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Effect of clinical decision support systems on clinical outcome for acute kidney injury: a systematic review and meta-analysis
Youlu Zhao, Xizi Zheng, Jinwei Wang, Damin Xu, Shuangling Li, Jicheng Lv and Li Yang
doi : 10.1186/s12882-021-02459-y
BMC Nephrology 2021 22:271
Clinical decision support systems including both electronic alerts and care bundles have been developed for hospitalized patients with acute kidney injury.
The causes and frequency of kidney allograft failure in a low-resource setting: observational data from Iraqi Kurdistan
Alaa Abbas Ali, Safaa E. Almukhtar, Kais H. Abd, Zana Sidiq M. Saleem, Dana A. Sharif and Michael D. Hughson
doi : 10.1186/s12882-021-02486-9
BMC Nephrology 2021 22:272
In the developing world, transplantation is the most common long-term treatment for patients with end-stage renal disease, but rates and causes of graft failure are uncertain.
Chronic kidney disease diagnosis using decision tree algorithms
Hamida Ilyas, Sajid Ali, Mahvish Ponum, Osman Hasan, Muhammad Tahir Mahmood, Mehwish Iftikhar and Mubasher Hussain Malik
doi : 10.1186/s12882-021-02474-z
BMC Nephrology 2021 22:273
Chronic Kidney Disease (CKD), i.e., gradual decrease in the renal function spanning over a duration of several months to years without any major symptoms, is a life-threatening disease. It progresses in six stages according to the severity level. It is categorized into various stages based on the Glomerular Filtration Rate (GFR), which in turn utilizes several attributes, like age, sex, race and Serum Creatinine. Among multiple available models for estimating GFR value, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), which is a linear model, has been found to be quite efficient because it allows detecting all CKD stages.
Real-time prediction of intradialytic relative blood volume: a proof-of-concept for integrated cloud computing infrastructure
Sheetal Chaudhuri, Hao Han, Caitlin Monaghan, John Larkin, Peter Waguespack, Brian Shulman, Zuwen Kuang, Srikanth Bellamkonda, Jane Brzozowski, Jeffrey Hymes, Mike Black, Peter Kotanko, Jeroen P. Kooman, Franklin W. Maddux and Len Usvyat
doi : 10.1186/s12882-021-02481-0
BMC Nephrology 2021 22:274
Inadequate refilling from extravascular compartments during hemodialysis can lead to intradialytic symptoms, such as hypotension, nausea, vomiting, and cramping/myalgia. Relative blood volume (RBV) plays an important role in adapting the ultrafiltration rate which in turn has a positive effect on intradialytic symptoms. It has been clinically challenging to identify changes RBV in real time to proactively intervene and reduce potential negative consequences of volume depletion. Leveraging advanced technologies to process large volumes of dialysis and machine data in real time and developing prediction models using machine learning (ML) is critical in identifying these signals.
Bone responsiveness to parathyroid hormone is negatively associated with parathyroid hormone-lowering drug use in patients undergoing hemodialysis: a cross-sectional study
Naoto Tominaga, Tomoki Yonaha, Masayuki Yamanouchi, Hirofumi Sumi, Yasuhiro Taki, Yugo Shibagaki, Kazuhiro Shiizaki and Shozo Yano
doi : 10.1186/s12882-021-02482-z
BMC Nephrology 2021 22:275
Parathyroid hormone (PTH) acts on bone to indirectly increase the number and activity of osteoclasts. Thus, PTH has a stimulatory effect on bone resorption and upregulates bone turnover. However, the responsiveness of bone to PTH varies widely among patients receiving dialysis. In fact, relative to the serum PTH level, the level of serum tartrate-resistant acid phosphatase-5b (TRACP-5b), a bone resorption marker derived from osteoclasts, varies as well. This study aimed to examine factors related to bone responsiveness to PTH in patients undergoing chronic hemodialysis (HD).
