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California v. Texas — Ending the Campaign to Undo the ACA in the Courts
Nicholas Bagley, J.D.
doi : 10.1056/nejmp2110516
N Engl J Med 2021; 385:673-675
Medicare Physician Payment Reform — Enhancing Incentives for Value-Based Care
Robert Mechanic, M.B.A., and Andrew Perlman, M.P.H.
doi : 10.1056/nejmp2106852
N Engl J Med 2021; 385:675-677
The Covid-19 Infodemic — Applying the Epidemiologic Model to Counter Misinformation
David Scales, M.D., Ph.D., Jack Gorman, M.D., and Kathleen H. Jamieson, Ph.D.
doi : 10.1056/nejmp2103798
N Engl J Med 2021; 385:678-681
Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma
Toni K. Choueiri, M.D., Piotr Tomczak, M.D., Ph.D., Se Hoon Park, M.D., Balaji Venugopal, M.D., Thomas Ferguson, M.D., Yen-Hwa Chang, M.D., Ph.D., Jaroslav Hajek, M.U.Dr., Stefan N. Symeonides, M.D., Ph.D., Jae Lyun Lee, M.D., Ph.D., Naveed Sarwar, M.D., Ph.D., Antoine Thiery-Vuillemin, M.D., Ph.D., Marine Gross-Goupil, M.D., Ph.D., Mauricio Mahave, M.D., Naomi B. Haas, M.D., Piotr Sawrycki, M.D., Howard Gurney, M.B., B.S., Christine Chevreau, M.D., Bohuslav Melichar, M.D., Ph.D., Evgeniy Kopyltsov, M.D., Ajjai Alva, M.D., John M. Burke, M.D., Gurjyot Doshi, M.D., Delphine Topart, M.D., Stephane Oudard, M.D., Ph.D., Hans Hammers, M.D., Ph.D., Hiroshi Kitamura, M.D., Ph.D., Jens Bedke, M.D., Rodolfo F. Perini, M.D., Pingye Zhang, Ph.D., Kentaro Imai, M.D., Jaqueline Willemann-Rogerio, M.D., David I. Quinn, M.D., Ph.D., and Thomas Powles, M.D. for the KEYNOTE-564 Investigators*
doi : 10.1056/nejmoa2106391
N Engl J Med 2021; 385:683-694
Patients with renal-cell carcinoma who undergo nephrectomy have no options for adjuvant therapy to reduce the risk of recurrence that have high levels of supporting evidence.
Atogepant for the Preventive Treatment of Migraine
Jessica Ailani, M.D., Richard B. Lipton, M.D., Peter J. Goadsby, M.D., Hua Guo, Ph.D., Rosa Miceli, B.S.N., Lawrence Severt, M.D., Michelle Finnegan, M.P.H., and Joel M. Trugman, M.D. for the ADVANCE Study Group*
doi : 10.1056/nejmoa2035908
N Engl J Med 2021; 385:695-706
Atogepant is an oral, small-molecule, calcitonin gene–related peptide receptor antagonist that is being investigated for the preventive treatment of migraine.
Variant PNLDC1, Defective piRNA Processing, and Azoospermia
Liina Nagirnaja, Ph.D., Nina M?rup, Ph.D., John E. Nielsen, M.Sc., Rytis Stakaitis, M.Sc., Ieva Golubickaite, M.Sc., Manon S. Oud, Ph.D., Sofia B. Winge, Ph.D., Filipa Carvalho, Ph.D., Kenneth I. Aston, Ph.D., Francesca Khani, M.D., Godfried W. van der Heijden, Ph.D., C. Joana Marques, Ph.D., Niels E. Skakkebaek, M.D., D.M.Sc., Ewa Rajpert–De Meyts, M.D., Ph.D., Peter N. Schlegel, M.D., Niels J?rgensen, M.D., Ph.D., Joris A. Veltman, Ph.D., Alexandra M. Lopes, Ph.D., Donald F. Conrad, Ph.D., and Kristian Almstrup, Ph.D.
doi : 10.1056/nejmoa2028973
N Engl J Med 2021; 385:707-719
P-element–induced wimpy testis (PIWI)–interacting RNAs (piRNAs) are short (21 to 35 nucleotides in length) and noncoding and are found almost exclusively in germ cells, where they regulate aberrant expression of transposable elements and postmeiotic gene expression. Critical to the processing of piRNAs is the protein poly(A)-specific RNase-like domain containing 1 (PNLDC1), which trims their 3? ends and, when disrupted in mice, causes azoospermia and male infertility.
Adjunct Immune Globulin for Vaccine-Induced Immune Thrombotic Thrombocytopenia
Alex Bourguignon, M.D., Donald M. Arnold, M.D., Theodore E. Warkentin, M.D., James W. Smith, B.Sc., Tania Pannu, M.D., Jeffrey M. Shrum, M.D., Zainab A.A. Al Maqrashi, M.D., Anjali Shroff, M.D., Marie-Claude Lessard, M.D., Normand Blais, M.D., John G. Kelton, M.D., and Ishac Nazy, Ph.D.
doi : 10.1056/nejmoa2107051
N Engl J Med 2021; 385:720-728
Long-Term Survival after Kidney Transplantation
Sundaram Hariharan, M.D., Ajay K. Israni, M.D., and Gabriel Danovitch, M.D.
doi : 10.1056/nejmra2014530
N Engl J Med 2021; 385:729-743
Mobility Assessment in Older Adults
Kirstyn James, M.D., Andrea Wershof Schwartz, M.D., M.P.H., and Ariela R. Orkaby, M.D., M.P.H.
doi : 10.1056/nejmvcm2009406
N Engl J Med 2021; 385:e22
Intussusception in the Peutz–Jeghers Syndrome
Khalid Akbari, B.M., and Bruno Sgromo, M.D.
doi : 10.1056/nejmicm2013175
N Engl J Med 2021; 385:744
Malignant Peripheral Nerve-Sheath Tumor
Michael H. Berger, M.D., and Yarah M. Haidar, M.D.
doi : 10.1056/nejmicm2033082
N Engl J Med 2021; 385:e23
Case 25-2021: A 48-Year-Old Man with Fatigue and Leg Swelling
Amber B. Moore, M.D., M.P.H., Jonathan R. Wing, M.D., Reece J. Goiffon, M.D., Ph.D., Rebecca K. Leaf, M.D., Lana Tsao, M.D., and Joseph Misdraji, M.D.
doi : 10.1056/nejmcpc2100282
N Engl J Med 2021; 385:745-754
The Promise of Adjuvant Immunotherapy in Renal-Cell Carcinoma
Rana R. McKay, M.D.
doi : 10.1056/nejme2109354
N Engl J Med 2021; 385:756-758
Audio Interview: Aspects of Covid-19 Immunity
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/nejme2113747
N Engl J Med 2021; 385:e31
Effect of Vaccination on Household Transmission of SARS-CoV-2 in England
doi : 10.1056/nejmc2107717
N Engl J Med 2021; 385:759-760
Lorlatinib in a Child with ALK-Fusion–Positive High-Grade Glioma
doi : 10.1056/nejmc2101264
N Engl J Med 2021; 385:761-763
Hypothermic Machine Perfusion in Liver Transplantation
doi : 10.1056/nejmc2108879
N Engl J Med 2021; 385:766-768
