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Advance care planning for adolescents with cancer and their parents: study protocol of the BOOST pACP multi-centre randomised controlled trial and process evaluation
Anne van Driessche, Aline De Vleminck, Joni Gilissen, Marijke C. Kars, Jutte van der Werff ten Bosch, Luc Deliens, Joachim Cohen & Kim Beernaert
doi : 10.1186/s12887-021-02841-7
BMC Pediatrics volume 21, Article number: 376 (2021)
Research has highlighted the need for evidence-based interventions to improve paediatric advance care planning (pACP) in adolescents with cancer. Although adolescents express the desire and ability to share their values, beliefs and preferences for treatment, there is a lack of structured multicomponent interventions to improve parent-adolescent communication on different ACP themes including those not limited to end-of-life care. The aim of this study is to evaluate the effectiveness and implementation, context and mechanisms of impact of a novel ACP program in paediatric oncology.
The effect of intervelar veloplasty under magnification (Sommerlad’s Technique) without tympanostomy on middle ear effusion in cleft palate patients
Mohammad Ali Hoghoughi, Tayebeh Kazemi, Ali Khojasteh, Raha Habibagahi, Zahra Kalkate, Zeynab Zarei, Hamidreza Hosseinpour & Maryam Salimi
doi : 10.1186/s12887-021-02856-0
BMC Pediatrics volume 21, Article number: 377 (2021)
Different surgical techniques and management approaches have been introduced to manage the cleft palate (CP) and its complications, such as otitis media with effusion (OME) and auditory problems. The optimal method, as well as the ideal time for palatoplasty and ventilation tube insertion, are the subject of controversy in the literature. We aimed to evaluate The Effect of Intervelar Veloplasty under Magnification (Sommerlad’s Technique) without Tympanostomy on Middle Ear Effusion in Cleft Palate Patients.
Vitamin D status in full-term exclusively breastfed infants versus full-term breastfed infants receiving vitamin D supplementation in Thailand: a randomized controlled trial
Chayatat Ruangkit, Sukrit Suwannachat, Pornchanok Wantanakorn, Napapailin Sethaphanich, Surapat Assawawiroonhakarn & Oraporn Dumrongwongsiri
doi : 10.1186/s12887-021-02849-z
BMC Pediatrics volume 21, Article number: 378 (2021)
Many international medical organizations recommend vitamin D supplementation for infants, especially exclusively breastfed infants. In Thailand, however, data regarding the vitamin D status in Thai infants are lacking. Such data would help to support physician decisions and guide medical practice.
Characteristics and surgical outcomes of cleft palate in kabuki syndrome: a case series of 11 patients
Jong-Ho Kim, Jiwon Kang, Joon Seok Oh, Taeseon Ahn, Baek-kyu Kim & Rong-Min Baek
doi : 10.1186/s12887-021-02852-4
BMC Pediatrics volume 21, Article number: 379 (2021)
A significant number of patients with KS have cleft palate (CP) or submucous cleft palate (SMCP) and show delayed speech development. However, few reports have discussed the characteristics of CP in KS and the outcomes of postoperative speech development. The purpose of this study was to investigate the characteristics and surgical outcomes of CP in patients with KS, and to discuss the importance of the diagnosis of CP or SMCP.
Vitamin D, pregnancy and caries in children in the INMA-Asturias birth cohort
Claudia Su?rez-Calleja, Jaime Aza-Morera, Tania Iglesias-Cabo & Adonina Tard?n
doi : 10.1186/s12887-021-02857-z
BMC Pediatrics volume 21, Article number: 380 (2021)
Vitamin D is traditionally associated with the metabolism of calcium and phosphorus, a process essential for the mineralization of hard tissue such as bone or tooth. Deficiency of this vitamin is a problem worldwide, however. Given the possibly significant role of Vitamin D in odontogenesis in children, the objective of our study was to determine the influence of vitamin D levels in the blood on dental anomalies in children between 6 and 10?years of age, by means of 25-hydroxy vitamin D tests performed during pregnancy and the first years of life.
Childhood adversity subtypes and violence victimization and perpetration among early adolescents in Shanghai, China
Xiayun Zuo, Ziwei Zhang, Li Yan, Qiguo Lian, Chunyan Yu, Xiaowen Tu & Chaohua Lou
doi : 10.1186/s12887-021-02853-3
BMC Pediatrics volume 21, Article number: 381 (2021)
This cross-sectional study aimed to identify adverse childhood experience (ACE) subtypes using variable- and person-centered approaches and examine the possible sex-differentiated associations with violence involvement as victim, perpetrator, and victim-perpetrator.
Factors associated with bone health status of Malaysian pre-adolescent children in the PREBONE-Kids Study
Chung Yuan Chang, Kanimolli Arasu, Soon Yee Wong, Shu Hwa Ong, Wai Yew Yang, Megan Hueh Zan Chong, Meenal Mavinkurve, Erwin Jiayuan Khoo, Karuthan Chinna, Connie Marie Weaver & Winnie Siew Swee Chee
doi : 10.1186/s12887-021-02842-6
BMC Pediatrics volume 21, Article number: 382 (2021)
Modifiable lifestyle factors and body composition can affect the attainment of peak bone mass during childhood. This study performed a cross-sectional analysis of the determinants of bone health among pre-adolescent (N?=?243) Malaysian children with habitually low calcium intakes and vitamin D status in Kuala Lumpur (PREBONE-Kids Study).
