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Interproximal attachment gain: The challenge of periodontal regeneration
Giulio Rasperini,Lorenzo Tavelli,Shayan Barootchi,Michael K. McGuire,Giovanni Zucchelli,Giorgio Pagni,Martina Stefanini,Hom-Lay Wang,William V. Giannobile
doi : 10.1002/JPER.20-0587
Volume 92, Issue 7 p. 931-946
The new classification of periodontal diseases recognizes the key role of the interdental clinical attachment for defining the periodontal status and the extent of disease severity. Regenerating interdental clinical attachment not only improves the prognosis of the tooth, but it also lessens the severity of the disease condition. This manuscript provides a state-of-the-art review on surgical reconstructive approaches for treating papillary deficiency associated with soft and hard tissue interproximal defects. Combination therapy of papilla preservation, connective tissue grafting, and coronally advanced flaps may result in regeneration of the intrabony defect coupled with root coverage. Future research highlighted here may have the potential, especially in combination approaches, to repair challenging interproximal soft and hard tissue deficiencies.
Peri-implant marginal mucosa defects: Classification and clinical management
I?±aki Gamborena,Gustavo Avila-Ortiz
doi : 10.1002/JPER.20-0519
Volume 92, Issue 7 p. 947-957
Peri-implant marginal mucosa defects (PMMDs) are alterations of the peri-implant soft tissue architecture characterized by an apical discrepancy of the mucosal margin respective to its ideal position with or without exposure of transmucosal prosthetic components or the implant fixture surface. PMMDs may not only represent an esthetic concern but also predispose to biofilm accumulation and subsequent initiation and progression of peri-implant inflammatory diseases. A treatment-driven classification for tooth-bound, facial PMMDs in non-molar sites, consisting of three different levels of complexity, is proposed. Clinical recommendations pertaining to the prosthetic and surgical management of each type of PMMD, illustrated with practical examples, are provided with the purpose of facilitating decision-making processes in daily practice.
Comparisons of various anthropometric indexes with localized Stage II/III periodontitis in young adults: The CHIEF oral health study
Kun-Zhe Tsai,Ren-Yeong Huang,Wan-Chien Cheng,Fang-Ying Su,Yen-Po Lin,Chan-Yuan Chang,Gen-Min Lin
doi : 10.1002/JPER.20-0275
Volume 92, Issue 7 p. 958-967
A J-shaped relationship of body mass index (BMI) with severe periodontitis has been reported. However, it is unknown for other anthropometric indexes in young adults.
Utility of procalcitonin as an early diagnostic marker of bacteremia in individuals with periodontitis Stage II and III
Ranjitha Mohan,Srirangarajan,Ravi J. Rao,Srikumar Prabhu,Vinaya Rudresh
doi : 10.1002/JPER.20-0513
Volume 92, Issue 7 p. 968-974
The aim of the present study is to assess the ability of procalcitonin (PCT) to differentiate between periodontal health and Stage II and III periodontitis. We further assessed, if PCT can reflect early bacteremia induced by non-surgical periodontal treatment (NSPT).
Quantile regression to estimate the survivor average causal effect of periodontal treatment effects on birthweight and gestational age
Anwar T. Merchant,Jihong Liu,Mark A. Reynolds,James D. Beck,Jiajia Zhang
doi : 10.1002/JPER.20-0376
Volume 92, Issue 7 p. 975-982
Survival average causal effect (SACE) can give valid estimates of the periodontal treatment effect on birth outcomes in randomized controlled trials when fetal losses are unequal across the treatment arms. A regression-based method to estimate SACE using ordinary least squares (OLS) regression can be biased if the treatment effect varies across the outcome distribution. In this case quantile regression may be a suitable alternative.
