One-year access to more than 500 world journals available in the system
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From Crime to Care — On the Front Lines of Decarceration
Nathaniel P. Morris, M.D.
doi : 10.1056/NEJMp2107013
N Engl J Med 2021; 385:385-387
Health Care Budgets for Rural Providers — Opportunities for Payment Reform
Joseph T. Kannarkat, M.P.P., and Eric T. Roberts, Ph.D.
doi : 10.1056/NEJMp2103431
N Engl J Med 2021; 385:387-389
Identifying and Tracking SARS-CoV-2 Variants — A Challenge and an Opportunity
Scott J. Becker, M.S., Jill Taylor, Ph.D., and Joshua M. Sharfstein, M.D.
doi : 10.1056/NEJMp2103859
N Engl J Med 2021; 385:389-391
Duration of Adjuvant Aromatase-Inhibitor Therapy in Postmenopausal Breast Cancer
Michael Gnant, M.D., Florian Fitzal, M.D., Gabriel Rinnerthaler, M.D., Guenther G. Steger, M.D., Sigrun Greil-Ressler, M.D., Marija Balic, M.D., Dietmar Heck, M.D., Raimund Jakesz, M.D., Josef Thaler, M.D., Daniel Egle, M.D., Diether Manfreda, M.D., Vesna Bjelic-Radisic, M.D., Ursula Wieder, M.D., Christian F. Singer, M.D., Elisabeth Melbinger-Zeinitzer, M.D., Ferdinand Haslbauer, M.D., Paul Sevelda, M.D., Harald Trapl, M.D., Viktor Wette, M.D., Kerstin Wimmer, M.D., Simon P. Gampenrieder, M.D., Rupert Bartsch, M.D., Stephanie Kacerovsky-Strobl, M.D., Christoph Suppan, M.D., Christine Brunner, M.D., Christine Deutschmann, M.D., Lidija Soelkner, M.Sc., Christian Fesl, Ph.D., and Richard Greil, M.D. for the Austrian Breast and Colorectal Cancer Study Group*
doi : 10.1056/NEJMoa2104162
N Engl J Med 2021; 385:395-405
Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia
Patr?cia O. Guimar?es, M.D., Ph.D., Daniel Quirk, M.D., M.P.H., Remo H. Furtado, M.D., Ph.D., Lilia N. Maia, M.D., Ph.D., José F. Saraiva, M.D., Ph.D., Murillo O. Antunes, M.D., Ph.D., Roberto Kalil Filho, M.D., Ph.D., Vagner M. Junior, M.D., Alexandre M. Soeiro, M.D., Alexandre P. Tognon, M.D., Ph.D., Viviane C. Veiga, M.D., Ph.D., Priscilla A. Martins, M.D., et al., for the STOP-COVID Trial Investigators*
doi : 10.1056/NEJMoa2101643
N Engl J Med 2021; 385:406-415
The efficacy and safety of tofacitinib, a Janus kinase inhibitor, in patients who are hospitalized with coronavirus disease 2019 (Covid-19) pneumonia are unclear.
Long-Term Complications in Youth-Onset Type 2 Diabetes
TODAY Study Group
doi : 10.1056/NEJMoa2100165
N Engl J Med 2021; 385:416-426
The prevalence of type 2 diabetes in youth is increasing, but little is known regarding the occurrence of related complications as these youths transition to adulthood.
Risdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls
Basil T. Darras, M.D., Riccardo Masson, M.D., Maria Mazurkiewicz-Be?dzi?ska, M.D., Kristy Rose, Ph.D., Hui Xiong, M.D., Edmar Zanoteli, M.D., Giovanni Baranello, M.D., Ph.D., Claudio Bruno, M.D., Ph.D., Dmitry Vlodavets, M.D., Yi Wang, M.D., Ph.D., Muna El-Khairi, Ph.D., Marianne Gerber, Ph.D., et al., for the FIREFISH Working Group*
doi : 10.1056/NEJMoa2102047
N Engl J Med 2021; 385:427-435
Type 1 spinal muscular atrophy (SMA) is a progressive neuromuscular disease characterized by an onset at 6 months of age or younger, an inability to sit without support, and deficient levels of survival of motor neuron (SMN) protein. Risdiplam is an orally administered small molecule that modifies SMN2 pre–messenger RNA splicing and increases levels of functional SMN protein in blood.
