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First things first: a step in the right direction for the preanalytical phase of thiamine measurements
Christine M Pfeiffer, Zia Fazili, Ekaterina M Mineva, Phuong K Ngac
doi : 10.1093/ajcn/nqab186
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 829–830
From gut to blood: the travels and travails of vitamin D supplementation
Clifford J Rosen
doi : 10.1093/ajcn/nqab125
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 831–832
Insects on the menu: characterization of protein quality to evaluate potential as an alternative protein source for human consumption
Juliane Calvez, Claire Gaudichon
doi : 10.1093/ajcn/nqab170
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 833–834
All moderately wasted children are at risk, but some are more at risk than others
Ayesha De Costa, Christopher P Duggan
doi : 10.1093/ajcn/nqab187
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 835–836
Junk food consumption trends point to the need for retail policies
Melissa L Jensen, Marlene B Schwartz
doi : 10.1093/ajcn/nqab189
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 837–838
The multifactorial consequences of sulfur amino acid deficiency
Robert F Bertolo
doi : 10.1093/ajcn/nqab197
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 839–840
Postprandial metabolism and inflammation—a comprehensive model to advance Precision Nutrition? Lessons learned from the Personalised REsponses to DIetary Composition Trial (PREDICT study)
Helen M Roche
doi : 10.1093/ajcn/nqab200
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 841–842
Using naso- and oro-intestinal catheters in physiological research for intestinal delivery and sampling in vivo: practical and technical aspects to be considered.
Mara PH van Trijp, Ellen Wilms, Melany Ríos-Morales, Ad Am Masclee, Robert Jan Brummer, Ben Jm Witteman, Freddy J Troost, Guido Jej Hooiveld
doi : 10.1093/ajcn/nqab149
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 843–861
Intestinal catheters have been used for decades in human nutrition, physiology, pharmacokinetics, and gut microbiome research, facilitating the delivery of compounds directly into the intestinal lumen or the aspiration of intestinal fluids in human subjects. Such research provides insights about (local) dynamic metabolic and other intestinal luminal processes, but working with catheters might pose challenges to biomedical researchers and clinicians. Here, we provide an overview of practical and technical aspects of applying naso- and oro-intestinal catheters for delivery of compounds and sampling luminal fluids from the jejunum, ileum, and colon in vivo. The recent literature was extensively reviewed, and combined with experiences and insights we gained through our own clinical trials. We included 60 studies that involved a total of 720 healthy subjects and 42 patients. Most of the studies investigated multiple intestinal regions (24 studies), followed by studies investigating only the jejunum (21 studies), ileum (13 studies), or colon (2 studies). The ileum and colon used to be relatively inaccessible regions in vivo. Custom-made state-of-the-art catheters are available with numerous options for the design, such as multiple lumina, side holes, and inflatable balloons for catheter progression or isolation of intestinal segments. These allow for multiple controlled sampling and compound delivery options in different intestinal regions. Intestinal catheters were often used for delivery (23 studies), sampling (10 studies), or both (27 studies). Sampling speed decreased with increasing distance from the sampling syringe to the specific intestinal segment (i.e., speed highest in duodenum, lowest in ileum/colon). No serious adverse events were reported in the literature, and a dropout rate of around 10% was found for these types of studies. This review is highly relevant for researchers who are active in various research areas and want to expand their research with the use of intestinal catheters in humans in vivo.
