and safety of infliximab treatment in neuro-Behçet’s disease patients with parenchymal involvement.
The relationship of ocular parameters with clinical parameters and disease-related quality of life in patients with systemic sclerosis: A cross-sectional study
Serdar Kaymaz,Y?lmaz Halil,Hüseyin Kaya,Ugur Karasu,Veli Cobankara
doi : 10.1111/1756-185X.14216
Volume 24, Issue 10 p. 1308-1316
To evaluate choroidal thickness (CT), corneal parameters, and scleral thickness (ST) in patients with systemic sclerosis (SSc) and to determine their relationship with disease-related quality of life (QoL).
A bond between rheumatic diseases and cancer in the elderly: The interleukin-6 pathway
Giuseppe Carlo Iorio,Antonio Ammendolia,Nicola Marotta,Umberto Ricardi,Alessandro de Sire
doi : 10.1111/1756-185X.14194
Volume 24, Issue 10 p. 1317-1320
Interleukin (IL)-6 is a soluble factor secreted by T lymphocytes, involved in antibody generation by B lymphocytes. The IL-6 pathway has risen as a pivotal pathway implicated in immune regulation and dysregulation in various rheumatic diseases. Nonetheless, elevated IL-6 levels can also play a role in cancer. Targeting the IL-6 pathway has led to innovative therapeutic approaches for rheumatic diseases and for COVID-19, particularly in the elderly. Indeed, tocilizumab, an agent targeting IL-6, has recently amassed significant attention as a promising univocal agent for different conditions. In this viewpoint, we sought to recall and describe the common pathway among osteoarthritis, rheumatoid arthritis, and cancer, suggesting that anti-IL-6 may be considered a jack-of-all-trades against inflammaging in the elderly.
Recent advances in pediatric rheumatology: April to June 2021
Prabal Barman,Archan Sil,Surjit Singh
doi : 10.1111/1756-185X.14212
Volume 24, Issue 10 p. 1321-1324
Kawasaki disease with dilatation of the common bile duct: A case report and review of literature
Atsushi Morita,Kazuo Imagawa,Takumi Ishiodori,Manabu Tagawa,Hidetoshi Takada
doi : 10.1111/1756-185X.14208
Volume 24, Issue 10 p. 1325-1330
Kawasaki disease (KD) is a syndrome that results in acute systemic vasculitis and is a major cause of acquired heart disease in developed countries. KD is diagnosed based on certain characteristic symptoms and echocardiogram results. It has been reported that abdominal ultrasound is of value in supporting the diagnosis of KD. Nevertheless, abdominal ultrasound is not a routine procedure in KD. Moreover, dilatation of the common bile duct (CBD) has been rarely reported in previous cases.
What are the benefits and harms of belimumab for patients with systemic lupus erythematosus?: A Cochrane Review summary with commentary
Giovanni Iolascon
doi : 10.1111/1756-185X.14214
Volume 24, Issue 10 p. 1331-1333
Your help is needed in the fight against COVID-19: Please contribute to the COVID-19 Global rheumatology alliance registry
doi : 10.1111/1756-185X.14190
Volume 24, Issue 10 p. 1334-1334
