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Enrichment and characterization of extracellular vesicles from ex vivo one-sided human placenta perfusion
Rachel R. Zabel,Christin B?r,Jinlu Ji,Rowena Schultz,Martin Hammer,Tanja Groten,Ekkehard Schleussner,Diana M. Morales-Prieto,Udo R. Markert,Rodolfo R. Favaro
doi : 10.1111/aji.13377
Volume 86, Issue 2 e13377
Extracellular vesicles (EVs) released by the placenta are packed with biological information and play a major role in fetomaternal communication. Here, we describe a comprehensive set-up for the enrichment and characterization of EVs from human placenta perfusion and their application in further assays.
Decidual-derived RANKL facilitates macrophages accumulation and residence at the maternal-fetal interface in human early pregnancy
Hai-Qiong Liao,Mu-Tian Han,Wei Cheng,Ce Zhang,Hong Li,Ming-Qing Li,Rui Zhu
doi : 10.1111/aji.13406
Volume 86, Issue 2 e13406
During the first trimester, the accumulation of macrophages, which is the second largest decidual leukocyte population (~20%) at the maternal-fetal interface, is quite vital for a successful pregnancy, including embryo implantation, trophoblast invasion, and vascular remodeling. The mechanism of the enrichment and redistribution of macrophages in the uterine decidua of early pregnancy is largely unclear.
Association of circulating monocyte chemoattractant protein-1 levels with polycystic ovary syndrome: A meta-analysis
Ze Wu,Lanlan Fang,Yuxi Li,Yang Yan,Avinash Thakur,Jung-Chien Cheng,Ying-Pu Sun
doi : 10.1111/aji.13407
Volume 86, Issue 2 e13407
Polycystic ovary syndrome (PCOS) is a common hormonal disorder that has a huge impact on the human infertility. Increased levels of various circulating inflammatory cytokines have been observed in PCOS patients, which can contribute to the pathogenesis of PCOS. Monocyte chemoattractant protein-1 (MCP-1), a secretory chemokine, is a potent chemotactic factor that recruits monocytes/macrophages to inflammatory foci. Several previous studies comparing the circulating MCP-1 levels between non-PCOS and PCOS patients have yielded contradictory results. Therefore, the aim of this meta-analysis was to investigate whether circulating MCP-1 levels vary between non-PCOS and PCOS patients.
miR-27b-5p inhibits BeWo cells fusion by regulating WNT2B and enzyme involved in progesterone synthesis
Sonam Verma,Richa Mishra,Ankita Malik,Piyush Chaudhary,Sudha Saryu Malhotra,Amulya K. Panda,Satish Kumar Gupta
doi : 10.1111/aji.13409
Volume 86, Issue 2 e13409
The miRNAs show placenta-specific expression patterns, which alter during pregnancy-related complications. In present study, the role of miR-27b-5p during forskolin-mediated BeWo cells fusion has been investigated.
Chronic endometritis in women with suspected retained products of conception and their reproductive outcomes
Simone Elder,Pietro Bortoletto,Phillip A. Romanski,Steven Spandorfer
doi : 10.1111/aji.13410
Volume 86, Issue 2 e13410
To determine whether women who underwent operative hysteroscopy for suspected retained products of conception (rPOC) have histopathologic evidence of chronic endometritis (CE).
Genital and systemic immune effects of the injectable, contraceptive norethisterone enanthate (NET-EN), in South African women
Refilwe P. Molatlhegi,Samkelisiwe Ngcobo,Lenine J. P. Liebenberg,Sinaye Ngcapu,Amanda Mabhula,Alasdair Leslie,Nobuhle Mchunu,Mthobisi M. Zondi,John H. Adamson,Katya Govender,Natasha Samsunder,Salim S. Abdool Karim,Quarraisha Abdool Karim,Jo-Ann S. Passmore,Aida Sivro,Lyle R. McKinnon
doi : 10.1111/aji.13411
Volume 86, Issue 2 e13411
Injectable hormonal contraceptives (IHC) have been associated with altered mucosal and systemic milieu which might increase HIV risk, but most studies have focused on DMPA and not NET-EN, despite the growing popularity and lower HIV risk associated with the latter in observational studies.
Impact of the menstrual cycle and ethinyl estradiol/etonogestrel contraceptive vaginal ring on granulysin and other mucosal immune mediators
Sean M. Hughes,Urvashi Pandey,Christine Johnston,Jeanne Marrazzo,Florian Hladik,Elizabeth Micks
doi : 10.1111/aji.13412
Volume 86, Issue 2 e13412
Changes in sex hormones during the menstrual cycle and contraceptive vaginal ring (CVR) use influence immunity within the female genital tract, but the magnitude of these effects and their anatomical location are unclear.
