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Confronting Our Next National Health Disaster — Long-Haul Covid
Steven Phillips, M.D., M.P.H., and Michelle A. Williams, Sc.D.
doi : 10.1056/nejmp2109285
N Engl J Med 2021; 385:577-579
Criminalization of Gender-Affirming Care — Interfering with Essential Treatment for Transgender Children and Adolescents
Simona Martin, B.S., Elizabeth S. Sandberg, M.D., and Daniel E. Shumer, M.D., M.P.H.
doi : 10.1056/nejmp2106314
N Engl J Med 2021; 385:579-581
When Low Tech Wins
Jacqueline Baras Shreibati, M.D.
doi : 10.1056/nejmp2104234
N Engl J Med 2021; 385:581-583
Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
Jamie Lopez Bernal, F.F.P.H., Ph.D., Nick Andrews, Ph.D., Charlotte Gower, D.Phil., Eileen Gallagher, Ph.D., Ruth Simmons, Ph.D., Simon Thelwall, Ph.D., Julia Stowe, Ph.D., Elise Tessier, M.Sc., Natalie Groves, M.Sc., Gavin Dabrera, M.B., B.S., F.F.P.H., Richard Myers, Ph.D., Colin N.J. Campbell, M.P.H., F.F.P.H., Gayatri Amirthalingam, M.F.P.H., Matt Edmunds, M.Sc., Maria Zambon, Ph.D., F.R.C.Path., Kevin E. Brown, M.R.C.P., F.R.C.Path., Susan Hopkins, F.R.C.P., F.F.P.H., Meera Chand, M.R.C.P., F.R.C.Path., and Mary Ramsay, M.B., B.S., F.F.P.H.
doi : 10.1056/nejmoa2108891
N Engl J Med 2021; 385:585-594
The B.1.617.2 (delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), has contributed to a surge in cases in India and has now been detected across the globe, including a notable increase in cases in the United Kingdom. The effectiveness of the BNT162b2 and ChAdOx1 nCoV-19 vaccines against this variant has been unclear.
Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women
Raphael J. Landovitz, M.D., Deborah Donnell, Ph.D., Meredith E. Clement, M.D., Brett Hanscom, Ph.D., Leslie Cottle, B.A., Lara Coelho, M.D., Robinson Cabello, M.D., Suwat Chariyalertsak, M.D., Dr.P.H., Eileen F. Dunne, M.D., M.P.H., Ian Frank, M.D., Jorge A. Gallardo-Cartagena, M.D., Aditya H. Gaur, M.D., Pedro Gonzales, M.D., Ha V. Tran, M.D., Juan C. Hinojosa, M.D., Esper G. Kallas, M.D., Ph.D., Colleen F. Kelley, M.D., M.P.H., Marcelo H. Losso, M.D., J. Valdez Madruga, M.D., Keren Middelkoop, M.B., Ch.B., Ph.D., M.P.H., Nittaya Phanuphak, M.D., Ph.D., Breno Santos, M.D., Omar Sued, M.D., Ph.D., Javier Valencia Huaman?, M.D., Edgar T. Overton, M.D., Shobha Swaminathan, M.D., Carlos del Rio, M.D., Roy M. Gulick, M.D., M.P.H., Paul Richardson, M.S., Philip Sullivan, M.P.H., Estelle Piwowar-Manning, B.S., Mark Marzinke, Ph.D., Craig Hendrix, M.D., Maoji Li, M.S., Zhe Wang, M.S., Jeanne Marrazzo, M.D., M.P.H., Eric Daar, M.D., Aida Asmelash, M.D., M.P.H., Todd T. Brown, M.D., Ph.D., Peter Anderson, Pharm.D., Susan H. Eshleman, M.D., Ph.D., Marcus Bryan, Ph.D., Cheryl Blanchette, M.S., Jonathan Lucas, M.P.H., Christina Psaros, Ph.D., Steven Safren, Ph.D., Jeremy Sugarman, M.D., M.P.H., Hyman Scott, M.D., M.P.H., Joseph J. Eron, M.D., Sheldon D. Fields, Ph.D., Nirupama D. Sista, Ph.D., Kailazarid Gomez-Feliciano, M.P.M., Andrea Jennings, B.A., Ryan M. Kofron, M.S., Timothy H. Holtz, M.D., Ph.D., Katherine Shin, Pharm.D., James F. Rooney, M.D., Kimberly Y. Smith, M.D., William Spreen, Pharm.D., David Margolis, M.D., M.P.H., Alex Rinehart, Ph.D., Adeola Adeyeye, M.D., Myron S. Cohen, M.D., Marybeth McCauley, M.P.H., and Beatriz Grinsztejn, M.D., Ph.D. for the HPTN 083 Study Team*
doi : 10.1056/nejmoa2101016
N Engl J Med 2021; 385:595-608
Safe and effective long-acting injectable agents for preexposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection are needed to increase the options for preventing HIV infection.
