JAMA Ophthalmology

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Addressing Disparities in Eye Care—The Time Is Now

Adrienne W. Scott, MD1; Angela R. Elam, MD2; Kristen Nwanyanwu, MD, MBA, MHS3

doi : 10.1001/jamaophthalmol.2021.2053

JAMA Ophthalmol. 2021;139(9):935-936

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Ophthalmic Injuries After the Port of Beirut Blast—One of Largest Nonnuclear Explosions in History

Wajiha Jurdi Kheir, MD1; Shady T. Awwad, MD1; Alaa Bou Ghannam, MD1; Ali A. Khalil, MD1; Perla Ibrahim, MD1; Elza Rachid, MD1; Nasrine Anais El Salloukh, MD1; Madeleine Yehia, MD1; Julien Torbey, MD1; Lulwa El Zein, MD1; Nada S. Jabbur, MD1,2,3; Baha Noureddin, MD1; Ramzi M. Alameddine, MD1

doi : 10.1001/jamaophthalmol.2021.2742

JAMA Ophthalmol. 2021;139(9):937-943

A review of the injury patterns, treatment strategies, and responding physicians’ experience during the Port of Beirut blast may help guide future ophthalmic disaster response plans.

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Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial

David M. Brown, MD1; Charles C. Wykoff, MD, PhD1,2; David Boyer, MD3; Jeffrey S. Heier, MD4; W. Lloyd Clark, MD5; Andres Emanuelli, MD6,7; Patrick M. Higgins, MD8; Michael Singer, MD9; David M. Weinreich, MD10; George D. Yancopoulos, MD, PhD10; Alyson J. Berliner, MD, PhD10; Karen Chu, MS10; Kimberly Reed, OD10; Yenchieh Cheng, PhD10; Robert Vitti, MD10

doi : 10.1001/jamaophthalmol.2021.2809

JAMA Ophthalmol. 2021;139(9):946-955

Proactive treatment of nonproliferative diabetic retinopathy (NPDR) reduces the risk of progression to vision-threatening complications.

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SARS-CoV-2 on Ocular Surfaces in a Cohort of Patients With COVID-19 From the Lombardy Region, Italy

Claudio Azzolini, MD1; Simone Donati, MD1; Elias Premi, MD1; Andreina Baj, MD2; Claudia Siracusa, BMedBiol3; Angelo Genoni, BMedSci4; Paolo A. Grossi, MD5; Lorenzo Azzi, MD6; Fausto Sessa, MD7; Francesco Dentali, MD8; Paolo Severgnini, MD9; Giulio Minoja, MD10; Luca Cabrini, MD11; Maurizio Chiaravalli, MD12; Giovanni Veronesi, MD13; Giulio Carcano, MD14; Lorenzo S. Maffioli, MD15; Angelo Tagliabue, MD6,16

doi : 10.1001/jamaophthalmol.2020.5464

JAMA Ophthalmol. 2021;139(9):956-963

Since February 2020, coronavirus disease 2019 (COVID-19) has spread rapidly all over the world, with an epidemiological cluster in Lombardy, Italy. The viral communicability may be mediated by various body fluids, but insufficient information is available on the presence of the virus in human tears.

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Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning

Marc Wilson, BCom, BIT1; Reena Chopra, BSc1,2,3; Megan Z. Wilson, MSci1; Charlotte Cooper, DPhil1; Patricia MacWilliams, MSc1; Yun Liu, PhD4; Ellery Wulczyn, MS4; Daniela Florea, PhD2,3; C?an O. Hughes, MBChB, MSc1; Alan Karthikesalingam, MSc, MA, PhD1; Hagar Khalid, MD2,3; Sandra Vermeirsch, MD2,3; Luke Nicholson, MD2,3; Pearse A. Keane, MD2,3; Konstantinos Balaskas, MD2,3; Christopher J. Kelly, MB BChir, PhD1

doi : 10.1001/jamaophthalmol.2021.2273

JAMA Ophthalmol. 2021;139(9):964-973

Quantitative volumetric measures of retinal disease in optical coherence tomography (OCT) scans are infeasible to perform owing to the time required for manual grading. Expert-level deep learning systems for automatic OCT segmentation have recently been developed. However, the potential clinical applicability of these systems is largely unknown.

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Application of 5G Technology to Conduct Real-Time Teleretinal Laser Photocoagulation for the Treatment of Diabetic Retinopathy

Huan Chen, MD1; Xuefeng Pan, MD2; Jingyuan Yang, MD1; Jing Fan, MD3; Mingwei Qin, MD3; Hu Sun, BSc4; Jinxin Liu, PhD5; Na Li, PhD5; Daniel Shu Wei Ting, MD, PhD6; Youxin Chen, MD, PhD1

doi : 10.1001/jamaophthalmol.2021.2312

JAMA Ophthalmol. 2021;139(9):975-982

Interest in teleophthalmology has been growing, especially during the COVID-19 pandemic. The advent of fifth-generation (5G) wireless systems has the potential to revolutionize teleophthalmology, but these systems have not previously been leveraged to conduct therapeutic telemedicine in the ophthalmology field.

