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Case report: Osteomalacia due to bisphosphonate treatment in a patient on hemodialysis
Masaki Hatano, Izuru Kitajima, Seizo Yamamoto, Masaki Nakamura, Kazuya Isawa, Yutaka Hirota, Junichi Hoshino, Naoki Sawa & Yoshifumi Ubara
doi : 10.1186/s12882-021-02509-5
BMC Nephrology volume 22, Article number: 298 (2021)
No publications have reported on osteomalacia in patients receiving intermittent cyclical therapy with etidronate (a bisphosphonate) and undergoing long-term hemodialysis (HD).
Renal biomarkers of acute kidney injury in response to increasing intermittent hypoxia episodes in the neonatal rat
Anano Zangaladze, Charles L. Cai, Matthew Marcelino, Jacob V. Aranda & Kay D. Beharry
doi : 10.1186/s12882-021-02507-7
BMC Nephrology volume 22, Article number: 299 (2021)
We tested the hypotheses that: 1) early exposure to increasing episodes of clinically relevant intermittent hypoxia (IH) is detrimental to the developing kidneys; and 2) there is a critical number of daily IH episodes which will result in irreparable renal damage that may involve angiotensin (Ang) II and endothelin (ET)-1.
Timing of AKI after urgent percutaneous coronary intervention and clinical outcomes: a high-dimensional propensity score analysis
Alan S. Go, Thida C. Tan, Rishi V. Parikh, Andrew P. Ambrosy, Leonid V. Pravoverov, Sijie Zheng & Thomas K. Leong
doi : 10.1186/s12882-021-02513-9
BMC Nephrology volume 22, Article number: 300 (2021)
Acute kidney injury is a common complication of percutaneous coronary intervention and has been associated with an increased risk of death and progressive chronic kidney disease. However, whether the timing of acute kidney injury after urgent percutaneous coronary intervention could be used to improve patient risk stratification is not known.
Experiences of renal healthcare practitioners during the COVID-19 pandemic: a multi-methods approach
Clare Mc Keaveney, Joanne Reid, Claire Carswell, Ann Bonner, Ilaria de Barbieri, William Johnston, Alexander P. Maxwell, Julien O’Riordan, Veronica Strini, Ian Walsh & Helen Noble
doi : 10.1186/s12882-021-02500-0
BMC Nephrology volume 22, Article number: 301 (2021)
Globally, renal healthcare practitioners provide intensive and protracted support to a highly complex multi-morbid patient population however knowledge about the impact of COVID-19 on these practitioners is extremely limited.
Association of elevated serum aminotransferase levels with chronic kidney disease measures: hispanic community health study/study of latinos
Celestin Missikpode, Holly Kramer, Scott J. Cotler, Ramon Durazo-Arvizu, James P. Lash, Eric Kallwitz, Jianwen Cai, Mark H. Kuniholm, Sylvia E. Rosas, Ana C. Ricardo, Gregory A. Talavera, Leopoldo Raij, Amber Pirzada & Martha L. Daviglus
doi : 10.1186/s12882-021-02483-y
BMC Nephrology volume 22, Article number: 302 (2021)
Previous studies have shown an association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD), but it is unclear whether the association is independent of metabolic syndrome.
Efficacy of rituximab in thymoma associated minimal change disease: case report
Zhour El Ouafi, Clovis Mugnier, Robin Jeannet, Clément Danthu, Marion Duval, Valère Belle Mbou & Fatouma Touré
doi : 10.1186/s12882-021-02479-8
BMC Nephrology volume 22, Article number: 303 (2021)
Thymomas have been associated with a broad spectrum of autoimmune diseases. Minimal change disease (MCD) is the most frequent pathological lesion reported. Pathophysiological mechanisms involved in secondary MCD, and linking MCD to thymoma are not yet fully explained, although the hypothesis of T cell dysfunction has been suggested. The fundamental therapeutic principles are steroids and surgical treatment of thymoma, but failures and relapses often require immunosuppressant combinations.
Efficacy of tripterygium glycosides for diabetic nephropathy: a meta-analysis of randomized controlled trials
Hua-Bin Guo, Jia-Qing Peng, Xuan Wang, Ke-Kai Zhang, Guang-Zhi Zhong, Wei-Hong Chen & Gui-Xin Shi
doi : 10.1186/s12882-021-02487-8
BMC Nephrology volume 22, Article number: 304 (2021)
Diabetic nephropathy (DN) is one of the most important clinical complications of diabetes mellitus (DM) and is the most common cause of end-stage renal disease. Currently, there is no highly effective medicine that can prevent, halt, or reverse the progressive course of DN. Initial clinical data showed that Tripterygium glycosides (TGs), a traditional Chinese medicine, can decrease proteinuria in patients with DN.
