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Insights into the Spectrum of Chronic Lower respiratory Disease: Low Lung Function Is still Bad
David M. Mannino
doi : 10.1164/rccm.202107-1637ed
Volume 204, Issue 8, pp. 873–874
Seek and Ye Shall Find: COVID-19 and Bacterial Superinfection
Georgios D. Kitsios 1,2,3 and Alison Morris 1,2,4,5
doi : 10.1164/rccm.202107-1790ed
Volume 204, Issue 8, pp. 875–877
Inhaled CO2 to reduce Lung Ischemia and reperfusion Injuries: Moving toward Clinical Translation?
Claire H. Masterson 1,2, Daniel O’Toole 1,2, and John G. Laffey 1,2,3
doi : 10.1164/rccm.202107-1665ed
Volume 204, Issue 8, pp. 878–879
Foretelling Early Lung Disease Progression in Cystic Fibrosis: The Combined Benefits of Magnetic resonance imaging and Newborn Screening
Jennifer L. Goralski
doi : 10.1164/rccm.202107-1727ed
Volume 204, Issue 8, pp. 880–881
The Epigenomic Landscape: A Cornerstone of Macrophage Phenotype regulation in the Fibrotic Lung
Megan N. Ballinger and Ana L. Mora
doi : 10.1164/rccm.202107-1760ed
Volume 204, Issue 8, pp. 881–883
Using Automated radiographic Signatures to Prognosticate Chronic Lung Allograft Dysfunction: What Does the Future Hold?
Dmitry rozenberg 1,2,3, Micheal McInnis 4,5, and Chung-Wai Chow 1,2,3
doi : 10.1164/rccm.202107-1726ed
Volume 204, Issue 8, pp. 883–885
Epinephrine Administration Intervals: Seeing the Forest for the Trees
Donald H. Shaffner 1 and Clifton W. Callaway 2
doi : 10.1164/rccm.202107-1667ed
Volume 204, Issue 8, pp. 885–887
Philips respironics recall of Positive Airway Pressure and Noninvasive Ventilation Devices: A Brief statement to Inform response Efforts and Identify Key steps Forward
robert L. Owens 1, Kevin C. Wilson 2, Indira Gurubhagavatula 3,4, and reena Mehra 5*
doi : 10.1164/rccm.202107-1666ed
Volume 204, Issue 8, pp. 887–890
A research Agenda for Precision Medicine in Sepsis and Acute respiratory Distress Syndrome: An Official American Thoracic Society research statement
Faraaz Ali Shah *, Nuala J. Meyer *, Derek C. Angus , rana Awdish , Élie Azoulay , Carolyn S. Calfee , Gilles Clermont , Anthony C. Gordon , Arthur Kwizera , Aleksandra leligdowicz , John C. Marshall , Carmen Mikacenic , Pratik Sinha , Balasubramanian Venkatesh , Hector r. Wong , Fernando G. Zampieri , and Sachin Yende ; on behalf of the American Thoracic Society Assembly on Critical Care
doi : 10.1164/rccm.202108-1908st
Volume 204, Issue 8, pp. 891–901
Precision medicine focuses on the identification of therapeutic strategies that are effective for a group of patients based on similar unifying characteristics. The recent success of precision medicine in non–critical care settings has resulted from the confluence of large clinical and biospecimen repositories, innovative bioinformatics, and novel trial designs. Similar advances for precision medicine in sepsis and in the acute respiratory distress syndrome (ArDS) are possible but will require further investigation and significant investment in infrastructure.
Hospital-Free Days: A Pragmatic and Patient-centered Outcome for Trials among Critically and Seriously Ill Patients
Catherine L. Auriemma 1,2,3, stephanie P. Taylor 4, Michael O. Harhay 1,5,6, Katherine r. Courtright 1,2,3, and Scott D. Halpern 1,2,3,6,7
doi : 10.1164/rccm.202104-1063pp
Volume 204, Issue 8, pp. 902–909
Trajectory of Preserved ratio impaired Spirometry: Natural History and Long-Term Prognosis
Jacob Louis Marott 1, Truls Sylvan Ingebrigtsen 1, Yunus Çolak 1,2, Jørgen Vestbo 3,4, and Peter Lange 1,2,5
doi : 10.1164/rccm.202102-0517oc
Volume 204, Issue 8, pp. 910–920
Natural history of preserved ratio impaired spirometry (PrISm), often defined as FEV1/FVC ?lower limit of normal and FEV1 <80% of predicted value, is not well described.
Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia
Chiagozie O. Pickens 1, Catherine A. Gao 1, Michael J. Cuttica 1, Sean B. Smith 1, Lorenzo L. Pesce 2, rogan A. Grant 1, Mengjia Kang 1, Luisa Morales-Nebreda 1, Avni A. Bavishi 3, Jason M. Arnold 3, Anna Pawlowski 4, Chao Qi 5*, G. r. Scott Budinger 1*, Benjamin D. Singer 1*, and richard G. Wunderink 1; for the NU COVID Investigators
doi : 10.1164/rccm.202106-1354oc
Volume 204, Issue 8, pp. 921–932
Current guidelines recommend patients with severe acute respiratory syndrome coronavirus 2 (SArS-CoV-2) pneumonia receive empirical antibiotics for suspected bacterial superinfection on the basis of weak evidence. rates of ventilator-associated pneumonia (VAP) in clinical trials of patients with SArS-CoV-2 pneumonia are unexpectedly low.
Addition of 5% CO2 to Inspiratory Gas Prevents Lung Injury in an Experimental Model of Pulmonary Artery Ligation
Ines Marongiu 1, Elena Spinelli 2, Eleonora Scotti 2, Alessandra Mazzucco 3, Yu-Mei Wang 2,4, leonardo Manesso 1, Giulia Colussi 2, Osvaldo Biancolilli 2, Michele Battistin 2, Thomas Langer 5, Francesca roma 2, Gianluca Lopez 6,7, Caterina Lonati 8, Valentina Vaira 1,7, Lorenzo rosso 3, stefano Ferrero 6,7, stefano Gatti 8, Alberto Zanella 1,2, Antonio Pesenti 1,2, and Tommaso Mauri 1,2
doi : 10.1164/rccm.202101-0122oc
Volume 204, Issue 8, pp. 933–942
Unilateral ligation of the pulmonary artery may induce lung injury through multiple mechanisms, which might be dampened by inhaled CO2.
Magnetic resonance imaging Detects Progression of Lung Disease and impact of Newborn Screening in Preschool Children with Cystic Fibrosis
Mirjam stahl 1,2,3,4,5,6*, Eva steinke 1,3,4,5*, Simon Y. Graeber 1,2,3,4,5,6, Cornelia Joachim 4,5, Christoph Seitz 7,8, Hans-Ulrich Kauczor 3,5,9, Monika Eichinger 5,9,10, Susanne Hämmerling 4, Olaf Sommerburg 3,4,5, Mark O. Wielpütz 5,9,11‡, and Marcus A. Mall 1,2,3,4,5,6‡
doi : 10.1164/rccm.202102-0278oc
Volume 204, Issue 8, pp. 943–953
Previous cross-sectional studies have demonstrated that chest magnetic resonance imaging (MrI) is sensitive to detect early lung disease in infants and preschool children with cystic fibrosis (CF) without radiation exposure. However, the ability of MrI to detect the progression of lung disease and the impact of early diagnosis in preschool children with CF remains unknown.
DNA Methylome Alterations Are Associated with Airway Macrophage Differentiation and Phenotype during Lung Fibrosis
Peter McErlean 1, Christopher G. Bell 2, richard J. Hewitt 1,3, Zabreen Busharat 1, Patricia P. Ogger 1, Poonam Ghai 1, Gesa J. Albers 1, Emily Calamita 1, Shaun Kingston 3, Philip L. Molyneaux 1,3, stephan Beck 4, Clare M. Lloyd 1, Toby M. Maher 1,3,5,6*‡, and Adam J. Byrne 1* .
doi : 10.1164/rccm.202101-0004oc
Volume 204, Issue 8, pp. 954–966
Airway macrophages (AMs) are key regulators of the lung environment and are implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a fatal respiratory disease with no cure. However, knowledge about the epigenetics of AMs in IPF is limited.
