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Table of Contents

doi : 10.1016/S0923-7534(25)06353-7

Volume 37, Issue 2, February 2026, Pages i-ii

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Antibody–drug conjugates in combination therapy: defining the next chapter☆

doi : 10.1016/j.annonc.2025.10.013

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Long-term outcomes with adjuvant CDK4/6 inhibitors: who benefits most?

doi : 10.1016/j.annonc.2025.10.012

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The Achilles heel of precision AKT-targeted therapies in advanced prostate cancer: therapeutic promise constrained by the test

doi : 10.1016/j.annonc.2025.12.010

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Optimizing pathological response assessment after neoadjuvant immunotherapy: linking clinical practice to drug development

doi : 10.1016/j.annonc.2025.12.016

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Updated pan-tumor guidelines for neoadjuvant scoring of pathologic response: a joint SITC and INMC effort

doi : 10.1016/j.annonc.2025.10.018

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Overall survival with abemaciclib in early breast cancer☆

doi : 10.1016/j.annonc.2025.10.005

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Neoadjuvant trastuzumab deruxtecan alone or followed by paclitaxel, trastuzumab, and pertuzumab for high-risk HER2-positive early breast cancer (DESTINY-Breast11): a randomised, open-label, multicentre, phase III trial☆

doi : 10.1016/j.annonc.2025.10.019

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Patient-reported outcomes in the SERENA-6 trial of camizestrant plus CDK4/6 inhibitor in patients with advanced breast cancer and emergent ESR1 mutations during first-line endocrine-based therapy☆

doi : 10.1016/j.annonc.2025.10.006

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Palbociclib plus letrozole versus weekly paclitaxel, both in combination with trastuzumab plus pertuzumab, as neoadjuvant treatment for patients with HR-positive/HER2-positive early breast cancer: primary results from the randomized phase II TOUCH trial (IBCSG 55-17)☆

doi : 10.1016/j.annonc.2025.10.016

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Pathological response calculation assessment remains accurate with reduced tumor bed examination after neoadjuvant immunotherapy in clinically detectable stage III melanoma

doi : 10.1016/j.annonc.2025.10.1237

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Rucaparib maintenance for newly diagnosed advanced ovarian cancer: interim overall survival, progression-free survival, and safety at 5 years of follow-up from the phase III ATHENA-MONO/GOG-3020/ENGOT-ov45 study☆

doi : 10.1016/j.annonc.2025.10.007

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Novel pembrolizumab-based treatments as first-line therapy in advanced clear-cell renal cell carcinoma: substudy 03A of the open-label, umbrella platform, phase I/II KEYMAKER-U03 trial☆

doi : 10.1016/j.annonc.2025.10.010

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A multicenter randomized phase II trial of lenvatinib plus everolimus versus cabozantinib in patients with metastatic clear-cell RCC that progressed on PD-1 immune checkpoint inhibition (LenCabo)☆

doi : 10.1016/j.annonc.2025.10.009

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Three versus six cycles of platinum-based chemotherapy followed by avelumab maintenance as first-line treatment for advanced urothelial cancer: the phase II DISCUS trial☆

doi : 10.1016/j.annonc.2025.10.011

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Personalised antiemetic prophylaxis with NEPA for patients at high risk of chemotherapy-induced nausea and vomiting receiving moderately emetogenic chemotherapy: results from the randomised, multinational MyRisk trial☆

doi : 10.1016/j.annonc.2025.10.017

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Palbociclib with adjuvant endocrine therapy in early breast cancer: 5-year follow-up analysis of the global multicenter, open-label, randomized phase III PALLAS trial (ABCSG-42/AFT-05/PrE0109/BIG-14-13)

doi : 10.1016/j.annonc.2025.10.003

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