Reduced serum albumin as a risk factor for poor prognosis in critically ill patients receiving renal replacement therapy
Lang Jing Zheng, Weiming Jiang, Lingling Pan & Jingye Pan
doi : 10.1186/s12882-021-02512-w
BMC Nephrology volume 22, Article number: 305 (2021)
Albumin is the primary body protein, which can predict the poor prognosis of several critical diseases. However, there are a few scientific studies on the relationship between albumin and the prognosis of dialysis patients. This study aims to explore the impact of hypoalbuminemia on the prognosis of critically ill patients with acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT).
The association of urine osmolality with decreased kidney function and/or albuminuria in the United States
Boonsong K. Kitiwan, Sarinnapha M. Vasunilashorn, Heather J. Baer, Kenneth Mukamal & Stephen P. Juraschek
doi : 10.1186/s12882-021-02478-9
BMC Nephrology volume 22, Article number: 306 (2021)
Decreased kidney function is commonly caused by hypovolemia. When hypovolemic, the kidney reabsorbs water resulting in concentrated urine. Osmolality is a measure of urine concentration which is more objective than self-reported fluid intake. It has a positive association with hypovolemia. However, it remains controversial whether osmolality is associated with decreased kidney function and/or albuminuria.
Does conservative kidney management offer a quantity or quality of life benefit compared to dialysis? A systematic review
Buur Louise Engelbrecht, Madsen Jens Kristian, Eidemak Inge, Krarup Elizabeth, Lauridsen Thomas Guldager, Taasti Lena Helbo & Finderup Jeanette
doi : 10.1186/s12882-021-02516-6
BMC Nephrology volume 22, Article number: 307 (2021)
Patients with stage 5 chronic kidney disease (CKD5) collaborate with their clinicians when choosing their future treatment modality. Most elderly patients with CKD5 may only have two treatment options: dialysis or conservative kidney management (CKM). The objective of this systematic review was to investigate whether CKM offers a quantity or quality of life benefit compared to dialysis for some patients with CKD5.
The best solution down the line: an observational study on taurolidine- versus citrate-based lock solutions for central venous catheters in hemodialysis patients
Sonja van Roeden, Mathijs van Oevelen, Alferso C. Abrahams, Friedo W. Dekker, Joris I. Rotmans & Sabine C. A. Meijvis on behalf of the DUCATHO study group
doi : 10.1186/s12882-021-02519-3
BMC Nephrology volume 22, Article number: 308 (2021)
To prevent infection and thrombosis of central venous catheters (CVCs) in hemodialysis patients, different CVC lock solutions are available. Taurolidine-based solutions and citrate in different concentrations are frequently used, but no definite conclusions with regard to superiority have been drawn.
Person centred care provision and care planning in chronic kidney disease: which outcomes matter? A systematic review and thematic synthesis of qualitative studies
Ype de Jong, Esmee M. van der Willik, Jet Milders, Yvette Meuleman, Rachael L. Morton, Friedo W. Dekker & Merel van Diepen
doi : 10.1186/s12882-021-02489-6
BMC Nephrology volume 22, Article number: 309 (2021)
Explore priorities related to outcomes and barriers of adults with chronic kidney disease (CKD) regarding person centred care and care planning.
Comprehensive analysis of lysine crotonylation modification in patients with chronic renal failure
Jiahuang Huang, Donge Tang, Fengping Zheng, Huixuan Xu & Yong Dai
doi : 10.1186/s12882-021-02445-4
BMC Nephrology volume 22, Article number: 310 (2021)
Post-translational modifications (PTMs) are at the heart of many cellular signaling events, which changes the function of protein. Crotonylation, one of the most important and common PTMs, plays a crucial role in the regulation of various biological processes. However, no study has evaluated the role of lysine crotonylation modification in chronic renal failure (CRF) patients.
Association of uric acid and uric acid to creatinine ratio with chronic kidney disease in hypertensive patients
Nathalia Rabello Silva, Camila Evangelista Torres Gonçalves, Danilo Lemes Naves Gonçalves, Rosângela Minardi Mitre Cotta & Luciana Saraiva da Silva
doi : 10.1186/s12882-021-02521-9
BMC Nephrology volume 22, Article number: 311 (2021)
Recent studies have shown that the serum uric acid/creatinine ratio (SUA/SCr) is a better predictor of chronic kidney disease (CKD) than serum uric acid (SUA) isolated. The aim of the present study was to evaluate the association of isolated SUA and the SUA/SCr with CKD in hypertensive patients.
