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Criteria, criteria all around but not an insight into lupus
George C Tsokos
doi : 10.1093/rheumatology/keab287
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3037–3038
The intima-media thickness in suspected giant cell arteritis—sometimes it is worth taking a closer look
Luca Seitz, Fabian L?tscher
doi : 10.1093/rheumatology/keab316
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3039–3041
‘Too much of a good thing’: can network meta-analysis guide treatment decision-making in psoriatic arthritis?
Helena Marzo-Ortega, Jon Packham, Mar Pujades-Rodriguez
doi : 10.1093/rheumatology/keab329
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3042–3044
The IL-18/IFN? axis in systemic JIA and MAS—new answers, more questions
Grant S. Schulert
doi : 10.1093/rheumatology/keab342
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3045–3047
The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?
Raewyn C Poulsen, James I Hearn, Nicola Dalbeth
doi : 10.1093/rheumatology/keab197
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3048–3057
The circadian clock is a specialized cell signalling pathway present in all cells. Loss of clock function leads to tissue degeneration and premature ageing in animal models demonstrating the fundamental importance of clocks for cell, tissue and organism health. There is now considerable evidence that the chondrocyte circadian clock is altered in OA. The purpose of this review is to summarize current knowledge regarding the nature of the change in the chondrocyte clock in OA and the implications of this change for disease development. Expression of the core clock component, BMAL1, has consistently been shown to be lower in OA chondrocytes. This may contribute to changes in chondrocyte differentiation and extracellular matrix turnover in disease. Circadian clocks are highly responsive to environmental factors. Mechanical loading, diet, inflammation and oxidative insult can all influence clock function. These factors may contribute to causing the change in the chondrocyte clock in OA.
The use and context of the term ‘multimorbidity’ in rheumatoid arthritis: a systematic literature review
Mrinalini Dey, Amanda Busby, Helen Elwell, Arthur Pratt, Adam Young, John Isaacs, Elena Nikiphorou
doi : 10.1093/rheumatology/keab214
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3058–3071
This systematic literature review aimed to analyse terms describing coexisting conditions in the RA literature, informing the need for an operationalized definition of multimorbidity. Articles discussing RA with multimorbidity, published 1946 until August 2020, were identified. The primary outcome was the use and/or definition of ‘multimorbidity’ in RA. Information extracted included terms defining coexisting conditions, the use of a comorbidity/multimorbidity score and the use of ‘index disease’ to describe RA (more applicable to comorbidity than multimorbidity).
Emerging roles for chemokines and cytokines as orchestrators of immunopathology in Sj?gren’s syndrome
Sofie L. M Blokland, Christina-Maria Flessa, Joel A. G van Roon, Clio P Mavragani
doi : 10.1093/rheumatology/key438
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3072–3087
In primary SS (pSS), chemokines and cytokines orchestrate immunopathology driven by a complex network of interacting inflammatory cells. In recent years, the importance of chemotactic and non-chemotactic cytokines that control function, movement and placing of all cells within the inflamed exocrine glands and directing immunopathology has become increasingly clear. This paper reviews the current knowledge on chemokines and focuses on the emerging roles of novel chemotactic and non-chemotactic mediators in pSS. It highlights their contribution to pathogenic processes such as B cell hyperactivity and the formation of ectopic lymphoid structures. To this end, the role of acquired (CXCR5/CCR9 Th-cell–mediated) and innate (inflammasome/IL-1/IL-18–mediated) pathways in steering immunopathology is discussed.
T cells in primary Sj?gren’s syndrome: targets for early intervention
Gwenny M Verstappen, Frans G. M Kroese, Hendrika Bootsma
doi : 10.1093/rheumatology/kez004
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3088–3098
A histologic hallmark of primary SS (pSS) is lymphocytic infiltration of the salivary and lacrimal glands, in particular by CD4+ T and B cells. In the early stages of the disease, infiltrates are dominated by CD4+ T cells, while B cell accumulation occurs at later stages. Activated T cells contribute to pathogenesis by producing pro-inflammatory cytokines and by inducing B cell activation, which results in the establishment of a positive feedback loop. In the inflamed glandular tissues, many different CD4+ effector subsets are present, including IFN-?-producing Th1 cells, IL-17-producing Th17 cells and IL-21-producing T follicular helper cells. In blood from pSS patients, frequently observed abnormalities of the T cell compartment are CD4+ T cell lymphopenia and enrichment of circulating follicular helper T (Tfh) cells. Tfh cells are critical mediators of T cell–dependent B cell hyperactivity and these cells can be targeted by immunotherapy. Inhibition of T cell activation, preferably early in the disease process, can mitigate B cell activity and may be a promising treatment approach in this disease.
