European Heart Journal




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The ESC Guidelines on cardiac pacing and resynchronization, and the many facets of atrial fibrillation 

Filippo Crea

doi : 10.1093/eurheartj/ehab628

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3411–3414

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COVID-19 and Emissions: An Opportunity for Sustainable Global Health 

Sanjay Rajagopalan, MD, Robert B Jackson, PhD, Jagat Narula, MD

doi : 10.1093/eurheartj/ehab156

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3415–3417

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Prevention is ‘close to our hearts’ 

Mark Nicholls

doi : 10.1093/eurheartj/ehab302

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3417–3419

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Optimizing Cardiovascular Risk Factors 

Mark Nicholls

doi : 10.1093/eurheartj/ehab303

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3420–3421

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The impossible interviews—Sherlock Holmes interviews David Sackett: ‘how much can we trust the guidelines?’ 

Claudio Rapezzi, Gianfranco Sinagra, Marco Merlo, Roberto Ferrari

doi : 10.1093/eurheartj/ehab187

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3422–3424

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Exploring RNA biomarkers in patients with acute myocarditis 

Francesco Paneni, Massimo Volpe

doi : 10.1093/eurheartj/ehab435

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3425–3426

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2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA) 

Michael Glikson, Jens Cosedis Nielsen, Mads Brix Kronborg, Yoav Michowitz, Angelo Auricchio, Israel Moshe Barbash, José A Barrabés, Giuseppe Boriani, Frieder Braunschweig, Michele Brignole, Haran Burri, Andrew J S Coats, Jean-Claude Deharo, Victoria Delgado, Gerhard-Paul Diller, Carsten W Israel, Andre Keren, Reinoud E Knops, Dipak Kotecha, Christophe Leclercq, Béla Merkely, Christoph Starck, Ingela Thylén, José Maria Tolosana, ESC Scientific Document Group

doi : 10.1093/eurheartj/ehab364

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3427–3520

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Does gut microbiota affect atrial rhythm? Causalities and speculations

Dominik Linz, Monika Gawa?ko, Prashanthan Sanders, John Penders, Na Li, Stanley Nattel, Dobromir Dobrev

doi : 10.1093/eurheartj/ehab467

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3521–3525

Dietary intake has been shown to change the composition of gut microbiota and some changes in microbiota (dysbiosis) have been linked to diabetes, hypertension, and obesity, which are established risk factors for atrial fibrillation (AF). In addition, intestinal dysbiosis generates microbiota-derived bioactive metabolites that might exert proarrhythmic actions. Although emerging preclinical investigations and clinical observational cohort studies suggest a possible role of gut dysbiosis in AF promotion, the exact mechanisms through which dysbiosis contributes to AF remain unclear. This Viewpoint article briefly reviews evidence suggesting that abnormalities in the intestinal microbiota play an important and little-recognized role in the pathophysiology of AF and that an improved understanding of this role may open up new possibilities in the management of AF.

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Ageing, comorbidities, and the complex determinants of atrial fibrillation in athletes

Eduard Guasch, Stanley Nattel

doi : 10.1093/eurheartj/ehab473

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3526–3528

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Driving following defibrillator implantation: a nationwide register-linked survey study

Jenny Bjerre, Simone Hofman Rosenkranz, Morten Schou, Christian J?ns, Berit Thornvig Philbert, Charlotte Larroudé, Jens Cosedis Nielsen, Jens Brock Johansen, Sam Riahi, Thomas Maria Melchior, Christian Torp-Pedersen, Mark Hlatky, Gunnar Gislason, Anne-Christine Ruwald

doi : 10.1093/eurheartj/ehab253

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3529–3537

Patients are restricted from driving following implantable cardioverter defibrillator (ICD) implantation or shock. We sought to investigate how many patients are aware of, and adhere to, the driving restrictions, and what proportion experience an ICD shock or other cardiac symptoms while driving.

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To drive or NOT to drive: that’s the question after ICD implantation 

Harry J G M Crijns, Kevin Vernooy

doi : 10.1093/eurheartj/ehab490

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3538–3540

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Prevalence, management and impact of chronic obstructive pulmonary disease in atrial fibrillation: a systematic review and meta-analysis of 4,200,000 patients 

Giulio Francesco Romiti, Bernadette Corica, Eugenia Pipitone, Marco Vitolo, Valeria Raparelli, Stefania Basili, Giuseppe Boriani, Sergio Harari, Gregory Y H Lip, Marco Proietti, the AF-COMET International Collaborative Group

doi : 10.1093/eurheartj/ehab453

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3541–3554

Prevalence of chronic obstructive pulmonary disease (COPD) in atrial fibrillation (AF) patients is unclear, and its association with adverse outcomes is often overlooked. Our aim was to estimate the prevalence of COPD, its impact on clinical management and outcomes in patients with AF, and the impact of beta-blockers (BBs) on outcomes in patients with COPD.

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When two is not better than one: the amalgamation of atrial fibrillation and chronic obstructive pulmonary disease 

James A Reiffel

doi : 10.1093/eurheartj/ehab366

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3555–3557

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Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice

Yen-Nien Lin, Thassio Mesquita, Lizbeth Sanchez, Yin-Huei Chen, Weixin Liu, Chang Li, Russell Rogers, Yizhou Wang, Xinling Li, Di Wu, Rui Zhang, Ahmed Ibrahim, Eduardo Marb?n, Eugenio Cingolani

doi : 10.1093/eurheartj/ehab419

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3558–3571

Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs) secreted by cardiosphere-derived cells, immortalized, and engineered to express high levels of ?-catenin, exert anti-inflammatory, and anti-fibrotic effects. The aim of the current study was to assess efficacy of EVs in an ACM murine model.

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Arrhythmogenic cardiomyopathy: the ongoing search for mechanism-driven therapies meets extracellular vesicles 

Cristina Basso, Tania Zaglia, Kalliopi Pilichou

doi : 10.1093/eurheartj/ehab512

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3572–3574

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Methodological considerations when discussing the fracture risk of atrial fibrillation patients taking different drug 

Ping-Hao Chiang, Yung-Chih Hsu, James Cheng-Chung Wei

doi : 10.1093/eurheartj/ehab459

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Page 3575

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Fracture risk associated with different oral anticoagulants in patients with atrial fibrillation: updated evidence from real-world observational studies and clinical trials 

Huei-Kai Huang, Yu-Kang Tu, Ching-Hui Loh

doi : 10.1093/eurheartj/ehab461

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Pages 3576–3577

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In vivo evaluation of coronary arteritis by serial optical coherence tomography in large vessel vasculitis

Shunsuke Sakai, Akira Sato, Tomoya Hoshi, Masaki Ieda

doi : 10.1093/eurheartj/ehaa991

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Page 3525

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A floating thrombus in the ascending aorta, as a complication of a percutaneous coronary angiography

Francesca Cortese, Michelle Magli, Serena Di Marino

doi : 10.1093/eurheartj/ehaa1001

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Page 3578

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Multifocal intra-wall gas appearance of the aorta was the presage of an infectious aneurysm

Tomohisa Nakamura, Makoto Hyodo, Kenichiro Murata, Hiroaki Miyazaki, Kenji Ando

doi : 10.1093/eurheartj/ehaa1045

European Heart Journal, Volume 42, Issue 35, 14 September 2021, Page 3579

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