Prevalence of impaired renal function and determinants in the southwest of Iran
Saba Alvand, Farhad Abolnezhadian, Sudabeh Alatab, Zahra Mohammadi, Fatemeh Hayati, Mohammad Noori, Leila Danehchin, Yousef Paridar, Bahman Cheraghian, Zahra Rahimi, Sanam Hariri, Sahar Masoudi, Seyed Ali Mard, Ali Akbar Shayesteh and Hossein Poustchi
doi : 10.1186/s12882-021-02484-x
BMC Nephrology 2021 22:276
Chronic kidney disease (CKD) is a growing global health problem with faster progression in developing countries such as Iran. Here we aimed to evaluate the prevalence and determinants of CKD stage III+.
Horseshoe kidney with PLA2R-positive membranous nephropathy
Shuai-Shuai Shi, Xian-Zu Yang, Xiao-Ye Zhang, Hui-Dan Guo, Wen-Feng Wang, Li Zhang, Peng Wu, Wei Zhang, Wen-Bin Wen, Xiao-Lei Huo and Yi-Qiang Zhang
doi : 10.1186/s12882-021-02488-7
BMC Nephrology 2021 22:277
Horseshoe kidney (HSK) is a common congenital defect of the urinary system. The most common complications are urinary tract infection, urinary stones, and hydronephrosis. HSK can be combined with glomerular diseases, but the diagnosis rate of renal biopsy is low due to structural abnormalities. There are only a few reports on HSK with glomerular disease. Here, we have reported a case of PLA2R-positive membranous nephropathy occurring in a patient with HSK.
Chronic kidney disease linked to SARS-CoV-2 infection: a case report
Georges Tarris, Alexis de Rougemont, Marie-Anaïs Estienney, Julien Journet, Anne-Cécile Lariotte, Damien Aubignat, Jean-Michel Rebibou, Mathilde Funes De La Vega, Mathieu Legendre, Gael Belliot and Laurent Martin
doi : 10.1186/s12882-021-02490-z
BMC Nephrology 2021 22:278
The recent COVID-19 pandemic has raised concerns about patient diagnosis and follow-up of chronically ill patients. Patients suffering from chronic illnesses, concomitantly infected by SARS-CoV-2, globally tend to have a worse prognosis and poor outcomes. Renal tropism and acute kidney injury following SARS-CoV-2 infection has recently been described in the literature, with elevated mortality rates. Furthermore, patients with pre-existing chronic kidney disease, infected by SARS-CoV-2, should be monitored carefully. Here, we report the case of a 69-year-old patient with splenic marginal zone lymphoma, suffering from longstanding chronic kidney disease following SARS-CoV-2 infection.
Co-occurrence of IgA nephropathy and IgG4-Tubulointersitial nephritis effectively treated with tacrolimus: a case report
Mi Tian, Junjun Luan, Congcong Jiao, Qing Chang, Jeffrey B. Kopp and Hua Zhou
doi : 10.1186/s12882-021-02477-w
BMC Nephrology 2021 22:279
Cases of concurrent immunoglobulin A nephropathy (IgAN) and IgG4-related tubulointerstitial nephritis (IgG4-TIN) are rare and previous case reports have lacked important data. KDIGO suggests a treatment with systemic glucocorticoids in IgAN patients. Glucocorticoids are recommended as the first-line therapy for IgG4-TIN. The use of tacrolimus as a long-term maintenance treatment has not been described. We report the case of a man who developed IgAN and IgG4-TIN without abnormalities in extra-renal tissue, without renal function abnormalities or impairment as well, and was treated by tacrolimus as a long-term maintenance during 45?months follow-up.
Health related quality of life (HRQOL) of patients with End Stage Kidney Disease (ESKD) on hemodialysis in Addis Ababa, Ethiopia: a cross-sectional study
Sujin Kim, Yemisrach Nigatu, Tekebash Araya, Zewdu Assefa and Nebiyu Dereje
doi : 10.1186/s12882-021-02494-9
BMC Nephrology 2021 22:280
End-Stage Kidney Disease, the most severe form of chronic kidney disease, is fatal if not treated by renal replacement therapy. Thus, patients with End-Stage Kidney Disease depend on hemodialysis as a lifesaving treatment for the remainder of their lives. However, the health-related quality of life (HRQOL) of patients on hemodialysis is much more underappreciated in resource limited countries.
