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Circulating endothelin-1 levels are positively associated with chronic kidney disease in women but not in men: a longitudinal study in the Vara-Skövde cohort
Margareta I. Hellgren, Per-Anders Jansson, Hormoz Alayar, Ulf Lindblad & Bledar Daka
doi : 10.1186/s12882-021-02525-5
BMC Nephrology volume 22, Article number: 327 (2021)
The vasoconstricting peptide endothelin-1 (ET-1) is associated with endothelial dysfunction. The aim of this paper was to investigate whether circulating ET-1 levels predicts chronic kidney disease (CKD) in a prospective population study.
Conversion from mycophenolate mofetil to mizoribine in the early stages of BK polyomavirus infection could improve kidney allograft prognosis: a single-center study from China
Ping Li, Dongrui Cheng, Jiqiu Wen, Xuefeng Ni, Kenan Xie, Xue Li & Jinsong Chen
doi : 10.1186/s12882-021-02527-3
BMC Nephrology volume 22, Article number: 328 (2021)
Some studies have suggested mizoribine (MZR) could inhibit the replication of BK polyomavirus (BKPyV). The purpose of this study was to explore whether conversion from mycophenolate mofetil (MMF) to MZR in the early stages of BKPyV infection can improve kidney allograft prognosis.
Longitudinal change in c-terminal fibroblast growth factor 23 and outcomes in patients with advanced chronic kidney disease
Helen V. Alderson, Rajkumar Chinnadurai, Sara T. Ibrahim, Ozgur Asar, James P. Ritchie, Rachel Middleton, Anders Larsson, Peter J. Diggle, Tobias E. Larsson & Philip A. Kalra
doi : 10.1186/s12882-021-02528-2
BMC Nephrology volume 22, Article number: 329 (2021)
Fibroblast growth factor23 (FGF23) is elevated in CKD and has been associated with outcomes such as death, cardiovascular (CV) events and progression to Renal Replacement therapy (RRT). The majority of studies have been unable to account for change in FGF23 over time and those which have demonstrate conflicting results. We performed a survival analysis looking at change in c-terminal FGF23 (cFGF23) over time to assess the relative contribution of cFGF23 to these outcomes.
The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study
Ensieh Memarian, Peter M. Nilsson, Isac Zia, Anders Christensson & Gunnar Engström
doi : 10.1186/s12882-021-02531-7
BMC Nephrology volume 22, Article number: 330 (2021)
It has been shown that individuals with obesity have a higher risk for chronic kidney disease (CKD). However, it is unclear which measure of obesity is most useful for prediction of CKD in the general population. The aim of this large prospective study was to explore the association between several anthropometric measures of obesity, i. e., body mass index (BMI), waist circumference (WC), waist circumference to height ratio (WHtR), waist-to-hip ratio (WHR), percentage of body fat (BF%), weight, height and incidence of hospitalizations due to CKD, in a population-based cohort study.
Establishment of dry chemistry based reference intervals of renal function test parameters for the adult population of Kaski District, Nepal
Goma Kathayat, Daya Ram Pokharel, Naval Kishor Yadav & Manoj Sigdel
doi : 10.1186/s12882-021-02542-4
BMC Nephrology volume 22, Article number: 331 (2021)
Reference intervals (RIs) for clinical chemistry test parameters are specific to the method of measurement and population under service. However, there has been no locally available dry chemistry based RIs for the Nepalese population. Thus, the present study aimed to establish dry chemistry based RIs for sodium, potassium, urea, and creatinine specific to adult populations of Kaski districts, Nepal
Online clinical pathway for chronic kidney disease management in primary care: a retrospective cohort study
Maoliosa Donald, Michelle D. Smekal, Meghan J. Elliott, Kerry McBrien, Robert G. Weaver, Braden J. Manns, Marcello Tonelli, Aminu Bello, Sharon E. Straus, Nairne Scott-Douglas, Kailash Jindal & Brenda R. Hemmelgarn
doi : 10.1186/s12882-021-02533-5
BMC Nephrology volume 22, Article number: 332 (2021)
Clinical pathways aim to improve patient care. We sought to determine whether an online chronic kidney disease (CKD) clinical pathway was associated with improvements in CKD management.