A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection
Brenna L. Hughes, M.D., Rebecca G. Clifton, Ph.D., Dwight J. Rouse, M.D., George R. Saade, M.D., Mara J. Dinsmoor, M.D., M.P.H., Uma M. Reddy, M.D., Robert Pass, M.D., Donna Allard, R.N., Gail Mallett, R.N., Lida M. Fette, M.S., Cynthia Gyamfi-Bannerman, M.D., Michael W. Varner, M.D., William H. Goodnight, M.D., Alan T.N. Tita, M.D., Ph.D., Maged M. Costantine, M.D., Geeta K. Swamy, M.D., Ronald S. Gibbs, M.D., Edward K. Chien, M.D., Suneet P. Chauhan, M.D., Yasser Y. El-Sayed, M.D., Brian M. Casey, M.D., Samuel Parry, M.D., Hyagriv N. Simhan, M.D., Peter G. Napolitano, M.D., and George A. Macones, M.D. for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network*
doi : 10.1056/NEJMoa1913569
N Engl J Med 2021; 385:436-444
Primary cytomegalovirus (CMV) infection during pregnancy carries a risk of congenital infection and possible severe sequelae. There is no established intervention for preventing congenital CMV infection.
Depression in Adolescents
Leslie Miller, M.D., and John V. Campo, M.D.
doi : 10.1056/NEJMra2033475
N Engl J Med 2021; 385:445-449
Axillary Mass after Delivery
Cristiana Marinho-Soares, M.D., and Maria Pulido-Valente, M.D.
doi : 10.1056/NEJMicm2033023
N Engl J Med 2021; 385:450
An Icteric Tongue
David Avelar Rodriguez, M.D., and Julia Orkin, M.D.
doi : 10.1056/NEJMicm2034755
N Engl J Med 2021; 385:e16
Case 23-2021: A 41-Year-Old Woman with Bloody Stools and Thrombocytopenia
Olivia C. Smibert, M.B., B.S., Onofrio A. Catalano, M.D., Katayoon Goodarzi, M.D., and Matthew B. Roberts, M.B., B.S.
doi : 10.1056/NEJMcpc2103461
N Engl J Med 2021; 385:451-460
Extended Aromatase Inhibitors in Hormone-Receptor–Positive Breast Cancer
Pamela J. Goodwin, M.D.
doi : 10.1056/NEJMe2109356
N Engl J Med 2021; 385:462-463
JAK Inhibitors — More Than Just Glucocorticoids
Justin Stebbing, M.D., Ph.D., and Volker M. Lauschke, Ph.D.
doi : 10.1056/NEJMe2108667
N Engl J Med 2021; 385:463-465
Audio Interview: Looking Back and Looking Forward — Part 1
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2112684
N Engl J Med 2021; 385:e24
Anticoagulation after Ablation for Atrial Fibrillation
Siri R. Kadire, M.D., Sana M. Al-Khatib, M.D., M.H.S., and Hugh Calkins, M.D.
doi : 10.1056/NEJMclde2103770
N Engl J Med 2021; 385:466-468
To Scar or Not to Scar
Richard A.F. Clark, M.D.
doi : 10.1056/NEJMcibr2107204
N Engl J Med 2021; 385:469-471
BNT162b2-Elicited Neutralization against New SARS-CoV-2 Spike Variants
doi : 10.1056/NEJMc2106083
N Engl J Med 2021; 385:472-474
Incident SARS-CoV-2 Infection among mRNA-Vaccinated and Unvaccinated Nursing Home Residents
doi : 10.1056/NEJMc2104849
N Engl J Med 2021; 385:474-476
Insights into Glomerular Filtration and Albuminuria
doi : 10.1056/NEJMc2108129
N Engl J Med 2021; 385:477-478
Diversity of the National Medical Student Body
doi : 10.1056/NEJMc2109411
N Engl J Med 2021; 385:479-480
The Number Needed to Prescribe — What Would It Take to Expand Access to Buprenorphine?
doi : 10.1056/NEJMx210008
N Engl J Med 2021; 385:480
STEP 1 for Effective Weight Control — Another First Step?
doi : 10.1056/NEJMx210009
N Engl J Med 2021; 385:480