Prolactin modifies the in vitro LPS-induced chemotactic capabilities in human fetal membranes at the term of gestation
Estefan?a N??ez-S?nchez,Mar?a Del Pilar Flores-Espinosa,Ismael Mancilla-Herrera,Leticia Gonz?lez,José Cisneros,Andrea Olmos-Ortiz,Braulio Quesada-Reyna,Martha Granados-Cepeda,Veronica Zaga-Clavellina
doi : 10.1111/aji.13413
Volume 86, Issue 2 e13413
Immune responses of fetal membranes involve the production of chemoattractant mediators causing infiltration of maternal and fetal leukocytes, intrauterine inflammation and potentially the disruption of maternal-fetal tolerance. Prolactin (PRL) has deep immunoregulatory effects in the fetal-maternal interface. We aimed to test the in vitro PRL effect upon chemotactic capacities of human fetal membranes.
Serum markers of B-cell activation in pregnant women with atopic asthma
Catarina Martins,Jorge Lima,Geraldine Cambridge,Miguel ?ngelo-Dias,Maria Leandro,Lu?s Miguel Borrego
doi : 10.1111/aji.13414
Volume 86, Issue 2 e13414
As maternal atopy represents a risk factor for the development of atopy in offspring, we aimed to assess how pregnancy affects B-cell activation markers in women with atopic asthma and whether they correlate with risk manifestations for allergy in newborns from mothers with atopic asthma.
Evaluation of paternal lymphocyte immunotherapy and potential biomarker mixed lymphocyte reaction-blocking factor in an Argentinian cohort of women with unexplained recurrent spontaneous abortion and unexplained infertility
Leonardo Fainboim,Santiago Belén,Ver?nica Gonz?lez,Pablo Fern?ndez
doi : 10.1111/aji.13422
Volume 86, Issue 2 e13422
Analyze the effect of paternal immunotherapy treatment (PIT) in primary and secondary unexplained recurrent spontaneous abortion (URSA) and unexplained infertility (UI).
Granulocyte-macrophage colony-stimulating factor initiates amniotic membrane rupture and preterm birth in a mouse model
Christopher Nold,Kristyn Esteves,Todd Jensen,Anthony T. Vella
doi : 10.1111/aji.13424
Volume 86, Issue 2 e13424
Preterm premature rupture of membranes is associated with 30% of all preterm births. The weakening of amniotic membranes is associated with an increase in matrix metallopeptidases (MMPs) along with a decrease in their inhibitors, tissue inhibitor metallopeptidases (TIMPs). Additionally, granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to weaken fetal membranes in-vitro. We hypothesize pregnant mice treated with GM-CSF lead to increased MMPs:TIMPs resulting in membrane rupture and preterm birth.
Unexplained recurrent miscarriages: predictive value of immune biomarkers and immunomodulatory therapies for live birth
Kamila Kolanska,Yohann Dabi,Agnès Dechartres,Jonathan Cohen,Yasmine Ben Kraiem,Lise Selleret,Emmanuelle Mathieu d’Argent,Leo Placais,Meryem Cheloufi,Catherine Johanet,Audrey Rosefort,Marie Bornes,Ludovic Suner,Francois Delhommeau,Nathalie Ledée,Nathalie Chabbert Buffet,Emile Darai,Jean Marie Antoine,Olivier Fain,Gilles Kayem,Arsène Mekinian
doi : 10.1111/aji.13425
Volume 86, Issue 2 e13425
Recurrent miscarriages are defined as three or more early miscarriages before 12 weeks of gestation. The aim of this study was to describe a cohort of women with unexplained recurrent miscarriages, evaluate several potential biomarkers of immune origin, and describe the outcome of pregnancies under immunomodulatory therapies.
Functional NK surrogate biomarkers for inflammatory recurrent pregnancy loss and recurrent implantation failure
Alejandra Comins-Boo,Ignacio Crist?bal,Miguel Fern?ndez-Arquero,Edgard Rodr?guez de Fr?as,Marta Calvo Urrutia,Lydia Pilar Su?rez,Pilar Gasca Escorial,Miguel ?ngel Herr?iz,Silvia S?nchez-Ram?n
doi : 10.1111/aji.13426
Volume 86, Issue 2 e13426
Expansion of circulating NK cells has been related to pregnancy complications. This study aims at investigating several surface NK cell markers to identify a baseline inflammatory profile in women with recurrent pregnancy loss (iRPL) and recurrent implantation failure (iRIF).
Uterine natural killer cells and recurrent spontaneous abortion
Yao-Yao Fu,Chun-E. Ren,Peng-Yun Qiao,Yu-Han Meng
doi : 10.1111/aji.13433
Volume 86, Issue 2 e13433
Recurrent spontaneous abortion (RSA), termed as two or more consecutive pregnancy loss is a great problem for some women of childbearing age. A large number of evidence confirm that there may be an immune background of RSA. As a member of the innate immune system, uterine natural killer (uNK) cells account for about 70% of total lymphocytes during pregnancy and play a critical role in the establishment and maintenance of pregnancy. This review mainly introduces the phenotype, origin, receptor, and function of uNK cells to illuminate its relationship with RSA.