Improvements in six aspects of quality of care of incident hemodialysis patients – a real-world experience
Maciej Drozdz, João Frazão, Fatima Silva, Partha Das, Werner Kleophas, Wisam Al Badr, Szymon Brzosko & Stefan H. Jacobson
doi : 10.1186/s12882-021-02529-1
BMC Nephrology volume 22, Article number: 333 (2021)
The transition from chronic kidney disease stage 5 to initiation of hemodialysis has gained increased attention in recent years as this period is one of high risk for patients with an annual mortality rate exceeding 20%. Morbidity and mortality in incident hemodialysis patients are partially attributed to failure to attain guideline-based targets. This study focuses on improvements in six aspects of quality of dialysis care (adequacy, anemia, nutrition, chronic kidney disease-mineral bone disorder (CKD-MBD), blood pressure and vascular access) aligning with KDIGO guidelines, during the first 6 months of hemodialysis.
Is health-related quality of life associated with adequacy of hemodialysis in chronic kidney disease patients?
Lamia M. Hasan, Dina A. H. Shaheen, Ghada A. H. El Kannishy, Nagy A. H. Sayed-Ahmed & Ahmed M. Abd El Wahab
doi : 10.1186/s12882-021-02539-z
BMC Nephrology volume 22, Article number: 334 (2021)
Monitoring Health Related Quality of Life (HRQoL) in different stages of chronic kidney disease is advised by all nephrology societies. We aimed to study the relation between quality of life and dialysis adequacy.
Impact of AKI care bundles on kidney and patient outcomes in hospitalized patients: a systematic review and meta-analysis
Hannah A. I. Schaubroeck, Diana Vargas, Wim Vandenberghe & Eric A. J. Hoste
doi : 10.1186/s12882-021-02534-4
BMC Nephrology volume 22, Article number: 335 (2021)
A bundle of preventive measures can be taken to avoid acute kidney injury (AKI) or progression of AKI. We performed a systematic review and meta-analysis to evaluate the compliance to AKI care bundles in hospitalized patients and its impact on kidney and patient outcomes.
Renal angina index predicts fluid overload in critically ill children: an observational cohort study
Stephen M. Gorga, Erin F. Carlton, Joseph G. Kohne, Ryan P. Barbaro & Rajit K. Basu
doi : 10.1186/s12882-021-02540-6
BMC Nephrology volume 22, Article number: 336 (2021)
Fluid overload and acute kidney injury are common and associated with poor outcomes among critically ill children. The prodrome of renal angina stratifies patients by risk for severe acute kidney injury, but the predictive discrimination for fluid overload is unknown.
Hemophagocytic lymphohistiocytosis and thrombotic microangiopathy after parvovirus B19 infection and renal transplantation: a case report
C. J. Steffen, N. Koch, K. U. Eckardt, K. Amann, E. Seelow & A. Schreiber
doi : 10.1186/s12882-021-02538-0
BMC Nephrology volume 22, Article number: 337 (2021)
Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease characterized by hyperactivation of the immune system that causes hypercytokinemia and potentially multi organ failure. HLH can occur in patients with underlying rheumatic or autoinflammatory disorders. Additionally, HLH can develop in patients during infections or malignancies without a known genetic predisposition.
Renal infarction associated with low dose intravenous immunoglobulin in a kidney transplant recipient with sepsis: a case report and literature review
Eun Woo Choi, Jun Young Do, A. Young Kim & Seok Hui Kang
doi : 10.1186/s12882-021-02545-1
BMC Nephrology volume 22, Article number: 338 (2021)
The use of human intravenous immunoglobulin gamma (IVIG) is associated with thromboembolic events as a complication. There are few reported cases of renal infarction during IVIG use in the general population, but transplant kidney may be more susceptible to thromboembolic events following IVIG use.
Changes in practice patterns in Japan from before to after JSDT 2013 guidelines on hemodialysis prescriptions: results from the JDOPPS
Tadashi Tomo, Maria Larkina, Ayumi Shintani, Tomonari Ogawa, Bruce M. Robinson, Brian Bieber, Lisa Henn & Ronald L. Pisoni
doi : 10.1186/s12882-021-02543-3
BMC Nephrology volume 22, Article number: 339 (2021)
The Japanese Society for Dialysis Therapy (JSDT) published in 2013 inaugural hemodialysis (HD) guidelines. Specific targets include 1.4 for single-pool Kt/V (spKt/V) with a minimum dose of 1.2, minimum dialysis session length of 4 hours, minimum blood flow rate (BFR) of 200 mL/min, fluid removal rate no more than 15 mL/kg/hr, and hemodiafiltration (HDF) therapy for certain identified symptoms. We evaluated the effect of these guidelines on actual practice in the years spanning 2005 – 2018.