Increasing the availability and utilization of reliable data on population micronutrient (MN) status globally: the MN Data Generation Initiative
Kenneth H Brown, Sophie E Moore, Sonja Y Hess, Christine M McDonald, Kerry S Jones, Sarah R Meadows, Mari S Manger, Jennifer Coates, Silvia Alayon, Saskia J M Osendarp
doi : 10.1093/ajcn/nqab173
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 862–870
Micronutrient (MN) deficiencies can produce a broad array of adverse health and functional outcomes. Young, preschool children and women of reproductive age in low- and middle-income countries are most affected by these deficiencies, but the true magnitude of the problems and their related disease burdens remain uncertain because of the dearth of reliable biomarker information on population MN status. The reasons for this lack of information include a limited understanding by policy makers of the importance of MNs for human health and the usefulness of information on MN status for program planning and management; insufficient professional capacity to advocate for this information and design and implement related MN status surveys; high costs and logistical constraints involved in specimen collection, transport, storage, and laboratory analyses; poor access to adequately equipped and staffed laboratories to complete the analyses reliably; and inadequate capacity to interpret and apply this information for public health program design and evaluation. This report describes the current situation with regard to data availability, the reasons for the lack of relevant information, and the steps needed to correct this situation, including implementation of a multi-component MN Data Generation Initiative to advocate for critical data collection and provide related technical assistance, laboratory services, professional training, and financial support.
Adherence to dietary guidelines and cognitive decline from middle age: the Doetinchem Cohort Study
Astrid C J Nooyens, Berivan Yildiz, Lisa G Hendriks, Sharell Bas, Martin P J van Boxtel, H Susan J Picavet, Jolanda M A Boer, W M Monique Verschuren
doi : 10.1093/ajcn/nqab109
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 871–881
Diet, in particular the Mediterranean diet, has been associated with better cognitive function and less cognitive decline in older populations.
Impact of low-fat and full-fat dairy foods on fasting lipid profile and blood pressure: exploratory endpoints of a randomized controlled trial
Kelsey A Schmidt, Gail Cromer, Maggie S Burhans, Jessica N Kuzma, Derek K Hagman, Imashi Fernando, Merideth Murray, Kristina M Utzschneider, Sarah Holte, Jana Kraft, Mario Kratz
doi : 10.1093/ajcn/nqab131
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 882–892
Dietary guidelines traditionally recommend low-fat dairy because dairy's high saturated fat content is thought to promote cardiovascular disease (CVD). However, emerging evidence indicates that dairy fat may not negatively impact CVD risk factors when consumed in foods with a complex matrix.
Associations of circulating choline and its related metabolites with cardiometabolic biomarkers: an international pooled analysis
Xiong-Fei Pan, Jae Jeong Yang, Xiao-Ou Shu, Steven C Moore, Nicholette D Palmer, Marta Guasch-Ferré, David M Herrington, Sei Harada, Heather Eliassen, Thomas J Wang, Robert E Gerszten, Demetrius Albanes, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Huilian Zhu, Lynne E Wagenknecht, Wei Zheng, Hui Cai, Qiuyin Cai, Charles E Matthews, Cristina Menni, Katie A Meyer, Loren P Lipworth, Jennifer Ose, Myriam Fornage, Cornelia M Ulrich, Danxia Yu
doi : 10.1093/ajcn/nqab152
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 893–906
Choline is an essential nutrient; however, the associations of choline and its related metabolites with cardiometabolic risk remain unclear.
Different associations between HDL cholesterol and cardiovascular diseases in people with diabetes mellitus and people without diabetes mellitus: a prospective community-based study
Zhijun Wu, Zhe Huang, Alice H Lichtenstein, Cheng Jin, Shuohua Chen, Shouling Wu, Xiang Gao
doi : 10.1093/ajcn/nqab163
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 907–913
Experimental studies have found that the functionality of HDL cholesterol may be lost in the presence of diabetes mellitus (DM).
Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials
Michael J Patan, David O Kennedy, Cathrine Husberg, Svein Olaf Hustvedt, Philip C Calder, Julie Khan, Joanne Forster, Philippa A Jackson
doi : 10.1093/ajcn/nqab174
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 914–924
Evidence regarding the effects of the omega-3 (?-3) PUFAs (n–3 PUFAs) DHA and EPA on cognition is lacking.