Pain and fatigue in primary Sj?gren’s syndrome
Roald Omdal, Svein Ivar Mellgren, Katrine Br?kke Norheim
doi : 10.1093/rheumatology/kez027
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3099–3106
Chronic fatigue, pain and depression are common in patients with primary Sj?gren’s syndrome. These phenomena mutually affect each other and have a considerable impact on the patients’ quality of life. While pain is usually regarded as a fairly somatic phenomenon, both fatigue and depression have traditionally been regarded as more-or-less of psychological origin. There is an increasing understanding that this picture is multifaceted; that there is a genetic foundation, and that biological mechanisms regulate the clinical expression through activation of evolutionary, deeply conserved neuronal pathways in the brain. This pattern is evident not only in primary Sj?gren’s syndrome, but also in other systemic inflammatory autoimmune diseases, in cancer and in neurodegenerative diseases like Parkinson’s disease. This article will mainly focus on the biology of pain and fatigue. We describe how these factors influence each other, and act with the overarching purpose of defending the organism against harm and danger.
Effects of physical activity on vascular function in autoimmune rheumatic diseases: a systematic review and meta-analysis
Tiago Peçanha, Daniel J Bannell, Sofia Mendes Sieczkowska, Nicola Goodson, Hamilton Roschel, Victoria S Sprung, David A Low
doi : 10.1093/rheumatology/keab094
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3107–3120
To summarize existing evidence and quantify the effects of physical activity on vascular function and structure in autoimmune rheumatic diseases (ARDs).
Incidence and prevalence of systemic sclerosis globally: a comprehensive systematic review and meta-analysis
Majd Bairkdar, Marios Rossides, Helga Westerlind, Roger Hesselstrand, Elizabeth V Arkema, Marie Holmqvist
doi : 10.1093/rheumatology/keab190
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3121–3133
We aimed to conduct a systematic review and meta-analysis on the incidence and prevalence of SSc covering the entire literature.
Different treatment options for Takayasu arteritis patients with moderate-to-severe aortic regurgitation: long-term outcomes
Xuesen Cheng, Zuozhi Li, Aimin Dang, Naqiang Lv, Qian Chang, Yunhu Song, Guozhang Liu
doi : 10.1093/rheumatology/keaa647
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3134–3143
To determine the prognosis of Takayasu arteritis (TA) patients with moderate-to-severe aortic regurgitation treated with surgical vs conservative treatment and to identify independent prognostic factors of long-term outcomes.
Childhood Sj?gren syndrome: features of an international cohort and application of the 2016 ACR/EULAR classification criteria
Matthew L Basiaga, Sara M Stern, Jay J Mehta, Cuoghi Edens, Rachel L Randell, Anna Pomorska, Ninela Irga-Jaworska, Maria F Ibarra, Claudia Bracaglia, Rebecca Nicolai, Gordana Susic, Alexis Boneparth, Hemalatha Srinivasalu, Brian Dizon, Ankur A Kamdar, Baruch Goldberg, Sheila Knupp-Oliveira, Jordi Ant?n, Juan M Mosquera, Simone Appenzeller, Kathleen M O’Neil, Stella A Protopapas, Claudia Saad-Magalh?es, Jonathan D Akikusa, Akaluck Thatayatikom, Seunghee Cha, Juan Carlos Nieto-Gonz?lez, Mindy S Lo, Erin Brennan Treemarcki, Naoto Yokogawa, Scott M Lieberman, for the Childhood Arthritis and Rheumatology Research Alliance and the International Childhood Sj?gren Syndrome Workgroup
doi : 10.1093/rheumatology/keaa757
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3144–3155
Sj?gren syndrome in children is a poorly understood autoimmune disease. We aimed to describe the clinical and diagnostic features of children diagnosed with Sj?gren syndrome and explore how the 2016 ACR/EULAR classification criteria apply to this population.
In anti-CCP+ at-risk individuals, radiographic bone erosions are uncommon and are not associated with the development of clinical arthritis
Andrea Di Matteo, Kulveer Mankia, Jacqueline L Nam, Edoardo Cipolletta, Leticia Garcia-Montoya, Laurence Duquenne, Emma Rowbotham, Paul Emery
doi : 10.1093/rheumatology/keaa761
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3156–3164
To investigate the prevalence, distribution and predictive value for the development of inflammatory arthritis (IA) of conventional radiography (CR) bone erosions (BE) in anti-CCP positive (CCP+) at-risk individuals with musculoskeletal (MSK) symptoms but without clinical synovitis.
Measuring disease activity in psoriatic arthritis: PASDAS implementation in a tightly monitored cohort reveals residual disease burden
Michelle L M Mulder, Tamara W van Hal, Frank H J van den Hoogen, Elke M G J de Jong, Johanna E Vriezekolk, Mark H Wenink
doi : 10.1093/rheumatology/keaa766
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3165–3175
We aimed to investigate the disease activity and overall disease burden of (subgroups of) patients with PsA using the Psoriatic Arthritis Disease Activity Score (PASDAS) in an already tightly monitored cohort.
Serum IgG2 antibody multicomposition in systemic lupus erythematosus and lupus nephritis (Part 1): cross-sectional analysis
Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Leda Cipriani, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Paride Fenaroli, Isabella Pisani, Giacomo Garibotto, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Stefano Volpi, Enrico Verrina, Andrea Angeletti, Angelo Ravelli, Gian Marco Ghiggeri
doi : 10.1093/rheumatology/keaa767
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3176–3188
Serum anti-dsDNA and anti-nucleosome IgGs have been proposed as signatures for SLE and LN in limited numbers of patients. We sought to show higher sensitivity and specificity of the same antibodies with the IgG2 isotype and included IgG2 antibodies vs specific intracellular antigens in the analysis.
