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A Close Look at the Clinical Efficacy of Rho-Associated Protein Kinase Inhibitor Eye Drops for Fuchs Endothelial Corneal Dystrophy
Kinoshita, Shigeru MD, PhD*; Colby, Kathryn A. MD, PhD†; Kruse, Friedrich E. MD, PhD‡
doi : 10.1097/ICO.0000000000002642
October 2021 - Volume 40 - Issue 10 - p 1225-1228
The current understanding on the clinical efficacy of Rho-associated protein kinase (ROCK) inhibitor for treating Fuchs endothelial corneal dystrophy is summarized to clarify whether the “off-label” ROCK-inhibitor eye-drop application are appropriate. ROCK-inhibitor eye drops may eventually be deemed a cutting-edge therapy for Fuchs endothelial corneal dystrophy patients with acute corneal endothelial defect.
Supply and Demand of Domestic Corneal Tissue and Its Implications on Export Potential—Using Australia as an Example
Machin, Heather RN, MBA*; Buckland, Lisa GCQM†; Georges, Pierre MScMed‡; Ghabcha, Mona BMedSc‡; Golding-Holbrook, Tamme BMSc, SCEB§; Leighton, Candice BSc, CTBS¶; Mackey, Adrienne BSc, GCPH?,**; Weinel, Luke BHSc (Hons)§; Whiting, Victoria BApplSci¶; Sutton, Gerard MBBS, FRANZCO PhD‡,††,‡‡; Baird, Paul N. PhD**
doi : 10.1097/ICO.0000000000002599
October 2021 - Volume 40 - Issue 10 - p 1229-1235
Corneal tissue importation is only possible if another country is able to export corneas without impacting its own domestic demand. Currently, there is little evidence to indicate whether export nations have such surplus capacity and in a position to export. To explore this concept, we examined our nation, Australia, which is reported to routinely decline donations because of its ability to meet domestic corneal transplant demand. Our research offers insights and opportunities for Australia and other nations to evaluate their domestic and international supply and allocation of corneal tissue in this space.
Sutured Custom Foldable Silicone Artificial Iris Implantation Combined With Intraocular Lens Implantation and Penetrating Keratoplasty: Safety and Efficacy Outcomes
Bonnet, Clemence MD*,†; Vazirnia, Parsia*; Deng, Sophie X. MD, PhD*; Aldave, Anthony J. MD*; Miller, Kevin M. MD*
doi : 10.1097/ICO.0000000000002564
October 2021 - Volume 40 - Issue 10 - p 1236-1247
To assess safety and efficacy outcomes of sutured custom silicone artificial iris and intraocular lens implantation combined with penetrating keratoplasty (triple procedure).
Efficacy of Long-term Use of 0.3% Sodium Hyaluronate Eye Drops for Traumatic Corneal Abrasion: A Randomized Controlled, Pilot Trial
Wei, Menghuan MD Candidate; Zou, Yingshi MD Candidate; Duan, Fang PhD; Ding, Xiaohu PhD; Zhuang, Jiejie BSc; Deng, Jiayu BSc; Yuan, Zhaohui PhD
doi : 10.1097/ICO.0000000000002625
October 2021 - Volume 40 - Issue 10 - p 1248-1252
Traumatic corneal abrasion (TCA) causes damage to both corneal epithelium and the underlying hemidesmosomal junctions. Delayed recovery of hemidesmosomal junctions causes symptomatic episodes. However, there is no recommended treatment for recovery of hemidesmosomal junctions, indicating that a blank period exists in TCA treatment. In this study, the efficacy of long-term use of sodium hyaluronate on recovery of hemidesmosomal junctions during the blank period in TCA healing was investigated.
Outcomes of Pseudophakic, Phakic, and Triple DMEK
Moshiri, Isabella MD; Karimi-Golkar, Damian; Schrittenlocher, Silvia MD; Cursiefen, Claus MD, PhD; Bachmann, Björn MD, PhD
doi : 10.1097/ICO.0000000000002723
October 2021 - Volume 40 - Issue 10 - p 1253-1257
To evaluate the outcome of phakic and pseudophakic eyes treated by Descemet membrane endothelial keratoplasty (DMEK) versus DMEK combined with cataract surgery (triple DMEK).