Reliability of visual assessment of neonatal jaundice among neonates of black descent: a cross-sectional study from Tanzania
Ikunda Dionis, Omary Chillo, George M. Bwire, Calvin Ulomi, Manase Kilonzi & Emmanuel Balandya
doi : 10.1186/s12887-021-02859-x
BMC Pediatrics volume 21, Article number: 383 (2021)
Jaundice is common among neonates and if untreated can lead to kernicterus. Diagnosing neonatal jaundice (NJ) using Kramer’s method (visual assessment) is considered user-friendly in resource-limited areas. However, there are conflicting findings on reliability of the Kramer’s method in the diagnosis of NJ, particularly of black descent. Therefore, study aimed to determine the accuracy of Kramer’s method in comparison to the total serum bilirubin (TSB) test in the diagnosis of NJ among neonates of black descent in Tanzania.
Novel CLCN4 variant associated with syndromic X-linked intellectual disability in a Chinese girl: a case report
Xin Xu, Fen Lu, Li Zhang, Hongying Li, Senjie Du & Jian Tang
doi : 10.1186/s12887-021-02860-4
BMC Pediatrics volume 21, Article number: 384 (2021)
The Raynaud-Claes type of X-linked syndromic mental retardation (MRXSRC) is a very rare condition, by intellectual disability ranged from borderline to profound, impaired language development, brain abnormalities, facial dysmorphisms and seizures. MRXSRC is caused by variants in CLCN4 which encodes the 2Cl?/H+ exchanger ClC-4 prominently expressed in brain.
Higher BMI predicts liver fibrosis among obese children and adolescents with NAFLD - an interventional pilot study
Hadar Moran-Lev, Shlomi Cohen, Muriel Webb, Anat Yerushalmy-Feler, Achiya Amir, Dana L. Gal & Ronit Lubetzky
doi : 10.1186/s12887-021-02839-1
BMC Pediatrics volume 21, Article number: 385 (2021)
Non-alcoholic fatty liver disease (NAFLD) can range from simple steatosis to steatohepatitis with or without fibrosis. The predictors for liver fibrosis and the effect of nutritional intervention on hepatic fibrosis in pediatric population are not well established. We aimed to investigate the predictors for liver fibrosis and the effects of short-term nutritional intervention on steatosis and fibrosis among obese adolescents with NAFLD.
The role of the household in the social inclusion of children with special needs in Uganda – a photovoice study
Caroline Masquillier, Sara De Bruyn & David Musoke
doi : 10.1186/s12887-021-02805-x
BMC Pediatrics volume 21, Article number: 386 (2021)
Social inclusion establishes a basis for the overall wellbeing of children with special needs. Although children’s lives are centred around the household, little is known about the household’s influence on social inclusion. Therefore, the aim is to investigate the household’s role in the social inclusion of children with special needs in Uganda.
The full spectrum of ethical issues in pediatric genome-wide sequencing: a systematic qualitative review
Johanna Eichinger, Bernice S. Elger, Insa Koné, Isabel Filges, David Shaw, Bettina Zimmermann & Stuart McLennan
doi : 10.1186/s12887-021-02830-w
BMC Pediatrics volume 21, Article number: 387 (2021)
The use of genome-wide sequencing in pediatric medicine and research is growing exponentially. While this has many potential benefits, the normative and empirical literature has highlighted various ethical issues. There have not been, however, any systematic reviews of these issues. The aim of this systematic review is to determine systematically the spectrum of ethical issues that is raised for stakeholders in in pediatric genome-wide sequencing.
Effects of the PRIMROSE prevention trial of childhood obesity on parental self-efficacy
Nora D?ring, Ata Ghaderi, Johanna En? Persson, Per Tynelius, Finn Rasmussen & Benjamin Bohman
doi : 10.1186/s12887-021-02862-2
BMC Pediatrics volume 21, Article number: 388 (2021)
Parental self-efficacy (PSE) has been suggested as a key factor for enabling parents to support children in the development of healthy dietary and physical activity behaviors and to prevent childhood obesity. However, studies of intervention effects on PSE are lacking. The present study involved a secondary analysis of data on PSE collected in a previous primary prevention trial of childhood obesity called the PRIMROSE trial. The trial involved a family-based intervention using motivational interviewing and principles of cognitive-behavioral therapy within a social-cognitive theory framework.
Clinical profile of reading ability and reading and writing achievement of children with borderline full-scale intellectual quotient: a prospective study
Riyo Ueda, Yoshimi Kaga, Yosuke Kita, Eiji Nakagawa, Takashi Okada & Masumi Inagaki
doi : 10.1186/s12887-021-02865-z
BMC Pediatrics volume 21, Article number: 389 (2021)
Poor reading ability is one of the common causes of low academic performance. In previous studies, children with dyslexia were found to demonstrate poor academic achievement due to poor reading ability. However, the relationship between academic achievement and reading ability in children with a borderline full-scale intellectual quotient (FSIQ) is unknown. This study aimed to clarify the clinical characteristics of children with borderline FSIQ and poor reading ability, and differentiate these characteristics from those of children with higher FSIQ and poor reading ability.
