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Are SARS-CoV-2 Human Challenge Trials Ethical?
Daniel P. Sulmasy, MD, PhD1
doi : 10.1001/jamainternmed.2021.2614
JAMA Intern Med. 2021;181(8):1031-1032
Active Surveillance as a Management Option for Low-risk Basal Cell Carcinoma
Eleni Linos, MD, DrPH1; Mary-Margaret Chren, MD2
doi : 10.1001/jamainternmed.2021.2643
JAMA Intern Med. 2021;181(8):1032-1033
Will Ending the Medicaid Drug Rebate Cap Lower Drug Prices?
Benjamin N. Rome, MD, MPH1,2; Aaron S. Kesselheim, MD, JD, MPH1,2
doi : 10.1001/jamainternmed.2021.2696
JAMA Intern Med. 2021;181(8):1034-1035
We Can Heal From Hate Crimes by Practicing Solidarity
Christopher Cai, MD1
doi : 10.1001/jamainternmed.2021.2754
JAMA Intern Med. 2021;181(8):1036-1037
Comparative Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors vs Sulfonylureas in Patients With Type 2 Diabetes
Yan Xie, MPH1,2,3; Benjamin Bowe, MPH1,2,3; Andrew K. Gibson, MPH1,3; Janet B. McGill, MD4; Geetha Maddukuri, MD5; Ziyad Al-Aly, MD1,3,4,5,6
doi : 10.1001/jamainternmed.2021.2488
JAMA Intern Med. 2021;181(8):1043-1053
In the treatment of type 2 diabetes, evidence of the comparative effectiveness of sodium-glucose cotransporter 2 (SGLT2) inhibitors vs sulfonylureas—the second most widely used antihyperglycemic class after metformin—is lacking.
Risk of Subsequent Fractures in Postmenopausal Women After Nontraumatic vs Traumatic Fractures
Carolyn J. Crandall, MD, MS1; Joseph C. Larson, MS2; Andrea Z. LaCroix, PhD3; John A. Robbins, MD, MHS4; Jean Wactawski-Wende, PhD5; Karen C. Johnson, MD, MPH6; Maryam Sattari, MD, MS7; Katie L. Stone, PhD8; Julie C. Weitlauf, PhD9,10; Tanya R. Gure, MD11,12; Jane A. Cauley, DrPH13
doi : 10.1001/jamainternmed.2021.2617
JAMA Intern Med. 2021;181(8):1055-1063
The burden of fractures among postmenopausal women is high. Although nontraumatic fractures are strong risk factors for future fracture, current clinical guidelines do not address traumatic fractures.
External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients
Andrew Wong, MD1; Erkin Otles, MEng2,3; John P. Donnelly, PhD4; Andrew Krumm, PhD4; Jeffrey McCullough, PhD5; Olivia DeTroyer-Cooley, BSE6; Justin Pestrue, MEcon6; Marie Phillips, BA7; Judy Konye, MSN, RN8; Carleen Penoza, MHSA, RN8; Muhammad Ghous, MBBS4; Karandeep Singh, MD, MMSc1,4
doi : 10.1001/jamainternmed.2021.2626
JAMA Intern Med. 2021;181(8):1065-1070
The Epic Sepsis Model (ESM), a proprietary sepsis prediction model, is implemented at hundreds of US hospitals. The ESM’s ability to identify patients with sepsis has not been adequately evaluated despite widespread use.
Longitudinal Assessment of Safety of Femoropopliteal Endovascular Treatment With Paclitaxel-Coated Devices Among Medicare Beneficiaries
Eric A. Secemsky, MD, MSc1,2,3; Changyu Shen, PhD1,2; Marc Schermerhorn, MD1,2,4; Robert W. Yeh, MD1,2,3
doi : 10.1001/jamainternmed.2021.2738
JAMA Intern Med. 2021;181(8):1071-1080
Paclitaxel-coated peripheral devices have been associated with increased mortality, yet this harm signal has not been replicated outside of meta-analyses of small trials.
Brief Advice, Nicotine Replacement Therapy Sampling, and Active Referral for Expectant Fathers Who Smoke Cigarettes
Tzu Tsun Luk, PhD1; Tai Hing Lam, MD(HK)2; Wing Cheong Leung, MD(HK)3; Kwok-Yin Leung, MD(HK)4; Ka Wang Cheung, MBBS5; Carina Kwa, MBChB6; Kar-Hung Siong, MBBS7; Kwok-Keung Tang, MBChB8; Kai-Wan Lee, MBBS9; Chi Ju Hsieh, MSc1; Yongda Socrates Wu, PhD1; William Ho-Cheung Li, PhD1; Man Ping Wang, PhD1
doi : 10.1001/jamainternmed.2021.2757
JAMA Intern Med. 2021;181(8):1081-1089
Pregnancy presents an opportunity to engage expectant fathers in smoking cessation, but evidence from randomized clinical trials is scarce.