Association between comorbidities and disease activity in axial spondyloarthritis: results from the BSRBR-AS
Sizheng Steven Zhao, Gareth T Jones, Gary J Macfarlane, David M Hughes, Robert J Moots, Nicola J Goodson
doi : 10.1093/rheumatology/keaa768
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3189–3198
Whether comorbidities influence disease activity assessment in axial SpA (axSpA) is unclear. Comorbidities inflate DAS28 in rheumatoid arthritis through the patient global score. We examined whether axSpA disease activity measures are differentially affected, and whether comorbidities inflate the AS disease activity score (ASDAS) through the patient global component.
Pulmonary manifestations and outcomes in paediatric ANCA–associated vasculitis: a single-centre experience
Edouard Sayad, Tiphanie P Vogel, R Paul Guillerman, David Spielberg, David Moreno McNeill, Marietta De Guzman, Gunes Orman, Manuel Silva-Carmona
doi : 10.1093/rheumatology/keaa769
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3199–3208
ANCA-associated vasculitis (AAV) usually involves the renal and respiratory systems, but the paediatric literature on pulmonary manifestations and outcomes is limited. We aimed to describe pulmonary manifestations and outcomes after therapy in a cohort of paediatric AAV (pAAV) patients.
Upadacitinib monotherapy improves patient-reported outcomes in rheumatoid arthritis: results from SELECT-EARLY and SELECT-MONOTHERAPY
Vibeke Strand, Namita Tundia, Alvin Wells, Maya H Buch, Sebastiao C Radominski, Heidi S Camp, Alan Friedman, Jessica L Suboticki, Kendall Dunlap, Debbie Goldschmidt, Martin Bergman
doi : 10.1093/rheumatology/keaa770
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3209–3221
To evaluate the effect of upadacitinib (UPA) monotherapy vs MTX on patient-reported outcomes (PROs) in patients with RA who were MTX-naïve or who had an inadequate response to MTX (MTX-IR).
Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study
Jennifer C E Lane, James Weaver, Kristin Kostka, Talita Duarte-Salles, Maria Tereza F Abrahao, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Carlos Areia, Patricia Biedermann, Juan M Banda, Edward Burn, Paula Casajust, Kristina Fister, Jill Hardin, Laura Hester, George Hripcsak, Benjamin Skov Kaas-Hansen, Sajan Khosla, Spyros Kolovos, Kristine E Lynch, Rupa Makadia, Paras P Mehta, Daniel R Morales, Henry Morgan-Stewart, Mees Mosseveld, Danielle Newby, Fredrik Nyberg, Anna Ostropolets, Rae Woong Park, Albert Prats-Uribe, Gowtham A Rao, Christian Reich, Peter Rijnbeek, Anthony G Sena, Azza Shoaibi, Matthew Spotnitz, Vignesh Subbian, Marc A Suchard, David Vizcaya, Haini Wen, Marcel de Wilde, Junqing Xie, Seng Chan You, Lin Zhang, Simon Lovestone, Patrick Ryan, Daniel Prieto-Alhambra, for the OHDSI-COVID-19 consortium
doi : 10.1093/rheumatology/keaa771
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3222–3234
Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used in the coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with HCQ as used for RA.
Amyloid storm: acute kidney injury and massive proteinuria, rapidly progressing to end-stage kidney disease in AA amyloidosis of familial Mediterranean fever
Olga L Kukuy, Pazit Beckerman, Dganit Dinour, Ilan Ben-Zvi, Avi Livneh
doi : 10.1093/rheumatology/keaa772
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3235–3242
Amyloid A nephropathy of FMF usually progresses over many years to end-stage renal disease (ESRD). We aim to describe an acute condition, termed here ‘amyloid storm’, typically manifesting with a rapid (?2?weeks) increase in serum creatinine and urine protein, that has never been characterized in FMF amyloidosis.
Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank
Gabriela Sandoval-Plata, Georgina Nakafero, Mithun Chakravorty, Kevin Morgan, Abhishek Abhishek
doi : 10.1093/rheumatology/keaa773
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3243–3251
To examine the association between comorbidities and serum urate (SU), gout and comorbidities, and to determine whether the association between gout and comorbidities is independent of SU.
UPLC-MS based plasma metabolomics and lipidomics reveal alterations associated with IgG4-related disease
Yiyi Gong, Panpan Zhang, Zheng Liu, Jieqiong Li, Hui Lu, Yujie Wang, Bintao Qiu, Mu Wang, Yunyun Fei, Hua Chen, Linyi Peng, Jing Li, Jiaxin Zhou, Qun Shi, Xuan Zhang, Min Shen, Xiaofeng Zeng, Fengchun Zhang, Wen Zhang
doi : 10.1093/rheumatology/keaa775
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3252–3261
The pathogenesis of IgG4-related disease (IgG4-RD) remains unclear. Metabolomic profiling of IgG4-RD patients offers an opportunity to identify novel pathophysiological targets and biomarkers. This study aims to identify potential plasma biomarkers associated with IgG4-RD.