Saving babies’ lives (SBL) – a programme to reduce neonatal mortality in rural Cambodia: study protocol for a stepped-wedge cluster-randomised trial
Kaajal Patel, Sopheakneary Say, Daly Leng, Manila Prak, Koung Lo, Mavuto Mukaka, Arthur Riedel & Claudia Turner
doi : 10.1186/s12887-021-02833-7
BMC Pediatrics volume 21, Article number: 390 (2021)
Neonatal mortality remains unacceptably high. Many studies successful at reducing neonatal mortality have failed to realise similar gains at scale. Effective implementation and scale-up of interventions designed to tackle neonatal mortality is a global health priority. Multifaceted programmes targeting the continuum of neonatal care, with sustainability and scalability built into the design, can provide practical insights to solve this challenge. Cambodia has amongst the highest neonatal mortality rates in South-East Asia, with rural areas particularly affected. The primary objective of this study is the design, implementation, and assessment of the Saving Babies’ Lives programme, a package of interventions designed to reduce neonatal mortality in rural Cambodia.
Vision screening in newborns and early childhood
Sophie Jullien
doi : 10.1186/s12887-021-02606-2
BMC Pediatrics volume 21, Article number: 306 (2021)
We looked at existing recommendations and supporting evidence on the effectiveness of screening for visual disorders in newborns and small infants, and in children between six months and five years of age.
Prevention of unintentional injuries in children under five years
Sophie Jullien
doi : 10.1186/s12887-021-02517-2
BMC Pediatrics volume 21, Article number: 311 (2021)
We looked at existing recommendations for preventing unintentional injuries in children under five years of age, and we attempted to identify the main sources used as evidence for formulating these recommendations.
Vitamin D prophylaxis in infancy
Sophie Jullien
doi : 10.1186/s12887-021-02776-z
BMC Pediatrics volume 21, Article number: 319 (2021)
We looked at existing recommendations and supporting evidence on the effectiveness of vitamin D supplementation in infancy for reducing vitamin D deficiency and for preventing rickets and infections. We also looked at optimal dose of vitamin D and the age until which vitamin D supplementation is beneficial.
Screening for autistic spectrum disorder in early childhood
Sophie Jullien
doi : 10.1186/s12887-021-02700-5
BMC Pediatrics volume 21, Article number: 349 (2021)
We looked at existing recommendations and supporting evidence on the effectiveness of screening young children for autistic spectrum disorder (ASD) for improving short- and long-term outcomes.
Newborn pulse oximetry screening for critical congenital heart defects
Sophie Jullien
doi : 10.1186/s12887-021-02520-7
BMC Pediatrics volume 21, Article number: 305 (2021)
We looked at existing recommendations and supporting evidence addressing the effectiveness of pulse oximetry effective for detecting critical congenital heart defects (CCHDs) in newborns. We also looked at the impact of timing of oximetry and the site of testing in the accuracy of screening, and at the potential harms and limitations of pulse oximetry screening,
Sudden infant death syndrome prevention
Sophie Jullien
doi : 10.1186/s12887-021-02536-z
BMC Pediatrics volume 21, Article number: 320 (2021)
We looked at existing recommendations and supporting evidence for successful strategies to prevent the sudden infant death syndrome (SIDS).
Primary health care for children - evidence for prevention
Susanne Carai & Martin W. Weber
doi : 10.1186/s12887-021-02787-w
BMC Pediatrics volume 21, Article number: 328 (2021)
Screening of iron deficiency anaemia in early childhood
Sophie Jullien
doi : 10.1186/s12887-021-02725-w
BMC Pediatrics volume 21, Article number: 337 (2021)
We looked at existing recommendations and supporting evidence on the effectiveness of universal screening of iron deficiency anaemia (IDA) in children under five years of age for improving growth, cognitive function, and psychomotor development. We assessed the accuracy of the screening tests for detecting IDA, the efficacy of existing treatment for children with IDA, and the potential harms associated with screening and treatment.
Vitamin K prophylaxis in newborns
Sophie Jullien
doi : 10.1186/s12887-021-02701-4
BMC Pediatrics volume 21, Article number: 350 (2021)
We looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN).
Prophylaxis of caries with fluoride for children under five years
Sophie Jullien
doi : 10.1186/s12887-021-02702-3
BMC Pediatrics volume 21, Article number: 351 (2021)
We looked at existing recommendations and supporting evidence on the effectiveness and potential harms of the different fluoride interventions in preventing dental caries in children under 5 years of age.
Supporting recommendations for childhood preventive interventions for primary health care: elaboration of evidence synthesis and lessons learnt
Sophie Jullien, Gottfried Huss & Ralf Weigel
doi : 10.1186/s12887-021-02638-8
BMC Pediatrics volume 21, Article number: 356 (2021)
Recommendations to prevent morbidity and mortality in children was a high priority for the editorial group of a WHO pocket book for primary health care in the European region. However, the benefit of preventive interventions is not always clear and recommendations differ across countries and institutions. Here, we summarize the existing recommendations and the most recent evidence on ten selected preventive interventions applied to children under five years to inform this group. In addition, we reflect on the process and challenges of developing these summaries.