Endophthalmitis in Eyes With the Boston Type I Keratoprosthesis: Incidence, Recurrence, Risk Factors, and Outcomes
Bostan, Cristina MD, MSc*; Nayman, Taylor MD*; Szigiato, Andrei-Alexandru MD*; Morfeq, Hussein MD*,†; Harissi-Dagher, Mona MD, FRCSC*
doi : 10.1097/ICO.0000000000002641
October 2021 - Volume 40 - Issue 10 - p 1258-1266
To determine the incidence and recurrence of Boston type I keratoprosthesis (KPro)-associated endophthalmitis, and its microbiological profile, risk factors, and outcomes.
Corneal Edema Visualization With Optical Coherence Tomography Using Deep Learning: Proof of Concept
Zéboulon, Pierre MD*; Ghazal, Wassim MD*; Gatinel, Damien MD, PhD*,†
doi : 10.1097/ICO.0000000000002640
October 2021 - Volume 40 - Issue 10 - p 1267-1275
Optical coherence tomography (OCT) is essential for the diagnosis and follow-up of corneal edema, but assessment can be challenging in minimal or localized edema. The objective was to develop and validate a novel automated tool to detect and visualize corneal edema with OCT.
Optical Quality in Keratoconus Is Associated With Corneal Biomechanics
Shugyo, Akiko MD*; Koh, Shizuka MD, PhD*,†; Inoue, Ryota MS†,‡; Ambrósio, Renato Jr MD, PhD§; Miki, Atsuya MD, PhD*,†; Maeda, Naoyuki MD, PhD*; Nishida, Kohji MD, PhD*,¶
doi : 10.1097/ICO.0000000000002631
October 2021 - Volume 40 - Issue 10 - p 1276-1281
To evaluate the correlations between corneal biomechanical indices from dynamic Scheimpflug assessment and optical quality assessed as higher-order aberrations (HOAs) using a Hartmann–Shack ocular wavefront sensor in patients with keratoconus (KC).
Four-Year Survival Comparison of Endothelial Keratoplasty Techniques in Patients With Previous Glaucoma Surgery
Alshaker, Sara MD*; Mimouni, Michael MD*; Batawi, Hatim MD*; Cohen, Eyal MD*; Trinh, Tanya MBBS, FRANZCO*; Santaella, Gisella MD*; Chan, Clara C. MD, FACS, FRCSC*; Slomovic, Allan R. MD, FRCSC*; Rootman, David S. MD, FRCSC*; Sorkin, Nir MD*,†
doi : 10.1097/ICO.0000000000002585
October 2021 - Volume 40 - Issue 10 - p 1282-1289
To compare 4-year survival outcomes of Descemet membrane endothelial keratoplasty (DMEK) and Descemet-stripping automated endothelial keratoplasty (DSAEK) in eyes with previous glaucoma surgery.
A Water-free 0.1% Cyclosporine A Solution for Treatment of Dry Eye Disease: Results of the Randomized Phase 2B/3 ESSENCE Study
Sheppard, John D. MD*; Wirta, David L. MD†; McLaurin, Eugene MD‡; Boehmer, Blair E. MD§; Ciolino, Joseph B. MD¶; Meides, Alice S. PhD?; Schlüter, Thomas PhD?; Ousler, George W.**; Usner, Dale PhD††; Krösser, Sonja PhD?
doi : 10.1097/ICO.0000000000002633
October 2021 - Volume 40 - Issue 10 - p 1290-1297
To assess the efficacy, safety, and tolerability of a topical water-free cyclosporine A formulation (CyclASol 0.1% ophthalmic solution) in comparison with vehicle for the treatment of dry eye disease (DED).
Infectious Keratitis After Boston Type 1 Keratoprosthesis Implantation
Ghaffari, Reza MD*,†; Bonnet, Clemence MD*,‡; Yung, Madeline MD*; Bostan, Cristina MD, MSc§; Harissi-Dagher, Mona MD§; Aldave, Anthony J. MD*
doi : 10.1097/ICO.0000000000002649
October 2021 - Volume 40 - Issue 10 - p 1298-1308
To identify the incidence, risk factors, and outcomes of infectious keratitis after Boston type 1 keratoprosthesis (kpro) implantation.