Abelacimab for Prevention of Venous Thromboembolism
Peter Verhamme, M.D., B. Alexander Yi, M.D., Ph.D., Annelise Segers, M.D., Janeen Salter, B.S.N., Daniel Bloomfield, M.D., Harry R. Büller, M.D., Gary E. Raskob, Ph.D., and Jeffrey I. Weitz, M.D. for the ANT-005 TKA Investigators*
doi : 10.1056/nejmoa2105872
N Engl J Med 2021; 385:609-617
The role of factor XI in the pathogenesis of postoperative venous thromboembolism is uncertain. Abelacimab is a monoclonal antibody that binds to factor XI and locks it in the zymogen (inactive precursor) conformation.
Year 1 of the Bundled Payments for Care Improvement–Advanced Model
Karen E. Joynt Maddox, M.D., M.P.H., E. John Orav, Ph.D., Jie Zheng, Ph.D., and Arnold M. Epstein, M.D.
doi : 10.1056/nejmsa2033678
N Engl J Med 2021; 385:618-627
Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs
Georg Schett, M.D., Iain B. McInnes, M.D., Ph.D., and Markus F. Neurath, M.D.
doi : 10.1056/nejmra1909094
N Engl J Med 2021; 385:628-639
Copper Deficiency
Carmelo Gurnari, M.D., and Heesun J. Rogers, M.D., Ph.D.
doi : 10.1056/nejmicm2103532
N Engl J Med 2021; 385:640
Myiasis from Larvae of Human Botfly
Genevieve Kaunitz, M.D., and Miriam Keltz Pomeranz, M.D.
doi : 10.1056/nejmicm2101473
N Engl J Med 2021; 385:e20
Case 24-2021: A 63-Year-Old Woman with Fever, Sore Throat, and Confusion
Robert H. Goldstein, M.D., Ph.D., William A. Mehan, M.D., Bailey Hutchison, M.D., and Gregory K. Robbins, M.D.
doi : 10.1056/nejmcpc2107345
N Engl J Med 2021; 385:641-648
Vaccine Effectiveness Studies in the Field
Stephen J.W. Evans, M.Sc., and Nicholas P. Jewell, Ph.D.
doi : 10.1056/nejme2110605
N Engl J Med 2021; 385:650-651
Enhancing HIV Prevention with Injectable Preexposure Prophylaxis
Quarraisha Abdool Karim, Ph.D.
doi : 10.1056/nejme2110665
N Engl J Med 2021; 385:652-653
Reviewers for the Journal, January–June 2021
Eric J. Rubin, M.D., Ph.D.
doi : 10.1056/nejme2111561
N Engl J Med 2021; 385:654
Audio Interview: Monoclonal Antibodies and Booster Shots
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/nejme2113398
N Engl J Med 2021; 385:e29
Imaging in Coronary Artery Disease Risk Stratification
Siri R. Kadire, M.D., James Udelson, M.D., and Matthew J. Budoff, M.D.
doi : 10.1056/nejmclde2104532
N Engl J Med 2021; 385:655-657
New Vistas for Cell-Surface GlycoRNAs
Sigrid Nachtergaele, Ph.D., and Yamuna Krishnan, Ph.D.
doi : 10.1056/nejmcibr2108679
N Engl J Med 2021; 385:658-660
Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients
doi : 10.1056/nejmc2108861
N Engl J Med 2021; 385:661-662
Delayed Large Local Reactions to mRNA Covid-19 Vaccines in Blacks, Indigenous Persons, and People of Color
doi : 10.1056/nejmc2108620
N Engl J Med 2021; 385:662-664
Infection and Vaccine-Induced Neutralizing-Antibody Responses to the SARS-CoV-2 B.1.617 Variants
doi : 10.1056/nejmc2107799
N Engl J Med 2021; 385:664-666
Glucose-Lowering Drugs to Reduce Cardiovascular Risk in Type 2 Diabetes
doi : 10.1056/nejmc2107340
N Engl J Med 2021; 385:669-672
Holding Open the Door for Others Like Me
Laer H. Streeter, M.D., M.P.H.
doi : 10.1056/nejmpv2111269
N Engl J Med 2021; 385:e27