Screening for language and speech delay in children under five years
Sophie Jullien
doi : 10.1186/s12887-021-02817-7
BMC Pediatrics volume 21, Article number: 362 (2021)
We looked at existing recommendations and supporting evidence on the effectiveness of universal screening for language and speech delay in children under 5 years of age for short- and long-term outcomes.
Leflunomide therapy for IgA vasculitis with nephritis in children
Ling Hou, Zhou Zhang & Yue Du
doi : 10.1186/s12887-021-02866-y
BMC Pediatrics volume 21, Article number: 391 (2021)
Henoch-Sch?nlein purpura (HSP), also called IgA vasculitis, is a systemic vasculitis characterized by deposits of immunoglobulin A in blood vessels. Renal impairment of these patients is the main determinant of prognosis. The optimal treatment of HSP nephritis (HSPN) in children remains controversial, but many clinicians administer an immunosuppressive agent with a corticosteroid. A previous study reported that leflunomide (LEF) with a corticosteroid was effective for adult patients with HSPN and nephrotic proteinuria. However, data on this treatment in pediatric patients is limited.
Endoscopic features for early decision to evaluate superior mesenteric artery syndrome in children
Jae Young Kim, Myung Seok Shin & Sunho Lee
doi : 10.1186/s12887-021-02848-0
BMC Pediatrics volume 21, Article number: 392 (2021)
Diagnostic delay of superior mesenteric artery syndrome (SMAS) is common due to its rarity and lack of index of clinical suspicion. Early diagnosis under suspicion is pivotal for adequate treatment. Present study aims to explore the endoscopic features for early decision to evaluate SMAS in children.
The diagnostic trajectory in autism and intellectual disability in Quebec: pathways and parents’ perspective
Mélina Rivard, Coulombe Patrick, Catherine Mello, Diane Morin & Marjorie Morin
doi : 10.1186/s12887-021-02864-0
BMC Pediatrics volume 21, Article number: 393 (2021)
This paper aimed to describe the diagnostic service trajectory of families of children with autism or intellectual disability in the province of Québec and identify predictors of parents’ perceptions of its quality.
A multicenter study of incidence, risk factors and outcomes of babies with birth asphyxia in Nepal
Avinash K. Sunny, Prajwal Paudel, Jagannath Tiwari, Bishow Bandhu Bagale, Antti Kukka, Zhou Hong, Uwe Ewald, Sara Berkelhamer & Ashish KC
doi : 10.1186/s12887-021-02858-y
BMC Pediatrics volume 21, Article number: 394 (2021)
Perinatal events which result in compromised oxygen delivery to the fetus can lead to Birth Asphyxia (BA). While the incidence, risk factors and outcomes of BA have been characterized, less is known in low resource settings.
Feeding the critically ill child in intensive care units: a descriptive qualitative study in two tertiary hospitals in Ghana
Alhassan Sibdow Abukari & Angela Kwartemaa Acheampong
doi : 10.1186/s12887-021-02854-2
BMC Pediatrics volume 21, Article number: 395 (2021)
Critically ill children require optimum feeding in the intensive care units for speedy recovery. Several factors determine their feeding and the feeding method to adopt to address this phenomenon. The aim of this study was to explore and describe the feeding criteria of critically ill children at the neonatal and paediatric intensive care units.
Quality of inpatient care of small and sick newborns in Pakistan: perceptions of key stakeholders
Nousheen Akber Pradhan, Ammarah Ali, Sana Roujani, Sumera Aziz Ali, Samia Rizwan, Sarah Saleem & Sameen Siddiqi
doi : 10.1186/s12887-021-02850-6
BMC Pediatrics volume 21, Article number: 396 (2021)
In LMICs including Pakistan, neonatal health and survival is a critical challenge, and therefore improving the quality of facility-based newborn care services is instrumental in averting newborn mortality. This paper presents the perceptions of the key stakeholders in the public sector to explore factors influencing the care of small and sick newborns and young infants in inpatient care settings across Pakistan.
Paternal childcare in early childhood and problematic behavior in children: a population-based prospective study in Japan
Manami Ochi & Takeo Fujiwara
doi : 10.1186/s12887-021-02838-2
BMC Pediatrics volume 21, Article number: 397 (2021)
There have been numerous reports on the effects of paternal childcare on children’s behavioral development. However, little is known about these effects in Asian countries such as Japan, where fathers do not have sufficient time for childcare due to long working hours. This study explored the association between paternal childcare during toddlerhood in terms of childcare hours and the type of caregiving behavior and subsequent behavioral problems in children aged 5.5?years, stratified by sex.
Dandy-Walker malformation in methylmalonic acidemia: a rare case report
Jingwei Liu, Zhuohang Liu, Haibo Yan & Yumei Li
doi : 10.1186/s12887-021-02874-y
BMC Pediatrics volume 21, Article number: 398 (2021)
Methylmalonic acidemia is an organic acid metabolism disorder that usually has nonspecific clinical manifestations.