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Minimally Invasive Glaucoma Surgical Techniques for Open-Angle Glaucoma: An Overview of Cochrane Systematic Reviews and Network Meta-analysis

Amanda K. Bicket, MD, MSE1; Jimmy T. Le, MA, ScD2; Augusto Azuara-Blanco, PhD, FRCSEd, FRCOphth3; Gus Gazzard, MA, MB BChir, MD, FRCOphth4,5; Richard Wormald, MSc, FRCS, FRCOphth6,7; Catey Bunce, DSc8; Kuang Hu, MA, MBBChir, PhD, FRCOphth4; Hari Jayaram, MBBS, PhD, FRCSEd4,5; Anthony King, MD, FRCOphth9; Francisco Ot?rola, MD4,10; Eleni Nikita, FRCOphth4; Anupa Shah, BA6; Richard Stead, FCOphth9; M?rta T?th, MD, PhD4; Tianjing Li, MD, MHS, PhD11

doi : 10.1001/jamaophthalmol.2021.2351

JAMA Ophthalmol. 2021;139(9):983-989

Glaucoma affects more than 75 million people worldwide. Intraocular pressure (IOP)–lowering surgery is an important treatment for this disease. Interest in reducing surgical morbidity has led to the introduction of minimally invasive glaucoma surgeries (MIGS). Understanding the comparative effectiveness and safety of MIGS is necessary for clinicians and patients.

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Effect of Combined Atropine and Patching vs Patching Alone for Treatment of Severe Amblyopia in Children Aged 3 to 12 Years: A Randomized Clinical Trial

Shu Wang, MD1,2,3; Wen Wen, MD, PhD1,2,3; Wenqing Zhu, MD, PhD1,2,3; Yan Liu, MD, PhD1,2,3; Leilei Zou, MD, PhD1,2,3; Tian Tian, MD, PhD1,2,3; Jing Lin, Jnr Tech1,2,3; Rui Liu, MD, PhD1,2,3; Hong Liu, MD, PhD1,4

doi : 10.1001/jamaophthalmol.2021.2413

JAMA Ophthalmol. 2021;139(9):990-996

Patching is often less effective for severe amblyopia because of poor adherence. For the treatment of severe amblyopia, although combined atropine and patching therapy (CAPT) has been found to be efficacious, it is currently unknown whether CAPT is more efficacious than patching alone.

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Home-Use Evaluation of a Wearable Collision Warning Device for Individuals With Severe Vision Impairments: A Randomized Clinical Trial

Shrinivas Pundlik, PhD1,2; Vilte Baliutaviciute, BS1,3; Mojtaba Moharrer, PhD1,2; Alex R. Bowers, PhD1,2; Gang Luo, PhD1,2

doi : 10.1001/jamaophthalmol.2021.2624

JAMA Ophthalmol. 2021;139(9):998-1005

There is scant rigorous evidence about the real-world mobility benefit of electronic mobility aids.

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Efficacy of a Web App–Based Music Intervention During Cataract Surgery: A Randomized Clinical Trial

Gilles Guerrier, MD, PhD1,2; Hendy Abdoul, MD, PhD3; Lea Jilet, MsC3; Pierre-Raphaël Rothschild, MD, PhD2,4; Christophe Baillard, MD, PhD1

doi : 10.1001/jamaophthalmol.2021.2767

JAMA Ophthalmol. 2021;139(9):1007-1013

Hypertensive events during cataract surgery may induce complications. Information and communication technologies applied to health are popular, but clinical evidence of its usefulness is rare and limited to treating anxiety without specific analysis. Recent publications have described the potential effects of personalized music choices as mobile-based intervention on pain but not on anxiety.

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Presumed SARS-CoV-2 Viral Particles in the Human Retina of Patients With COVID-19

Carlla A. Araujo-Silva, MSc1,2,3; Alléxya A. A. Marcos, MD4,5; Paula M. Marinho, MD4,5,6; Ana M. C. Branco, MD4; Alexandre Roque, MD6; André C. Romano, MD4,5; Mateus L. Matuoka, MD6; Michel Farah, MD, PhD4,5; Miguel Burnier, MD, PhD7; Nara F. Moraes, MD6; Paulo F. G. M. M. Tierno, MD6; Paulo Schor, MD, PhD4,5; Victoria Sakamoto, MD4; Heloisa Nascimento, MD, PhD4,5,6; Wanderley de Sousa, MD, PhD1,2,3; Rubens Belfort Jr, MD, PhD4,5

doi : 10.1001/jamaophthalmol.2021.2795

JAMA Ophthalmol. 2021;139(9):1015-1021

The presence of the SARS-CoV-2 virus in the retina of deceased patients with COVID-19 has been suggested through real-time reverse polymerase chain reaction and immunological methods to detect its main proteins. The eye has shown abnormalities associated with COVID-19 infection, and retinal changes were presumed to be associated with secondary microvascular and immunological changes.

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Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma

Owen M. Siggs, MD, DPhil1,2; Xikun Han, MSc3; Ayub Qassim, MBBS, PhD1; Emmanuelle Souzeau, PhD1; Shilpa Kuruvilla, MBBS1; Henry N. Marshall1; Sean Mullany, MD1; David A. Mackey, MD4,5; Alex W. Hewitt, MBBS, PhD4,6; Puya Gharahkhani, PhD3; Stuart MacGregor, PhD3; Jamie E. Craig, MBBS, DPhil1

doi : 10.1001/jamaophthalmol.2021.2440

JAMA Ophthalmol. 2021;139(9):1023-1028

Early diagnosis of open-angle glaucoma can lead to vision-saving treatment, and genetic variation is an increasingly powerful indicator in disease risk stratification.

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Clinical and Histopathologic Correlates of Asymmetric Retinitis Pigmentosa

Trisha Lal, BS1; Zu-Xi Yu, MD, PhD2; Bin Guan, PhD1; Chelsea Bender, BS3; Chi-Chao Chan, MD4; Catherine A. Cukras, MD, PhD5; Robert B. Hufnagel, MD, PhD1

doi : 10.1001/jamaophthalmol.2021.2688

JAMA Ophthalmol. 2021;139(9):1029-1032

Asymmetric retinitis pigmentosa (RP) is a rare presentation of a normally symmetric condition. Histopathologic evidence should be examined to see if this asymmetry extends to the tissue and cellular levels.

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