Dietary intake of sulfur amino acids and risk of kwashiorkor malnutrition in eastern Democratic Republic of the Congo
Merry C Fitzpatrick, Anura V Kurpad, Christopher P Duggan, Shibani Ghosh, Daniel G Maxwell
doi : 10.1093/ajcn/nqab136
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 925–933
Kwashiorkor is an often-fatal type of severe acute malnutrition affecting hundreds of thousands of children annually, but whose etiology is still unknown. Evidence suggests inadequate sulfur amino acid (SAA) status may explain many signs of the condition but studies evaluating dietary protein intake in relation to the genesis of kwashiorkor have been conflicting. We know of no studies of kwashiorkor that have measured dietary SAAs.
Insects are a viable protein source for human consumption: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial
Wesley J H Hermans, Joan M Senden, Tyler A Churchward-Venne, Kevin J M Paulussen, Cas J Fuchs, Joey S J Smeets, Joop J A van Loon, Lex B Verdijk, Luc J C van Loon
doi : 10.1093/ajcn/nqab115
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 934–944
Insects have recently been identified as a more sustainable protein-dense food source and may represent a viable alternative to conventional animal-derived proteins.
Habitual use of fish oil supplements, genetic predisposition, and risk of fractures: a large population-based study
Zhendong Mei, Guo-Chong Chen, Jianying Hu, Chenhao Lin, Zhonghan Sun, Chenglin Liu, Xin Geng, Changzheng Yuan, Qibin Qi, Yan Zheng
doi : 10.1093/ajcn/nqab157
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 945–954
Epidemiologic studies have suggested an inverse association between circulating concentrations of long-chain ?-3 PUFAs and fracture risk. However, whether supplementation of long-chain ?-3 PUFA (i.e. fish oil) is associated with fracture risk, and whether the association is modified by genetic predisposition to fracture risk remain unclear.
Treating high-risk moderate acute malnutrition using therapeutic food compared with nutrition counseling (Hi-MAM Study): a cluster-randomized controlled trial
Natasha Lelijveld, Claire Godbout, Destiny Krietemeyer, Alyssa Los, Donna Wegner, David T Hendrixson, Robert Bandsma, Aminata Koroma, Mark Manary
doi : 10.1093/ajcn/nqab137
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 955–964
There is a lack of consensus on what is the most appropriate treatment of moderate acute malnutrition (MAM).
Correlates of serum IGF-1 in young children with moderate acute malnutrition: a cross-sectional study in Burkina Faso
Thora W Kjaer, Benedikte Grenov, Charles W Yaméogo, Christian Fabiansen, Ann-Sophie Iuel-Brockdorff, Bernardette Cichon, Nick S Nielsen, Suzanne Filteau, André Briend, Jonathan C K Wells, Kim F Michaelsen, Henrik Friis, Daniel Faurholt-Jepsen, Vibeke B Christensen
doi : 10.1093/ajcn/nqab120
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 965–972
Serum insulin-like growth factor 1 (sIGF-1) is an important growth factor in childhood. However, studies on sIGF-1 among children from low-income countries are few, and the role of body composition is unknown.
Effectiveness and cost-effectiveness of 4 supplementary foods for treating moderate acute malnutrition: results from a cluster-randomized intervention trial in Sierra Leone
Stacy P Griswold, Breanne K Langlois, Ye Shen, Ilana R Cliffer, Devika J Suri, Shelley Walton, Ken Chui, Irwin H Rosenberg, Aminata S Koroma, Donna Wegner, Amir Hassan, Mark J Manary, Stephen A Vosti, Patrick Webb, Beatrice L Rogers
doi : 10.1093/ajcn/nqab140
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 973–985
Moderate acute malnutrition (MAM) affects 33 million children annually. Investments in formulations of corn-soy blended flours and lipid-based nutrient supplements have effectively improved MAM recovery rates. Information costs and cost-effectiveness differences are still needed.
Isotopic measurement of iron requirements in sub-Saharan African children
Cornelia Speich, Gary M Brittenham, Colin I Cercamondi, Christophe Zeder, Thandile Nkosi-Gondwe, Kamija S Phiri, Diego Moretti, Michael B Zimmermann
doi : 10.1093/ajcn/nqab161
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 986–996
Prevention of iron deficiency in African children is a public health priority. Current WHO/FAO estimations of iron requirements are derived from factorial estimates based on healthy, iron-sufficient “model” children using data derived mainly from adults.