Clinical practice guidelines standardisation of immunosuppressive and anti-infective drug regimens in UK paediatric renal transplantation: the harmonisation programme
Jan Dudley, Martin Christian, Alice Andrews, Nicola Andrews, Julie Baker, Sheila Boyle, Mairead Convery, Fiona Gamston, Martin Garcia, Shuman Haq, Shivaram Hegde, Richard Holt, Helen Jones, Shakeeb Khan, Jennifer McCaughan, David Milford, Charlie Pickles, Ben Reynolds, Vijaya Sathyanarayana, Jelena Stojanovic, Yincent Tse, Dean Wallace, Grainne Walsh, Nick Ware, Alun Williams, Pallavi Yadav & Stephen Marks -Show fewer authors
doi : 10.1186/s12882-021-02460-5
BMC Nephrology volume 22, Article number: 312 (2021)
Transmission of SARS-CoV-2 considering shared chairs in outpatient dialysis: a real-world case-control study
Ravi Thadhani, Joanna Willetts, Catherine Wang, John Larkin, Hanjie Zhang, Lemuel Rivera Fuentes, Len Usvyat, Kathleen Belmonte, Yuedong Wang, Robert Kossmann, Jeffrey Hymes, Peter Kotanko & Franklin Maddux
doi : 10.1186/s12882-021-02518-4
BMC Nephrology volume 22, Article number: 313 (2021)
SARS-CoV-2 can remain transiently viable on surfaces. We examined if use of shared chairs in outpatient hemodialysis associates with a risk for indirect patient-to-patient transmission of SARS-CoV-2.
Processing speed is affected by early impairment in kidney function in the general elder population
Tomas M?nsson & S?lve Elmst?hl
doi : 10.1186/s12882-021-02517-5
BMC Nephrology volume 22, Article number: 314 (2021)
Chronic kidney disease, cardiovascular disease, and cognitive dysfunction are common in the elder population. There is evidence of a connection between these conditions, possibly by a shared vascular pathogenesis. Processing speed is commonly impaired in cerebrovascular disease.
Practices and pitfalls in medication adherence in hemodialysis settings – a focus-group study of health care professionals
Trine Mechta Nielsen, Nina Schjerning, Gudrun Kaldan, Mads Hornum, Bo Feldt-Rasmussen & Thordis Thomsen
doi : 10.1186/s12882-021-02514-8
BMC Nephrology volume 22, Article number: 315 (2021)
Medication nonadherence is common among patients with hemodialysis, leading to poorer patient outcomes. Health care professionals have an important role in assessing risk of nonadherence and intervening to support adherence. The aim of this study was to explore physicians’ and nurses’ current medication adherence practices in hemodialysis settings.
LDLR gene polymorphism (rs688) affects susceptibility to cardiovascular disease in end-stage kidney disease patients
Monika Buraczynska, Jerry Jacob, Karolina Gwiazda-Tyndel & Andrzej Ksiazek
doi : 10.1186/s12882-021-02532-6
BMC Nephrology volume 22, Article number: 316 (2021)
The low-density lipoprotein receptor (LDLR) plays a significant role in maintaining the cellular cholesterol homeostasis. Mutations in the LDLR gene can lead to a significant rise in plasma LDL levels that may result in an increased risk of atherosclerosis and coronary heart disease. The purpose of this study was to assess the potential association of the LDLR rs688 polymorphism with cardiovascular disease (CVD) in patients with end-stage kidney disease (ESKD) undergoing hemodialysis.
Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort
Ver?nica Valdivia-Cerda, Monserrat Alvarez-Zavala, Karina S?nchez-Reyes, Rodolfo I. Cabrera-Silva, Vida V. Ruiz-Herrera, Aldo D. Loza-Salazar, Pedro Mart?nez-Ayala, Juan C. V?zquez-Lim?n, Guillermo Garc?a-Garc?a, Jaime F. Andrade-Villanueva & Luz A. Gonz?lez-Hern?ndez
doi : 10.1186/s12882-021-02526-4
BMC Nephrology volume 22, Article number: 317 (2021)
HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8–16%; however, in HIV subjects, the prevalence varies between geographic regions (2–38%). The aim was to determine the prevalence of CKD and identify the associated risk factors.
Improving hospital safety for patients with chronic kidney disease: a mixed methods study
Lucia New, Donna Goodridge, Joanne Kappel, Joshua Lawson, Roy Dobson, Erika Penz, Gary Groot & John Gjevre
doi : 10.1186/s12882-021-02499-4
BMC Nephrology volume 22, Article number: 318 (2021)
People living with chronic kidney disease (CKD) require complex medical management and may be frequently hospitalized. Patient safety incidents during hospitalization can result in serious complications which may negatively affect health outcomes. There has been limited examination of how these patients perceive their own safety.