Modified arteriosclerosis score predicts the outcomes of diabetic kidney disease
Yifan Zhang, Qifeng Jiang, Jianteng Xie, Chunfang Qi, Sheng Li, Yanhui Wang, Yau Hok Him, Zujiao Chen, Shaogui Zhang, Qiuling Li, Yuan Zhu, Ruizhao Li, Xinling Liang, Xiaoyan Bai and Wenjian Wang
doi : 10.1186/s12882-021-02492-x
BMC Nephrology 2021 22:281
The significance of renal arteriosclerosis in the prediction of the renal outcomes of diabetic kidney disease (DKD) remains undetermined.
Commentary on the NICE guideline on renal replacement therapy and conservative management
Kunaal Kharbanda, Osasuyi Iyasere, Fergus Caskey, Matko Marlais and Sandip Mitra
doi : 10.1186/s12882-021-02461-4
BMC Nephrology 2021 22:282
NICE Guideline NG107, “Renal replacement therapy and conservative management” (Renal replacement therapy and conservative management (NG107); 2018:1–33) was published in October 2018 and replaced the existing NICE guideline CG125, “Chronic Kidney Disease (Stage 5): peritoneal dialysis” (Chronic kidney disease (stage 5): peritoneal dialysis | Guidance | NICE; 2011) and NICE Technology Appraisal TA48, “Guidance on home compared with hospital haemodialysis for patients with end-stage renal failure”(Guidance on home compared with hospital haemodialysis for patients with end-stage renal failure (Technology appraisal guideline TA48); 2002) The aim of the NICE guideline (NG107) was to provide guidance on renal replacement therapy (RRT), including dialysis, transplant and conservative care, for adults and children with CKD Stages 4 and 5. The guideline is extremely welcomed by the Renal Association and it offers huge value to patients, clinicians, commissioners and key stakeholders. It overlaps and enhances current guidance published by the Renal Association including “Haemodialysis” (Clinical practice guideline: Haemodialysis; 2019) which was updated in 2019 after the publication of the NICE guideline, “Peritoneal Dialysis in Adults and Children” (Clinical practice guideline: peritoneal Dialysis in adults and children; 2017) and “Planning, Initiation & withdrawal of Renal Replacement Therapy” (Clinical practice guideline: planning, initiation and withdrawal of renal replacement therapy; 2014) (at present there are no plans to update this guideline).
Effect of far infrared therapy on arteriovenous fistula maturation, survival and stenosis in hemodialysis patients, a randomized, controlled clinical trial: the FAITH on fistula trial
K. Lindhard, M. Rix, J. G. Heaf, H. P. Hansen, B. L. Pedersen, B. L. Jensen and D. Hansen
doi : 10.1186/s12882-021-02476-x
BMC Nephrology 2021 22:283
An arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis treatment. After creation many of the AVFs will never mature or if functioning will need an intervention within 1 year due to an AVF stenosis. Studies investigating possible therapies that improves the AVF maturation and survival are scarce. Far infrared therapy (FIR) has shown promising results. In minor single centre and industry supported trials FIR has shown improved AVF maturation and survival. There is a need of a randomized multicentre controlled trial to examine the effect of FIR on the AVF maturation and survival and to explore the possible AVF protective mechanism induced by the FIR treatment.
Uptake of evidence by physicians: De-adoption of erythropoiesis-stimulating agents after the TREAT trial
Khoa Vu, Jiani Zhou, Alexander Everhart, Nihar Desai, Jeph Herrin, Anupam B. Jena, Joseph S. Ross, Nilay D. Shah and Pinar Karaca-Mandic
doi : 10.1186/s12882-021-02491-y
BMC Nephrology 2021 22:284
Variation in de-adoption of ineffective or unsafe treatments is not well-understood. We examined de-adoption of erythropoiesis-stimulating agents (ESA) in anemia treatment among patients with chronic kidney disease (CKD) following new clinical evidence of harm and ineffectiveness (the TREAT trial) and the FDA’s revision of its safety warning.
