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Clinical Risk Prediction in Patients With Left Ventricular Myocardial Noncompaction
GuillemCasasMDabJavierLimeresMDabcGerardOristrellMDabLauraGutierrez-GarciaMDabcDanieleAndreiniMD, PhDdeMarBorreganPhDfJose M.Larra?aga-MoreiraMDgAngelaLopez-SainzMD, PhDbhiMartaCodina-SolàPhDcGiselaTeixido-TuraMD, PhDabcJosé AntonioSorolla-RomeroMDjPaulaFern?ndez-?lvarezMDcJosefaGonz?lez-CarrilloMDkAndreaGualaPhDaLuciaLa MuraMDlRafaelaSoler-Fern?ndezMDmAugustoSao AvilésPhDnopJuan JoséSantos-MateoMDqJosep RamonMarsalPhDrsAidaRiberaPhDrsJosé Luisde la PompaPhDbtEduardoVillacortaMDbuJuanJiménez-J?imezMD, PhDbvTom?sRipoll-VeraMD, PhDbwAntoniBayes-GenisMD, PhDbxyzJosé ManuelGarcia-PinillaMD, PhDbaaJuli?nPalomino-DozaMD, PhDbbbColomaTironMDbccddGianlucaPontoneMD, PhDdJanBogaertMDeeGiovanni D.AquaroMDffJuan RamonGimeno-BlanesMD, PhDbkEstherZorioMD, PhDbgghhPabloGarcia-PaviaMD, PhDbhiiiRobertoBarriales-VillaMD, PhDbgArturEvangelistaMD, PhDabcPier GiorgioMasciMD, PhDjjIgnacioFerreira-Gonz?lezMD, PhDarsJosé F.Rodr?guez-PalomaresMD, PhDabc
doi : 10.1016/j.jacc.2021.06.016
Volume 78, Issue 7, 17 August 2021, Pages 643-662
Left ventricular noncompaction (LVNC) is a heterogeneous entity with uncertain prognosis.
Risk Prediction in a Debated Diagnosis: Is it Time for LVNC Guidelines??
John L.JefferiesMD, MPH
doi : 10.1016/j.jacc.2021.06.031
Volume 78, Issue 7, 17 August 2021, Pages 663-665
Lignan Intake and Risk of Coronary Heart Disease
YangHuScDaYanpingLiPhDaLauraSampsonRDaMolinWangPhDbcJoAnn E.MansonMD, DrPHbdeEricRimmScDabdQiSunMD, ScDabdf
doi : 10.1016/j.jacc.2021.05.049
Volume 78, Issue 7, 17 August 2021, Pages 666-678
Evidence regarding lignan consumption in relation to coronary heart disease (CHD) risk remains limited and mixed.
Plant Polyphenols Lignans and Cardiovascular Disease?
David J.A.JenkinsMD, PhDabcdeCyril W.C.KendallPhDacfJohn L.SievenpiperMD, PhDabcde
doi : 10.1016/j.jacc.2021.06.014
Volume 78, Issue 7, 17 August 2021, Pages 679-682
Association of Preterm Birth With Myocardial Fibrosis and Diastolic Dysfunction in Young Adulthood
Adam J.LewandowskiDPhilabcBettyRamanMBBS, DPhilbcMarianeBertagnolliPhDadAfifahMohamedDPhilaeWilbyWilliamsonBMBS, DPhilaJoana LealPeladoBScbcAngusMcCanceBMBChaWinokLapidairePhDaStefanNeubauerMDbcPaulLeesonMB, PhDac
doi : 10.1016/j.jacc.2021.05.053
Volume 78, Issue 7, 17 August 2021, Pages 683-692
Preterm birth affects about 10% of live births worldwide and is associated with cardiac alterations. Animal models of preterm birth suggest that left ventricular functional impairment may be due to an up-regulation of myocardial fibrosis.
Is Myocardial Fibrosis the Missing Link Between Prematurity, Cardiac Remodeling, and Long-Term Cardiovascular Outcomes??
TalGevaMDEmily M.BucholzMD, PhD, MPH
doi : 10.1016/j.jacc.2021.05.052
Volume 78, Issue 7, 17 August 2021, Pages 693-695
Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors
JonasGhouseMD, PhDabGustavAhlbergMSc, PhDabLauraAndreasenMDabKarinaBanasikMSc, PhDcS?renBrunakMSc, PhD, DMSccMichaelSchwinnMSc, PhDdIna HolstLarsenMScdOscarPetersenMScdErikS?rensenMSc, PhDdHenrikUllumMD, PhDeEva RyeRasmussenMD, PhDfNiclasErikssonMSc, PhDgP?rHallbergMD, PhDhMiaWadeliusMD, PhDhHenningBundgaardMD, DMSciMorten S.OlesenMSc, PhDab
doi : 10.1016/j.jacc.2021.05.054
Volume 78, Issue 7, 17 August 2021, Pages 696-709
Angioedema is a rare but potentially life-threatening adverse reaction associated with angiotensin-converting enzyme (ACE) inhibitors. Identification of potential genetic factors related to this adverse event may help identify at-risk patients.
Novel Pharmacogenomic Locus Implicated in Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema?