Emulsion acid colloidal stability and droplet crystallinity modulate postprandial gastric emptying and short-term satiety: a randomized, double-blinded, crossover, controlled trial in healthy adult males
Samar Hamad, Niloufar Rafiee Tari, Gajuna Mathiyalagan, Amanda J Wright
doi : 10.1093/ajcn/nqab116
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 997–1011
Emulsion droplet triacylglycerol (TAG) crystallinity and colloidal stability can alter the postprandial metabolism, although evidence of their interactive effects is limited.
Improved diet quality is associated with decreased concentrations of inflammatory markers in adults with uncontrolled asthma
Unni C Nygaard, Lan Xiao, Kari C Nadeau, Kinjal M Hew, Nan Lv, Carlos A Camargo, Jr, Peg Strub, Jun Ma
doi : 10.1093/ajcn/nqab063
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1012–1027
Asthma has become one of the major public health challenges, and recent studies show promising clinical benefits of dietary interventions, such as the Dietary Approaches to Stop Hypertension (DASH) diet.
Meal-induced inflammation: postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants
Mohsen Mazidi, Ana M Valdes, Jose M Ordovas, Wendy L Hall, Joan C Pujol, Jonathan Wolf, George Hadjigeorgiou, Nicola Segata, Naveed Sattar, Robert Koivula, Tim D Spector, Paul W Franks, Sarah E Berry
doi : 10.1093/ajcn/nqab132
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1028–1038
Meal-induced metabolic changes trigger an acute inflammatory response, contributing to chronic inflammation and associated diseases.
Trends in junk food consumption among US children and adults, 2001–2018
Junxiu Liu, Yujin Lee, Renata Micha, Yan Li, Dariush Mozaffarian
doi : 10.1093/ajcn/nqab129
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1039–1048
Trends in junk food consumption, a risk for obesity, are not well established.
Associations of unprocessed and processed meat intake with mortality and cardiovascular disease in 21 countries [Prospective Urban Rural Epidemiology (PURE) Study]: a prospective cohort study
Romaina Iqbal, Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Andreas Wielgosz, Alvaro Avezum, Pamela Seron, Khalid F AlHabib, Patricio Lopez-Jaramillo, Sumathi Swaminathan, Noushin Mohammadifard, Katarzyna Zato?ska, Hu Bo, Ravi Prasad Varma, Omar Rahman, AfzalHussein Yusufali, Yin Lu, Noorhassim Ismail, Annika Rosengren, Ne?e Imeryuz, Karen Yeates, Jephat Chifamba, Antonio Dans, Rajesh Kumar, Liu Xiaoyun, Lungi Tsolekile, Rasha Khatib, Rafael Diaz, Koon Teo, Salim Yusuf on behalf of the PURE study
doi : 10.1093/ajcn/nqaa448
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1049–1058
Dietary guidelines recommend limiting red meat intake because it is a major source of medium- and long-chain SFAs and is presumed to increase the risk of cardiovascular disease (CVD). Evidence of an association between unprocessed red meat intake and CVD is inconsistent.
Association of food insecurity with dietary intakes and nutritional biomarkers among US children, National Health and Nutrition Examination Survey (NHANES) 2011–2016
Shinyoung Jun, Alexandra E Cowan, Kevin W Dodd, Janet A Tooze, Jaime J Gahche, Heather A Eicher-Miller, Patricia M Guenther, Johanna T Dwyer, Nancy Potischman, Anindya Bhadra, Michele R Forman, Regan L Bailey
doi : 10.1093/ajcn/nqab113
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1059–1069
Food insecurity is associated with poorer nutrient intakes from food sources and lower dietary supplement use. However, its association with total usual nutrient intakes, inclusive of dietary supplements, and biomarkers of nutritional status among US children remains unknown.