Impact of adjunctive procedures on recombinant human fibroblast growth factor-2–mediated periodontal regeneration therapy: A retrospective study
Yohei Nakayama,Hideo Matsuda,Shoichi Itoh,Yasunobu Iwai,Hideki Takai,Masaru Mezawa,Shoichi Yoshino,Yorimasa Ogata
doi : 10.1002/JPER.20-0481
Volume 92, Issue 7 p. 983-994
Human fibroblast growth factor-2 (rhFGF-2) therapy has been used for periodontal tissue regeneration. However, few studies have reported their adjunctive procedures based on strategy of tissue engineering. The aim of this retrospective study is to assess the adjunctive effects of modified papilla preservation technique (mPPT) and combination with autogenous bone grafts (AG) on the rhFGF-2 therapy.
Clinical, radiographic, and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis: A 12-month multicenter clinical trial
Ana L?via Fileto Mazzonetto,Renato Corr??a Viana Casarin,Mauro Pedrine Santamaria,Naira Maria Rebelatto Bechara Andere,C??ssia Fernandes Ara??jo,Rafaela Videira Clima da Silva,Javier Eduardo Vivanco Purisaca,Enilson Antonio Sallum,Antonio Wilson Sallum
doi : 10.1002/JPER.20-0493
Volume 92, Issue 7 p. 995-1006
The aim of this study was to evaluate the clinical, radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients.
Do periodontal defects affect periodontal inflammation and destruction? Histological/microbiological changes and gene expression profiles of a pilot study in beagle dogs
Yin-Zhe An,Kyung-A Ko,Chang-Sung Kim,Reinhard Gruber,Xinhong Wang,Jung-Seok Lee
doi : 10.1002/JPER.20-0508
Volume 92, Issue 7 p. 1007-1017
The present study focused on the inflammatory disease progress after periodontal defect induction and aimed to specifically determine periodontal tissue responses following dental plaque accumulation by ligatures on a site with/without standardized periodontal defect induction.
Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis
Jun Wang,Xudong Xie,Nicole A. Muench,Dawiyat Massoudi,Chunmei Xu,Daniel S. Greenspan,Jian Q. Feng
doi : 10.1002/JPER.20-0354
Volume 92, Issue 7 p. 1018-1029
Periodontitis is caused by multiple factors involving a bacterial challenge and a susceptible host, although there is no report on gene mutation directly linked to this common disease. Mutations in the proteinase bone morphogenetic protein 1 (BMP1) were identified in patients with osteogenesis imperfecta, who display some dentin defects and alveolar bone loss. We previously reported essential roles of BMP1 and tolloid-like 1 (TLL1), two closely related extracellular proteinases with overlapping functions, in mouse periodontium growth by simultaneous knockout (KO) of both genes, although the separate roles of BMP1 and TLL1 have remained unclear. Here, we have investigated whether and how BMP1 and TLL1 separately maintain periodontal homeostasis by comparing single Bmp1 KO and Tll1 KO with double KO (dKO) phenotypes.
Evaluation of the need to prescribe opioid medication to control post-surgical pain of different periodontal/oral surgeries
Omar Al-Bayati,Kerri Font,Nikolaos Soldatos,Emanouela Carlson,Joseph Parsons,Charles A. Powell
doi : 10.1002/JPER.20-0315
Volume 92, Issue 7 p. 1030-1035
To determine the level of perceived pain after different types of periodontal/oral surgical procedures, and the differences in patients’ selection of pain management, over the counter (OTC) versus opioid, based on procedure type.
Inhibition of yes-associated protein dephosphorylation prevents aggravated periodontitis with occlusal trauma
Wei Wei,Lili Xue,Liangyu Tan,Jie Liu,Qin Yang,Jiajia Wang,Bing Yan,Qiaoling Cai,Li Yang,Yuan Yue,Liang Hao,Min Wang,Jinle Li
doi : 10.1002/JPER.19-0338
Volume 92, Issue 7 p. 1036-1048
Occlusal trauma can aggravate periodontitis, but the mechanism remains unclear. Yes-associated protein (YAP), a mechanical stressor protein, may play an important role in this process.
