One-year access to more than 500 world journals available in the system
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Cardiac Scintigraphy and Screening for Transthyretin Cardiac Amyloidosis
Mathew S. Maurer, Frederick L. Ruberg
doi : 10.1161/CIRCULATIONAHA.121.055517
Circulation. 2021;144:1005–1007
Natural History of Patients With Ischemia and No Obstructive Coronary Artery Disease
Harmony R. Reynolds, Michael H. Picard, John A. Spertus, Jesus Peteiro, Jose Luis Lopez Sendon, Roxy Senior, Mohammad C. El-Hajjar, Jelena Celutkiene, Michael D. Shapiro, Patricia A. Pellikka, Dennis F. Kunichoff, Rebecca Anthopolos, Khaled Alfakih, Khaled Abdul-Nour, Michel Khouri, Leonid Bershtein, Mark De Belder, Kian Keong Poh, John F. Beltrame, James K. Min, Jerome L. Fleg, Yi Li, David J. Maron, Judith S. Hochman
doi : 10.1161/CIRCULATIONAHA.120.046791
Circulation. 2021;144:1008–1023
Ischemia with no obstructive coronary artery disease (INOCA) is common and has an adverse prognosis. We set out to describe the natural history of symptoms and ischemia in INOCA.
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity
Harmony R. Reynolds, Leslee J. Shaw, James K. Min, Courtney B. Page, Daniel S. Berman, Bernard R. Chaitman, Michael H. Picard, Raymond Y. Kwong, Sean M. O’Brien, Zhen Huang, Daniel B. Mark, Ranjit K. Nath, Sudhanshu K. Dwivedi, Paola E.P. Smanio, Peter H. Stone, Claes Held, Matyas Keltai, Sripal Bangalore, Jonathan D. Newman, John A. Spertus, Gregg W. Stone, David J. Maron, Judith S. Hochman
doi : 10.1161/CIRCULATIONAHA.120.049755
Circulation. 2021;144:1024–1038
The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) and moderate or severe ischemia would benefit from revascularization. We investigated the relationship between severity of CAD and ischemia and trial outcomes, overall and by management strategy.
Forget Ischemia: It’s All About the Plaque
David E. Newby, Michelle C. Williams, Marc R. Dweck
doi : 10.1161/CIRCULATIONAHA.121.054102
Circulation. 2021;144:1039–1041
Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease
Hui Qi, Hang Liu, Soni Savai Pullamsetti, Stefan Günther, Carsten Kuenne, Ann Atzberger, Natascha Sommer, Stefan Hadzic, Andreas Günther, Norbert Weissmann, Yonggang Zhou, Xuejun Yuan, Thomas Braun
doi : 10.1161/CIRCULATIONAHA.120.051680
Circulation. 2021;144:1042–1058
The pathogenesis of life-threatening cardiopulmonary diseases such as pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD) originates from a complex interplay of environmental factors and genetic predispositions that is not fully understood. Likewise, little is known about developmental abnormalities or epigenetic dysregulations that might predispose for PH or COPD in adult individuals.
MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions
Andreas Schober, Richard M. Blay, Saffiyeh Saboor Maleki, Farima Zahedi, Anja E. Winklmaier, Mati Y. Kakar, Isabelle M. Baatsch, Mengyu Zhu, Claudia Geißler, Anja E. Fusco, Anna Eberlein, Nan Li, Remco T.A. Megens, Ramin Banafsche, Jörg Kumbrink, Christian Weber, Maliheh Nazari-Jahantigh
doi : 10.1161/CIRCULATIONAHA.120.051614
Circulation. 2021;144:1059–1073
The necrotic core partly formed by ineffective efferocytosis increases the risk of an atherosclerotic plaque rupture. Microribonucleic acids contribute to necrotic core formation by regulating efferocytosis and macrophage apoptosis. Atherosclerotic plaque rupture occurs at increased frequency in the early morning, indicating diurnal changes in plaque vulnerability. Although circadian rhythms play a role in atherosclerosis, the molecular clock output pathways that control plaque composition and rupture susceptibility are unclear.
Highlights From the Circulation Family of Journals
doi : 10.1161/CIRCULATIONAHA.121.057292
Circulation. 2021;144:1074–1079
From the Literature
Tracy Hampton
doi : 10.1161/CIRCULATIONAHA.121.056990
Circulation. 2021;144:1080–1082
Effects of Walnut Consumption for 2 Years on Lipoprotein Subclasses Among Healthy Elders
Sujatha Rajaram, Montserrat Cofán, Aleix Sala-Vila, Ella Haddad, Mercè Serra-Mir, Edward Bitok, Irene Roth, Tania M. Freitas-Simoes, Amandeep Kaur, Cinta Valls-Pedret, Mónica Doménech, Keiji Oda, Dolores Corella, Joan Sabaté, Emilio Ros
doi : 10.1161/CIRCULATIONAHA.121.054051
Circulation. 2021;144:1083–1085
Letter by Varricchi et al Regarding Article, “Role of IgE-Fc?R1 in Pathological Cardiac Remodeling and Dysfunction”
Gilda Varricchi, Giuseppe Rengo, Stephen J. Galli
doi : 10.1161/CIRCULATIONAHA.121.055167
Circulation. 2021;144:e214–e215
Response by Zhao et al to Letter Regarding Article, “Role of IgE-Fc?RI in Pathological Cardiac Remodeling and Dysfunction”
Hongmei Zhao, Chi Geng, Chen Yan, Jing Wang
doi : 10.1161/CIRCULATIONAHA.121.055680
Circulation. 2021;144:e216–e217
Opioid Use and Its Relationship to Cardiovascular Disease and Brain Health: A Presidential Advisory From the American Heart Association
Sheryl L. Chow, Comilla Sasson, Ivor J. Benjamin, Robert M. Califf, Wilson M. Compton, Elizabeth M. Oliva, Chester Robson, Eduardo J. Sanchez, on behalf of the American Heart Association
doi : 10.1161/CIR.0000000000001007
Circulation. 2021;144:e218–e232