Fewer US adults had low or transitional vitamin B12 status based on the novel combined indicator of vitamin B12 status compared with individual, conventional markers, NHANES 1999–2004
Ekaterina M Mineva, Maya R Sternberg, Regan L Bailey, Renee J Storandt, Christine M Pfeiffer
doi : 10.1093/ajcn/nqab122
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1070–1079
Elevated plasma methylmalonic acid (MMA) and/or total homocysteine (tHcy), as well as low serum vitamin B12 and/or holotranscobalamin (holoTC) are indicative of vitamin B12 deficiency. Combined indicators (cB12), which pool some or all 4 markers into an index, may be a more reliable diagnostic tool to overcome inconclusive diagnoses with individual markers.
Mediterranean diet and prudent diet are both associated with low circulating esterified 3-hydroxy fatty acids, a proxy of LPS burden, among older adults
Perrine André, Jean-Paul Pais de Barros, Bénédicte MJ Merle, Cécilia Samieri, Catherine Helmer, Cécile Delcourt, Catherine Féart
doi : 10.1093/ajcn/nqab126
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1080–1091
LPS-type endotoxins, naturally found in the gut microbiota, are recognized as triggers of inflammation and emerge as detrimental factors of healthy aging. Nutrition represents a promising strategy to reduce LPS burden, yet little is known about the relation of diet to circulating LPS concentrations.
Contribution of reformulation, product renewal, and changes in consumer behavior to the reduction of salt intakes in the UK population between 2008/2009 and 2016/2017
Mathilde Gressier, Franco Sassi, Gary Frost
doi : 10.1093/ajcn/nqab130
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1092–1099
The UK salt reduction program started in 2003, consisting of education campaigns to raise awareness about the risks associated with a high-salt diet and of a reformulation strategy for food manufacturers. This program is often cited as an example of a successful public health program.
Association between maternal plasma ferritin concentration, iron supplement use, and the risk of gestational diabetes: a prospective cohort study
Xu Zhang, Meng Wu, Chunrong Zhong, Li Huang, Yu Zhang, Renjuan Chen, Xuezhen Zhou, Shangzhi Xu, Qian Li, Wenli Cui, Xiaoyi Wang, Xi Chen, Lixia Lin, Guofu Zhang, Guoping Xiong, Guoqiang Sun, Xuefeng Yang, Liping Hao, Zhichun Jin, Nianhong Yang
doi : 10.1093/ajcn/nqab162
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1100–1106
The association between iron supplementation and gestational diabetes mellitus (GDM) is still inconclusive, and this association has not been extensively studied in relation to plasma ferritin in the early second trimester.
Prenatal alcohol-related alterations in maternal, placental, neonatal, and infant iron homeostasis
R Colin Carter, Michael K Georgieff, Kathleen M Ennis, Neil C Dodge, Helen Wainwright, Ernesta M Meintjes, Christopher P Duggan, Christopher D Molteno, Joseph L Jacobson, Sandra W Jacobson
doi : 10.1093/ajcn/nqab165
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1107–1122
Prenatal alcohol exposure (PAE) is associated with postnatal iron deficiency (ID), which has been shown to exacerbate deficits in growth, cognition, and behavior seen in fetal alcohol spectrum disorders. However, the mechanisms underlying PAE-related ID remain unknown.
A multicenter propensity score matched analysis in 73,843 patients of an association of nutritional risk with mortality, length of stay and readmission rates
Ann Meulemans, Christophe Matthys, Roman Vangoitsenhoven, Joao Sabino, Bart Van Der Schueren, Pieter Maertens, Chantal Pans, Pieter Stijnen, Luk Bruyneel
doi : 10.1093/ajcn/nqab135
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1123–1130
The reported prevalences and effects of nutritional risk vary widely in the literature because of both methodological differences (e.g., screening tools and statistical analyses) and different patient populations.