radiographic Graft Surveillance in Lung Transplantation: Prognostic role of Parametric response Mapping
Elizabeth A. Belloli 1, Tian Gu 2, Yizhuo Wang 2, Dharshan Vummidi 3, Dennis M. Lyu 1, Michael P. Combs 1, Aamer Chughtai 3, Susan Murray 2*, Craig J. Galbán 3, and Vibha N. Lama 1
doi : 10.1164/rccm.202012-4528oc
Volume 204, Issue 8, pp. 967–976
Chronic lung allograft dysfunction (CLAD) results in significant morbidity after lung transplantation. Potential CLAD occurs when lung function declines to 80–90% of baseline. Better noninvasive tools to prognosticate at potential CLAD are needed.
The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest
Martha F. Kienzle 1, ryan W. Morgan 1, Jennifer A. Faerber 2, Kathryn Graham 1, Hannah Katcoff 2, William P. Landis 1, Alexis A. Topjian 1, Todd J. Kilbaugh 1, Vinay M. Nadkarni 1, robert A. Berg 1, and robert M. Sutton 1
doi : 10.1164/rccm.202012-4437oc
Volume 204, Issue 8, pp. 977–985
Animal studies of cardiac arrest suggest that shorter epinephrine dosing intervals than currently recommended (every 3–5 min) may be beneficial in select circumstances.
Alternative Therapies for Obstructive Sleep Apnea
Brandon Nokes , Erica Lin , W. Cameron McGuire , and Atul Malhotra
doi : 10.1164/rccm.202102-0359rr
Volume 204, Issue 8, pp. 986–988
Spontaneous Pneumomediastinum in COVID-19: The Macklin Effect?
Mypinder S. Sekhon , Sharanjit Thiara , Hussein D. Kanji , and Juan J. ronco
doi : 10.1164/rccm.202105-1179im
Volume 204, Issue 8, pp. 989–990
Epirubicin and Cyclophosphamide–induced Acute Fibrinous and Organizing Pneumonia
Taeka Naraoka 1, Toshiyuki Sumi 1,2, Yoshiko Keira 3, Hisashi Nakata 1, and Hirofumi Chiba 2
doi : 10.1164/rccm.202101-0020im
Volume 204, Issue 8, pp. e92–e93
High In-Hospital Mortality rate in Patients with COVID-19 receiving Extracorporeal Membrane Oxygenation in Germany: A Critical Analysis
Christian Karagiannidis 1,2*, stephan strassmann 1,2, Michaela Merten 1,2, Thomas Bein 3, Wolfram Windisch 1,2, Patrick Meybohm 4, and steffen Weber-Carstens 5
doi : 10.1164/rccm.202105-1145le
Volume 204, Issue 8, pp. 991–994
Outcomes of Patients Denied Extracorporeal Membrane Oxygenation during the COVID-19 Pandemic in Greater Paris, France
David levy 1,2, Guillaume lebreton 1,2, Marc Pineton de Chambrun 1,2, Guillaume Hékimian 1,2, Juliette Chommeloux 1,2, Nicolas Bréchot 1,2, Charles-edouard Luyt 1,2, Pascal leprince 1,2, Alain Combes 1,2, and Matthieu Schmidt 1,2*
doi : 10.1164/rccm.202105-1312le
Volume 204, Issue 8, pp. 994–997
Dysanapsis and the Spirometric response to Inhaled Bronchodilators
Motahareh Vameghestahbanati 1, Miranda Kirby 2, François Maltais 3, Dennis Jensen 1, Dany Doiron 1, Wan C. Tan 4, Jean Bourbeau 1, and Benjamin M. Smith 1,5*; on behalf of the CanCOLD Investigators
doi : 10.1164/rccm.202107-1574le
Volume 204, Issue 8, pp. 997–1001
relevant Factors for Physical, Mental, and Cognitive Problems in ICU Survivors
Tomoharu Suzuki 1*, Hiroshi Ueta 2, and Shunsuke Taito 3
doi : 10.1164/rccm.202107-1714le
Volume 204, Issue 8, pp. 1001
reply to Suzuki et al.
Wytske W. Geense and Mark van den Boogaard *
doi : 10.1164/rccm.202107-1778le
Volume 204, Issue 8, pp. 1001–1002