Flares in patients with systemic lupus erythematosus
Kathleen McElhone, Janice Abbott, Margaret Hurley, Jane Burnell, Peter Lanyon, Anisur Rahman, Chee-Seng Yee, Mohammed Akil, Ian N Bruce, Yasmeen Ahmad, Caroline Gordon, Lee-Suan Teh
doi : 10.1093/rheumatology/keaa777
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3262–3267
SLE is characterized by relapses and remissions. We aimed to describe the frequency, type and time to flare in a cohort of SLE patients.
Mediation of the association between obesity and osteoarthritis by blood pressure, vessel wall stiffness and subclinical atherosclerosis
Marieke Loef, Rob J van der Geest, Hildo J Lamb, Renée de Mutsert, Saskia le Cessie, Frits R Rosendaal, Margreet Kloppenburg
doi : 10.1093/rheumatology/keaa778
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3268–3277
We investigated the role of blood pressure, vessel wall stiffness [pulse wave velocity (PWV)] and subclinical atherosclerosis markers [carotid intima-media thickness (cIMT), popliteal vessel wall thickness (pVWT)] as mediators of the association of obesity with OA.
Quantitative MRI adds to neuropsychiatric lupus diagnostics
Giuseppe A Ramirez, Maria A Rocca, Paolo Preziosa, Enrica P Bozzolo, Elisabetta Pagani, Valentina Canti, Lucia Moiola, Patrizia Rovere-Querini, Angelo A Manfredi, Massimo Filippi
doi : 10.1093/rheumatology/keaa779
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3278–3288
Attributing neuropsychiatric manifestations to SLE is often challenging. Brain white matter lesions are frequent in SLE at MRI, but their diagnostic role is unclear. Here, we assessed whether white matter lesions count, volume and distribution measurement can help in the diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE).
Comorbidities, pain and fatigue in psoriatic arthritis, psoriasis and healthy controls: a clinical cohort study
Christine Ballegaard, Marie Skougaard, J?rgen Guldberg-M?ller, Christoffer V Nissen, Kirstine Amris, Tanja S J?rgensen, Lene Dreyer, Lars E Kristensen
doi : 10.1093/rheumatology/keaa780
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3289–3300
To explore the prognostic value of pre-specified comorbidities on treatment outcomes in PsA, and to compare baseline data with cutaneous psoriasis without arthritis and healthy controls (HC).
Altered retinal oxygen metabolism in patients with combined ocular and central nervous system sarcoidosis
Astrid Kindt, Keld-Erik Byg, Jimmi Wied, Torkell Ellingsen, Jesper R?mhild Davidsen, Jakob Grauslund
doi : 10.1093/rheumatology/keaa781
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3301–3306
To evaluate retinal oxygen metabolism by retinal oximetry for ocular and CNS diseases in a cross-sectional study of sarcoidosis.
Role of placental inflammatory mediators and growth factors in patients with rheumatic diseases with a focus on systemic sclerosis
Francesca Motta, Veronica Codullo, Véronique Ramoni, Stefania Cesari, Giuseppina Ferrario, Giacomo Fiandrino, Fausta Beneventi, Stefania Rampello, Hanna Johnsson, Carlomaurizio Montecucco, Gerard J Graham
doi : 10.1093/rheumatology/keaa782
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3307–3316
Pregnancy in SSc is burdened with an increased risk of obstetric complications. Little is known about the underlying placental alterations. This study aimed to better understand pathological changes and the role of inflammation in SSc placentas. Leucocyte infiltration, inflammatory mediators and atypical chemokine receptor 2 (ACKR2) expression in SSc placentas were compared with those in other rheumatic diseases (ORD) and healthy controls (HC).
Positive disease-specific autoantibodies have limited clinical significance in diagnosing IgG4-related disease in daily clinical practice
Ichiro Mizushima, Takahiro Yamano, Hiroyuki Kawahara, Shinya Hibino, Ryo Nishioka, Takeshi Zoshima, Satoshi Hara, Kiyoaki Ito, Hiroshi Fujii, Hideki Nomura, Mitsuhiro Kawano
doi : 10.1093/rheumatology/keaa783
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3317–3325
The 2019 ACR/EULAR classification criteria for IgG4-related disease (IgG4-RD) have exclusion criteria including positive disease-specific autoantibodies, and these have been documented to have a high specificity. This study aimed to further validate these criteria as well as identify characteristics of patients showing false-negative results.
Increased risk of rheumatoid arthritis among patients with endometriosis: a nationwide population-based cohort study
Yu-Hao Xue, Liang-Tian You, Hsin-Fu Ting, Yu-Wen Chen, Zi-Yun Sheng, Yi-Dong Xie, Yu-Hsun Wang, Jeng-Yuan Chiou, James Cheng-Chung Wei
doi : 10.1093/rheumatology/keaa784
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3326–3333
Autoimmunity may play a role in endometriosis. The association between endometriosis and RA remains unknown. This study was conducted to identify any evidence for this relationship.