Temporal changes in cardiovascular disease and infections in dialysis across a 22-year period: a nationwide study
Kamal Preet Kaur, Mavish Safdar Chaudry, Emil Loldrup Fosbøl, Lauge Østergaard, Christian Torp-Pedersen & Niels Eske Bruun
doi : 10.1186/s12882-021-02537-1
BMC Nephrology volume 22, Article number: 340 (2021)
Cardiovascular diseases (CVD) and infections are recognized as serious complications in patients with end stage kidney disease. However, little is known about the change over time in incidence of these complications. This study aimed to investigate temporal changes in CVD and infective diseases across more than two decades in chronic dialysis patients.
Patient, family and productivity costs of end-stage renal disease in the Netherlands; exposing non-healthcare related costs
Eline F. de Vries, Jeanine Los, G. Ardine de Wit & Leona Hakkaart - van Roijen
doi : 10.1186/s12882-021-02548-y
BMC Nephrology volume 22, Article number: 341 (2021)
Eline F. de Vries, Jeanine Los, G. Ardine de Wit & Leona Hakkaart - van Roijen
A longitudinal study of cardiac structure and function using echocardiography in patients undergoing peritoneal dialysis
Yunyun Zhu, Difei Zhang, Xiaoxuan Hu, Hui Liu, Yuan Xu, Haijing Hou, Yu Peng, Ying Lu, Xusheng Liu & Fuhua Lu
doi : 10.1186/s12882-021-02535-3
BMC Nephrology volume 22, Article number: 342 (2021)
Peritoneal dialysis (PD) can be associated with abnormal cardiac structure and function and increased mortality risk. Therefore, in this study, we analyzed the cardiac structure and function dynamic changes using echocardiography during the first 2 years of PD therapy. We also assessed its associations with all-cause mortality risk after 2 years of follow-up.
Hyperchloremia is associated with poor renal outcome after coronary artery bypass grafting
Jae Shin Choi, Donghwan Yun, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Ki Young Na & Seung Seok Han
doi : 10.1186/s12882-021-02554-0
BMC Nephrology volume 22, Article number: 343 (2021)
Hyperchloremia is associated with the risks of several morbidities and mortality. However, its relationship with acute kidney injury (AKI) and end-stage renal disease (ESRD) in patients undergoing coronary artery bypass grafting (CABG) remains unresolved.
A national cohort study on hemodialysis arteriovenous fistulas after kidney transplantation - long-term patency, use and complications
Barbara Vajdi? Trampuž, Miha Arnol, Jakob Gubenšek, Rafael Ponikvar & Jadranka Buturovi? Ponikvar
doi : 10.1186/s12882-021-02550-4
BMC Nephrology volume 22, Article number: 344 (2021)
To describe the long-term hemodialysis arteriovenous fistula (AVF) patency, incidence of AVF use, incidence and nature of AVF complications and surgery in patients after kidney transplantation.
Mycobacteria avium-related peritonitis in a patient undergoing peritoneal dialysis: case report and review of the literature
Jifang Lu, Zhou Jiang, Ling Wang, Shan Mou & Hao Yan
doi : 10.1186/s12882-021-02544-2
BMC Nephrology volume 22, Article number: 345 (2021)
Mycobacteria avium (M. avium) is a species of ubiquitous slowly growing nontuberculous mycobacteria. It causes opportunistic infections. However, M. avium-related peritonitis in peritoneal dialysis (PD) patients is rare.
Oral sodium bicarbonate in people on haemodialysis: a randomised controlled trial
Stella I. Kourtellidou, Damien R. Ashby & Lina R. Johansson
doi : 10.1186/s12882-021-02549-x
BMC Nephrology volume 22, Article number: 346 (2021)
Adverse events and mortality tend to cluster around dialysis sessions, potentially due to the impact of the saw-toothed profile of uraemic toxins such as potassium, peaking pre-dialysis and rapidly dropping during dialysis. Acidosis could be contributing to this harm by exacerbating a rise in potassium. The objectives of this study were to investigate the effects of oral bicarbonate treatment on reducing inter-dialytic potassium gain as well as other clinical consequences of preserving muscle mass and function and reducing intradialytic arrhythmia risk in people on haemodialysis.