Influence of Reading on Smartphone Screens on Visual Optical Quality Metrics and Tear Film Stability
Bettach, Emmanuel MD*,†; Zadok, David MD*,†; Abulafia, Adi MD*,†; Shoshani, Avi OD*,†; Ghebali, Rony A. MSc†; Weill, Yishay MD*,†; Smadja, David MD*,†
doi : 10.1097/ICO.0000000000002656
October 2021 - Volume 40 - Issue 10 - p 1309-1315
To evaluate the impact of a prolonged reading session on a smartphone screen on optical quality metrics and tear film stability.
Patient-Reported Outcomes After Corneal Transplantation
Dunbar, Grace E. MD*; Titus, Michael CEBT†; Stein, Joshua D. MD, MS, ABO*,‡; Meijome, Tomas E. MD, MS*; Mian, Shahzad I. MD*; Woodward, Maria A. MD, MSc*,‡,§
doi : 10.1097/ICO.0000000000002690
October 2021 - Volume 40 - Issue 10 - p 1316-1321
To characterize vision-related quality of life after penetrating keratoplasty (PKP), deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK), and Descemet membrane endothelial keratoplasty (DMEK) using the National Eye Institute Visual Function Questionnaire (NEI-VFQ 9).
The ABCD Keratoconus Grading System–A Useful Tool to Estimate Keratoconus Progression in the Pediatric Population
Dubinsky-Pertzov, Biana MD, MPH; Reinhardt, Ophir MD; Gazit, Inbal MD; Or, Lior MD; Hecht, Idan MD; Pras, Eran MD; Einan-Lifshitz, Adi MD
doi : 10.1097/ICO.0000000000002632
October 2021 - Volume 40 - Issue 10 - p 1322-1329
To evaluate the ABCD grading system in pediatric keratoconus.
Long-Term Outcome of Femtosecond Laser–Assisted Keratopigmentation: Using Intacs Channels for Precise Pigment Deposition Within the Cornea
Yin, Han Y. MD; Walter, Keith A. MD
doi : 10.1097/ICO.0000000000002667
October 2021 - Volume 40 - Issue 10 - p 1330-1335
To describe a long-term outcome of a new technique using the femtosecond laser to assist with keratopigmentation (corneal tattooing).
Effect of Face Mask on Tear Film Stability in Eyes With Moderate-to-Severe Dry Eye Disease
Arriola-Villalobos, Pedro MD, PhD*,†; Burgos-Blasco, Barbara MD†,‡; Vidal-Villegas, Beatriz MD†,‡; Oribio-Quinto, Carlos MD†,‡; Ariño-Gutiérrez, Mayte MD†,‡; Diaz-Valle, David MD, PhD*,†; Benitez-del-Castillo, Jose Manuel MD, PhD†,§
doi : 10.1097/ICO.0000000000002734
October 2021 - Volume 40 - Issue 10 - p 1336-1339
The purpose of this study was to evaluate whether tear film stability worsens with the use of masks in patients with dry eye disease, objectively analyzing the tear film stability using noninvasive tear film breakup time (NITBUT) with and without a face mask.
Combined Phialemonium curvatum and Acanthamoeba Keratitis: The Importance of Early Diagnosis and Specific Therapy
Roszkowska, Anna M. MD, PhD*; Severo, Alice A. MD*; Biondo, Carmelo MD†; Postorino, Elisa I. MD, PhD*; Inferrera, Leandro MD*; Aragona, Pasquale MD, PhD*
doi : 10.1097/ICO.0000000000002660
October 2021 - Volume 40 - Issue 10 - p 1340-1343
To report the clinical and confocal findings of a unique case of combined Phialemonium curvatum and Acanthamoeba keratitis and to highlight the role of the prompt diagnosis and specific medical treatment in preserving visual function.
A Case of Black Fungal Keratitis Caused by Biatriospora mackinnonii
Aoki, Takanori MD*; Fukuoka, Hideki MD, PhD*; Inatomi, Tsutomu MD, PhD*,†; Horiuchi, Noriko MD*; Kamei, Katsuhiko MD, PhD‡; Sotozono, Chie MD, PhD*
doi : 10.1097/ICO.0000000000002676
October 2021 - Volume 40 - Issue 10 - p 1344-1347
To report a novel case of fungal keratitis caused by Biatriospora mackinnonii (Pyrenochaeta mackinnonii), a dematiaceous fungus (black fungus) that rarely causes dermatological infection, in a patient treated for ocular cicatricial pemphigoid.