Patients’ and rheumatologists’ perspectives on the efficacy and safety of low-dose glucocorticoids in rheumatoid arthritis—an international survey within the GLORIA study
T Santiago, M Voshaar, M de Wit, P D Carvalho, F Buttgereit, M Cutolo, S Paolino, G R Castelar Pinheiro, M Boers, J A P Da Silva
doi : 10.1093/rheumatology/keaa785
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3334–3342
To evaluate the current perspectives of patients and health professionals regarding the efficacy and safety of low-dose glucocorticoids (GCs) in RA.
Prognostic values of anti-Ro52 antibodies in anti-MDA5-positive clinically amyopathic dermatomyositis associated with interstitial lung disease
Antao Xu, Yan Ye, Qiong Fu, Xinyue Lian, Sheng Chen, Qiang Guo, Liang-jing Lu, Min Dai, Xia Lv, Chunde Bao
doi : 10.1093/rheumatology/keaa786
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3343–3351
Anti-Ro52 antibody often co-occurs with anti-Jo1 antibody in antisynthetase syndrome and their co-occurrence correlates with a more aggressive clinical phenotype and poorer prognosis. The strong association of anti-Ro52 antibody with anti-melanoma differentiation-associated protein-5 (anti-MDA5) antibody has been indicated in juvenile myositis. The aim of this study was to assess the clinical significance of anti-Ro52 antibody in a cohort of adult patients with anti-MDA5-positive clinically amyopathic dermatomyositis with interstitial lung disease (CADM-ILD).
Cross-sectional and temporal differences in health-related quality of life of people with and without osteoarthritis: a 10-year prospective study
Ting Zhao, Hasnat Ahmad, Tania Winzenberg, Dawn Aitken, Barbara de Graaff, Graeme Jones, Andrew J Palmer
doi : 10.1093/rheumatology/keaa787
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3352–3359
To describe the impact of OA on health-related quality of life (HRQoL) in the forms of health state utilities (HSUs) and health-dimension scores, and to compare the longitudinal changes in HRQoL for people with and without OA, using an Australian population-based longitudinal cohort.
Arterial wall inflammation is increased in rheumatoid arthritis compared with osteoarthritis, as a marker of early atherosclerosis
Rabia Agca, Annelies B Blanken, Alper M van Sijl, Yvo M Smulders, Alexandre E Voskuyl, Conny van der Laken, Ronald Boellaard, Michael T Nurmohamed
doi : 10.1093/rheumatology/keaa789
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3360–3368
RA is associated with higher risk of cardiovascular (CV) disease. Ongoing systemic inflammation is presumed to accelerate atherosclerosis by increasing inflammation in the arterial wall. However, evidence supporting this hypothesis is limited. We aimed to investigate arterial wall inflammation in RA vs OA, and its association with markers of inflammation and CV risk factors.
Tele-rheumatology for overcoming socioeconomic barriers to healthcare in resource constrained settings: lessons from COVID-19 pandemic
Chengappa Kavadichanda, Sanket Shah, Anu Daber, Devender Bairwa, Anoop Mathew, , Saikumar Dunga, Anna C Das, Aishwarya Gopal, Karunya Ravi, Sitanshu Sekhar Kar, Vir Singh Negi
doi : 10.1093/rheumatology/keaa791
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3369–3379
To assess acceptability of teleconsultation among the socioeconomically marginalized sections of patients with rheumatic and musculoskeletal diseases (RMDs), to identify the socioeconomic barriers in continuing rheumatology care during the COVID-19 crisis and to identify patients who could benefit by shifting to tele-rheumatology consultations.
Perturbations of the gut microbiome in anti-CCP positive individuals at risk of developing rheumatoid arthritis
Christopher M Rooney, Kulveer Mankia, Suparna Mitra, Ines B Moura, Paul Emery, Mark H Wilcox
doi : 10.1093/rheumatology/keaa792
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3380–3387
Individuals with newly diagnosed RA have a distinct microbiome when compared with healthy controls. However, little is known as to when these microbiome perturbations begin. Using a prospective at-risk cohort of individuals positive for anti-citrullinated protein (anti-CCP) antibody with new onset musculoskeletal symptoms, but without clinical arthritis, we investigated for the presence of a gut dysbiosis before the onset of RA.
Serum IgG2 antibody multi-composition in systemic lupus erythematosus and in lupus nephritis (Part 2): prospective study
Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Leda Cipriani, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Matteo d’Alessandro, Paride Fenaroli, Isabella Pisani, Giacomo Garibotto, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Stefano Volpi, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Enrico Verrina, Andrea Angeletti, Angelo Ravelli, Gian Marco Ghiggeri
doi : 10.1093/rheumatology/keaa793
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3388–3397
Circulating anti-ENO1 and anti-H2A IgG2 have been identified as specific signatures of LN in a cross-over approach. We sought to show whether the same antibodies identify selected population of patients with LN with potentially different clinical outcomes.