Assessing the Association Between Social Gatherings and COVID-19 Risk Using Birthdays
Christopher M. Whaley, PhD1; Jonathan Cantor, PhD1; Megan Pera, MS2; Anupam B. Jena, MD, PhD3,4,5
doi : 10.1001/jamainternmed.2021.2915
JAMA Intern Med. 2021;181(8):1090-1099
Many policies designed to stop the spread of COVID-19 address formal gatherings, such as workplaces and dining locations. Informal social gatherings are a potentially important mode of SARS-CoV-2 transmission, but studying their role in transmission is challenged by data and methodological limitations; birthdays offer an opportunity to empirically quantify the potential role of small social gatherings in COVID-19 spread.
Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients
Sara L. Van Driest, MD, PhD1,2; Noura S. Abul-Husn, MD, PhD3,4; Joseph T. Glessner, PhD5,6; Lisa Bastarache, MS7; Sharon Nirenberg, MD8; Jonathan S. Schildcrout, PhD9; Meghana S. Eswarappa, MD4; Gillian M. Belbin, PhD3,4; Christian M. Shaffer, BS2; Frank Mentch, PhD6; John Connolly, PhD5; Mingjian Shi, MD, PhD7; C. Michael Stein, MD2,10; Dan M. Roden, MD2,7,10; Hakon Hakonarson, MD, PhD5; Nancy J. Cox, PhD2; Scott C. Borinstein, MD, PhD1; Jonathan D. Mosley, MD, PhD2,7
doi : 10.1001/jamainternmed.2021.3108
JAMA Intern Med. 2021;181(8):1100-1105
Up to two-thirds of African American individuals carry the benign rs2814778-CC genotype that lowers total white blood cell (WBC) count.
Equity and the JAMA Network
Phil B. Fontanarosa, MD, MBA1; Annette Flanagin, RN, MA2; John Z. Ayanian, MD, MPP3,4; Robert O. Bonow, MD, MS5,6; Neil M. Bressler, MD7,8; Dimitri Christakis, MD, MPH9,10; Mary L. Disis, MD11,12; S. Andrew Josephson, MD13,14; Melina R. Kibbe, MD15,16; Dost ?ngür, MD, PhD17,18; Jay F. Piccirillo, MD19,20; Rita F. Redberg, MD, MPH21,22; Frederick P. Rivara, MD, MPH23,24; Kanade Shinkai, MD, PhD25,26; Clyde W. Yancy, MD, MSc27,28
doi : 10.1001/jamainternmed.2021.3835
JAMA Intern Med. 2021;181(8):1038-1040
The Epic Sepsis Model Falls Short—The Importance of External Validation
Anand R. Habib, MD, MPhil1,2; Anthony L. Lin, MD1; Richard W. Grant, MD, MPH3,4
doi : 10.1001/jamainternmed.2021.3333
JAMA Intern Med. 2021;181(8):1040-1041
High Mortality Rates in Medicare Patients After Peripheral Artery Disease Revascularization
Rita F. Redberg, MD, MSc1,2; Mary M. McDermott, MD3,4
doi : 10.1001/jamainternmed.2021.2782
JAMA Intern Med. 2021;181(8):1041-1042
A Distinction Without a Difference—Does It Matter Whether Fractures Are Nontraumatic or Traumatic?