Altered B cell compartment associated with Tfh cells in children with Henoch-Schonlein Purpura
Ning Zhang, Ge Tian, Yuanyuan Sun, Jing Pan, Wei Xu & Zhe Li
doi : 10.1186/s12887-021-02873-z
BMC Pediatrics volume 21, Article number: 399 (2021)
IgA-producing B cells have been found to be associated with children diagnosed with Henoch-Schonlein purpura (HSP). The aim of the present study was to determine whether children with HSP possess altered B-cell subsets.
Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection
Vineet Lamba, Joan Lien, Jay Desai & Ajay J. Talati
doi : 10.1186/s12887-021-02872-0
BMC Pediatrics volume 21, Article number: 400 (2021)
We report here on the management and outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection.
Pediatric emergency department visits due to child abuse and neglect following COVID-19 public health emergency declaration in the Southeastern United States
Lindsey Rose Bullinger, Angela Boy, Stephen Messner & Shannon Self-Brown
doi : 10.1186/s12887-021-02870-2
BMC Pediatrics volume 21, Article number: 401 (2021)
The ongoing worldwide COVID-19 pandemic has heightened several risk factors for child abuse and neglect (CAN). We study whether COVID-19 and the public health response to it affected CAN-related pediatric emergency department (ED) visits in the southeastern United States (US).
A randomized EPIREMED protocol study on the long-term visuo spatial effects of very preterm children with a working memory deficit
Catherine Gire, Any Beltran Anzola, Monique Kaminski, Karine Baumstarck, Pierre-Yves Ancel & Julie Berbis for EPIREMED-Study Group
doi : 10.1186/s12887-021-02867-x
BMC Pediatrics volume 21, Article number: 402 (2021)
Very preterm children generally perform poorly in executive functions and particularly in working memory. Adaptive training tasks encouraging these children to work continuously on their personal working memory capacity can be very useful. Above all in preschool-age children, several cognitive training programs focused on improving working memory capacity. Cogmed is a computerized visuospatial cognitive training program that improves working memory in children and adolescents with attention-deficit/hyperactivity disorder. The main objective is to assess the long-term effects (18?months) of cognitive training (Cogmed) on visuospatial processing in preschool-age very preterm children with working memory impairment.
The first 1000 symptomatic pediatric SARS-CoV-2 infections in an integrated health care system: a prospective cohort study
Leigh M. Howard, Kathryn Garguilo, Jessica Gillon, Kerry LeBlanc, Adam C. Seegmiller, Jonathan E. Schmitz, Daniel W. Byrne, Henry J. Domenico, Ryan P. Moore, Steven A. Webber, Natasha B. Halasa & Ritu Banerjee
doi : 10.1186/s12887-021-02863-1
BMC Pediatrics volume 21, Article number: 403 (2021)
The spectrum of illness and predictors of severity among children with SARS-CoV-2 infection are incompletely understood.
A prospective investigation of developmental trajectories of psychosocial adjustment in adolescents facing a chronic condition - study protocol of an observational, multi-center study
Petra Warschburger, Ann-Christin Petersen, Roman E. von Rezori, Friederike Buchallik, Harald Baumeister, Reinhard W. Holl, Kirsten Minden, Annabel S. Müller-Stierlin, Christina Reinauer, Doris Staab & COACH consortium
doi : 10.1186/s12887-021-02869-9
BMC Pediatrics volume 21, Article number: 404 (2021)
Relatively little is known about protective factors and the emergence and maintenance of positive outcomes in the field of adolescents with chronic conditions. Therefore, the primary aim of the study is to acquire a deeper understanding of the dynamic process of resilience factors, coping strategies and psychosocial adjustment of adolescents living with chronic conditions.
Case Report:clinical experience of bilateral giant pediatric Testicular adrenal rest tumors with 3 Beta-Hydroxysteroid Dehydrogenase-2 family history
Lingyun Yu, Pengyu Chen, Wenbin Zhu, Junjie Sun & Shoulin Li
doi : 10.1186/s12887-021-02883-x
BMC Pediatrics volume 21, Article number: 405 (2021)
We reported a patient with Testicular adrenal rest tumors(TARTs) caused by congenital adrenal hyperplasia(CAH). TARTs occur frequently in CAH population with 21-hydroxylase deficiency(21-OHD). There are few reports of TARTs with 3?-hydroxysteroid dehydrogenase deficiency-2 (3?-2HSD).Furthermore,gaint TARTs are rarely mentioned in reported cases involving affected siblings.
Prediction of repeated intravenous immunoglobulin resistance in children with Kawasaki disease
Yaheng Lu, Tingting Chen, Yizhou Wen, Feifei Si, Xindan Wu & Yanfeng Yang
doi : 10.1186/s12887-021-02876-w
BMC Pediatrics volume 21, Article number: 406 (2021)
Repeated intravenous immunoglobulin (IVIG) resistance prediction is one of the pivotal topics in Kawasaki disease (KD). Those non-responders of repeated IVIG treatment might be improved by an early-intensified therapy to reduce coronary artery lesion and medical costs. This study investigated predictors of resistance to repeated IVIG treatment in KD.
Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis
Sabrina de Jesus Brito, Sabrina Pinheiro Tsopanoglou, Endi Lanza Galv?o, Franciele Angelo de Deus & Vanessa Pereira de Lima
doi : 10.1186/s12887-021-02881-z
BMC Pediatrics volume 21, Article number: 407 (2021)
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects the premature lung, and to reduce its incidence has been used non-invasive ventilatory support, such as continuous positive airway (CPAP) and high-flow nasal cannula (HFNC). Thus, the objective of this review was to assess whether the use of high flow nasal cannula (HFNC) compared to continuous positive airway pressure (CPAP) decreases the risk of bronchopulmonary dysplasia (BPD) in premature newborns.
The association between birth weight and proxy-reported health-related quality of life among children aged 5???10 years old: A linked data analysis
Tahir Ahmed Hassen, Catherine Chojenta, Nicholas Egan & Deborah Loxton
doi : 10.1186/s12887-021-02882-y
BMC Pediatrics volume 21, Article number: 408 (2021)
Birth weight has a substantial effect on children’s cognitive development, physical capability, and emotional development, which in turn impact on Health-Related Quality of Life (HRQoL). Generally, evidence indicates that children born with low birth weight tend to have poorer proxy-reported HRQoL, particularly at school age. However, there is limited evidence on whether variation in HRQoL exists across the entire range of possible birth weights. This study aimed to examine the association between birth weight and proxy-reported HRQoL among children aged 5–10 years old.
Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016–2018: a multicenter, retrospective study
Yuanyuan Qi, Peng Shi, Renjie Chen, Yufeng Zhou, Lijuan Liu, Jianguo Hong, Lanfang Cao, Yanming Lu, Xiaoyan Dong, Jing Li, Yu Shi, Min Xia, Bo Ding, Liling Qian, Libo Wang, Wenhao Zhou, Yonghao Gui & Xiaobo Zhang
doi : 10.1186/s12887-021-02880-0
BMC Pediatrics volume 21, Article number: 409 (2021)
The prevalence of allergic diseases (ADs), such as asthma and allergic rhinitis (AR), is increasing worldwide in both adults and children. Although ADs are common and frequently coexist in outpatient care, city-level data regarding the characteristics of childhood AD remain limited in China. This study aimed to assess the profile and characteristics of ADs in the city of Shanghai.
Predictive value of early amplitude integrated electroencephalogram (aEEG) in sleep related problems in children with perinatal hypoxic-ischemia (HIE)
Qiuyan Tian, Yizhi Pan, Zheng Zhang, Mei Li, Li-xiao Xu, Min Gong, Po Miao, Xiaolu Jiang, Xiaofeng Yang, Chen-Xi Feng, Jian Pan, Yun Yu, Bin Sun & Xin Ding
doi : 10.1186/s12887-021-02796-9
BMC Pediatrics volume 21, Article number: 410 (2021)
While great attention has been paid to motor and cognitive impairments in children with neonatal Hypoxic-Ischemic Encephalopathy (HIE), sleep related circadian rhythm problems, although commonly present, are often neglected. Subsequently, no early clinical indicators have been reported to correlate with sleep-related circadian dysfunction during development.
Pediatric hemophagocytic lymphohistiocytosis: A rarely diagnosed entity in a developing country
Daniela Cleves, Viviana Lotero, Diego Medina, Paola M Perez, Jaime A Pati?o, Laura Torres-Canchala & Manuela Olaya
doi : 10.1186/s12887-021-02879-7
BMC Pediatrics volume 21, Article number: 411 (2021)
Hemophagocytic lymphohistiocytosis (HLH) is an exaggerated inflammatory reaction secondary to a host’s inadequate immune response causing a self-perpetuating loop of altered regulation. Signs and symptoms of HLH are compatible with other common diseases and are nonspecific. Underdiagnosis makes it difficult to estimate the real incidence of HLH, especially in developing countries.
Cardiometabolic outcomes in children and adolescents with West syndrome
Inbar Gilboa, Galit Israeli, Avivit Brener, Michal Yackobovitch-Gavan, Uri Kramer, Shimrit Uliel-Sibony & Yael Lebenthal
doi : 10.1186/s12887-021-02871-1
BMC Pediatrics volume 21, Article number: 412 (2021)
West syndrome is a convulsive disorder of infancy with unique seizures and a characteristic background electroencephalograph pattern. Adrenocorticotropic hormone (ACTH) is effective in spasm cessation, yet metabolic consequences of this therapeutic agent in childhood have not been published.
Acute lower respiratory tract infections and associated factors among under-five children visiting Wolaita Sodo University Teaching and Referral Hospital, Wolaita Sodo, Ethiopia
Birhanu Wondimeneh Demissie, Esayas Aydiko Amele, Yibeltal Asmamaw Yitayew & Zemen Mengesha Yalew
doi : 10.1186/s12887-021-02888-6
BMC Pediatrics volume 21, Article number: 413 (2021)
Lower respiratory infections are a leading cause of morbidity and mortality worldwide, particularly in children younger than 5 years. Even if the burden of lower respiratory infections in children under 5 years old had decreased dramatically in the last 10 years, it is still the main cause of morbidity and mortality in children under-5 years old in developing countries, so the aim of this study was to assess the magnitude of lower respiratory tract infections and associated factors among under-five children visiting Wolaita Sodo University Teaching and Referral Hospital.