Cardiovascular outcomes after simultaneous pancreas kidney transplantation compared to kidney transplantation alone: a propensity score matching analysis
U. G. Lange, S. Rademacher, B. Zirnstein, R. Sucher, K. Semmling, P. Bobbert, A. A. Lederer, D. Buchloh, L. Seidemann, D. Seehofer, N. Jahn & H.-M. Hau
doi : 10.1186/s12882-021-02522-8
BMC Nephrology volume 22, Article number: 347 (2021)
Coronary heart disease due to arteriosclerosis is the leading cause of death in type 1 diabetic patients with end-stage renal disease (ESRD). The aim of this study was to evaluate the effect of simultaneous pancreas kidney transplantation (SPKT) compared to kidney transplantation alone (KTA) on survival, cardiovascular function and metabolic outcomes.
Employment of patients with kidney failure treated with dialysis or kidney transplantation—a systematic review and meta-analysis
Lilli Kirkeskov, Rasmus K. Carlsen, Thomas Lund & Niels Henrik Buus
doi : 10.1186/s12882-021-02552-2
BMC Nephrology volume 22, Article number: 348 (2021)
Patients with kidney failure treated with dialysis or kidney transplantation experience difficulties maintaining employment due to the condition itself and the treatment. We aimed to establish the rate of employment before and after initiation of dialysis and kidney transplantation and to identify predictors of employment during dialysis and posttransplant.
The effect of digoxin on renal function in patients with heart failure
Parin Shah, Pierpaolo Pellicori, Ian Hanning, Jufen Zhang, Andrew L. Clark & Sunil Bhandari
doi : 10.1186/s12882-021-02562-0
BMC Nephrology volume 22, Article number: 349 (2021)
Digoxin is used in patients with chronic heart failure (CHF) who remain symptomatic despite optimal medical treatment. Impaired renal function is commonly associated with CHF. We investigated the relation between digoxin use and change in renal function over time in patients with CHF.
High-dose versus low-dose iron sucrose in individuals undergoing maintenance haemodialysis: a retrospective study
Luojin Liu, Huihui Cheng, Yukai Lv, Weiguang Yu, Qilong Liu, Yanqing Wu & Bo Xu
doi : 10.1186/s12882-021-02570-0
BMC Nephrology volume 22, Article number: 350 (2021)
Intravenous iron sucrose is becoming a prevailing treatment for individuals undergoing maintenance haemodialysis, but comparisons of dosing regimens are lacking. The aim of this retrospective review was to evaluate the safety and efficacy of proactively administered high-dose iron sucrose versus reactively administered low-dose iron sucrose in patients undergoing maintenance haemodialysis.
Growth differentiation factor-15 and incident chronic kidney disease: a population-based cohort study
Xue Bao, Biao Xu, Yan Borné, Marju Orho-Melander, Olle Melander, Jan Nilsson, Anders Christensson & Gunnar Engström
doi : 10.1186/s12882-021-02558-w
BMC Nephrology volume 22, Article number: 351 (2021)
The relationship between growth differentiation factor 15 (GDF-15) and the development of chronic kidney disease (CKD) is still unclear. We sought to examine whether plasma GDF-15 was related to incident CKD and kidney function decline using a large prospective cohort study.
The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group
Kenan Turgutalp, Egemen Cebeci, Aydin Turkmen, Ulver Derici, Nurhan Seyahi, Necmi Eren, Fatih Dede, Mustafa Gullulu, Taner Basturk, Gulizar Manga Sahin, Murvet Yilmaz, Savas Sipahi, Garip Sahin, Sena Ulu, Erhan Tatar, Ali Gundogdu, Rumeyza Turan Kazancioglu, Can Sevinc, Ozkan Gungor, ?dris Sahin, Sim Kutlay, Ilhan Kurultak, Zeki Aydin, Bulent Altun, Belda Dursun, Zulfikar Yilmaz, Ozcan Uzun, Gultekin Suleymanlar, Ferhan Candan, Siren Sezer, Derya Basak Tanburoglu, Zerrin Bicik Bahcebasi, Dilek Taymez, Esra Akcali, Deren Oygar, Zulal Istemihan, Simge Bardak, Omer Faruk Akcay, Mevlut Tamer Dincer, Erkan Dervisoglu, Ezgi Yenigun, Kultigin Turkmen & Savas Ozturk
doi : 10.1186/s12882-021-02560-2
BMC Nephrology volume 22, Article number: 352 (2021)
Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis.