Anne L. Schafer, MD1,2; Dolores M. Shoback, MD1,2
doi : 10.1001/jamainternmed.2021.2599
JAMA Intern Med. 2021;181(8):1063-1064
Hospice Tax Status and Ownership Matters for Patients and Families
Melissa D. Aldridge, PhD, MBA1
doi : 10.1001/jamainternmed.2020.6300
JAMA Intern Med. 2021;181(8):1114-1115
Trial Reporting and the Clinical Trials Enterprise
Deborah A. Zarin, MD1; Robert M. Califf, MD2
doi : 10.1001/jamainternmed.2021.2041
JAMA Intern Med. 2021;181(8):1131-1132
Sodium-Glucose Cotransporter 2 Inhibitors vs Sulfonylureas
Vinay Guduguntla, MD1,2; Richard W. Grant, MD, MPH3,4
doi : 10.1001/jamainternmed.2021.2487
JAMA Intern Med. 2021;181(8):1054
Anticoagulation at the End of Life
Anna L. Parks, MD1; Kenneth E. Covinsky, MD, MPH2,3
doi : 10.1001/jamainternmed.2021.1804
JAMA Intern Med. 2021;181(8):1123
Acquisitions of Hospice Agencies by Private Equity Firms and Publicly Traded Corporations
Robert Tyler Braun, PhD1; David G. Stevenson, PhD2,3; Mark Aaron Unruh, PhD1
doi : 10.1001/jamainternmed.2020.6262
JAMA Intern Med. 2021;181(8):1113-1114
Patterns and Determinants of Low-Value Preoperative Testing in Michigan
Nicholas L. Berlin, MD, MPH, MS1,2; Monica L. Yost, MPH3; Bonnie Cheng, MPH3; James Henderson, PhD4; Eve Kerr, MD4,5,6; Hari Nathan, MD, PhD1,3; Lesly A. Dossett, MD, MPH1,4
doi : 10.1001/jamainternmed.2021.1653
JAMA Intern Med. 2021;181(8):1115-1118
Trends and Characteristics of Retracted Articles in the Biomedical Literature, 1971 to 2020
Mario Gaudino, MD, PhD, MSCE1; N. Bryce Robinson, MD1; Katia Audisio, MD1; Mohamed Rahouma, MD1; Umberto Benedetto, MD2; Paul Kurlansky, MD3; Stephen E. Fremes, MD4
doi : 10.1001/jamainternmed.2021.1807
JAMA Intern Med. 2021;181(8):1118-1121
Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life
Gregory M. Ouellet, MD, MHS1; Terri R. Fried, MD2; Lauren G. Gilstrap, MD, MPH3; John R. O’Leary, MA1; Andrea M. Austin, PhD3; Jonathan S. Skinner, PhD3; Andrew B. Cohen, MD, DPhil2
doi : 10.1001/jamainternmed.2021.1819
JAMA Intern Med. 2021;181(8):1121-1123
Market Exclusivity and Changes in Competition and Prices Associated With the US Food and Drug Administration Unapproved Drug Initiative
Simon J. Gunter, MPhil1,2; Aaron S. Kesselheim, MD, JD, MPH1,2; Benjamin N. Rome, MD1,2
doi : 10.1001/jamainternmed.2021.1989
JAMA Intern Med. 2021;181(8):1124-1126
Fitted Filtration Efficiency of Double Masking During the COVID-19 Pandemic
Emily E. Sickbert-Bennett, PhD, MS1; James M. Samet, PhD, MPH2; Steven E. Prince, PhD2; et al
doi : 10.1001/jamainternmed.2021.2033
JAMA Intern Med. 2021;181(8):1126-1128
Evaluation of Compliance With Legal Requirements Under the FDA Amendments Act of 2007 for Timely Registration of Clinical Trials, Data Verification, Delayed Reporting, and Trial Document Submission
Nicholas J. DeVito, MPH1; Ben Goldacre, MBBS1
doi : 10.1001/jamainternmed.2021.2036
JAMA Intern Med. 2021;181(8):1128-1130
Pathologic U Waves Secondary to Severe Hypophosphatemia During Refeeding Syndrome
George A. Weatherall, MBChB1; David L. Jardine, MD1,2
doi : 10.1001/jamainternmed.2021.2233
JAMA Intern Med. 2021;181(8):1106-1107
Paroxysmal Atrioventricular Block
Matthew C. Hyman, MD, PhD1; Muralidhar Papireddy, MD1; David S. Frankel, MD1
doi : 10.1001/jamainternmed.2021.2526
JAMA Intern Med. 2021;181(8):1108-1109
Acute Coronary Syndrome With ST-Segment Elevation in Inferior Leads
Anish Kapil, MD1; Abhishek Thakur, MD1; Satyavir Yadav, MD, DM1
doi : 10.1001/jamainternmed.2021.2901
JAMA Intern Med. 2021;181(8):1110-1111
The Problem With ICD-Coded Firearm Injuries
Catherine Barber, MPA1; Eric Goralnick, MD, MS2; Matthew Miller, MD, ScD1,3
doi : 10.1001/jamainternmed.2021.0382
