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Impact of Preoperative and Incident Musculoskeletal Problematic Areas on Postoperative Outcomes After Total Knee Replacement
MaryAnn Zhang,Faith Selzer,Elena Losina,Jamie E. Collins,Jeffrey N. Katz,
doi : 10.1002/acr2.11241
Volume 3, Issue 9 p. 583-592
To examine impact of pre-existing and incident problematic musculoskeletal (MSK) areas after total knee replacement (TKR) on postoperative 60-month Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain/function scores.
Improving the Efficiency of Clinical Trial Recruitment Using an Ensemble Machine Learning to Assist With Eligibility Screening
Tianrun Cai,Fiona Cai,Kumar P. Dahal,Gabrielle Cremone,Ethan Lam,Charlotte Golnik,Thany Seyok,Chuan Hong,Tianxi Cai,Katherine P. Liao,
doi : 10.1002/acr2.11289
Volume 3, Issue 9 p. 593-600
Efficiently identifying eligible patients is a crucial first step for a successful clinical trial. The objective of this study was to test whether an approach using electronic health record (EHR) data and an ensemble machine learning algorithm incorporating billing codes and data from clinical notes processed by natural language processing (NLP) can improve the efficiency of eligibility screening.
Patterns of T-Cell Phenotypes in Rheumatic Diseases From Single-Cell Studies of Tissue
Yidan Gao,Garrett Dunlap,Mehreen Elahee,Deepak A. Rao,
doi : 10.1002/acr2.11296
Volume 3, Issue 9 p. 601-613
High-dimensional analyses of tissue samples from patients with rheumatic diseases are providing increasingly detailed descriptions of the immune cell populations that infiltrate tissues in different rheumatic diseases. Here we review key observations emerging from high-dimensional analyses of T cells within tissues in different rheumatic diseases, highlighting common themes across diseases as well as distinguishing features. Single-cell RNA sequencing analyses capture several dimensions of T-cell states, yet surprisingly, these analyses generally have not demonstrated distinct clusters of paradigmatic T-cell effector subsets, such as T helper (Th) 1, Th2, and Th17 cells. Rather, global transcriptomics robustly identify both proliferating T cells and regulatory T cells and have also helped to reveal new effector subsets in inflamed tissues, including T peripheral helper cells and granzyme K+ T cells. Further characterization of the T-cell populations that accumulate within target tissues should enable more precise targeting of biologic therapies and accelerate development of more specific biomarkers to track activity of relevant immune pathways in patients with rheumatic diseases.
Effect of Heeled Shoes on Joint Symptoms and Knee Osteoarthritis in Older Adults: A 5-Year Follow-Up Study
Thomas A. Perry,Charlotte Dando,Tim D. Spector,Deborah J. Hart,Catherine Bowen,Nigel Arden,
doi : 10.1002/acr2.11298
Volume 3, Issue 9 p. 614-621
Our aims were to examine the effects of heeled shoes on incident knee osteoarthritis (OA) and joint pain.
Impaired Antibody Response to the BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine in Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis
Christian Ammitzbøll,Lars Erik Bartels,Jakob Bøgh Andersen,Signe Risbøl Vils,Clara Elbæk Mistegård,Anders Dahl Johannsen,Marie-Louise From Hermansen,Marianne Kragh Thomsen,Christian Erikstrup,Ellen-Margrethe Hauge,Anne Troldborg,
doi : 10.1002/acr2.11299
Volume 3, Issue 9 p. 622-628
With a vaccine effectiveness of 95% for preventing coronavirus disease 2019 (COVID-19), Pfizer-BioNTech BNT162b2 (BNT162b2) was the first vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to be approved. However, immunosuppressive therapy was an exclusion criterion in the phase 3 trial that led to approval. Thus, extrapolation of the trial results to patients with rheumatic diseases treated with immunosuppressive drugs warrants caution.
Using Parallel Streams of Evidence to Inform Guideline Development: The Case of the 2021 American College of Rheumatology Management of Rheumatoid Arthritis Guideline
Sally Yaacoub,Assem M. Khamis,Mounir Al-Gibbawi,Lara A Kahale,Joan Bathon,Bryant R England,Liana Fraenkel,E. William St. Clair,Amy S. Turner,Elie A. Akl,
doi : 10.1002/acr2.11300
Volume 3, Issue 9 p. 629-635
We aim to describe an evidence synthesis approach using parallel streams of evidence that informed the development of the 2021 American College of Rheumatology (ACR) guideline for the management of rheumatoid arthritis (RA).
Serum MMP3 Correlated With IL1? Messenger RNA Expressions of Peripheral Blood Mononuclear Cells in Patients With Relapsing Polychondritis With Respiratory Involvement
Jun Shimizu,Sueshige Wakisaka,Tomoko Suzuki,Noboru Suzuki,
doi : 10.1002/acr2.11301
Volume 3, Issue 9 p. 636-641
Respiratory involvement was intimately associated with poorer prognosis in patients with relapsing polychondritis (RP). We previously reported that high serum matrix metalloproteinase-3 (MMP3) was frequently observed in patients with RP with respiratory involvement. Elevated MMP3 secreted through local inflammation may be associated with the development of airway lesions.
Effects of Atorvastatin on T-Cell Activation and Apoptosis in Systemic Lupus Erythematosus and Novel Simulated Interactions With C-Reactive Protein and Interleukin 6
Jitong Sun,Pritam Kumar Panda,Shailesh Kumar Samal,Rajeev Ahuja,Sofia Ajeganova,Ingiäld Hafström,Anquan Liu,Johan Frostegård,
doi : 10.1002/acr2.11305
Volume 3, Issue 9 p. 642-653
We study activation of T helper 17 (Th17) and regulatory T (Treg) cells and induction of apoptosis in cells from patients with systemic lupus erythematosus (SLE) compared with controls and effects of atorvastatin and its simulated interactions with other compounds.
Perioperative Glucocorticoids in Patients With Rheumatoid Arthritis Having Total Joint Replacements: Help or Harm?
Tariq Chukir,Susan M. Goodman,Haley Tornberg,Huong Do,Charlene Thomas,Alana Sigmund,Peter Sculco,Mark Figgie,Bella Mehta,Linda Russell,Emily Stein,
doi : 10.1002/acr2.11306
Volume 3, Issue 9 p. 654-659
The optimal strategy for perioperative glucocorticoid (GC) management in patients with rheumatoid arthritis (RA) on chronic GCs is unknown. Although there is a concern for hypotension if inadequate doses are used, higher GC exposure may increase perioperative complications. We aimed to investigate the relationships between perioperative GCs with hemodynamic instability and short-term postoperative complications following total hip arthroplasty (THA) and total knee arthroplasty (TKA) in patients with RA.
Use of Complementary and Alternative Therapy for Knee Osteoarthritis: Race and Gender Variations
Ernest R. Vina,Ada O. Youk,Cristian Quinones,C. Kent Kwoh,Said A. Ibrahim,Leslie R.M. Hausmann,
doi : 10.1002/acr2.11307
Volume 3, Issue 9 p. 660-667
To evaluate race and gender variations in complementary and alternative medicine (CAM) use for knee osteoarthritis (OA) (unadjusted and adjusted for demographic and clinical factors).