A potential pathogenic role of interleukin-6 in a child with ANCA-negative pauci-immune crescentic glomerulonephritis: case report and literature review
Ling Hou, Lu Yin, Yubin Wu, Chengguang Zhao and Yue Du
doi : 10.1186/s12882-021-02504-w
BMC Nephrology 2021 22:285
Crescentic glomerulonephritis is a disease characterized by severe glomerular injuries that is classified into five different pathological types. Patients with type V disease have pauci-immune crescentic glomerulonephritis (PICGN) that is negative for anti-neutrophil cytoplasmic autoantibodies (ANCAs). There are limited clinical data on the manifestations, treatment, and prognosis of type V crescentic glomerulonephritis, especially in children.
Correction to: Severe restless legs syndrome in a family with Alport syndrome
Davide Sparasci, Andrea Rossinelli, Raffaele Ferri, Pietro Cippà, Andrea Rinaldi and Mauro Manconi
doi : 10.1186/s12882-021-02501-z
BMC Nephrology 2021 22:286
Overexpression of SGLT2 in the kidney of a P. gingivalis LPS-induced diabetic nephropathy mouse model
Koichiro Kajiwara and Yoshihiko Sawa
doi : 10.1186/s12882-021-02506-8
BMC Nephrology 2021 22:287
The overexpression of sodium-glucose cotransporter 2 (SGLT2) in diabetic kidneys has been reported. It has also been established that the diabetic glomerular endothelium expresses the toll-like receptors TLR2 and TLR4. The present study aims to examine the renal SGLT2 induction by the TLR2/4 ligand Porphyromonas (P.) gingivalis lipopolysaccharide (Pg-LPS) in mouse diabetic nephropathy.
Long non-coding RNA TUG1 knockdown promotes autophagy and improves acute renal injury in ischemia-reperfusion-treated rats by binding to microRNA-29 to silence PTEN
Zhiquan Xu, Xiaoyan Huang, Qiuyu Lin and Wei Xiang
doi : 10.1186/s12882-021-02473-0
BMC Nephrology 2021 22:288
Long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is increased under the condition of ischemia. This study intended to identify the mechanism of TUG1 in renal ischemia-reperfusion (I/R).
Risk factors, clinical features and outcome of new-onset acute kidney injury among critically ill patients: a database analysis based on prospective cohort study
Yi-Jia Jiang, Xiu-Ming Xi, Hui-Miao Jia, Xi Zheng, Mei-Ping Wang, Wen Li and Wen-Xiong Li
doi : 10.1186/s12882-021-02503-x
BMC Nephrology 2021 22:289
Acute kidney injury (AKI) newly-emerged in intensive care unit (ICU), has not been thoroughly studied in previous researches, is likely to differ from AKI developed before ICU admission. This study aimed to evaluate the incidence, risk factors, clinical features and outcome of new-onset AKI in critically ill patients.
Assessment of the correlation of commonly used laboratory tests with clinical activity, renal involvement and treatment of systemic small-vessel vasculitis with the presence of ANCA antibodies
Magdalena Mosakowska, Dorota Brodowska Kania, Katarzyna Szamotulska, Aleksandra Rymarz and Stanis?aw Niemczyk
doi : 10.1186/s12882-021-02495-8
BMC Nephrology 2021 22:290
The aim of the study was to assess the correlation of commonly used laboratory tests with clinical activity, degree of kidney involvement and treatment of systemic small-vessel vasculitis with the presence of ANCA antibodies.
Kidney biopsy practice amongst Australasian nephrologists
J. P Burke, T Pham, S May, S Okano, S. K Ratanjee, Z Thet, J. K.W Wong, S Venuthurupalli and D Ranganathan
doi : 10.1186/s12882-021-02505-9
BMC Nephrology 2021 22:291
Percutaneous kidney biopsy is the gold standard investigation for the diagnosis of kidney diseases. The associated risks of the procedure depend on the skill and experience of the proceduralist as well as the characteristics of the patient. The Kidney Health Australia – Caring for Australasians with Renal Impairment (KHA-CARI) guidelines on kidney biopsies, published in 2019, are the only published national kidney biopsy guidelines. As such, this study surveys current kidney biopsy practices in Australasia and examines how they align with the Australian guidelines, as well as international biopsy practice.
