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Hepatocellular Carcinoma: A Contemporary Approach to Locoregional Therapy
Ahmed, Osman; Pillai, Anjana
doi : 10.14309/ajg.0000000000000931
November 2020 - Volume 115 - Issue 11 - p 1733-1736
Colorectal Cancer Screening With the Multitarget Stool DNA Test
Kisiel, John B.; Limburg, Paul J.
doi : 10.14309/ajg.0000000000000968
November 2020 - Volume 115 - Issue 11 - p 1737-1740
Myths and Misconceptions About Constipation: A New View for the 2020s
Staller, Kyle; Cash, Brooks D.
doi : 10.14309/ajg.0000000000000947
November 2020 - Volume 115 - Issue 11 - p 1741-1745
Endoscopic Ultrasound-Guided Needle Aspiration Transversing the Portomesenteric Confluence. A Recklessness?
Garcia-Sumalla, Albert; Gornals, Joan B.
doi : 10.14309/ajg.0000000000000792
November 2020 - Volume 115 - Issue 11 - p 1746
Oleogranuloma of the Rectum Mimic Malignancy
NG, Benjamin Kwan Lok; Su, Harvey Yu-Li; Tsai, Kai-Lung
doi : 10.14309/ajg.0000000000000776
November 2020 - Volume 115 - Issue 11 - p 1747
Treatment of Bouveret Syndrome Using an Ultrathin Gastroscope: Making the Best out of a Tight Situation!
Kothari, Truptesh H.; Enslin, Sarah; Cheong, Janice; Kaul, Vivek; Ullah, Asad; Kothari, Shivangi
doi : 10.14309/ajg.0000000000000841
November 2020 - Volume 115 - Issue 11 - p 1748
Continuing Medical Education Questions: November 2020
Park, James S.
doi : 10.14309/ajg.0000000000001017
November 2020 - Volume 115 - Issue 11 - p 1749
Article Title: Hyponatremia in Cirrhosis: An Update
Continuing Medical Education Questions: November 2020
Richter, Seth J.
doi : 10.14309/ajg.0000000000001016
November 2020 - Volume 115 - Issue 11 - p 1750
Article Title: Use of Functional Lumen Imaging Probe (FLIP) in Clinical Esophagology
Endoscopic Recognition and Management Strategies for Malignant Colorectal Polyps: Recommendations of the US Multi-Society Task Force on Colorectal Cancer
Shaukat, Aasma; Kaltenbach, Tonya; Dominitz, Jason A.; Robertson, Douglas J.; Anderson, Joseph C.; Cruise, Michael; Burke, Carol A.; Gupta, Samir; Lieberman, David; Syngal, Sapna; Rex, Douglas K.
doi : 10.14309/ajg.0000000000001013
November 2020 - Volume 115 - Issue 11 - p 1751-1767
Effectiveness of Dose De-escalation of Biologic Therapy in Inflammatory Bowel Disease: A Systematic Review
Little, Derek H. W.; Tabatabavakili, Sahar; Shaffer, Seth R.; Nguyen, Geoffrey C.; Weizman, Adam V.; Targownik, Laura E.
doi : 10.14309/ajg.0000000000000783
November 2020 - Volume 115 - Issue 11 - p 1768-1774
De-escalation of biologic therapy is a commonly encountered clinical scenario. Although biologic discontinuation has been associated with high rates of relapse, the effectiveness of dose de-escalation is unclear. This review was performed to determine the effectiveness of dose de-escalation of biologic therapy in inflammatory bowel disease.
Hyponatremia in Cirrhosis: An Update
Alukal, Joseph J.; John, Savio; Thuluvath, Paul J.
doi : 10.14309/ajg.0000000000000786
November 2020 - Volume 115 - Issue 11 - p 1775-1785
Hyponatremia is frequently seen in patients with ascites secondary to advanced cirrhosis and portal hypertension. Although not apparent in the early stages of cirrhosis, the progression of cirrhosis and portal hypertension leads to splanchnic vasodilation, and this leads to the activation of compensatory mechanisms such as renin-angiotensin-aldosterone system (RAAS), sympathetic nervous system, and antidiuretic hormone (ADH) to ameliorate low circulatory volume. The net effect is the avid retention of sodium and water to compensate for the low effective circulatory volume, resulting in the development of ascites.