Rare novel LPL mutations are associated with neonatal onset lipoprotein lipase (LPL) deficiency in two cases
Yun Qin Wu, Yue Yuan Hu & Gui Nan Li
doi : 10.1186/s12887-021-02875-x
BMC Pediatrics volume 21, Article number: 414 (2021)
Lipoprotein lipase (LPL) deficiency is a monogenic lipid metabolism disorder biochemically characterized by hypertriglyceridemia (HTG) inherited in an autosomal recessive manner. Neonatal onset LPL deficiency is rare. The purpose of this study was to clarify the clinical features of neonatal LPL deficiency and to analyze the genetic characteristics of LPL gene.
Cecal epidermoid cyst: a neonatal case with clinicopathological consideration
Joo-Young Na, Soo-Hong Kim & Narae Lee
doi : 10.1186/s12887-021-02884-w
BMC Pediatrics volume 21, Article number: 415 (2021)
Only 10 cases of cecal epidermoid cyst (CEC) have been reported in the literature. Furthermore, its pathogenesis remains unclear. We report a rare case of congenital CEC in neonate, and discuss its clinicopathological findings.
Waitlist management in a pediatric weight management clinic: implementing an orientation session
Webb A. Smith, Emily Gray, Tamekia L. Jones, Joan C. Han & E. Thomaseo Burton
doi : 10.1186/s12887-021-02868-w
BMC Pediatrics volume 21, Article number: 416 (2021)
This study evaluates implementation of an orientation session to address a waitlist of more than 2000 referrals to a pediatric weight management clinic in the Mid-South United States.
Comparison of nostril sizes of newborn infants with outer diameter of endotracheal tubes
Bianca Haase, Ana-Maria Badinska, Christian A. Maiwald, Christian F. Poets & Laila Springer
doi : 10.1186/s12887-021-02889-5
BMC Pediatrics volume 21, Article number: 417 (2021)
Recommendations for endotracheal tube (ETT) size usually refer to the inner diameter (ID). Outer diameters (OD), however, vary greatly between manufacturers, which in some brands might cause difficulties in passing the ETT through the nostrils if choosing the nasal route for intubation. Even though the nostrils are dilatable by an ETT, it might be difficult to pass an ETT through the posterior naris (narrowest point of the nasal passage), if the OD is bigger than the nostrils. Therefore, nostril size may provide some guidance for the appropriate ETT size preventing unsuccessful intubation attempts. This study therefore compares nostril sizes of newborn infants with ODs of ETTs from several manufacturers.
Obesity determinants among Malaysian 12-year old school adolescents: findings from the HAT study
Aryati Ahmad, Nurzaime Zulaily, Mohd Razif Shahril, Sharifah Wajihah Wafa, Rahmah Mohd Amin, Carmen Piernas & Amran Ahmed
doi : 10.1186/s12887-021-02899-3
BMC Pediatrics volume 21, Article number: 418 (2021)
Childhood obesity has been associated with increased odds of adult obesity and co-morbidities in later life. Finding the key determinants may help in designing the most appropriate and effective interventions to prevent obesity. This study aimed to identify the determinants of obesity among school adolescents in a sub-urban state of Malaysia.
Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children’s Study (JECS)
Mari Nakamura, Kenta Matsumura, Yoshiko Ohnuma, Taketoshi Yoshida, Akiko Tsuchida, Kei Hamazaki, Hidekuni Inadera & the Japan Environment and Children’s Study Group
doi : 10.1186/s12887-021-02885-9
BMC Pediatrics volume 21, Article number: 419 (2021)
The association between delivery mode and subsequent development of diseases is a growing area of research. Cesarean delivery affects the diversity of the microbiota in the infant gut, which may be associated with gastrointestinal disorders, including functional constipation, in infants. In this study, we investigated the association between delivery mode and prevalence of functional constipation in 3-year-old Japanese toddlers.
Enteral feeding advancement and growth until 5?years in extremely preterm infants
Cornelia Wiechers, Jan-Niklas Doll, Christoph Maas, Kerstin Gründler, Katja Büchner, Christian F. Poets & Axel R. Franz
doi : 10.1186/s12887-021-02878-8
BMC Pediatrics volume 21, Article number: 420 (2021)
In-utero weight gain can be achieved in very preterm infants through rapid advancement of enteral feeds without increasing risk of necrotizing enterocolitis. There are concerns, however, that such rapid weight gain may lead to an increased childhood adiposity risk, although long-term data are sparse.
Physical activity and sedentary behaviors (screen time and homework) among overweight or obese adolescents: a cross-sectional observational study in Yazd, Iran
Ali Mohammad Hadianfard, Hassan Mozaffari-Khosravi, Majid Karandish & Maryam Azhdari
doi : 10.1186/s12887-021-02892-w
BMC Pediatrics volume 21, Article number: 421 (2021)
The growing number of adolescents who are overweight or obese (OW / OB) is a public concern. The present study was aimed to evaluate physical activity (PA) and sedentary behaviors (SB) (screen time (ST) and homework time (HT)) among Yazd OW/OB adolescents.