The weak correlation between serum vitamin levels and chronic kidney disease in hospitalized patients: a cross-sectional study
Yong Wang, Ying Zheng, Pu Chen, Shuang Liang, Pengfei He, Xiaolei Shao, Guangyan Cai and Xiangmei Chen
doi : 10.1186/s12882-021-02498-5
BMC Nephrology 2021 22:292
Chronic kidney disease (CKD) has become a global public health problem. Accumulating evidence suggested that vitamins play important roles in the progression of CKD.
Early identification of acute kidney injury in the ICU with real-time urine output monitoring: a clinical investigation
Dafna Willner, Aliza Goldman, Hagar Azran, Tal Stern, Dvora Kirshenbom and Guy Rosenthal
doi : 10.1186/s12882-021-02485-w
BMC Nephrology 2021 22:293
KDIGO (Kidney Disease: Improving Global Outcomes) provides two sets of criteria to identify and classify acute kidney injury (AKI): serum creatinine (SCr) and urine output (UO). Inconsistencies in the application of KDIGO UO criteria, as well as collecting and classifying UO data, have prevented an accurate assessment of the role this easily available biomarker can play in the early identification of AKI.
Acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody following cimetidine treatment: a case report
Keita Morimoto, Go Kanzaki, Takahito Niikura, Kentaro Koike, Nanae Matsuo, Yukio Maruyama, Nobuo Tsuboi and Takashi Yokoo
doi : 10.1186/s12882-021-02502-y
BMC Nephrology 2021 22:294
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis usually induces rapidly progressive glomerulonephritis, including pauci-immune necrotizing crescentic glomerulonephritis. Acute tubulointerstitial nephritis (ATIN), which is often drug-induced, is a frequent cause of kidney injury. However, ATIN associated with ANCA without any glomerular lesions has been rarely reported, and drug-induced ATIN associated with ANCA is not well recognized. Here we present a case of an older woman with ATIN associated with myeloperoxidase-ANCA (MPO-ANCA) following cimetidine treatment.
Contradiction between genetic analysis and diuretic loading test in type I Bartter syndrome: a case report
Jumpei Kuroda, Ryoko Harada, Riku Hamada, Yusuke Okuda, Yasuhiro Yoshida, Hiroshi Hataya, Kandai Nozu, Kazumoto Iijima, Masataka Honda and Kenji Ishikura
doi : 10.1186/s12882-021-02497-6
BMC Nephrology 2021 22:295
In typical cases of Bartter syndrome (BS), assessing response to diuretics (furosemide and thiazide), hereinafter referred to as diuretic loading test, may be used to diagnose the type by detecting which part of the kidney tubule is not functioning correctly. However, the diuretic loading test may not always agree with the results of genetic analyses.
Associations of CKD risk factors and longitudinal changes in urine biomarkers of kidney tubules among women living with HIV
Anthony N. Muiru, Rebecca Scherzer, Simon B. Ascher, Vasantha Jotwani, Carl Grunfeld, Judy Shigenaga, Kimberly A. Spaulding, Derek K. Ng, Deborah Gustafson, Amanda B. Spence, Anjali Sharma, Mardge H. Cohen, Chirag R. Parikh, Joachim H. Ix, Michelle M. Estrella and Michael G. Shlipak
doi : 10.1186/s12882-021-02508-6
BMC Nephrology 2021 22:296
Novel urine biomarkers have enabled the characterization of kidney tubular dysfunction and injury among persons living with HIV, a population at an increased risk of kidney disease. Even though several urine biomarkers predict progressive kidney function decline, antiretroviral toxicity, and mortality in the setting of HIV infection, the relationships among the risk factors for chronic kidney disease (CKD) and urine biomarkers are unclear.
Negative effects of iodine-based contrast agent on renal function in patients with moderate reduced renal function hospitalized for COVID-19
Anna Kistner, Chen Tamm, Ann Mari Svensson, Mats O. Beckman, Fredrik Strand, Magnus Sk?ld and Sven Nyrén
doi : 10.1186/s12882-021-02469-w
BMC Nephrology 2021 22:297
Kidney disease and renal failure are associated with hospital deaths in patients with COVID ??19. We aimed to test if contrast enhancement affects short-term renal function in hospitalized COVID ??19 patients.