Use of the Functional Lumen Imaging Probe in Clinical Esophagology
Savarino, Edoardo; di Pietro, Massimiliano; Bredenoord, Albert J.; Carlson, Dustin A.; Clarke, John O.; Khan, Abraham; Vela, Marcelo F.; Yadlapati, Rena; Pohl, Daniel; Pandolfino, John E.; Roman, Sabine; Gyawali, C. Prakash
doi : 10.14309/ajg.0000000000000773
November 2020 - Volume 115 - Issue 11 - p 1786-1796
The functional lumen imaging probe (FLIP) measures luminal dimensions using impedance planimetry, performed most often during sedated upper endoscopy. Mechanical properties of the esophageal wall and opening dynamics of the esophagogastric junction (EGJ) can be objectively evaluated in esophageal motor disorders, eosinophilic esophagitis, esophageal strictures, during esophageal surgery and in postsurgical symptomatic states. Distensibility index, the ratio of EGJ cross sectional area to intraballoon pressure, is the most useful FLIP metric.
Improving Hepatitis B Virus Vaccination Responses in Inflammatory Bowel Disease: Does Greater Dose and Greater Frequency Lead to Greater Protection?
Banty, Andrea; Melmed, Gil Y.
doi : 10.14309/ajg.0000000000000921
November 2020 - Volume 115 - Issue 11 - p 1797-1798
Prevention of hepatitis B (HBV) infection is particularly important for patients with inflammatory bowel disease because of risks of HBV reactivation on immunosuppressive therapies. However, immune responses to standard HBV vaccination regimens are suboptimal. Chaparro et al. compared immune responses to 2 vaccines, an adjuvanted HBV vaccine (Fendrix) and double-dosed standard vaccine (Engerix-B) using an accelerated, 4-dose regimen (0, 1, 2, and 6 months). Although the study did not demonstrate superiority of one vaccine over another, several lessons can be derived regarding immune response to vaccinations among patients with inflammatory bowel disease, including the need to consider nonstandard regimens for patients on immunosuppression. These lessons can be translated broadly, including to a potential future severe acute respiratory syndrome coronavirus 2 vaccine when one becomes available.
Clinical Functional Lumen Imaging Probe Testing in Esophageal Disorders: A Need for Better Quality Evidence
Massey, Benson T.
doi : 10.14309/ajg.0000000000000974
November 2020 - Volume 115 - Issue 11 - p 1799-1801
In their article “Use of the Functional Lumen Imaging Probe in Clinical Esophagology,” Savarino et al. report the outcomes of a Grading of Recommendations Assessment, Development, and Evaluation analysis performed by experts in the use of functional lumen imaging probe (FLIP) evaluation of esophageal disorders. For essentially all clinical indications, the recommendation for use was conditional with a very low quality of evidence. FLIP is an expensive, invasive technology examining limited aspects of esophageal function. Its role in complementing or replacing existing technology is uncertain, particularly when compared with manometric testing with additional provocative studies. Performing properly designed studies to demonstrate FLIP's true effectiveness and cost-effectiveness will be costly.
Fendrix vs Engerix-B for Primo-Vaccination Against Hepatitis B Infection in Patients With Inflammatory Bowel Disease: A Randomized Clinical Trial
Chaparro, Mar?a; Gordillo, Jordi; Domènech, Eugeni; Esteve, Maria; Barreiro-de Acosta, Manuel; Villoria, Albert; Iglesias-Flores, Eva; Blasi, Mercedes; Naves, Juan E.; Ben?tez, Olga; Nieto, Laura; Calvet, Xavier; Garc?a-S?nchez, Valle; Villagrasa, José Ram?n; Marin, Alicia C.; Donday, Mar?a G.; Abad-Santos, Francisco; Gisbert, Javier P.
doi : 10.14309/ajg.0000000000000926
November 2020 - Volume 115 - Issue 11 - p 1802-1811
To compare Engerix-B and Fendrix hepatitis B virus for primo vaccination in inflammatory bowel disease (IBD).