The role of PHF8 and TLR4 in osteogenic differentiation of periodontal ligament cells in inflammatory environment
Zhao Liu,Yiheng He,Chenrong Xu,Jianjia Li,Shuguang Zeng,Xi Yang,Qianqian Han
doi : 10.1002/JPER.20-0285
Volume 92, Issue 7 p. 1049-1059
Histone methylation is considered to play an important role in the occurrence and development of periodontitis. Plant homeodomain finger protein 8 (PHF8), a histone demethylase, has been shown to regulate inflammation and osteogenic differentiation of bone marrow stromal cells (BMSCs). This study aimed to detect the functions of PHF8 and TLR4 in osteogenic differentiation in an inflammatory environment induced by Porphyromonas gingivalis lipopolysaccharide (Pg-LPS)
microRNA-146a and -155, upregulated by periodontitis and type 2 diabetes in oral fluids, are predicted to regulate SARS-CoV-2 oral receptor genes
Jelena R. Roganovi?‡
doi : 10.1002/JPER.20-0623
Volume 92, Issue 7 p. e35-e43
Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent studies show upregulation of innate immuno-regulatory microRNA-146a and -155 in oral fluids of patients with type 2 diabetes as well as of patients with periodontitis. The aim was to investigate whether upregulation of these microRNAs may relate to patient susceptibility to the infection via modulation of SARS-CoV-2 cellular entry factors expression.
Extending the vitamin D pathway to vitamin D3 and CYP27A1 in periodontal ligament cells
Churen Zhang,Kaining Liu,Jianxia Hou
doi : 10.1002/JPER.20-0225
Volume 92, Issue 7 p. e44-e53
In periodontal connective tissue cells, the vitamin D pathway has been elucidated, and vitamin D3 in the main storage form, 25-hydroxy vitamin D3 (25[OH]D3), and the functional form, 1,25-dihydroxy vitamin D3 (1,25[OH]2D3), have been found to induce the expression of human cationic antimicrobial protein (hCAP-18)/LL-37. Moreover, synergistic effects between Toll-like receptor agonists and 25(OH)D3 have been reported. This research aimed at extending the vitamin D pathway to vitamin D3 and CYP27A1 in human periodontal ligament cells (hPDLCs) to further explore its function in periodontal inflammatory reaction.
Porphyromonas gingivalis infection alters Nrf2-phase II enzymes and nitric oxide in primary human aortic endothelial cells
Chethan Sampath,Emmanuel U. Okoro,Michael J. Gipson,Sasanka S. Chukkapalli,Cherae M. Farmer-Dixon,Pandu R. Gangula
doi : 10.1002/JPER.20-0444
Volume 92, Issue 7 p. e54-e65
Periodontal disease (PD) is known to be associated with endothelial dysfunction in patients with coronary artery and/or cardiovascular disease. In our study, we sought to explore the virulence of P. gingivalis (Pg) affecting glycogen synthase kinase 3 beta (GSK-3?²)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/tetrahydrobiopterin (BH4)/ nitric oxide synthase (NOS) expression in primary human aortic endothelial cells (pHAECs).
Microstructural volumetric analysis of the jaw following dental implantation under systemic bisphosphonate delivery: An in vivo and ex vivo rat study
Kristian Kniha,Anna Bock,Florian Peters,Zuzanna Anna Magnuska,Felix Gremse,Stephan Christian M?hlhenrich,Frank H?lzle,Ali Modabber
doi : 10.1002/JPER.20-0547
Volume 92, Issue 7 p. e66-e75
Because of bisphosphonate medication, dental implantation with a subsequent infection poses a relevant risk factor to suffer from medication-related osteonecrosis of the jaw. This rat study evaluated different implant materials under systemic bisphosphonate delivery using micro-computed tomography (?CT) images.