Assessment of Antimicrobial Activity of Dehydrated Amniotic Membrane in Infectious Keratitis: A Small Retrospective Case Series and In Vitro Study
Oji, Nnaoma M. BS*; Lin, Yijie B. MD, MBA†; Lee, Michele D. MD‡; Cevallos, Ada V. MS†; Keenan, Jeremy D. MD, MPH†; Seitzman, Gerami D. MD†
doi : 10.1097/ICO.0000000000002627
October 2021 - Volume 40 - Issue 10 - p 1348-1352
To describe a small case series of infectious keratitis with poor visual outcomes after amniotic membrane (AM) placement and to prospectively evaluate whether AM demonstrates antibacterial activity in vitro against pathogens commonly isolated from infectious corneal ulcers.
Atypical Case of Bilateral Chandler Syndrome With Recurrent Band Keratopathy
Agarwal, Mamta MD, FRCS Edin*; Dhiman, Richa MD†; Subramanian, Krishnakumar MD‡
doi : 10.1097/ICO.0000000000002610
October 2021 - Volume 40 - Issue 10 - p 1353-1356
To report a unique case of bilateral Chandler syndrome with recurrent band keratopathy.
Silk Suture Granuloma 37 Years After Scleral Buckle Surgery: A Case Report
Zein, Mike MD*; Theotoka, Despoina MD, MSc*; Wall, Sarah BS*; Galor, Anat MD, MSPH*,†; Cabot, Florence MD*; Patel, Umangi MD*,‡; Dubovy, Sander MD*,‡; Karp, Carol L. MD*
doi : 10.1097/ICO.0000000000002637
October 2021 - Volume 40 - Issue 10 - p 1357-1359
To present a rare presentation of pyogenic granuloma arising almost 4 decades after a scleral buckle for retinal detachment.
Simplified, Readily Available Method for the Treatment of Band Keratopathy With Ethylenediaminetetraacetic Acid
Narvaez, Julio MD*,†; Chang, Matthew BS‡; Ing, Jeffrey MD†; De Chance, Daniel§; Narvaez, Joshua J.*
doi : 10.1097/ICO.0000000000002635
October 2021 - Volume 40 - Issue 10 - p 1360-1362
To compare 3 methods for creating ethylenediaminetetraacetic acid (EDTA) solution using readily available Vacutainer tubes for the treatment of band keratopathy.
Corneal Effects of Tea Tree Oil
Tharmarajah, Brindhan BMed, MD, BScMed (Hons1)*; Coroneo, Minas Theodore BSc (Med) MB BS, MSc, Syd, MD, MS UNSW, FRACS, FRANZCO, FARVO*,†
doi : 10.1097/ICO.0000000000002776
October 2021 - Volume 40 - Issue 10 - p 1363-1364
The purpose of this study is to report a case of corneal epithelial defects resulting from topical treatment of blepharitis with tea tree oil (TTO).
Cool Cross-Linking: Riboflavin at 4°C for Pain Management After Cross-Linking for Keratoconus Patients, a Randomized Clinical Trial
Saluja, Gunjan MD; Maharana, Prafulla K. MD
doi : 10.1097/ICO.0000000000002703
October 2021 - Volume 40 - Issue 10 - p e19
Outcomes of ipsilateral Simple Limbal Epithelial Transplantation, Tenonectomy, Mitomycin, and Amniotic Membrane Transplantation for Treatment of Recurrent Pterygium- Letter to editor
Singh, Prabhakar MD; Raj, Amit MS; Gupta, Abhishek MS
doi : 10.1097/ICO.0000000000002726
October 2021 - Volume 40 - Issue 10 - p e19-e20
Author’s Response to Letter: Outcomes of Ipsilateral Simple Limbal Epithelial Transplant (SLET), Mitomycin, Tenonectomy and Amniotic Membrane Transplantation for Treatment of Recurrent Pterygium
Trinh, Tanya MBBS, FRANZCO*; Mimouni, Michael MD*; Mednick, Zale MD, FRCSC*; Einan-Lifshitz, Adi MD*; Cohen, Eyal MD*; Santaella, Gisella MD*; Sorkin, Nir MD*,†; Slomovic, Allan MD, FRCSC*
doi : 10.1097/ICO.0000000000002749
October 2021 - Volume 40 - Issue 10 - p e20-e21