Ustekinumab for Perianal Crohn's Disease: The BioLAP Multicenter Study From the GETAID
Chapuis-Biron, Constance; Kirchgesner, Julien; Pariente, Benjamin; Bouhnik, Yoram; Amiot, Aurélien; Viennot, Stéphanie; Serrero, Mélanie; Fumery, Mathurin; Allez, Matthieu; Siproudhis, Laurent; Buisson, Anthony; Pineton de Chambrun, Guillaume; Abitbol, Vered; Nancey, Stéphane; Caillo, Ludovic; Plastaras, Laurianne; Savoye, Guillaume; Chanteloup, Elise; Simon, Marion; Dib, Nina; Rajca, Sylvie; Amil, Morgane; Parmentier, Anne-Laure; Peyrin-Biroulet, Laurent; Vuitton, Lucine; the GETAID BioLAP Study Group
doi : 10.14309/ajg.0000000000000810
November 2020 - Volume 115 - Issue 11 - p 1812-1820
New therapeutic options for patients with Crohn's disease (CD) with perianal lesions failing anti–tumor necrosis factor (TNF) agents are needed. We aimed to assess the effectiveness of ustekinumab in perianal CD (pCD) and predictors of clinical success in a real-life multicenter cohort.
Healthcare Resource Utilization and Costs in Celiac Disease: A US Claims Analysis
Cappell, Katherine; Taylor, Aliki; Johnson, Barbara H.; Gelwicks, Steve; Wang, Song; Gerber, Michele; Leffler, Daniel A.
doi : 10.14309/ajg.0000000000000759
November 2020 - Volume 115 - Issue 11 - p 1821-1829
Celiac disease (CeD) is a lifelong immune-mediated enteropathy in which dietary gluten triggers an inflammatory reaction in the small intestine. This retrospective cohort study examines healthcare resource utilization (HRU) and costs between patients with CeD and matched controls.
Pediatric Solid Gastric Emptying Scintigraphy: Normative Value Guidelines and Nonstandard Meal Alternatives
Ng, Thomas S.C.; Putta, Niharika; Kwatra, Neha S.; Drubach, Laura A.; Rosen, Rachel; Fahey, Frederic H.; Flores, Alejandro; Nurko, Samuel; Voss, Stephan D.
doi : 10.14309/ajg.0000000000000831
November 2020 - Volume 115 - Issue 11 - p 1830-1839
Adult standards for gastric emptying scintigraphy, including the type of meal and range of normative values for percent gastric emptying, are routinely used in pediatric practice, but to date have not been validated. The purpose of this study is to determine whether the use of adult criteria for gastric emptying scintigraphy is valid for children and whether alternative nonstandard meals can also be offered based on these criteria.
Glycemic Status, Insulin Resistance, and Risk of Pancreatic Cancer Mortality in Individuals With and Without Diabetes
Kim, Nam Hee; Chang, Yoosoo; Lee, Sung Ryol; Ryu, Seungho; Kim, Hong Joo
doi : 10.14309/ajg.0000000000000956
November 2020 - Volume 115 - Issue 11 - p 1840-1848
The impact of glycemic status and insulin resistance on the risk of pancreatic cancer in the nondiabetic population remains uncertain. We aimed to examine the association of glycemic status and insulin resistance with pancreatic cancer mortality in individuals with and without diabetes.
Improving Outcomes of Bariatric Surgery in Patients With Cirrhosis in the United States: A Nationwide Assessment
Are, Vijay S.; Knapp, Shannon M.; Banerjee, Ambar; Shamseddeen, Hani; Ghabril, Marwan; Orman, Eric; Patidar, Kavish R.; Chalasani, Naga; Desai, Archita P.
doi : 10.14309/ajg.0000000000000911
November 2020 - Volume 115 - Issue 11 - p 1849-1856
With increasing burden of obesity and liver disease in the United States, a better understanding of bariatric surgery in context of cirrhosis is needed. We described trends of hospital-based outcomes of bariatric surgery among cirrhotics and determined effect of volume status and type of surgery on these outcomes.