Impact of the relationship between hemoglobin levels and renal interstitial fibrosis on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy
Miho Shimizu, Kengo Furuichi, Shinji Kitajima, Tadashi Toyama, Megumi Oshima, Hisayuki Ogura, Koichi Sato, Shiori Nakagawa, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Hitoshi Yokoyama & Takashi Wada
doi : 10.1186/s12882-021-02510-y
BMC Nephrology volume 22, Article number: 319 (2021)
Progression of renal anemia has been shown to be associated with advanced renal tubulointerstitial lesions. This retrospective study investigated the impact of lower hemoglobin (Hb) levels and renal interstitial fibrosis and tubular atrophy (IFTA) on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy.
LAMA2 and LOXL4 are candidate FSGS genes
Poornima Vijayan, Saidah Hack, Tony Yao, Mohammad Azfar Qureshi, Andrew D. Paterson, Rohan John, Bernard Davenport, Rachel Lennon, York Pei & Moumita Barua
doi : 10.1186/s12882-021-02524-6
BMC Nephrology volume 22, Article number: 320 (2021)
Focal and segmental glomerulosclerosis (FSGS) is a histologic pattern of injury that characterizes a wide spectrum of diseases. Many genetic causes have been identified in FSGS but even in families with comprehensive testing, a significant proportion remain unexplained.
Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI
You-Zhen Feng, Xiao-Qiao Chen, Zhong-Yuan Cheng, Qi-Ting Lin, Ping-Kang Chen, Ding-Kun Si-Tu, Rui Cao, Long Qian, Baoli Heng & Xiang-Ran Cai
doi : 10.1186/s12882-021-02530-8
BMC Nephrology volume 22, Article number: 321 (2021)
The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats.
Nomogram predicting the risk of three-year chronic kidney disease adverse outcomes among East Asian patients with CKD
Huizhen Ye, Youyuan Chen, Peiyi Ye, Yu Zhang, Xiaoyi Liu, Guanqing Xiao, Zhe Zhang, Yaozhong Kong & Gehao Liang
doi : 10.1186/s12882-021-02496-7
BMC Nephrology volume 22, Article number: 322 (2021)
Chronic kidney disease (CKD) is a common health challenge. There are some risk models predicting CKD adverse outcomes, but seldom focus on the Mongoloid population in East Asian. So, we developed a simple but intuitive nomogram model to predict 3-year CKD adverse outcomes for East Asian patients with CKD.
Case report: a 5-year-old with new onset nephrotic syndrome in the setting of COVID-19 infection
Kelsi M. Morgan & Peace D. Imani
doi : 10.1186/s12882-021-02520-w
BMC Nephrology volume 22, Article number: 323 (2021)
This is a case report of an asymptomatic SARS-CoV-2 infection associated with new-onset nephrotic syndrome in a pediatric patient. This is the third case of new-onset nephrotic syndrome in children associated with SARS-CoV-2 infection, but is the first case report describing a new-onset nephrotic syndrome presentation in a patient who had asymptomatic COVID-19 infection.
A case report of breast cancer and membranous nephropathy with positive anti phospholipase A2 receptor antibodies
David Mathew, Sanjana Gupta & Neil Ashman
doi : 10.1186/s12882-021-02511-x
BMC Nephrology volume 22, Article number: 324 (2021)
Testing for antibodies against podocyte phospholipase A2 receptor-1 (PLA2R) allows clinicians to accurately identify primary membranous nephropathy (MN). Secondary MN is associated with a spectrum of pathology including solid organ malignancy. PLA2R positivity in these patients occurs, although no case of PLA2R-positive MN has been definitively linked to cancer.
Relationship between renal function and blood pressure dipping status in renal transplant recipients: a longitudinal study
David A. Jaques, Patrick Saudan, Chantal Martinez, Axel Andres, Pierre-Yves Martin, Antoinette Pechere-Bertschi & Belen Ponte
doi : 10.1186/s12882-021-02523-7
BMC Nephrology volume 22, Article number: 325 (2021)
Hypertension (HT) is associated with adverse outcomes in kidney transplant (KTX) recipients. Blunting of physiological decrease in nighttime compared to daytime blood pressure (non-dipping status) is frequent in this setting. However, weather non-dipping is independently associated with renal function decline in KTX patients is unknown.
Correction to: Negative effects of iodine-based contrast agent on renal function in patients with moderate reduced renal function hospitalized for COVID-19
Anna Kistner, Chen Tamm, Ann Mari Svensson, Mats O. Beckman, Fredrik Strand, Magnus Sk?ld & Sven Nyrén
doi : 10.1186/s12882-021-02536-2
BMC Nephrology volume 22, Article number: 326 (2021)