Associations of childhood unintentional injuries with maternal emotional status during COVID-19
Xiangrong Guo, Hui Hua, Jian Xu & Zhiwei Liu
doi : 10.1186/s12887-021-02846-2
BMC Pediatrics volume 21, Article number: 422 (2021)
To explore the characteristics of unintentional childhood-injury during the COVID-19 pandemic and assess the association of unintentional-injury with maternal emotional status.
Prevalence of urinary iodine concentration among school children: in Dessie City, Ethiopia
Birtukan Shiferaw Ayalew, Seid Legesse Hassen, Tefera Alemu Marefiyaw, Mohammed Seid Yesuf, Daniel Dagne Abebe & Minwuyelet Maru Temesgen
doi : 10.1186/s12887-021-02887-7
BMC Pediatrics volume 21, Article number: 423 (2021)
Urinary iodine is recommended by the world health organization as the main indicator to assess iodine status in a population. Despite this recommendation little is known about urinary iodine concentration in the study area. Therefore, this study aimed to determine the level of urinary iodine concentration among school-aged children.
Epidemiology of childhood injuries in Saudi Arabia: a scoping review
Hadeel Albedewi, Nouf Al-Saud, Abdulhameed Kashkary, Ada Al-Qunaibet, Salem M. AlBalawi & Suliman Alghnam
doi : 10.1186/s12887-021-02886-8
BMC Pediatrics volume 21, Article number: 424 (2021)
Injury is the leading cause of death among Saudi children. Despite that, much remains unknown on the epidemiology and the extent of burden. This scoping review aims to describe previous literature on injury burden, including types, causes, and outcomes.
Response to: Low gestational age is associated with less anastomotic complications after open primary repair of esophageal atresia with tracheoesophgeal fistula. BMC Paediatric 2020; 20:267
V. Coles & I. Yardley
doi : 10.1186/s12887-021-02900-z
BMC Pediatrics volume 21, Article number: 425 (2021)
The impact of childhood injury and injury severity on school performance and high school completion in Australia: a matched population-based retrospective cohort study
Rebecca J. Mitchell, Cate M. Cameron, Anne McMaugh, Reidar P. Lystad, Tim Badgery-Parker & Tayhla Ryder
doi : 10.1186/s12887-021-02891-x
BMC Pediatrics volume 21, Article number: 426 (2021)
Exploring the impact of injury and injury severity on academic outcomes could assist to identify characteristics of young people likely to require learning support services. This study aims to compare scholastic performance and high school completion of young people hospitalised for an injury compared to young people not hospitalised for an injury by injury severity; and to examine factors influencing scholastic performance and school completion.
Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design
A. M. van Hulst, E. J. Verwaaijen, M. F. Fiocco, S. M. F. Pluijm, M. A. Grootenhuis, R. Pieters, E. L. T. van den Akker & M. M. van den Heuvel-Eibrink
doi : 10.1186/s12887-021-02896-6
BMC Pediatrics volume 21, Article number: 427 (2021)
Dexamethasone, a highly effective drug in treating pediatric acute lymphoblastic leukemia (ALL), can induce serious neurobehavioral side effects. These side effects are experienced by patients and parents as detrimental with respect to health related quality of life (HRQoL). Based on previous studies, it has been suggested that neurobehavioral side effects are associated to cortisol depletion of the mineralocorticoid receptor in the brain. Our previously reported randomized controlled trial, the Dexadagen study (NTR3280), suggests that physiological hydrocortisone addition during dexamethasone treatment may overcome clinically relevant neurobehavioral problems in patients who experience these problems during dexamethasone treatment. With our current study, we aim to replicate these results in a targeted larger sample before further implementing this intervention into standard of care.
Identifying pain trajectories in children and youth with cerebral palsy: a pilot study
Heather M. Shearer, Pierre Côté, Sheilah Hogg-Johnson, Patricia McKeever & Darcy L. Fehlings
doi : 10.1186/s12887-021-02861-3
BMC Pediatrics volume 21, Article number: 428 (2021)
Although chronic pain is common in children with cerebral palsy (CP), little is known about short-term pain fluctuations and their impact on children’s well-being. High-quality cohort studies are needed to understand the clinical course of pain in this population. We aimed to determine the feasibility of conducting a multicentre cohort study. In this pilot study we assessed: 1) study processes, 2) resource and 3) management indicators including recruitment and follow-up rates, data completeness, participant characteristics, and successes and barriers in the study conduct.
Establishing an appropriate Z score regression equation for Chinese pediatric coronary artery echocardiography: a multicenter prospective cohort study
Shu-min Fan, Bei Xia, Wei-xiang Liu, Wei Yu, Zhi-xia Wu, Shu-Bao Chen, Qing-Hua Liu, Wen-juan Chen, Shan-liang Zhu, Mei Jin, Jie-Qing Min & Yang Xu
doi : 10.1186/s12887-021-02877-9
BMC Pediatrics volume 21, Article number: 429 (2021)
Z score utility is emphasized in classifying coronary artery lesions in Kawasaki disease patients. The present study is the largest such multicenter Chinese pediatric study about coronary artery diameter reference values and Z score regression equation to date. It is useful in Chinese pediatric echocardiography.