In Severe Alcoholic Hepatitis, Serum Keratin-18 Fragments Are Diagnostic, Prognostic, and Theragnostic Biomarkers
Atkinson, Stephen R.; Grove, Jane I.; Liebig, Stephanie; Astbury, Stuart; Vergis, Nikhil; Goldin, Robert; Quaglia, Alberto; Bantel, Heike; Guha, Indra Neil; Thursz, Mark R.; Newcombe, Paul; Strnad, Pavel; Aithal, Guruprasad P.
doi : 10.14309/ajg.0000000000000912
November 2020 - Volume 115 - Issue 11 - p 1857-1868
Up to 40% of patients with severe alcoholic hepatitis (AH) die within 6 months of presentation, making prompt diagnosis and appropriate treatment essential. We determined the associations between serum keratin-18 (K18) and histological features, prognosis, and differential response to prednisolone in patients with severe AH.
An Analysis of the GIQuIC Nationwide Quality Registry Reveals Unnecessary Surveillance Endoscopies in Patients With Normal and Irregular Z-Lines
Wani, Sachin; Williams, J. Lucas; Falk, Gary W.; Komanduri, Srinadh; Muthusamy, V. Raman; Shaheen, Nicholas J.
doi : 10.14309/ajg.0000000000000960
November 2020 - Volume 115 - Issue 11 - p 1869-1878
Population-based estimates of adherence to Barrett's esophagus (BE) guidelines are not available. Using a national registry, we assessed surveillance intervals for patients with normal and irregular Z-lines based on the presence or absence of intestinal metaplasia (IM) and among patients with suspected or confirmed BE.
Multifocal Cryoballoon Ablation for Eradication of Barrett's Esophagus-Related Neoplasia: A Prospective Multicenter Clinical Trial
Canto, Marcia Irene; Trindade, Arvind J.; Abrams, Julian; Rosenblum, Michael; Dumot, John; Chak, Amitabh; Iyer, Prasad; Diehl, David; Khara, Harshit S.; Corbett, F. Scott; McKinley, Matthew; Shin, Eun Ji; Waxman, Irving; Infantolino, Anthony; Tofani, Christina; Samarasena, Jason; Chang, Kenneth; Wang, Bingkai; Goldblum, John; Voltaggio, Lysandra; Montgomery, Elizabeth; Lightdale, Charles J.; Shaheen, Nicholas J.
doi : 10.14309/ajg.0000000000000822
November 2020 - Volume 115 - Issue 11 - p 1879-1890
Ablation of Barrett's esophagus (BE) is the preferred approach for the treatment of neoplasia without visible lesions. Limited data on cryoballoon ablation (CBA) suggest its potential clinical utility. We evaluated the safety and efficacy of CBA in a multicenter study of patients with neoplastic BE.
Evidence of Duodenal Epithelial Barrier Impairment and Increased Pyroptosis in Patients With Functional Dyspepsia on Confocal Laser Endomicroscopy and “Ex Vivo” Mucosa Analysis
Nojkov, Borko; Zhou, Shi-Yi; Dolan, Russell D.; Davis, Elisabeth M.; Appelman, Henry D.; Guo, Xueyan; Jackson, Kenya; Sturm, Matthew B.; Wang, Thomas D.; Owyang, Chung; Liu, Julia J.; Chey, William D.
doi : 10.14309/ajg.0000000000000827
November 2020 - Volume 115 - Issue 11 - p 1891-1901
Duodenal epithelial barrier impairment and immune activation may play a role in the pathogenesis of functional dyspepsia (FD). This study was aimed to evaluate the duodenal epithelium of patients with FD and healthy individuals for detectable microscopic structural abnormalities.
Normal Lactate and Unenhanced CT-Scan Result in Delayed Diagnosis of Acute Mesenteric Ischemia
Nuzzo, Alexandre; Joly, Francisca; Ronot, Maxime; Castier, Yves; Huguet, Audrey; Paugam-Burtz, Catherine; Cazals-Hatem, Dominique; Tran-Dinh, Alexy; Becq, Aymeric; Panis, Yves; Bouhnik, Yoram; Maggiori, Leon; Corcos, Olivier
doi : 10.14309/ajg.0000000000000836
November 2020 - Volume 115 - Issue 11 - p 1902-1905
To investigate the factors associated with a delayed diagnosis (DD) of acute mesenteric ischemia (AMI).