Polymyositis: is there anything left? A retrospective diagnostic review from a tertiary myositis centre
Jesus Loarce-Martos, James B Lilleker, Matthew Parker, Neil McHugh, Hector Chinoy
doi : 10.1093/rheumatology/keaa801
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3398–3403
The current classification criteria for idiopathic inflammatory myopathy (IIM) retain PM as a major disease subgroup. However, evolution in the understanding of IIM has suggested that many of these patients could be better described as having an alternative diagnosis. In the present study, we apply the latest understanding of IIM subtyping to retrospectively review PM diagnoses in a large cohort of IIM patients.
Low dose IL-2 in patients with steroid-dependent dysimmune manifestations associated with myelodysplastic syndromes: a three-case report
Marion Corfmat, Christophe Willekens, Julien Vinit, Guillaume Bussone, Pierre Fenaux, Olivier Fain, David Klatzmann, Arsene Mekinian, Thibault Comont, MINHEMON (French network of dysimmune disorders associated to hematological malignancies)
doi : 10.1093/rheumatology/keaa696
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3404–3408
Systemic inflammatory and autoimmune diseases can be associated with myelodysplastic syndromes. Current treatments (steroids, immunosuppressive agents, biologics) are unsatisfactory because of their low response rate, dependence or adverse events. We aimed at evaluating the effects of low doses of IL-2 (ld-IL2) as a regulatory T-cell inducer in this context.
Mendelian randomization study on vitamin D levels and osteoarthritis risk: a concise report
Arjan P Bergink, Katerina Trajanoska, André G Uitterlinden, Joyce B J van Meurs
doi : 10.1093/rheumatology/keaa697
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3409–3412
The role of vitamin D in OA is unclear and previous epidemiological studies have provided inconsistent results. We conducted a two-sample Mendelian randomization (MR) study to investigate the causal relationship between genetically determined serum vitamin D levels and hip/knee OA.
Macrophage activation syndrome in children with Kawasaki disease: an experience from a tertiary care hospital in northwest India
Rakesh Kumar Pilania, Ankur Kumar Jindal, Nameirakpam Johnson, Ashwini Prithvi, Pandiarajan Vignesh, Deepti Suri, Amit Rawat, Anju Gupta, Surjit Singh
doi : 10.1093/rheumatology/keaa715
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3413–3419
To carry out a review of clinical characteristics, laboratory profiles, management and outcomes of patients with Kawasaki disease (KD) and macrophage activation syndrome (MAS).
Deep phenotyping of synovial molecular signatures by integrative systems analysis in rheumatoid arthritis
Seung Min Jung, Kyung-Su Park, Ki-Jo Kim
doi : 10.1093/rheumatology/keaa751
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3420–3431
RA encompasses a complex, heterogeneous and dynamic group of diseases arising from molecular and cellular perturbations of synovial tissues. The aim of this study was to decipher this complexity using an integrative systems approach and provide novel insights for designing stratified treatments.
Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27
Lu Pan, Jinghua Wang, Jinxiang Liu, Lishuang Guo, Sirui Yang
doi : 10.1093/rheumatology/keaa752
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3432–3442
Type 1 regulatory T (Tr1) cells are involved in the pathogenesis of numerous immune-mediated diseases. However, little is known about whether and how Tr1 cells affect the development of IgA vasculitis (IgAV). We aimed to investigate this question in IgAV patients.
Resorption of immune deposits in membranous lupus nephritis following rituximab vs conventional immunosuppressive treatment
Agneta Zickert, Klas Lannfelt, Jan Schmidt Mende, Birgitta Sundelin, Iva Gunnarsson
doi : 10.1093/rheumatology/keaa788
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3443–3450
Studies on repeat renal biopsies in membranous LN (MLN) are limited, and evaluation of treatment response is mainly based on proteinuria. EM of renal biopsies from rituximab (RTX)-treated MLN patients has revealed resorption of sub-epithelial ICs. Whether resorption phenomena are useful for treatment evaluation, or differs between treatment regimens is not known. We studied EM findings and clinical treatment response in MLN patients after RTX vs conventional immunosuppressive treatment.
Detection of circulating highly expanded T-cell clones in at-risk individuals for rheumatoid arthritis before the clinical onset of the disease
Céline Lamacchia, Zuleika Calderin Sollet, Delphine Courvoisier, Denis Mongin, Gaby Palmer, Oliva Studer, Cem Gabay, Jean Villard, Stéphane Buhler, Axel Finckh
doi : 10.1093/rheumatology/keaa790
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3451–3460
To quantitatively profile the T-cell repertoire in the peripheral blood of individuals genetically at risk for RA, namely first-degree relatives of RA patients (RA-FDR) at different phases of disease development.
Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation
Ayda Henriques Schneider, Caio Cavalcante Machado, Fl?vio Prot?sio Veras, Alexandre Gomes de Macedo Maganin, Fl?vio Falc?o Lima de Souza, L?via Corrêa Barroso, Renê Donizeti Ribeiro de Oliveira, José Carlos Alves-Filho, Thiago Mattar Cunha, Sandra Yasuyo Fukada, Paulo Louzada-J?nior, Tarc?lia Aparecida da Silva, Fernando Queiroz Cunha
doi : 10.1093/rheumatology/keaa794
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3461–3473
To evaluate the role of neutrophil extracellular traps (NETs) in the genesis of joint hyperalgesia using an experimental model of arthritis and transpose the findings to clinical investigation.
Survey of adult and paediatric rheumatology patients suggests information about COVID-19 vaccination will aid uptake
Richard P Beesley, Wendy Costello, Saskya P Angevare, Carine Wouters, Nico Wulffraat, Yosef Uziel
doi : 10.1093/rheumatology/keab169
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3474–3475
Timing of rituximab and immunoglobulin level influence the risk of death for COVID-19 in ANCA-associated vasculitis
Luca Quartuccio, Elena Treppo, Marco Binutti, Giulia Del Frate, Salvatore De Vita
doi : 10.1093/rheumatology/keab175
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3476–3477
The impact of telerheumatology and COVID-19 on outcomes in a tertiary rheumatology service: a retrospective audit
Wendy Zhu, Thilinie De Silva, Laura Eades, Susan Morton, Sally Ayoub, Eric Morand, Anna Antony
doi : 10.1093/rheumatology/keab201
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3478–3480
Multiple calcifications of fingers in patients with rheumatoid arthritis after intra-articular triamcinolone acetonide injections
Kentaro Isoda, Shosuke Akita, Jun Hashimoto, Shiro Ohshima
doi : 10.1093/rheumatology/keaa795
Rheumatology, Volume 60, Issue 7, July 2021, Page 3071
Polyarteritis nodosa: resolution of radiological changes
Naman Jain, Balasubramanyam Shankar, Somnath Mitra, Yogesh Preet Singh
doi : 10.1093/rheumatology/keaa734
Rheumatology, Volume 60, Issue 7, July 2021, Pages 3481–3482
Psoriasiform rashes as the first manifestation of anti-MDA5 associated myositis
Upendra Rathore, Saloni Haldule, Latika Gupta
doi : 10.1093/rheumatology/keaa821
Rheumatology, Volume 60, Issue 7, July 2021, Page 3483
Corrigendum to: Haploidentical ?/? T-cell and B-cell depleted stem cell transplantation in severe mevalonate kinase deficiency
Maura Faraci, Stefano Giardino, Marina Podestà, Filomena Pierri, Gianluca Dell’Orso, Andrea Beccaria, Jo?o Farela Neves, Stefano Volpi, Marco Gattorno
doi : 10.1093/rheumatology/keab208
Rheumatology, Volume 60, Issue 7, July 2021, Page 3484
Corrigendum to: Focal small bowel thrombotic microvascular injury in COVID-19 mediated by the lectin complement pathway masquerading as lupus enteritis
Benjamin Plotz, Rochelle Castillo, Jonathan Melamed, Gerard Nuovo, Cynthia Magro, Pamela Rosenthal, H Michael Belmont
doi : 10.1093/rheumatology/keab350
Rheumatology, Volume 60, Issue 7, July 2021, Page 3485
Induction of remission in biologic-naive, severe psoriasis and PsA with dual anti-cytokine combination
Rebecca H Haberman, Rochelle Castillo, Jose U Scher
doi : 10.1093/rheumatology/keaa880
Rheumatology, Volume 60, Issue 7, July 2021, Pages e225–e226
Tocilizumab for refractory rapidly progressive interstitial lung disease related to anti-MDA5-positive dermatomyositis
Xiao Zhang, Shuang Zhou, Chanyuan Wu, Mengtao Li, Qian Wang, Yan Zhao, Xiaofeng Zeng
doi : 10.1093/rheumatology/keaa906
Rheumatology, Volume 60, Issue 7, July 2021, Pages e227–e228
GATA2 mutation with recurrent haemophagocytic lymphohistiocytosis and panniculitis: a case report
Luxi Sun, Na Xu, Min Shen, Rongrong Wang, Yang Sun, Junling Zhuang, Yan Zhao, Xuejun Zeng, Xue Zhang
doi : 10.1093/rheumatology/keaa913
Rheumatology, Volume 60, Issue 7, July 2021, Pages e229–e231
Axial presentation of reactive arthritis secondary to COVID-19 infection
Fiona Louise Coath, James Mackay, John Karl Gaffney
doi : 10.1093/rheumatology/keab009
Rheumatology, Volume 60, Issue 7, July 2021, Pages e232–e233
Sideroblastic anaemia, immunodeficiency, periodic fevers and developmental delay (SIFD) presenting as systemic inflammation with arthritis
I Maccora, A V Ramanan, S Vergnano, M R Roderick