Stuart A.ScottPhDabPaolaNicolettiMD, PhDcd
doi : 10.1016/j.jacc.2021.05.050
Volume 78, Issue 7, 17 August 2021, Pages 710-712
Coronary Computed Tomographic Angiography for Complete Assessment of Coronary Artery Disease: JACC State-of-the-Art Review
Patrick W.SerruysMD, PhDab?HironoriHaraMDac?ScotGargMD, PhDdHideyukiKawashimaMDacBjarne L.N?rgaardMD, PhDeMarc R.DweckMD, PhDfJeroen J.BaxMD, PhDgJuhaniKnuutiMD, PhDhKoenNiemanMD, PhDiJonathon A.LeipsicMDjSaimaMushtaqMDkDanieleAndreiniMD, PhDklYoshinobuOnumaMD, PhDa
doi : 10.1016/j.jacc.2021.06.019
Volume 78, Issue 7, 17 August 2021, Pages 713-736
Coronary computed tomography angiography (CTA) has shown great technological improvements over the last 2 decades. High accuracy of CTA in detecting significant coronary stenosis has promoted CTA as a substitute for conventional invasive coronary angiography in patients with suspected coronary artery disease. In patients with coronary stenosis, CTA-derived physiological assessment is surrogate for intracoronary pressure and velocity wires, and renders possible decision-making about revascularization solely based on computed tomography. Computed tomography coronary anatomy with functionality assessment could potentially become a first line in diagnosis. Noninvasive imaging assessment of plaque burden and morphology is becoming a valuable substitute for intravascular imaging. Recently, wall shear stress and perivascular inflammation have been introduced. These assessments could support risk management for both primary and secondary cardiovascular prevention. Anatomy, functionality, and plaque composition by CTA tend to replace invasive assessment. Complete CTA assessment could provide a 1-stop-shop for diagnosis, risk management, and decision-making on treatment.
Increasing Participation of Women in Cardiovascular Trials: JACC Council Perspectives
LeslieChoMDaAmanda R.VestMBBS, MPHbMichelle L.O’DonoghueMD, MPHcModele O.OgunniyiMDdAmy A.SarmaMDeKara J.DenbyMDaEmily S.LauMDeJeanne E.PooleMDfKathryn J.LindleyMDgRoxanaMehranMDhCardiovascular Disease in Women Committee Leadership Council
doi : 10.1016/j.jacc.2021.06.022
Volume 78, Issue 7, 17 August 2021, Pages 737-751
Although some progress has been made in the last 3 decades to increase the number of women in clinical cardiology trials, review of recent cardiovascular literature demonstrates that women and underrepresented minority women are still underrepresented in most clinical cardiology trials. This is especially notable in trials of patients with coronary artery disease, heart failure with reduced ejection fraction, and arrhythmia studies, especially those involving devices and procedures. Despite the call from National Institutes of Health, Food and Drug Administration, Institute of Medicine, and various professional societies, the gap remains. This paper seeks to identify the barriers for low enrollment and retention from patient, clinician, research team, study design, and system perspectives, and offers recommendations to improve recruitment and retention in the current era.
Clinician Well-Being: Addressing Global Needs for Improvements in the Health Care Field A Joint Opinion From the American College of Cardiology, American Heart Association, European Society of Cardiology, and the World Heart Federation
Laxmi S.MehtaMD, FACC, FAHAaMitchell S.V.ElkindMD, MS, FAHAbcStephanAchenbachMD, FACC, FESCdeFausto J.PintoMD, FACC, FESCfgAthenaPoppasMD, MACC, FAHAhi
doi : 10.1016/j.jacc.2021.04.043
Volume 78, Issue 7, 17 August 2021, Pages 752-756
Rivaroxaban in Patients With Recent Peripheral Artery Revascularization and Renal Impairment: The VOYAGER PAD Trial
JudithHsiaMDMichaelSzarekPhDSoniaAnandMDManesh R.PatelMDSebastianDebusMD, PhDScott D.BerkowitzMDEvaMuehlhoferMDLloyd P.HaskellMDRupert M.BauersachsMDMarc P.BonacaMD, MPH
doi : 10.1016/j.jacc.2021.06.021
Volume 78, Issue 7, 17 August 2021, Pages 757-759
Pneumonia in Chronic Heart Failure: What About a Full Picture of the Puzzle?
NathanMewtonMD, PhDGuillaumeBaudryMDLaurentSebbagMD, PhD
doi : 10.1016/j.jacc.2021.04.107
Volume 78, Issue 7, 17 August 2021, Page 759
Infection and Adverse Outcomes in People With Chronic Heart Failure: Highlighting a Neglected Problem
MichaelDrozdMBChBRichard M.CubbonMBChB, PhD
doi : 10.1016/j.jacc.2021.04.106
Volume 78, Issue 7, 17 August 2021, Page 760
Reply: Pneumonia and the Bigger Picture of Infection in Heart Failure
LiShenMBChB, PhDPardeep S.JhundMBChB, MSc, PhDJohn J.V.McMurrayMD
doi : 10.1016/j.jacc.2021.06.006
Volume 78, Issue 7, 17 August 2021, Pages 760-761