JAMA Intern Med. 2021;181(8):1132-1133
The Problem With ICD-Coded Firearm Injuries—Reply
Elinore J. Kaufman, MD, MSHP1; Douglas J. Wiebe, PhD2; M. Kit Delgado, MD, MS3
doi : 10.1001/jamainternmed.2021.0385
JAMA Intern Med. 2021;181(8):1133-1134
COVID-19 Mortality and Stress to the Hospital System From High Patient Load
Alessandro Soria, MD1; Giuseppe Lapadula, MD, PhD1; Paolo Bonfanti, MD1
doi : 10.1001/jamainternmed.2021.0599
JAMA Intern Med. 2021;181(8):1134
COVID-19 Mortality and Stress to the Hospital System from High Patient Load—Reply
David A. Asch, MD1
doi : 10.1001/jamainternmed.2021.0602
JAMA Intern Med. 2021;181(8):1134
Buprenorphine Opioid Treatment During the COVID-19 Pandemic
Mimosa Luigi, MSc1; Michael Luo, MSc1; Etienne J. P. Maes, BSc1
doi : 10.1001/jamainternmed.2021.0777
JAMA Intern Med. 2021;181(8):1135
Buprenorphine Opioid Treatment During the COVID-19 Pandemic—Reply
Thuy D. Nguyen, PhD1; Brendan Saloner, PhD2; Bradley D. Stein, MD, PhD3
doi : 10.1001/jamainternmed.2021.0774
JAMA Intern Med. 2021;181(8):1135-1136
A Charge to Academic Chairs
Laurie G. Jacobs, MD1
doi : 10.1001/jamainternmed.2021.0843
JAMA Intern Med. 2021;181(8):1136
A Charge to Academic Chairs—Reply
Bismarck C. Odei, MD1; Fumiko Chino, MD2; Darrion Mitchell, MD, PhD1
doi : 10.1001/jamainternmed.2021.0832
JAMA Intern Med. 2021;181(8):1136-1137
Association Between Cigarette Smoking and COVID-19 Outcomes
Alain Braillon, MD, PhD1
doi : 10.1001/jamainternmed.2021.1920
JAMA Intern Med. 2021;181(8):1137-1138
Lipoprotein(a) Measurement in Clinical Practice
Yannick Kaiser, MD1; Nick S. Nurmohamed, MD1; Erik S. G. Stroes, MD, PhD1
doi : 10.1001/jamainternmed.2021.2193
JAMA Intern Med. 2021;181(8):1138
Lipoprotein(a) Measurement in Clinical Practice—Reply
Ludovico Furlan, MD1; Patrick Azcarate, MD2; Rita F. Redberg, MD, MSc3,4
doi : 10.1001/jamainternmed.2021.2190
JAMA Intern Med. 2021;181(8):1138-1139
Fishing for an Association With Sudden Cardiac Death
Emily R. Siegel, BS1; Zian H. Tseng, MD, MAS2
doi : 10.1001/jamainternmed.2021.3039
JAMA Intern Med. 2021;181(8):1139-1140
Fishing for an Association With Sudden Cardiac Death—Reply
Andrew Mente, PhD1; Mahshid Dehghan, PhD2; Salim Yusuf, DPhil, FRCPC, FRSC2
doi : 10.1001/jamainternmed.2021.3036
JAMA Intern Med. 2021;181(8):1140-1141
Advanced Cardiac Life Support Algorithms
Rory Gallen, MB, BcH, BAO1; Myles McKittrick, MB, BcH, BAO1; Stephen Tuohy, MB, BcH, BAO, MSc, MD1
doi : 10.1001/jamainternmed.2021.3177
JAMA Intern Med. 2021;181(8):1141
Advanced Cardiac Life Support Algorithms—Reply
Takahiro Tsushima, MD1; Toral R. Patel, MD2; Jayakumar Sahadevan, MD3
doi : 10.1001/jamainternmed.2021.3174
JAMA Intern Med. 2021;181(8):1141-1142
Osteopathic Manipulative Treatment for Chronic Low Back Pain
John C. Licciardone, DO, MS, MBA1
doi : 10.1001/jamainternmed.2021.3180
JAMA Intern Med. 2021;181(8):1142-1143
Osteopathic Manipulative Treatment for Chronic Low Back Pain
Paul Quesnay, DO1; Johann Cailhol, MD, PhD1,2; Géraldine Falgarone, MD, PhD3,4
doi : 10.1001/jamainternmed.2021.3183
JAMA Intern Med. 2021;181(8):1143
Osteopathic Manipulative Treatment for Chronic Low Back Pain—Reply
Christelle Nguyen, MD, PhD1,2,3; Rafael Zegarra-Parodi4,5,6; Isabelle Boutron, MD, PhD1,7,8
doi : 10.1001/jamainternmed.2021.3186
JAMA Intern Med. 2021;181(8):1143-1144
Errors in Reported SOFA Scores and Added Supplement Listing STOP-COVID Investigators
doi : 10.1001/jamainternmed.2021.0317
JAMA Intern Med. 2021;181(8):1144
Updated Website Address Throughout Article
doi : 10.1001/jamainternmed.2021.2878
JAMA Intern Med. 2021;181(8):1144
Errors in Table 2 and Results
doi : 10.1001/jamainternmed.2021.3907
JAMA Intern Med. 2021;181(8):1144