Nutrient intakes of Canadian adults: results from the Canadian Community Health Survey (CCHS)–2015 Public Use Microdata File
Mavra Ahmed, Alena (Praneet) Ng, Mary R L'Abbe
doi : 10.1093/ajcn/nqab143
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1131–1140
Accurate estimates of the usual intake of nutrients are important for monitoring nutritional adequacy and diet quality of populations. In Canada, comprehensive, nationally representative nutrient estimates have not been available since the Canadian Community Health Survey (CCHS)–Nutrition 2004 survey.
Association between meal-specific daily protein intake and lean mass in older adults: results of the cross-sectional BASE-II study
Jivko Nikolov, Kristina Norman, Nikolaus Buchmann, Joachim Spranger, Ilja Demuth, Elisabeth Steinhagen-Thiessen, Dominik Spira, Knut Mai
doi : 10.1093/ajcn/nqab144
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1141–1147
Adequate total and meal-specific protein intake is considered an important prerequisite to preserve appendicular lean mass (ALM) in older adults and to prevent sarcopenia.
Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study
Jananee Muralidharan, Isabel Moreno-Indias, Mónica Bulló, Jesús Vioque Lopez, Dolores Corella, Olga Castañer, Josep Vidal, Alessandro Atzeni, Jose Carlos Fernandez-García, Laura Torres-Collado, Rebeca Fernández-Carrión, Monsterrat Fito, Romina Olbeyra, Ana Maria Gomez-Perez, Serena Galiè, Maria Rosa Bernal-López, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvadó, Francisco Jose Tinahones
doi : 10.1093/ajcn/nqab150
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1148–1158
The Mediterranean diet is a well-recognized healthy diet that has shown to induce positive changes in gut microbiota. Lifestyle changes such as diet along with physical activity could aid in weight loss and improve cardiovascular risk factors.
Anabolic effects of oral leucine-rich protein with and without ?-hydroxybutyrate on muscle protein metabolism in a novel clinical model of systemic inflammation—a randomized crossover trial
M Mose, K Brodersen, N Rittig, J Schmidt, N Jessen, U R Mikkelsen, J O L Jørgensen, N Møller
doi : 10.1093/ajcn/nqab148
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1159–1172
?-lactoglobulin (BLG) stimulates muscle protein synthesis and ?-hydroxybutyrate (BHB) inhibits muscle breakdown. Whether combining the 2 can additively attenuate disease-induced muscle loss is unknown.
Comparing success rates in central venous catheter salvage for catheter-related bloodstream infections in adult patients on home parenteral nutrition: a systematic review and meta-analysis
Michelle Gompelman, Carmen Paus, Ashley Bond, Reinier P Akkermans, Chantal P Bleeker-Rovers, Simon Lal, Geert J A Wanten
doi : 10.1093/ajcn/nqab164
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1173–1188
Catheter-related bloodstream infection (CRBSI) is a life-threatening complication of parenteral nutrition. Therefore, optimal management, ideally with catheter salvage, is required to maintain long-term venous access.
A pilot-randomized, double-blind crossover trial to evaluate the pharmacokinetics of orally administered 25-hydroxyvitamin D3 and vitamin D3 in healthy adults with differing BMI and in adults with intestinal malabsorption
Nipith Charoenngam, Tyler A Kalajian, Arash Shirvani, Grace H Yoon, Suveer Desai, Ashley McCarthy, Caroline M Apovian, Michael F Holick
doi : 10.1093/ajcn/nqab123
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1189–1199
Obese and malabsorptive patients have difficulty increasing serum 25-hydroxyvitamin D [25(OH)D] after taking vitamin D supplementation. Since 25(OH)D is more hydrophilic than vitamin D, we hypothesized that oral 25(OH)D supplementation is more effective in increasing serum 25(OH)D concentrations in these patients.