Three-Dimensional-Printed Liver Model Helps Learners Identify Hepatic Subsegments: A Randomized-Controlled Cross-Over Trial
Chedid, Victor G.; Kamath, Amika A.; M. Knudsen, John; Frimannsdottir, Katrin; Yost, Kathleen J.; R. Geske, Jennifer; Morris, Jonathan M.; Taner, Timucin; Matsumoto, Jane M.; Kamath, Patrick S.
doi : 10.14309/ajg.0000000000000958
November 2020 - Volume 115 - Issue 11 - p 1906-1910
The purpose of this study was to find out whether 3-dimensional (3D)–printed models improved the learners' ability to identify liver segments.
Sarcopenia Does Not Worsen Survival in Patients With Cirrhosis Undergoing Transjugular Intrahepatic Portosystemic Shunt for Refractory Ascites
Benmassaoud, Amine; Roccarina, Davide; Arico, Francesco; Leandro, Gioacchino; Yu, Becky; Cheng, Felix; Yu, Dominic; Patch, David; Tsochatzis, Emmanuel
doi : 10.14309/ajg.0000000000000959
November 2020 - Volume 115 - Issue 11 - p 1911-1914
The impact of sarcopenia in patients undergoing transjugular intrahepatic portosystemic shunt (TIPSS) insertion for refractory ascites is unknown.
Long-Term Self-Expandable Metal Stent (SEMS) for Esophageal Variceal Bleeding: A Picture of the Natural History
Santos, Sara; Sim?es, Guilherme; Lemos, Joana; Saiote, Joana; Loureiro, Rafaela; Seves, Isabel
doi : 10.14309/ajg.0000000000000802
November 2020 - Volume 115 - Issue 11 - p 1915-1917
We aim to discuss the utility of self-expandable esophageal metal stent (SEMS) in variceal bleeding in challenging cases.
Proton Pump Inhibitors and Mortality in Individuals With COVID-19
Aby, Elizabeth S.; Rodin, Holly; Debes, Jose D.
doi : 10.14309/ajg.0000000000000992
November 2020 - Volume 115 - Issue 11 - p 1918
Regarding “Increased Risk of COVID-19 in Patients Taking Proton Pump Inhibitors”
Hajifathalian, Kaveh; Katz, Philip O.
doi : 10.14309/ajg.0000000000000920
November 2020 - Volume 115 - Issue 11 - p 1918-1919
Risk of COVID-19 in Patients Taking Proton Pump Inhibitors
Hadi, Yousaf B.; Naqvi, Syeda Fatima; Kupec, Justin T.
doi : 10.14309/ajg.0000000000000949
November 2020 - Volume 115 - Issue 11 - p 1919-1920
Are Proton Pump Inhibitors Contributing to SARS-COV-2 Infection?
Tarlow, Branden; Gubatan, John; Khan, Muhammad Ali; Cholankeril, George
doi : 10.14309/ajg.0000000000000933
November 2020 - Volume 115 - Issue 11 - p 1920-1921
Comment on Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors
Boushey, Homer; Gonda, Igor
doi : 10.14309/ajg.0000000000001014
November 2020 - Volume 115 - Issue 11 - p 1921
Response to Hajifathalian and Katz Regarding Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors
Almario, Christopher V.; Chey, William D.; Spiegel, Brennan M.R.
doi : 10.14309/ajg.0000000000000993
November 2020 - Volume 115 - Issue 11 - p 1922-1923
Data Visualization in the Era of COVID-19: An Interactive Map of the SECURE-IBD Registry
Windsor, Joseph W.; Underwood, Fox E.; Brenner, Erica; Colombel, Jean-Frederic; Kappelman, Michael D.; Ungaro, Ryan; Zhang, Xian; Kaplan, Gilaad G.
doi : 10.14309/ajg.0000000000000953
November 2020 - Volume 115 - Issue 11 - p 1923-1924
Calendar of Courses, Symposiums and Conferences
doi : 10.14309/ajg.0000000000001019
November 2020 - Volume 115 - Issue 11 - p 1925