doi : 10.1093/rheumatology/keab010
Rheumatology, Volume 60, Issue 7, July 2021, Pages e234–e236
ADA2 deficiency (DADA2) associated with Evans syndrome and a severe ADA2 genotype
Mariana P L Ferriani, Elvis T Valera, Graziella R de Sousa, Paula Sandrin-Garcia, Ronald R de Moura, Michel S Hershfield, Luciana M de Carvalho
doi : 10.1093/rheumatology/keab011
Rheumatology, Volume 60, Issue 7, July 2021, Pages e237–e239
Atypical phenotype? The answer’s in the genotype: AGS caused by a novel RNASEH2C variant combined with XLA caused by a BTK deficiency
Cécile Boulanger, Olga Chatzis, Delphine Nolf, Bénédicte Brichard, Bernard Lauwerys, Marie-Cécile Nassogne, Nisha Limaye
doi : 10.1093/rheumatology/keab051
Rheumatology, Volume 60, Issue 7, July 2021, Pages e240–e242
Stauffer’s syndrome presenting as polymyalgia rheumatica
Ciro Manzo
doi : 10.1093/rheumatology/keab054
Rheumatology, Volume 60, Issue 7, July 2021, Pages e243–e244
After all, still a magnificent impersonator
Luis F Flores-Su?rez, M?nica Fern?ndez-S?nchez, V?ctor H Ahumada-Topete, M?nica Rodr?guez, Yann Charli-Joseph
doi : 10.1093/rheumatology/keab077
Rheumatology, Volume 60, Issue 7, July 2021, Pages e245–e246
TNF inhibitors for the management of inflammatory heart disease in spondyloarthritis: French multicentre case-series and literature review
Juliette Tennenbaum, Noémie Abisror, Jérémie Sellam, Adrien Bigot, Clément Gourguechon, Amir Adedjouma, Azeddine Dellal, Olivier Fain, Arsène Mekinian, Club Rhumatismes et Inflammations (CRI)
doi : 10.1093/rheumatology/keab082
Rheumatology, Volume 60, Issue 7, July 2021, Pages e247–e249
Refractory systemic juvenile idiopathic arthritis successfully treated with rapamycin
Sara Concha, Emma Rey-Jurado, M Cecilia Poli, Rodrigo Hoyos-Bachiloglu, Arturo Borzutzky
doi : 10.1093/rheumatology/keab114
Rheumatology, Volume 60, Issue 7, July 2021, Pages e250–e251
Anti-PL-7 antisynthetase syndrome presenting as COVID-19
Tim Blake, Basil Noureldin
doi : 10.1093/rheumatology/keab129
Rheumatology, Volume 60, Issue 7, July 2021, Pages e252–e254
Disappearance of bilateral adrenal tumours: immunodeficiency-associated lymphoproliferative disorder in a patient with rheumatoid arthritis
Shunichiro Hanai, Kei Kobayashi, Ichiro Kawashima, Masashi Ichijo, Daiki Nakagomi
doi : 10.1093/rheumatology/keab138
Rheumatology, Volume 60, Issue 7, July 2021, Pages e255–e257
Comment on: Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis
Lu-Wei Huang, Jui-Hung Weng, James Cheng-Chung Wei
doi : 10.1093/rheumatology/keab132
Rheumatology, Volume 60, Issue 7, July 2021, Pages e258–e259
Comment on: Obstetric antiphospholipid syndrome is not associated with an increased risk of subclinical atherosclerosis. Reply
Alessandra Bettiol, Irene Mattioli, Giacomo Emmi, Matteo Nicola Dario Di Minno, Domenico Prisco
doi : 10.1093/rheumatology/keab136
Rheumatology, Volume 60, Issue 7, July 2021, Pages e260–e261
Comment on: Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis: reply
Karin Wadstr?m, Lennart Jacobsson, Aladdin J Mohammad, Kenneth J Warrington, Eric L Matteson, Carl Turesson
doi : 10.1093/rheumatology/keab143
Rheumatology, Volume 60, Issue 7, July 2021, Pages e262–e263
Comment on: Focal vasculitic myositis as a primvary manifestation of Behçet's disease
Otto Jesus Hernandez Fustes, Carlos Arteaga Rodriguez
doi : 10.1093/rheumatology/keab181
Rheumatology, Volume 60, Issue 7, July 2021, Pages e264–e265
Comment on: The risk and trend of pulmonary embolism and deep vein thrombosis in rheumatoid arthritis: a general population-based study
Maria I Zervou, George N Goulielmos
doi : 10.1093/rheumatology/keab182
Rheumatology, Volume 60, Issue 7, July 2021, Pages e266–e267
Comment on: Proprotein convertase subtilisin/kexin type 9 in the dyslipidaemia of patients with axial spondyloarthritis is related to disease activity: reply
Miguel ? Gonz?lez-Gay, Iv?n Ferraz-Amaro
doi : 10.1093/rheumatology/keab183
Rheumatology, Volume 60, Issue 7, July 2021, Pages e268–e269
Comment on: Muscle fluorodeoxyglucose uptake assessed by positron emission tomography-computed tomography as a biomarker of inflammatory myopathies disease activity
Edoardo Conticini, Enrico Selvi, Luca Cantarini, Bruno Frediani
doi : 10.1093/rheumatology/kez608
Rheumatology, Volume 60, Issue 7, July 2021, Pages e270–e271