Volumetric absorptive microsampling (VAMS) as a reliable tool to assess thiamine status in dried blood microsamples: a comparative study
Jana Verstraete, Christophe Stove
doi : 10.1093/ajcn/nqab146
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1200–1207
Although populations from low- and middle-income countries are at higher risk for thiamine (vitamin B-1) deficiency, accurate data on the global prevalence of thiamine deficiency are still lacking due to the difficult blood collection in remote regions. Volumetric absorptive microsampling (VAMS) from finger prick blood, generating dried blood microsamples, could simplify blood collection and allow the setup of epidemiological studies to improve the diagnosis, treatment, and prevention of thiamine deficiency.
Maternal obesity and baseline vitamin D insufficiency alter the response to vitamin D supplementation: a double-blind, randomized trial in pregnant women
Raghad M Alhomaid, Maria S Mulhern, Jj Strain, Eamon Laird, Martin Healy, Michael J Parker, Mary T McCann
doi : 10.1093/ajcn/nqab112
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1208–1218
The achievement of target 25-hydroxyvitamin D [25(OH)D] concentrations in pregnancy may be altered by maternal obesity.
The association of maternal gestational hyperglycemia with breastfeeding duration and markers of milk production
Wei Wei Pang, Donna T Geddes, Ching-Tat Lai, Shiao-Yng Chan, Yiong Huak Chan, Clara Y Cheong, Doris Fok, Mei Chien Chua, Sok Bee Lim, Jonathan Huang, Shikha Pundir, Kok Hian Tan, Fabian Yap, Keith M Godfrey, Peter D Gluckman, Lynette P Shek, Mark H Vickers, Johan G Eriksson, Yap-Seng Chong, Mary E Wlodek
doi : 10.1093/ajcn/nqab142
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1219–1228
Previous studies focusing on the association between gestational diabetes and breastfeeding duration have been inconclusive.
Healthy dietary patterns and common pregnancy complications: a prospective and longitudinal study
Mengying Li, Jagteshwar Grewal, Stefanie N Hinkle, Samrawit F Yisahak, William A Grobman, Roger B Newman, Daniel W Skupski, Edward K Chien, Deborah A Wing, Katherine L Grantz, Cuilin Zhang
doi : 10.1093/ajcn/nqab145
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1229–1237
Adherence to alternate Healthy Eating Index (AHEI), alternate Mediterranean diet (AMED), and Dietary Approaches to Stop Hypertension (DASH) has been linked to lower risks of chronic diseases. However, their associations with common pregnancy complications are unclear.
Early prenatal use of a multivitamin diminishes the risk for inadequate vitamin D status in pregnant women: results from the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort study
Hope A Weiler, Stephen P J Brooks, Kurtis Sarafin, Mandy Fisher, Isabelle Massarelli, The Minh Luong, Markey Johnson, Anne-Sophie Morisset, Linda Dodds, Shayne Taback, Michael Helewa, Peter von Dadelszen, Graeme Smith, Bruce P Lanphear, William D Fraser, Tye E Arbuckle
doi : 10.1093/ajcn/nqab172
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1238–1250
Reports on the adequacy of vitamin D status of pregnant women are not available in Canada.
Vitamin D3 and 25(OH)D3: an open debate
Salvatore Minisola, Viviana De Martino, Cristiana Cipriani, Jessica Pepe, Luciano Colangelo, Chiara Sonato
doi : 10.1093/ajcn/nqab254
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Page 1251
Reply to S Minisola et al.
Nipith Charoenngam, Tyler A Kalajian, Arash Shirvani, Grace H Yoon, Suveer Desai, Ashley McCarthy, Caroline M Apovian, Michael F Holick
doi : 10.1093/ajcn/nqab255
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Pages 1252–1253
Corrigendum for Babateen et al. (Assessment of dietary nitrate intake in humans: a systematic review). Am J Clin Nutr 2018;108(4)878–88.
doi : 10.1093/ajcn/nqab271
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Page 1254
Calendar of Events
doi : 10.1093/ajcn/nqab296
The American Journal of Clinical Nutrition, Volume 114, Issue 3, September 2021, Page 1255