Clinicopathological characteristics and prognosis of patients with IgA nephropathy and renal vasculitic lesions
Xueqing Tang, Qiong Wen, Qian Zhou & Wei Chen
doi : 10.1186/s12882-021-02556-y
BMC Nephrology volume 22, Article number: 353 (2021)
We studied patients with IgA nephropathy (IgAN) and compared those with and without renal vasculitic lesions (RVLs).
High risk of acute kidney injury in Malawian trauma patients: a prospective observational cohort study
Erica C. Bjornstad, Zachary H. Smith, William Muronya, Charles K. Munthali, Amy K. Mottl, Stephen W. Marshall, Yvonne M. Golightly, Keisha Gibson, Anthony Charles & Emily W. Gower
doi : 10.1186/s12882-021-02564-y
BMC Nephrology volume 22, Article number: 354 (2021)
Trauma is a common cause of acute kidney injury (AKI). Yet little data exist regarding trauma-related-AKI in low-resourced settings, where the majority of deaths from AKI and trauma occur. We prospectively evaluated epidemiology of AKI in hospitalized Malawian trauma patients.
Risk factors for impaired renal function in HIV-infected and HIV-uninfected adults: cross-sectional study in North-Western Tanzania
Bazil Baltazar Kavishe, Belinda V. Kweka, Dorothea Nitsch, George PrayGod, Kidola Jeremiah, Daniel Faurholt-Jepsen, Suzanne Filteau, Mette Frahm Olsen, Brenda W. Kitilya, Rikke Krogh-Madsen, Henrik Friis & Robert Peck
doi : 10.1186/s12882-021-02563-z
BMC Nephrology volume 22, Article number: 355 (2021)
Although the burden of impaired renal function is rising in sub-Saharan Africa (SSA), little is known about correlates of impaired renal function in the region. We determined factors associated with estimated glomerular filtration rate (eGFR) and impaired renal function in HIV-infected and HIV-uninfected adults.
Xanthogranulomatous pyelonephritis infected with the Providencia stuartii: a case report and literature review
Zhunan Xu, Tong Cai, Xuebao Zhang, Jitao Wu & Chu Liu
doi : 10.1186/s12882-021-02565-x
BMC Nephrology volume 22, Article number: 356 (2021)
Xanthogranulomatous pyelonephritis (XGP) is a rare and severe chronic inflammatory disease of the renal parenchyma, which is most commonly associated with super-infections by bacteria such as E. coli, Proteus mirabilis, and occasionally Pseudomonas species.
Patient-reported outcome measures in hemodialysis patients: results of the first multicenter cross-sectional ePROMs study in France
Abdallah Guerraoui, Mathilde Prezelin-Reydit, Anne Kolko, Marie Lino-Daniel, Charlotte Dumas de Roque, Pablo Urena, Philippe Chauveau, Catherine Lasseur, Julie Haesebaert & Agnes Caillette-Beaudoin
doi : 10.1186/s12882-021-02551-3
BMC Nephrology volume 22, Article number: 357 (2021)
Kidney failure with replacement therapy and hemodialysis are associated with a decrease in quality of life (QOL). Self-reported QOL symptoms are not always prioritized by the medical team, potentially leading to conflicting priorities with patients. Electronic patient-reported outcome measures (ePROMs) allow physicians to better identify these symptoms. The objective was to describe the prevalence of symptoms self-reported by hemodialysis (HD) patients.
Tale of two nephropathies; co-occurring Alport syndrome and IgA nephropathy, a case report
Aniruddha Bhattacharyya, Yuting Huang, Sarah Hussain Khan, Cinthia Beskow Drachenberg & Laura C. Malone
doi : 10.1186/s12882-021-02567-9
BMC Nephrology volume 22, Article number: 358 (2021)
Alport Syndrome and IgA Nephropathy (IgAN) are both disorders that can cause hematuria. Alport syndrome is most commonly an X-linked disease, caused by COL4A5 mutation. Mutations of COL4A3 and COL4A4 on chromosome two are also common causes of Alport syndrome. IgAN is the most common glomerulonephritis worldwide. Though IgAN is usually sporadic, an estimated 15% of cases have an inheritable component. These cases of Familal IgA Nephropathy (FIgAN) can have mutations on genes which are known to cause Alport Syndrome.
